著者

緒方 秀教 平山 弘

出版者

一般社団法人 日本応用数理学会

雑誌

日本応用数理学会論文誌 (ISSN:24240982)

巻号頁・発行日

vol.26, no.1, pp.33-43, 2016 (Released:2016-08-19)

参考文献数

6

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概要. 本論文では,平山が提案した有限区間積分に対する数値積分法 —本論文では「超函数法」と呼ぶ —について解析を行う.超函数法では,問題とする積分を閉積分路上の複素積分に変換して,周期関数に対して性能の良い台形公式で近似計算する.数値実験により,超函数法は積分区間端点の特異性が強い積分に対して有効であることがわかる.また,超函数法と佐藤超函数論との関係についても触れる.

著者

狩谷望之

出版者

写

著者

Eikan Mishima Naohiko Anzai Mariko Miyazaki Takaaki Abe

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.251, no.2, pp.87-90, 2020 (Released:2020-06-12)

参考文献数

20

被引用文献数

47 60

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In light of the recent pandemic, favipiravir (Avigan®), a purine nucleic acid analog and antiviral agent approved for use in influenza in Japan, is being studied for the treatment of coronavirus disease 2019 (COVID-19). Increase in blood uric acid level is a frequent side effect of favipiravir. Here, we discussed the mechanism of blood uric acid elevation during favipiravir treatment. Favipiravir is metabolized to an inactive metabolite M1 by aldehyde oxidase and xanthine oxidase, and excreted into urine. In the kidney, uric acid handling is regulated by the balance of reabsorption and tubular secretion in the proximal tubules. Favipiravir and M1 act as moderate inhibitors of organic anion transporter 1 and 3 (OAT1 and OAT3), which are involved in uric acid excretion in the kidney. In addition, M1 enhances uric acid reuptake via urate transporter 1 (URAT1) in the renal proximal tubules. Thus, favipiravir is thought to decrease uric acid excretion into urine, resulting in elevation of uric acid levels in blood. Elevated uric acid levels were returned to normal after discontinuation of favipiravir, and favipiravir is not used for long periods of time for the treatment of viral infection. Thus, the effect on blood uric acid levels was subclinical in most studies. Nevertheless, the adverse effect of favipiravir might be clinically important in patients with a history of gout, hyperuricemia, kidney function impairment (in which blood concentration of M1 increases), and where there is concomitant use of other drugs affecting blood uric acid elevation.

著者

水産講習所 編

出版者

農林省水産講習所

巻号頁・発行日

vol.大正11年, 1925

著者

水産講習所 編

出版者

農林省水産講習所

巻号頁・発行日

vol.自大正4年至5年, 1925

著者

高橋 明彦

出版者

金沢美術工芸大学

雑誌

金沢美術工芸大学紀要 = Bulletin of Kanazawa College of Art (ISSN:09146164)

巻号頁・発行日

no.65, pp.132-144, 2021-03-31

著者

Kento Yonezawa Masatsuyo Takahashi Keiko Yatabe Yasuko Nagatani Nobutaka Shimizu

出版者

The Biophysical Society of Japan

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

pp.e200001, (Released:2023-01-07)

被引用文献数

7

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Recent small-angle X-ray scattering (SAXS) for biological macromolecules (BioSAXS) is generally combined with size-exclusion chromatography (SEC-SAXS) at synchrotron facilities worldwide. For SEC-SAXS analysis, the final scattering profile for the target molecule is calculated from a large volume of continuously collected data. It would be ideal to automate this process; however, several complex problems exist regarding data measurement and analysis that have prevented automation. Here, we developed the analytical software MOLASS (Matrix Optimization with Low-rank factorization for Automated analysis of SEC-SAXS) to automatically calculate the final scattering profiles for solution structure analysis of target molecules. In this paper, the strategies for automatic analysis of SEC-SAXS data are described, including correction of baseline-drift using a low percentile method, optimization of peak decompositions composed of multiple scattering components using modified Gaussian fitting against the chromatogram, and rank determination for extrapolation to infinite dilution. In order to easily calculate each scattering component, the Moore-Penrose pseudo-inverse matrix is adopted as a basic calculation. Furthermore, this analysis method, in combination with UV–visible spectroscopy, led to better results in terms of accuracy in peak decomposition. Therefore, MOLASS will be able to smoothly suggest to users an accurate scattering profile for the subsequent structural analysis.

著者

片山 美由紀

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

vol.67, no.5, pp.351-358, 1996-12-26 (Released:2010-07-16)

参考文献数

38

被引用文献数

6 8

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Although self-disclosure after a negative experience may be good for our adjustment, we also feel hesitant to do so. This study investigated the relationship between self-esteem and hesitancy to disclose negative information about one's self. One hundred and fifty-five undergraduates imagined self-disclosure to a friend of high or low intimacy. They then answered a questionnaire concerning hesitancy to self-disclose negative information to friends, as well as expected negative consequences of such self disclosure. Main results were: (1) Low intimacy strongly affected the hesitancy. (2) Factor analysis of the negative consequences found three factors: interpersonal and intra-personal negative-effect, and no positive expectation. (3) Hesitancy of high self-esteem students was most affected by the interpersonal factor. Impression management may be the reason. (4) On the other hand, low students tended to feel hurt after negative self-disclosure. Theirs was affected by the intra-personal and no positive expectation factors. Defensiveness may be the reason. The results were discussed from the viewpoint of adjustment when people have had a negative experience.

著者

岩西 哲 高田 兼太

出版者

一般社団法人 日本生物教育学会

雑誌

生物教育 (ISSN:0287119X)

巻号頁・発行日

vol.63, no.2, pp.83-90, 2022 (Released:2022-08-23)

参考文献数

26

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本論では,自然史系博物館の来館者を対象としたアンケートから明らかとなった昆虫に対する好悪の傾向や,それらと昆虫採集・飼育経験との関係などについて報告した.昆虫に対する好悪は性別や年齢により違いが見られた他,昆虫の採集や飼育経験と関連していることが明らかとなった.これらの結果から,昆虫嫌いを軽減し,昆虫の重要性について理解を広めるためには,学校・保育の場や家庭において採集や飼育といった昆虫に触れ合う体験の機会を促進すること,それらの機会を通して,「好きな昆虫」のイメージを具体的に持たせることが重要となることが示唆された.

著者

戸倉 新樹

出版者

一般社団法人 日本アレルギー学会

雑誌

アレルギー (ISSN:00214884)

巻号頁・発行日

vol.66, no.1, pp.14-21, 2017 (Released:2017-02-17)

参考文献数

19

著者

山田 邦明

出版者

公益財団法人 史学会

雑誌

史学雑誌 (ISSN:00182478)

巻号頁・発行日

vol.96, no.3, pp.310-341,412-41, 1987-03-20 (Released:2017-11-29)

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Conventional research on Kamakura-Fu (鎌倉府), which ruled the ten eastern provinces of the Kanto region during the Muromachi period, has tended to concentrate more on its relationship with the Muromachi Bakufu in Kyoto and less on what kind of power structure supported it and how this government controlled the various classes in the Kanto area. The present paper starts out to consider Kamakura-Fu's power structure and its control over the Kanto Plain, especially the power base of the Kamakura Kubo (鎌倉公方). Then, the author switches attention to the Hoko-shu (奉公衆) itself, which formed the military and political base of the Kamakura Kubo's ruling power ; and together with identifying that group of attendants from existing documents, he summarizes the Hoko-shu's conditions of existence and its organizational process. Concerning the Hoko-shu's conditions of existence, from the historical source entitled Kamakura Nenchu Gyoji (鎌倉年中行事), describing yearly events and ceremonies in that administrative town, we find three statuses within the Hoko-shu, namely 1)the Hyojo-shu (評定衆), 2)the Hikitsuke-shu (引付衆) and 3)other members. We see clear status discrimination toward those "other members" excluded from (or positioned below) statuses 1) and 2). Also, as the Hoko-shu formed a rotation system for guarding the Kubo's palace (gosho 御所), there were also members located (or living) in the provinces. The author was able to identify from the available sources 74 members of the Kamakura-Fu Hoko-shu. Their names and conditions of membership may be summarized as follows : A)The Ashikaga clan families including the Kira (吉良), Shibukawa (渋川), Isshiki (一色), Imagawa (今川), Kako (加子) and Hatakeyama (畠山). B)The original Ashikaga family vassals including the Uesugi (上杉), Ko (高), Kido (木戸), Noda (野田), Teraoka (寺岡), Kajiwara (梶原), Ebina (海老名), Shidara (設楽) and Yanada (簗田). C)Traditional Kamakura based bureaucrats including the Nikaido (二階堂), Nagai (長井), and Machino (町野). All of the families included in A, B and C served the Kamakura Kubo from the inception of Kamakura-Fu ; and during the era of Kubo Motouji (1349-67), the B group of Ashikaga vassals formed the dominant power group of the Hoko-shu. However, beginning from the era of Kubo Ujimitsu (1367-98) the Kamakura Kubo more and more included in the Hoko-shu many provincial bigmen (kokujin 国人) throughout the Kanto Plain. And so, when Mitsukane became Kubo (1398-1409), the number of Hoko-shu members had greatly increased, and their main source of power had shifted to a new group (D) made up of these same Kanto Plain kokujin. These included the likes of the Ohmori (大森) of Suruga, the Honma (本間) and Miura (三浦) of Sagami, the Edo (江戸) of Musashi, the Satomi (里見), Yamana (山名), Nawa (那波) and Takayama (高山) of Kozuke, the Sano (佐野) of Shimotsuke, the Shishido (宍戸), Tsukuba (筑波) and Oda (小田) of Hitachi and the Unagami (海上), Indo (印東) and Ryugasaki (龍崎) of Shimousa. During Mitsukane's reign such families as the Shishido and Unagami even appear in the elite corps of Kubo palace functionaries (gosho bugyo 御所奉行). As a result of their personal hold over these Kanto Plain kokujin, the Kamakura Kubos were able to expand quite successfully their own direct military bases.

著者

今里 佳奈子

出版者

同志社大学

巻号頁・発行日

2015

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This study focuses on the characteristics of the welfare regime of Japan after the second world war with the aim of forecasting its future. This study has found one of the major features of the welfare regime of Japan in its strong demand on families to be financially and physically independent. The risks the Japanese families had been forced to take by themselves, however, reduced to some extent by the governmental policies I call "communalization" or "kyodotaika."

著者

大久保 暢俊 下田 俊介 鷹阪 龍太 山田 一成

出版者

日本社会心理学会

雑誌

社会心理学研究 (ISSN:09161503)

巻号頁・発行日

vol.33, no.3, pp.156-163, 2018-03-25 (Released:2018-03-25)

参考文献数

21

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The purpose of this study is to investigate consumer attitudes towards shopping in Japan. Factor analyses of data by 1,286 nonprobability online panels in a Web survey (in 2014) confirmed a hypothesized two-factor structure (the hedonic and utilitarian), but although the hedonic subscale had enough internal consistency, the utilitarian subscale had relatively low internal consistency. The correlations of the scores on consumer attitudes towards shopping with other measures, such as bargain orientation, impulsive buying tendency, and frugality, provided support for the criterion validity of each subscale. In many cases, these relationships were not affected by variables such as gender, life stage, and household income. Implications for the two-dimensional model of Japanese consumer attitudes towards shopping are discussed.

著者

西川 稿 土屋 昭彦 高森 頼雪 原田 容治 堀部 俊哉 広津 崇亮

出版者

一般社団法人 日本消化器がん検診学会

雑誌

日本消化器がん検診学会雑誌 (ISSN:18807666)

巻号頁・発行日

pp.20016, (Released:2021-04-15)

参考文献数

6

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【背景】がんの早期発見は重要であり,簡便で高精度ながん検査が求められている。広津らによって開発されたNematode-NOSE(以後N-NOSE)は,尿を検体として線虫Caenorhabditis elegans(以後C. elegans)の優れた嗅覚を利用した簡便ながん検査であり,先行研究では95.0%の特異度と95.8%の感度が報告されている。【対象】本研究では消化器系がん74例と非がん30例の尿検体を用いN-NOSEの性能の検証を行った。【結果】N-NOSEインデックスは,がんと非がんで有意差p<0.0001が認められ,ROC解析ではAUC=0.774が示された。がんの感度は81.1%と高く,特異度は70.0%であった。がん種別の感度は食道癌80.0%,胃癌68.8%,大腸癌80.0%,肝細胞癌90.9%,胆道癌100%,膵臓癌80.0%,ステージ別ではIで76.9%,IIで90.9%と早期から高い感度を示し,腫瘍マーカーとの大きな違いが見られた。N-NOSEインデックスと,被験者の年齢,性別,合併症,肝機能,腎機能,尿一般定性には有意な関係性は見られなかった。【結語】これらよりN-NOSEは非侵襲で高感度かつ簡便ながんのリスク検査となり得ることが示唆された。

著者

Kenji Suetsugu Jing-Zhi Lin Tian-Chuan Hsu Hiroshi Hayakawa

出版者

The Japanese Society for Plant Systematics

雑誌

Acta Phytotaxonomica et Geobotanica (ISSN:13467565)

巻号頁・発行日

vol.71, no.2, pp.177-184, 2020-06-30 (Released:2020-07-31)

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Two closely related species, Spiranthes sinensis and S. australis (Orchidaceae), have often been distinguished based on the presence or absence of hairs in their inflorescence and on the stems and ovaries: the stems and ovaries of S. australis are generally pubescent, whereas those of S. sinensis are reported to be glabrous. Although S. australis has not been documented to occur in Taiwan, we found a population of Spiranthes with slightly pubescent stems and ovaries at Tahanshan, southern Taiwan. Because the slightly pubescent plants may represent an undocumented extension of the distribution of S. australis, we attempted to identity the slightly pubescent plants by sequencing the ITS and trnL–F intergenic spacer regions. We also compared the lip and column morphology, which have diagnostic characteristics in Spiranthes, and the molecular and morphological data from S. australis, S. sinensis, their close relative, S. hongkongensis, and the unknown plants. The molecular analysis revealed the slightly pubescent plants to be heterozygous for the ITS sequences from S. australis and S. sinensis or from S. hongkongensis and S. sinensis, whereas the trnL–F intergenic spacer region was identical to that of S. sinensis. While we could not completely exclude the possibility that the unknown plants were hybrids between S. hongkongensis and S. sinensis based on the molecular data, we concluded that they were hybrids between the pubescent S. australis and the glabrous S. sinensis (Taiwan type) based on the lip and column morphology.

著者

池上 重康 木方 十根 砂本 文彦 鈴木 貴仁

出版者

一般財団法人 住総研

雑誌

住総研研究論文集 (ISSN:21878188)

巻号頁・発行日

vol.38, pp.53-64, 2012 (Released:2017-08-10)

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路面電車郊外とは,19世紀末に米国で展開した路面電車沿線に開発された郊外住宅地のことを指す。日本の地方都市における路面電車郊外像を探るべく,10の事例報告を通して類型化し,郊外住宅地の概念にどう位置づけられるか考察した。人口変動に伴う宅地化圧力と都市計画の実施状況を軸に以下の類型を見出した。人ロポテンシャルの高い都市では典型的な路面電車郊外が形成されたが,それ以外の都市では土地区画整理を計画したが連続的な宅地形成には至らず,都市計画事業を実現できず宅地化の萌芽に留まる例もあった。日本の路面電車郊外は自発性を含み,理念先行ではなく都市のポテンシャルに即して形成された郊外住宅地であると位置づけられる。

著者

金 善映

出版者

日本国際情報学会

雑誌

国際情報研究 (ISSN:18842178)

巻号頁・発行日

vol.14, no.1, pp.50-61, 2017-12-24 (Released:2017-12-24)

参考文献数

1

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The recent emerging 'Net Right-Wing' became an important variable in the new trend of conservative swing and hate speech in both Japan and South Korea. This study analyzed “2Channel (rebranded as“5Channel”in October 2017)1)” and “ILBE” bulletin boards, which have recently created a threatening and hostile atmosphere in both countries. The results of the study show that at the root of conservative swing and hate speech lies the frustration of Japan's post-war democracy and of Korea's 1987 system.

著者

坂根 政男

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集A編 (ISSN:18848338)

巻号頁・発行日

vol.77, no.779, pp.1078-1080, 2011 (Released:2011-07-25)

参考文献数

2

著者

浅野 良輔 堀毛 裕子 大坊 郁夫

出版者

日本パーソナリティ心理学会

雑誌

パーソナリティ研究 (ISSN:13488406)

巻号頁・発行日

vol.18, no.2, pp.129-139, 2010-01-31 (Released:2010-02-28)

参考文献数

53

被引用文献数

2 1 2

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本研究の目的は,失恋に対するコーピング(未練型,拒絶型,回避型)が,失恋相手からの心理的離脱を介して,成熟性としての首尾一貫感覚(Antonovsky, 1979, 1987)を予測するという仮説を検証することであった。過去1年以内に失恋を経験した大学生114名(男性60名,女性54名)を分析対象とした。対象者は,最近経験した失恋に対するコーピング,失恋相手からの心理的離脱,人生の志向性に関する質問票(首尾一貫感覚)の各尺度に回答した。構造方程式モデリングによる分析の結果,(a) 心理的離脱は首尾一貫感覚を直接的に向上させ,(b) 心理的離脱を介して,未練型コーピングは首尾一貫感覚を低下させる一方,回避型コーピングは首尾一貫感覚を向上させ,(c) 拒絶型コーピングは首尾一貫感覚を直接的に低下させることが示された。以上の結果から,失恋および継続中の恋愛関係と,成熟性としての首尾一貫感覚との関連性が議論された。

著者

ルーキアーノス 作

出版者

岩波書店

巻号頁・発行日

1961