1 0 0 0 小諸市誌

著者
小諸市誌編纂委員会 編纂
出版者
小諸市教育委員会
巻号頁・発行日
vol.歴史篇 3 近世史, 1991
著者
及川 伸二 山嶋 哲盛 小林 果
出版者
三重大学
雑誌
挑戦的研究(萌芽)
巻号頁・発行日
2018-06-29

アルツハイマー病の発症には多くの要因が関係すると考えられているが、近年脂質類のアルツハイマー病への関与を示す報告が多数なされている。脂質は、加熱などにより酸化され過酸化脂質を生じ、この過酸化脂質がさらに生体に酸化ストレスをもたらすことがよく知られている。本研究では、過酸化脂質などにより酸化ストレスを暴露したサルを用いて、細胞死誘導と酸化損傷タンパク質の変動について明らかにした。
著者
鈴木 悠介 永井 聖剛
出版者
日本認知科学会
雑誌
認知科学 (ISSN:13417924)
巻号頁・発行日
vol.27, no.3, pp.409-415, 2020-09-01 (Released:2020-09-15)
参考文献数
32

Previous studies have shown perceptual processing cross-modal correspondences between spatial high/low positions and auditory high/low pitches. Several studies also found that auditory pitch influences spatially defined motor responses, suggesting that perceptual and motoric information regarding spatial and auditory high/low stimuli are shared. However, it remains unclear whether spatial position influences auditorily defined motor responses. We addressed this question by examining vocal responses to high/low pitches. In our experiment, sixteen participants vocalized a meaningless sound (/a/) at high/low pitch in response to spatially high/low stimuli under compatible and incompatible conditions. Results showed that the onset of vocalization was shorter under the compatible condition than the incompatible conditions. Together with previous studies, the current results suggest that information regarding spatial high/low position and auditory high/low pitch are bidirectionally and consistently shared across perceptual and motor systems.
著者
河合 望
出版者
一般社団法人 日本オリエント学会
雑誌
オリエント (ISSN:00305219)
巻号頁・発行日
vol.51, no.2, pp.27-56, 2009-03-31 (Released:2014-03-30)

Scholars have discussed the individual roles of Ay and Horemheb, who were the most influential persons during Tutankhamun’s reign and its aftermath, as well as the relationship between them for ages. Did they work together cooperatively or did some form of competition or hostility exist between them? This article examines the interaction between Ay and Horemheb and their attitudes towards one another through a review of all the available evidence. The first part focuses on their relationship under Tutankhamun and the second with their interactions following Tutankhamun’s death. I demonstrate that they were the most prominent figures in different social groups, suggesting that Ay was the fatherly advisor of the king at the court, while Horemheb was the actual governor of all the administration in the country as the “Regent” and “Generalissimo” under Tutankhamun. By the end of Tutankhamun’s reign, however, Ay seems to have obtained the title “Vizier” and the epithets “doer of maat” and “the one who unites the hands of the god,” representing that he is now capable of governing the country. Ay was indeed on the verge of becoming the successor of Tutankhamun. Therefore, I do not agree with the recent suggestion that Horemheb was the designate successor of Tutankhamun while he was the regent of Tutankhamun. In the second part, I argue that there was strong antagonism between Ay and Horemheb after Tutankhamun’s death. The evidence indicates that Horemheb sought to discredit Ay as proper successor to the king. As a result, Ay appears to have excluded Horemheb from greater courtly influence by appointing Nakhtmin not only as his “Generalissimo” but also as “King’s son.” This squabbling even continued after Ay’s death as Horemheb, once ascended to the throne, soon endeavored to erase all memory of Ay, his men and even Queen Ankhesenamun in revenge.
著者
川島 春佳 木村 容子 伊藤 隆
出版者
一般社団法人 日本東洋医学会
雑誌
日本東洋医学雑誌 (ISSN:02874857)
巻号頁・発行日
vol.69, no.4, pp.359-365, 2018 (Released:2019-08-01)
参考文献数
21

アレルギー性鼻炎は,鼻粘膜のアレルギー性疾患であるが,様々な要因が増悪因子となる。今回,随証治療により用いた当帰芍薬散が奏功したアレルギー性鼻炎の4症例について報告する。症例1は31歳女性。冷え・月経不順に対して当帰芍薬散の内服を開始したところ,元々あった鼻炎症状が改善し,休薬により鼻炎症状が再燃した。症例2は40歳女性。子宮筋腫に対して内服していた桂枝茯苓丸加薏苡仁から当帰芍薬散に転方して,毎年認めていた花粉症状が軽快した。症例3は49歳女性。多種類の漢方薬を内服しても改善しなかった鼻炎症状が,当帰芍薬散に転方して速やかに消失した。症例4は65歳女性。葛根湯加川芎辛夷の内服後も残存した鼻炎症状に対し当帰芍薬散を併用して症状が改善した。古典では,当帰芍薬散の鼻炎に関する記載は見当たらないが,陰虚証で,水毒に加えて瘀血・血虚を認める鼻炎には,当帰芍薬散も鑑別処方の一つと考えられる。

1 0 0 0 民政

出版者
民政社
巻号頁・発行日
vol.3(金解禁號), no.11, 1929-11
著者
Keiko MAEKAWA Masaya ITODA Kimie SAI Yoshiro SAITO Nahoko KANIWA Kuniaki SHIRAO Tetsuya HAMAGUCHI Hideo KUNITOH Noboru YAMAMOTO Tomohide TAMURA Hironobu MINAMI Kaoru KUBOTA Atsushi OHTSU Teruhiko YOSHIDA Nagahiro SAIJO Naoyuki KAMATANI Shogo OZAWA Jun-ichi SAWADA
出版者
The Japanese Society for the Study of Xenobiotics
雑誌
Drug Metabolism and Pharmacokinetics (ISSN:13474367)
巻号頁・発行日
vol.21, no.2, pp.109-121, 2006 (Released:2006-05-10)
参考文献数
35
被引用文献数
36

The ATP-binding cassette transporter, ABCG2, which is expressed at high levels in the intestine and liver, functions as an efflux transporter for many drugs, including clinically used anticancer agents such as topotecan and the active metabolite of irinotecan (SN-38). In this study, to elucidate the linkage disequilibrium (LD) profiles and haplotype structures of ABCG2, we have comprehensively searched for genetic variations in the putative promoter region, all the exons, and their flanking introns of ABCG2 from 177 Japanese cancer patients treated with irinotecan. Forty-three genetic variations, including 11 novel ones, were found: 5 in the 5′-flanking region, 13 in the coding exons, and 25 in the introns. In addition to 9 previously reported nonsynonymous single nucleotide polymorphisms (SNPs), 2 novel nonsynonymous SNPs, 38C>T (Ser13Leu) and 1060G>A (Gly354Arg), were found with minor allele frequencies of 0.3%. Based on the LD profiles between the SNPs and the estimated past recombination events, the region analyzed was divided into three blocks (Block -1, 1, and 2), each of which spans at least 0.2 kb, 46 kb, and 13 kb and contains 2, 24, and 17 variations, respectively. The two, eight, and five common haplotypes detected in 10 or more patients accounted for most (>90%) of the haplotypes inferred in Block -1, Block 1, and Block 2, respectively. The SNP and haplotype distributions in Japanese were different from those reported previously in Caucasians. This study provides fundamental information for the pharmacogenetic studies investigating the relationship between the genetic variations in ABCG2 and pharmacokinetic/pharmacodynamic parameters.
著者
小松耕輔 等編
出版者
京文社
巻号頁・発行日
vol.第3巻, 1931
著者
相澤 杏莉 齋 綾乃 長井 幸美 堀井 旺歩 山田 佳奈 佐々木 誠
出版者
理学療法科学学会
雑誌
理学療法科学 (ISSN:13411667)
巻号頁・発行日
vol.37, no.1, pp.123-128, 2022 (Released:2022-02-20)
参考文献数
33

本稿の目的は,身体の柔らかさに着目し,その定義づけ,加齢変化,性差に言及し,スポーツ障害・外傷の発生に柔軟性と関節弛緩性がどう影響するかを示し,この発生の予防として行われているストレッチを中心とした介入の柔軟性向上に対する効果に言及することである.身体の柔らかさは,主に柔軟性と関節弛緩性で表現され,これらは加齢とともに低下し,関節弛緩性は女性の月経周期によって影響される.身体各部の柔軟性の低下は障害・外傷の発生頻度を高め,一方で関節弛緩性が高い場合には障害・外傷を起こしやすい.関節弛緩性を生じない範囲で柔軟性を向上させることは,スポーツに起因する怪我を予防するのに重要であり,いくつかのスポーツ種目について,障害・外傷を予防するための,主にストレッチの有意義性を提示した.

1 0 0 0 将棋月報

出版者
将棋月報社
巻号頁・発行日
no.225, 1941-10

1 0 0 0 東京パック

出版者
東京パック社
巻号頁・発行日
vol.9, no.32, 1913-11

1 0 0 0 OA 治水関係資料

著者
農林省山林局 編
出版者
農林省山林局
巻号頁・発行日
vol.第9輯 燒畑及切替畑ニ關スル調査, 1937