著者

清宮 啓之

出版者

日本DDS学会

雑誌

Drug Delivery System (ISSN:09135006)

巻号頁・発行日

vol.21, no.1, pp.24-31, 2006 (Released:2006-08-18)

参考文献数

25

被引用文献数

1 2

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染色体末端におけるテロメアの短縮は, DNA損傷応答を惹起して細胞老化を誘導することから, 発がん予防の一翼を担うと考えられている. がん細胞の無限増殖性はテロメラーゼによるテロメア長の維持に依存しているため, テロメラーゼ阻害剤は新たながん分子標的治療薬となりうる. テロメラーゼのテロメア会合を促進すると考えられるタンキラーゼ1もまた, 有望なテロメア分子標的である. テロメラーゼ阻害剤の制がん効果はテロメアの短縮に依存すると考えられてきたが, 最近ではテロメア非依存的な作用メカニズムの存在も示唆されている.

著者

鈴木 聡一郎 林 末義

出版者

Japan Society of Sports Industry

雑誌

スポーツ産業学研究 (ISSN:13430688)

巻号頁・発行日

vol.19, no.1, pp.1-8, 2009 (Released:2009-11-05)

参考文献数

19

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Ski boots are generally important for assisting progress in ski turn technique as an interface between a skier and a ski. This study is aimed at developing a new ski boot that can improve the results of alpine ski races for Japanese players. In this paper, a new design of a ski boot that is adjusted to the features of the frame of Japanese athletes was experimentally examined. As a result, it was demonstrated that the front part of the upper shell of a ski boot should be lower and the rear part should be higher than the normal upper shell for providing well-balanced quick leaning of the leg in the ski turn. Finally, the effect of the new upper shell was verified in giant slalom and slalom test by Japanese alpine ski players of the first rank.

著者

岡本 宏明

出版者

日本ウイルス学会

雑誌

ウイルス (ISSN:00426857)

巻号頁・発行日

vol.46, no.1, pp.13-21, 1996-06-01 (Released:2010-03-12)

参考文献数

47

著者

Takashi KAMEDA Kazuo OHKUMA Nozomu ISHII Natsuki SANO Hideo OGURA Kazuto TERADA

出版者

日本歯科理工学会

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

vol.31, no.5, pp.856-862, 2012-10-02 (Released:2012-10-02)

参考文献数

13

被引用文献数

3 5 4

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Magnetic fields can represent a health problem, especially low frequency electromagnetic fields sometimes induced by electric current in metallic objects worn or used in or on the body (as opposed to high frequency electromagnetic fields that produce heat). Electric toothbrushes are widely used because of their convenience, but the electric motors that power them may produce electromagnetic waves. In this study, we showed that electric toothbrushes generate low frequency (1-2000 Hz) magnetic fields and induce electric current in dental appliances (e. g. orthodontic and prosthetic appliances and dental implants). Current induced by electric toothbrushes might be dependent on the quantity and types of metals used, and the shape of the appliances. Furthermore, these induced currents in dental appliances could impact upon human oral health, producing pain and discomfort.

著者

田川 明広

出版者

一般社団法人 日本原子力学会

雑誌

日本原子力学会和文論文誌 (ISSN:13472879)

巻号頁・発行日

vol.11, no.2, pp.111-117, 2012 (Released:2012-05-15)

参考文献数

6

被引用文献数

2 3

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The Japan Atomic Energy Agency decontaminated schools, playgrounds, swimming pools, and houses in nonevacuated, less-contaminated areas in Fukushima for environmental restoration. A small, 150 m2 playground lot in the residential area was chosen for decontamination demonstration, which used routinely available tools and commodities to carry out the work. The surfaces of playground lot equipment, such as swings, slides, and horizontal iron bars, were completely decontaminated by brushing with water and/or detergent. Side gutters around the playground lot were cleaned by removing the mud and then brushed and washed with a high-pressure water jet (7 MPa). The air dose rate at the playground lot was dominated by radiation from the ground surface and adjacent surroundings, such as apartments and rice fields. Two or three centimeters of the surface soil contaminated with cesium was removed manually with shovels, hoes, and other gardening tools. This significantly reduced the average air dose rate of the entire playground lot from 1.5 μSv/h before decontamination to 0.6 μSv/h. These results showed that ground surface decontamination can contribute measurably to the reduction in air dose rate in relatively small areas in residential areas.

著者

Woo-Jin SHIN Young-Kyung KIM Kwang-Hee LEE Baik-Lin SEONG

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.76, no.3, pp.581-584, 2012-03-23 (Released:2012-03-23)

参考文献数

27

被引用文献数

8 1

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Based on the broad-spectrum antiviral effect of green tea catechins, we established an experimental skin contact model for influenza virus transmission and evaluated the use of a green tea solution as a first-hand disinfectant. The infectivity of the virus on the skin cell layer became obsolete when washed with the green tea solution. The skin contact model could be applied to develop non-pharmaceutical intervention measures for reducing human transmission of the influenza virus.

著者

倉田 敬子

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.55, no.5, pp.366-369, 2012-08-01 (Released:2012-08-01)

参考文献数

4

被引用文献数

2 2

著者

平原 憲道 山岸 侯彦

出版者

日本認知科学会

雑誌

認知科学 (ISSN:13417924)

巻号頁・発行日

vol.18, no.3, pp.534-545, 2011 (Released:2012-03-09)

参考文献数

30

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We investigated risk perception as it appears to breast cancer patients and how it develops. Wealth of anecdotal evidence as well as interview with both medical professionals and patients led us to hypothesize that patients' risk attitude would develop from incipience, wherein they are preoccupied by optimism toward complete treatment, to recurrence, wherein they become less optimistic and accept the realistic need to cohabitate with the disease. One-hundred breast cancer patients were recruited via voluntary patients organizations in Japan. The participants responded to either a 5-paged web questionnaire or a paper-pencil survey to judge the likelihood of certain risky treatment incidents happening to them, such as bad treatment result, side effects of chemotherapy, recurrence, and medical accident. The result showed that breast cancer patients did not differ as a whole in their optimism on medical risk perception between the two treatment stages. However, the result differed depending on patients' current treatment status: only in the regular treatment (defined as seeing a doctor once or twice a month) group patients were more optimistic in their incipient stage when compared with their recurrence stage, while there was no such difference in no treatment (defined as receiving a follow-up examination once a year) group. There was no difference in their optimism on medical risk perception among formally (medically) categorized cancer stages. Also, confirmatory factor analysis revealed that there were three distinctive factors to which the patients' optimism on risk perception was divided, namely “recurrence,” “aggressive treatment,” and “medical accident.” Hence, we uncovered a possible structure underneath “medical risk perception,” as well as successfully replicated the result of the past study. Implications and possible extension are discussed.

著者

白川 功

出版者

一般社団法人 電子情報通信学会

雑誌

電子情報通信学会 基礎・境界ソサイエティ Fundamentals Review (ISSN:18820875)

巻号頁・発行日

vol.5, no.1, pp.10-19, 2011-07-01 (Released:2011-07-01)

参考文献数

20

被引用文献数

1

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IEEE が認定する Milestones は,2010年10月現在,全世界で106件(我が国では14件)に達する.まず,我が国以外で認定されたものについては主なもの,我が国で認定されたものについては全て,のタイトルを記す.次いで,筆者がnominator として申請し,認定された関西発のイノベーション4件(①電卓の開発,②自動改札機の開発,③黒部川第4水力発電所建設,④太陽電池の商用化)について,その概略と歴史的意義について記述する.

著者

梅谷 英孝 富樫 宏由

出版者

公益社団法人 土木学会

雑誌

海岸工学論文集 (ISSN:09167897)

巻号頁・発行日

vol.48, pp.356-360, 2001-10-20 (Released:2010-03-17)

参考文献数

9

著者

鑛山 宗利 鈴木 茂之 蜂谷 欽司 小野 文一郎 多田 幹郎 佐藤 公行

出版者

公益社団法人 日本アイソトープ協会

雑誌

RADIOISOTOPES (ISSN:00338303)

巻号頁・発行日

vol.44, no.5, pp.310-314, 1995-05-15 (Released:2010-09-07)

参考文献数

6

被引用文献数

1 1 1

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Environmental ionizing radiations were surveyed in Okayama city during December of 1992, using a NaI (Tl) scintillation survey meter (TCS-161; Aloka, Japan) and a NaI (Tl) γ spectrometer (JSM-102; Aloka, Japan) ; measerments were carried out in fine days.Equivalent dose rate of environmental ionizing radiations was in the range of 0.048-0.171μSv/h, and the average was 0.082±0.019μSv/h. The dose rate was higher in hills than in fields. Therefore, it appears as if rocks have more radioactive materials than soils do.The distribution of the dose rates was analyzed from geological points of view. Mesozoic and Paleozoic layer was in the range of 0.067-0.095μSv/h, and the average was 0.080±0.008μSv/h. Rhyolitic layer was in the range of 0.076-0.105μSv/h, and the average was 0.088±0.010μSv/h. Granitic layer was in the range of 0.057-0.171μSv/h, and the average was 0.098±0.022μSv/h. Neogene Period layer was in the range of 0.057-0.114μSv/h, and the average was 0.076±0.015μSv/h. Quaternary Period layer was in the range of 0.048-0.114μSv/h, and the average was 0.076±0.013μSv/h.By γ spectrometry, 40K, 208Tl, 212Bi, 214Bi, and 228Ac were detected at Mt. Kaigara (0.171μSv/h), Tsushima (0.076μSv/h) and Fujita (0.048μSv/h), especially, 226Ra was detected at Mt. Kaigara. It seems that 40K was distributed uniformly in Okayama city area. Thas, the difference in the dose range is attributable to nuclides other than 40K.Now, we conclude that there has been no change of the dose rates of environmental radiation in Okayama city these 10 years.

著者

原田 正純

出版者

日本ハンセン病学会

雑誌

日本ハンセン病学会雑誌 (ISSN:13423681)

巻号頁・発行日

vol.78, no.1, pp.55-60, 2009 (Released:2010-12-21)

参考文献数

9

被引用文献数

1 2

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Minamata disease (MD) was first recognized in May 1956. Its first recognized victims were 3 and 5 years old children. Environmental contamination most rapidly and seriously affected the physiologically and socially weak among the residents. Methylmercury (MeHg) had accumulated in fishes and shellfishes and those who ate them had been poisoning with it.MD is an indirect poisoning by MeHg through the food chain as a result of environmental contamination, and is the first known disease to cause abnormalities in the fetus due to a toxic substances passing through the placenta. In 1962 MeHg poisoning through the placenta was found for the first time in the world. It used to be considered that poisoning was caused by direct exposure to a toxic substance, and that toxic substances did not pass the placenta. MD had implications in various fields. Namely it also stirred up legal, ethical, and eugenic arguments concerning fetal protection. Also man thought about a man's worth.

著者

伊藤 宏

出版者

公益社団法人 応用物理学会

雑誌

応用物理 (ISSN:03698009)

巻号頁・発行日

vol.21, no.2-3, pp.44-54, 1952 (Released:2009-02-09)

参考文献数

20

著者

Daisuke FUKUI Gen BANDO Koji FURUYA Masanori YAMAGUCHI Yuji NAKAOKA Masao KOSUGE Koichi MURATA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0231, (Released:2012-09-04)

被引用文献数

1 6

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An outbreak of encephalitozoonosis occurred in a rabbit colony at a zoo in Japan. Throughout the two years after the onset, all 42 rabbits were investigated clinically, pathologically and serologically for prevention and control of the disease. Eleven rabbits (11/42, 26.2%) showed clinical symptoms. Of 38 rabbits examined to detect specific antibodies against Encephalitozoon cuniculi, 71.1% (n=27) were found seropositive; 20 out of 30 clinically healthy rabbits (except for 8 clinical cases) were seropositive. The infection rate was 76.2% (32/42), including five pathologically diagnosed cases. The results of serological survey revealed that asymptomatic infection was widespread, even among clinically healthy rabbits. However, encephalitozoonosis was not found by pathological examination in any other species of animals kept in the same area within the zoo. Isolation and elimination of the rabbits with suspected infection based on the results of serological examination were carried out immediately; however, encephalitozoonosis continued to occur sporadically. Therefore, all the remaining rabbits were finally slaughtered. Then, the facility was closed, and all the equipment was disinfected. After a two-month interval, founder rabbits were introduced from encephalitozoonosis-free rabbitries for new colony formation. Since then, encephalitozoonosis has not been seen in any animals at the zoo. In this study, biosecurity countermeasures including staff education, epidemiological surveillance and application of an “all-out and all-in” system for rabbit colony establishment based on serological examination were successfully accomplished with regard to animal hygiene and public health for the eradication of E. cuniculi.

著者

Judy OU Steven M. THYGERSON

出版者

独立行政法人 労働安全衛生総合研究所

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

pp.MS1249, (Released:2012-08-08)

被引用文献数

2 5 1

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This study identified contributing risk factors in the occurrence of work-related injuries among university students employed at a single university. Four hundred seventy-six student employees completed the survey in March 2010. The majority of respondents were female (66%) and the average age of all respondents was 20.7 yr. A pre-validated survey instrument was taken from the Youth Employment and School Study (YESS) and contained scales for the risk factors of interest. Results show significant differences in the amount of work-school conflict, boredom, workplace hazards, and workload between injured and non-injured groups. Odds ratios show that physical hazards and heavy workload have a significant two-fold increase on the likelihood of 1–3 injuries (OR=1.80, 1.09–3.00; OR=1.72, 1.12–2.60), and a 2 to 3 fold increase in 4 or more injuries (OR=2.94, 1.65–5.24; OR=2.34,1.51–3.64). Good supervisor relations appear to reduce injury risk (OR=0.48, 0.25–0.91; OR=0.59, 0.32–1.09). Reducing workload stress, teaching students how to manage the workload, reducing exposure to physical hazards, and providing examples of standard work practices may reduce the number of injuries seen in the population.

著者

鈴木 崇彦

出版者

公益社団法人 日本アイソトープ協会

雑誌

RADIOISOTOPES (ISSN:00338303)

巻号頁・発行日

vol.51, no.10, pp.482-488, 2002-10-15 (Released:2010-07-21)

参考文献数

3

著者

森 傑

出版者

公益社団法人 都市住宅学会

雑誌

都市住宅学 (ISSN:13418157)

巻号頁・発行日

vol.2001, no.35, pp.33-38, 2001-10-31 (Released:2012-08-01)

参考文献数

5

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This study proposes an alternative approach in housing environment design drawn from recent ethnomethodological developments in sociology, pedagogy, and cognitive science.Though it was assumed as a “social fact” that the roles of client and specialist differ, and that this difference was an effect of institutional structures or rules, it now becomes possible to think the other way by ethnomethodology, and see how asymmetries are produced in and through the details of client' and specialist' situated interactions.The role relation between the client and the specialist in design action is constituted through the sequence construction of conversation, and the contents of housing environment design develop through the customary regulation and restriction in conversation.

著者

吉川 弘之

出版者

公益社団法人 精密工学会

雑誌

精密工学会誌 (ISSN:09120289)

巻号頁・発行日

vol.75, no.6, pp.707-707, 2009-06-05 (Released:2011-02-07)

著者

Nobuo TAKEICHI Masaharu HOSHI Shozo IIDA Kimio TANAKA Yuka HARADA Zhaxybay ZHUMADILOV Nailya CHAIZHUNUSOVA Kazbek N. APSALIKOV Yoshihiro NOSO Toshiya INABA Kenichi TANAKA Satoru ENDO

出版者

Journal of Radiation Research 編集委員会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.47, no.SupplementA, pp.A171-A177, 2006 (Released:2006-03-28)

参考文献数

25

被引用文献数

9

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Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52-63 years old, were performed in 2001-2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village, Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome aberrations and the previously estimated exposure dose was observed. Furthermore, apparent nuclear abnormalities (ANA) of thyroid follicular cells were studied in 30 out of 63 residents, who were examined for chromosome aberrations. A higher rate of ANA was also found in the residents in the exposed villages compared with those in the control village. These results suggest radiation effects both on the chromosomes in peripheral lymphocytes and on the follicular cells in the thyroid.

著者

Mohammad Zahangir ALAM Md. Golam YASIN Hirotomo KATO Tatsuya SAKURAI Ken KATAKURA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0134, (Released:2012-08-10)

被引用文献数

3 17

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Although Phlebotomus argentipes as the only known vector of visceral leishmaniasis (VL) is zoophilic in nature, VL is considered to be anthroponotic in the Indian subcontinent. Peripheral blood samples from 85 stray dogs were examined for any molecular evidence of Leishmania infection in VL endemic areas of Bangladesh. Parasite DNA was detected in a blood sample from 1 of 85 (1.2%) stray dogs using ITS1-PCR, and PCR sequencing of the rRNA-ITS and cytochrome b gene confirmed that the parasitic DNA was Leishmania donovani. The results support the assumption that dogs are a probable animal reservoir for the Leishmania parasite in Bangladesh. It will be important to investigate the possible epidemiological role of dogs in domestic foci of VL endemic areas in Bangladesh.