著者

西田 香利 山本 理恵 仲村 美幸 齋藤 誠司 今村 徹

出版者

一般社団法人 日本高次脳機能障害学会

雑誌

高次脳機能研究 (旧 失語症研究) (ISSN:13484818)

巻号頁・発行日

vol.31, no.2, pp.205-211, 2011-06-30 (Released:2012-07-01)

参考文献数

19

被引用文献数

1 2

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発症最初期にみられた anarthria による不規則な構音の歪みや置換の改善とともに,運動障害性構音障害や他の失語症状を伴わない純粋な foreign accent syndrome (FAS) を呈し,その後症状がほぼ消失した症例を報告した。症例は 47 歳,矯正右利きで,中枢性右顔面麻痺を伴う右片麻痺と呂律困難で発症した。頭部 MRI では中心前回中・下部を含む左前頭葉に梗塞を認めた。発症 5 日時点で見られた発話における音の不規則な歪み,置換や語頭音の繰り返しは発症 2 週後までに軽減,消失し,その一方で,自発話や単語,短文の音読,復唱時に prosody 障害が目立つようになった。すなわち,単語内のアクセントの移動や 1 単語における 2 単位のアクセントなどが頻発し,発話速度の増加もみられた。これらの特徴は患者の発話の聞き手に外国人様という印象を抱かせた。この prosody 障害は発症 7 ヵ月までに軽減,消失した。本症例の prosody 障害は,anarthria に随伴する prosody の平板化と発話速度の減少を主体とするタイプとも,右半球損傷でみられる感情表現の prosody 障害を主体とするタイプとも異なっており,平板化とは逆方向の prosody 障害や,発話速度の性急さなどの特徴から FAS と考えられた。

著者

Yejin Mok Soyoung Won Heejin Kimm Chungmo Nam Heechoul Ohrr Sun Ha Jee

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20110110, (Released:2012-07-28)

参考文献数

39

被引用文献数

6 14

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Background: Physical activity decreases deaths from cardiovascular disease and other causes; however, it is unclear whether physical activity is associated with cancer incidence and death in Asian populations.Methods: Data from 59 636 Koreans aged 30 to 93 years were collected using a questionnaire and medical examination at the Severance Hospital Health Promotion Center between 1994 and 2004. Study participants were followed for a mean duration of 10.3 years.Results: In the exercising group, the multivariate Cox proportional hazards model showed a lower risk of cancer death (hazard ratio [HR] = 0.72, 95% CI = 0.62–0.85) in men but not in women. Those who exercised, as compared with those who did not, had lower risks of all-cause death (men: HR = 0.68, 95% CI = 0.60–0.76; women: HR = 0.65, 95% CI = 0.53–0.79) and noncancer death (men: 0.63, 0.53–0.75; women: 0.52, 0.39–0.69). Physical activity was inversely associated with risk of noncancer death among men and women.Conclusions: Physical activity was associated with lower risks of cancer death and noncancer death.

著者

Kent R. Walters Jr. S. Indu Rupassara R.J. Cody Markelz Andrew D.B. Leakey William M. Muir Barry R. Pittendrigh

出版者

日本毒性学会

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.37, no.4, pp.773-790, 2012-08-01 (Released:2012-08-01)

参考文献数

55

被引用文献数

1 9 1

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Methamphetamine (MA) appears to produce neurotoxic effects, in part, through disruptions of energy metabolism. A recent study of the whole-body proteome of Drosophila melanogaster showed many changes in energy metabolism-related proteins, leading us to hypothesize that MA toxicity may cause whole-body disruptions of energy metabolism. To test this, we monitored the response of energy reserves and other metabolites to MA-exposure with and without the addition of dietary glucose. We also monitored changes in feeding behavior, locomotor activity and respiration rates associated with MA-exposure to investigate how MA affects energy balance. We observed that glycogen and triglyceride levels decreased dramatically within 48 hr of MA-exposure, indicating a strongly negative caloric balance. Behavioral assays revealed that MA-treated flies decreased food consumption by 60-80% and exhibited a 2-fold increase in locomotion. Caloric expenditure decreased with MA-exposure, apparently due to a compensatory decrease in resting metabolism, showing that anorexia was the primary driver of the negative caloric balance. Additionally, we observed that glucose supplementation of MA-containing diet increased glycogen reserves by 44% at 48 hr, leading to a commensurate increase in survivorship. We conclude that dietary sugar supplementation enhances survivorship by partially compensating for decreased caloric intake resulting from MA-induced anorexia. The observation that MA produces similar behavioral changes in Drosophila and humans, i.e. increased locomotor activity and anorexia, further supports the use of Drosophila as a model organism for the study of the effects of MA.

著者

北山 夏季

出版者

人間環境学研究会

雑誌

人間環境学研究 (ISSN:13485253)

巻号頁・発行日

vol.10, no.1, pp.17-24, 2012 (Released:2012-06-30)

参考文献数

17

被引用文献数

1

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In recent years, there have been more arguments on the importance of educating children not only in Japanese but also in their mother language from different viewpoints and backgrounds because the number of children who have foreign roots has rapidly increased in Japan. Some argue that it is important to involve parents as a support system for learning in their mother language in public schools but it is not necessarily easy due to a lack of understanding of Japanese education by parents, "the wall standing between school and parents", etc. This research, basing on hypothesis that to remove "the wall", setting classes for learning in their mother language in public schools is effective and involving parents in those classes encourages parents to participate in school education and children to study their language and their culture as well, considered how parents were involved in schools and classes for learning in their mother language and what influence did that had on learning attitude and motivation of children by actual setting of those classes from the data gained there. As a result, the following are revealed: 1) The significance of setting classes for learning in their mother language to parents: This research also confirmed that it is difficult to involve Vietnamese parents. 2) The relationship between children's motivation toward learning mother language and culture and involvement of parents: Children who had shown positive learning attitude in classes for learning in their mother language in the lower grades began to show defiant attitude in the fourth grade, which is said to be the time developmental stage changes greatly. It was considered that bringing in lion dance affected the improvement of motivation to take part in classes for learning in their mother language significantly in the time of overcoming this great change in developmental stage after the fourth grade. This enhanced willingness toward lion dance was thought to be the result of children themselves having recognized and been aware that their Vietnamese parents were involved in this lion dance. This positive attitude toward lion dance study also had a good effect on the motivation in the entire activity of classes for learning in their mother language and seemed to lead children to find the significance of those classes, "learning for their family".

著者

中林 保

出版者

一般社団法人 人文地理学会

雑誌

人文地理 (ISSN:00187216)

巻号頁・発行日

vol.24, no.2, pp.221-236, 1972-04-28 (Released:2009-04-28)

参考文献数

59

著者

中林 保

出版者

一般社団法人 人文地理学会

雑誌

人文地理 (ISSN:00187216)

巻号頁・発行日

vol.23, no.1, pp.91-103, 1971-02-28 (Released:2009-04-28)

参考文献数

57

著者

Shizukiyo Ishikawa Masatoshi Matsumoto Kazunori Kayaba Tadao Gotoh Naoki Nago Akizumi Tsutsumi Eiji Kajii the Jichi Medical School (JMS) Cohort Study Group

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.19, no.2, pp.101-106, 2009-03-05 (Released:2009-03-19)

参考文献数

36

被引用文献数

7 18

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Background: Risk charts are used to estimate the risk of cardiovascular diseases; however, most have been developed in Western countries. In Japan, currently available risk charts are based on mortality data. Using data on cardiovascular disease incidence from the JMS Cohort Study, we developed charts that illustrated the risk of stroke.Methods and Results: The JMS Cohort Study is a community-based cohort study of cardiovascular disease. Baseline data were obtained between 1992 and 1995. In the present analysis, the participants were 12 276 subjects without a history of stroke; the follow-up period was 10.7 years. Color-coded risk charts were created by using Cox’s proportional hazards models to calculate 10-year absolute risks associated with sex, age, smoking status, diabetes status, and systolic blood pressure. The risks of stroke and cerebral infarction rose as age and systolic blood pressure increased. Although the risk of cerebral hemorrhage were generally lower than that of cerebral infarction, the patterns of association with risk factors were similar.Conclusion: These risk charts should prove useful for clinicians and other health professionals who are required to estimate an individual’s risk for stroke.

著者

Lobna MKAOUAR Yoshifumi ENDO He Xi JUN Soo-Jung LEE Tassanee JAROENSONG Manabu MOCHIZUKI Kazuyuki UCHIDA Hiroyuki NAKAYAMA Nobuo SASAKI Takayuki NAKAGAWA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.6, pp.713-718, 2012 (Released:2012-07-04)

参考文献数

29

被引用文献数

2 5 1

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In this study, the nuclear expression of nuclear factor kappa B (NF-κB) in 48 tissues specimens from 25 canine spontaneous mammary gland tumor (MGT) patients was assessed by immunohistochemistry to compare their levels with clinical features, histological types, prognostic outcomes and proliferative activities, including the mitotic index (MI) and cylcinD1 expression. Twelve of eighteen (66.7%) malignant tumor tissues showed greater than 10% nuclear staining, while benign tumor and hyperplastic tissues showed less than 10% nuclear staining. Higher nuclear expression of NF-κB was positively correlated with larger tumor size, lymph node metastasis and higher MI; however, no correlation was observed with distant metastasis and cyclin D1 expression. Higher NF-κB nuclear expression correlated with shorter patient survival. These findings suggest that NF-κB is a useful prognostic factor for canine MGT patients.

著者

柴田 隆史 岩崎 常人 河合 隆史 野呂 影勇

出版者

一般社団法人 日本人間工学会

雑誌

人間工学 (ISSN:05494974)

巻号頁・発行日

vol.34, no.Supplement, pp.502-503, 1998-05-16 (Released:2010-03-12)

参考文献数

1

著者

青柳 真樹

出版者

日本地域学会

雑誌

地域学研究 (ISSN:02876256)

巻号頁・発行日

vol.18, pp.57-74, 1988-10-31 (Released:2008-10-10)

参考文献数

17

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This paper analytically investigates the validity of Eaton and Lipsey's (1976) conjecture that there exist more than one equilibrium configurations in an infinite two-dimensional market. The competition considered here is under the assumptions of (i) an infinite two-dimensional market, (ii) fixed and identical mill price for all firms, (iii) evenly spreading consumers endowed with inelastic demand functions, (iv) firm's zero conjectural variation. etc.It is scrutinized whether or not several configurations of the firms in a two-dimensional market are in Nash equilibrium, and among which regular hexagonal configuration and regular square configuration are proved to be in equilibrium.Comparison between equilibrium configurations of one-dimensional and two-dimensional markets shows that they are qualitatively different in terms of “strength of equilibrium” and “social optimality”.

著者

河野 功 杢野 正明 鈴木 孝 小山 浩 功刀 信

出版者

一般社団法人 日本航空宇宙学会

雑誌

日本航空宇宙学会論文集 (ISSN:13446460)

巻号頁・発行日

vol.49, no.575, pp.432-437, 2001 (Released:2002-04-26)

参考文献数

6

被引用文献数

2 2

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Engineering Test Satellite-VII (ETS-VII) is a test satellite to perform in-orbit demonstration of autonomous rendezvous docking (RVD) technology, which will be necessary for advanced space activities in the early 21st century. ETS-VII successfully performed the autonomous RVD by unmanned space vehicle for the first time in the world. For an unmanned space vehicle to perform rendezvous to a manned spacecraft, safe approach is needed. So we paid special attention to designing safe approach trajectory. There are other important points for approach trajectory design, for instance, coordination with guidance and control accuracy, performance of navigation sensors, and operability, etc. In this paper, we introduce the points, and show the result of ETS-VII RVD trajectory design.

著者

三原 健治

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.54, no.11, pp.738-749, 2012 (Released:2012-02-01)

参考文献数

15

被引用文献数

1 3

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特許を活用したイノベーションの測定において,「特許の価値とは何か」という問いに対する答えを求める努力が続けられている。特許の価値を評価するにあたり,特許分類や引用情報が活用されることも多い。また,バイオテクノロジー分野は環境・医療への応用面などで注目されており,特許の価値評価についても多くの研究が行われている。しかしながら,バイオテクノロジー分野については体系的な特許分類が確立しておらず分類情報をそのまま利用することは非常に慎重でなければならないこと,引用についても学術論文と特許の引用パターンは一般化できないくらい複雑なものであることについて十分に認識されているとはいえない。本論文は,以上の問題点についてバイオテクノロジー分野の特許審査官として職務を遂行した筆者の経験から検証し,特許の価値評価がいかなるものであるべきかについての考察を与えたものである。

著者

山下 祐介

出版者

日本都市社会学会

雑誌

日本都市社会学会年報 (ISSN:13414585)

巻号頁・発行日

vol.2006, no.24, pp.206-218, 2006-09-15 (Released:2011-02-07)

参考文献数

11

被引用文献数

1

著者

牛山 素行 松山 洋

出版者

水文・水資源学会編集出版委員会

雑誌

水文・水資源学会誌 (ISSN:09151389)

巻号頁・発行日

vol.8, no.5, pp.492-498, 1995-09-05 (Released:2009-10-22)

参考文献数

4

被引用文献数

1 6

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身近で得られる清涼飲料水のペットボトル,ポリ製ロートなどを用いて軽量・安価な簡易雨量計を作成した.最も一般的に利用されている転倒ます式雨量計との比較観測を行ったところ,降水量10mm以上で観測精度は±10%程度であった.受水部への雨滴飛び出し防止板の取り付けの有無では,取り付けない方が安定した観測値を得た.今回試作した簡易雨量計は10mm以上のまとまった降水量を把握するには十分実用的なものといえる.

著者

藤森 裕基

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.55, no.3, pp.176-182, 2012 (Released:2012-06-01)

参考文献数

10

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2009年度に文部科学省の私立大学戦略的研究基盤形成支援事業として認定された日本大学文理学部自然科学研究所の共同研究プロジェクト「構造制御および電子状態制御に基づく新物質の開発」では,研究成果の保存・公開を,独立行政法人物質・材料研究機構(NIMS)がドイツのマックスプランク研究所電子図書館(MPDL)と共同で開発を進めていたeSciDocを用いて行った。eSciDocのシステムは機関リポジトリとして研究者自身が利用するには最適なシステムのひとつである。

著者

Yuki Nagao

出版者

公益社団法人 日本表面科学会

雑誌

e-Journal of Surface Science and Nanotechnology (ISSN:13480391)

巻号頁・発行日

vol.10, pp.229-233, 2012-06-16 (Released:2012-06-16)

参考文献数

28

被引用文献数

1 5

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In this study, contact angle measurements and an infrared p-polarized multiple-angle incidence resolution spectrometry (p-MAIRS) technique were performed on MgO(100) and quartz substrates. The contact angle and IR spectra of the in-plane and out-of-plane vibration modes depended on the cleaning methods. The surface of the as-received substrates was contaminated in MgO(100) and quartz substrates. As determined by contact angle and p-MAIR spectra analysis, plasma treatment resulted in a relatively clean and superhydrophilic surface under atmospheric conditions. [DOI: 10.1380/ejssnt.2012.229]

著者

林 裕晃 西原 貞光 小沼 洋治

出版者

公益社団法人 日本放射線技術学会

雑誌

日本放射線技術学会雑誌 (ISSN:03694305)

巻号頁・発行日

vol.68, no.5, pp.545-553, 2012-05-20 (Released:2012-05-30)

参考文献数

6

被引用文献数

1

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Due to accidents of the nuclear power plants in Fukushima prefecture, a lot of radioisotopes were diffused into the environment. They adhered onto the surface of the X-ray detector (imaging plate; IP) and many black spots were seen on the medical images. The process to count them is important to evaluate the degree of contamination and/or removal. In this study, we aimed to develop a counting method for black spots. Based on the analysis of the medical images having black spots, we summarized that areas affected by the certain black spots were limited to the eight pixels surrounding the most intensive pixel. The newly developed counting method was applied to these nine pixels (3×3 pixels) and selection rules were based on the following two information: 1. differences between the digital value of the most intensive pixel and those of the surrounding eight pixels, and 2. total summation of the digital values in the nine pixels. The estimated image based on our method showed a good concordance with the original image. Therefore, we summarized that our counting method is a powerful tool for estimating numbers of black spots.

著者

Nozomiko Yasui Masanobu Miura Akitoshi Kataoka

出版者

一般社団法人 日本音響学会

雑誌

Acoustical Science and Technology (ISSN:13463969)

巻号頁・発行日

vol.33, no.3, pp.160-169, 2012-05-01 (Released:2012-04-29)

参考文献数

10

被引用文献数

2 4

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A tremolo produced by irregular plucking of a mandolin is characterized by the average plucking rate, as well as the onset and amplitude deviations. The fluctuation of a tremolo elicited by only the average plucking rate is called the “1st fluctuation,” and that elicited by onset and amplitude deviations is called the “2nd fluctuation.” The procedure for estimating the fluctuation strength, which represents the sensation of hearing fluctuation from sounds, such as amplitude-modulated or frequency-modulated sounds with only the 1st fluctuation, has been developed. However, a procedure for a tremolo with both 1st and 2nd fluctuations has not been investigated. Therefore, we developed a procedure for estimating fluctuation strength from a tremolo produced by irregular plucking of a mandolin. We calculated the feature parameters of a tremolo, and estimated fluctuation strength from the tremolo using the calculated parameters. We found that this procedure that is based on not only the 1st fluctuation but also the 2nd fluctuation approximately represents the sensation of hearing fluctuation (adjusted R2=0.76), and is better than the representation obtained using a procedure based on conventional methods (R2=0.58). Thus, we developed a procedure for estimating fluctuation strength from a tremolo produced by irregular plucking of a mandolin.

著者

山本 順一

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.55, no.3, pp.221-221, 2012 (Released:2012-06-01)

著者

大槻 明 岡田 謙一

出版者

情報知識学会

雑誌

情報知識学会誌 (ISSN:09171436)

巻号頁・発行日

vol.21, no.3, pp.350-361, 2011-09-27 (Released:2011-12-13)

参考文献数

17

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本研究では,筆者らが提案している知識を構造的に俯瞰表現する「構造化俯瞰図」をさらに発展し,同図を構成する各知識に属性情報や叙述を付与し,それら属性情報等を含めた知識同士の関係性を意味付けしたうえで俯瞰マップを作成するCosut(Concept Support Tool)について提案する.Cosutを使用することにより,当該知識群のさらなる整理や分析を実現することが可能となる.つまり,企業における新商品開発や課題解決時,さらには研究機関における新理論の検討時など,様々な場面における知識の有効活用に資することができるものと考える.評価実験では,構造化俯瞰図を使用した場合に比べた定量的分析及び概念構造の変化を分析した.その結果,仮説をまとめるためのアイディアの量的な増加傾向が確認され,さらには,Cosutが被験者の概念構造に直接影響を与えた部分を把握することが可能になるなどの発想支援的な効果が認められた.