著者

藤本 仰一 石原 秀至 金子 邦彦

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.50, no.1, pp.018-022, 2010 (Released:2010-01-25)

参考文献数

17

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One of the major goals in evolutionary developmental biology is to elucidate the relationship between gene regulatory networks and the diverse morphologies. Segmentation in arthropod embryogenesis represents a well-known example of body plan diversity. Striped patterns of gene expression that lead to the future body segments appear simultaneously or sequentially, respectively. To reveal the basic differences in the network structure, we have numerically evolved hundreds of gene regulatory networks. By analyzing the topologies of the generated networks, we show that the characteristics of striped pattern are determined by Feed-Forward Loops (FFLs) and negative Feed-Back Loops (nFBLs).

著者

中垣 隆雄

出版者

一般社団法人 日本原子力学会

雑誌

日本原子力学会誌ATOMOΣ (ISSN:18822606)

巻号頁・発行日

vol.62, no.6, pp.312-319, 2020 (Released:2020-12-01)

参考文献数

2

被引用文献数

1

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持続可能な開発目標(Sustainable Development Goals:SDGs)の達成やパリ協定を睨みつつ,世界的な脱化石化,分散化,効用の電化のメガトレンドの中,変動性再エネの主力化の期待が高まっているが,変動性再エネ導入増の本質的な課題は時空間の需給ミスマッチの解消であり,調整力の柔軟性向上と大容量のエネルギーストレージが主たる対策である。対策間の技術的な連携・補完・競合を考慮しながら,電力安定供給のための対策技術として地内・地域間連系線の増強および広域運用,火力・水力発電の出力調整機能の増強,エネルギーストレージの観点でまとめ,最後に今後の展望とCO2削減技術のリスクを述べた。

著者

金折 裕司 川上 紳一

出版者

公益社団法人 日本地震学会

雑誌

地震 第2輯 (ISSN:00371114)

巻号頁・発行日

vol.49, no.1, pp.125-139, 1996-05-24 (Released:2010-03-11)

参考文献数

57

被引用文献数

2 3

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Several boundaries of tectonic blocks can be defined as the lines linking large-scale active faults in Southwest Japan. Using available data concerning geology and geophysics, tectonic features of the block boundaries have been briefly reviewed. These features imply that Southwest Japan is separated into a few microplates. Based on the microplate model of Southwest Japan, sequential generation of large earthquakes including the 1995 M7.2 Hyogo-ken-nanbu earthquake can be interpreted. The Hyogo-ken-nanbu earthquake occurred in the middle of the 100-km long Takatsuki-Rokko-Awaji tectonic line (TATL). The aftershock distribution and the surface ruptures suggest that the main shock is caused by a 40-km long rupture of the central part of the TAIL. Thirty-kilometer long eastern and western parts of the TATL remain unruptured. The average moment-release rate of the 40-km central part of the TATL can be estimated from the slip-rate of constituent active faults. The magnitude of an earthquake generated at the central part can be predicted from the seismic moment, which is calculated from the moment-release rate and the elapsed time since the 1596 Keicho-Fushimi earthquake. The calculated magnitude of 6.8 to 7.2 is consistent with the actual magnitude of the Hyogo-ken-nanbu earthquake. If the eastern and western parts unruptured have the same slip-rate as that of the central part, the accumulated moments after the previous event amount to the earthquakes with a magnitude of 6.7 to 7.1. A two-meter right-lateral slip along the Nojima fault, which constitutes western-central part of the TATL, occurred at the time of the Hyogo-ken-nanbu earthquake. This slip may help a southward migration of the Kinki-Outer mircoplate. The movement may reduce normal stresses along the Median Tectonic Line and may increase stress concentration along the Nankai trough. The kinematics of the microplate and sequential generation of large earthquakes along the microplate boundaries suggest a high probability of generating an offshore earthquake along the Nankai trough in a period ranging from 2003 to 2040 A. D.

著者

Hitomi Horinouchi Tomoo Nagai Yohei Ohno Junichi Miyamoto Tsutomu Murakami Norihiko Kamioka Koichiro Yoshioka Yuji Ikari

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.0638-22, (Released:2023-02-01)

参考文献数

26

被引用文献数

1

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Objective This study retrospectively compared the outcomes of emergently admitted patients with aortic stenosis (AS) with or without urgent transcatheter aortic valve replacement (TAVR). Methods Patients hospitalized between February 2015 and December 2019 for symptomatic AS were retrospectively analyzed by comparing the received conservative management (continued medical therapy with or without elective surgical transcatheter replacement [SAVR] or TAVR scheduled after the index hospitalization) and urgent TAVR (TAVR during the index hospitalization). Results The cohort comprised 114 patients with symptomatic AS who required emergency admission. Urgent TAVR was performed for 37 patients, while conservative management was provided for 77 patients, including 1 who received urgent SAVR. Urgent TAVR was more likely to be performed in patients with a history of hospitalization for heart failure, high New York Heart Association class scores, a lower clinical frailty scale at admission, and a high aortic valve peak velocity (P = 0.01, P <0.001, P <0.01, and P = 0.02, respectively). Kaplan-Meier analyses with log-rank test revealed favorable outcomes of urgent TAVR in all-cause mortality and cardiovascular events within 60 days of admission (p <0.01, p <0.01, respectively). Conclusions Urgent TAVR had better short-term outcomes in patients with symptomatic AS who required emergency hospital admission than conservative management. When considering urgent TAVR, patients with typical heart failure symptoms due to AS with a history of heart failure hospitalization and relatively little frailty can be selected.

著者

岡﨑 真紀子

出版者

中世文学会

雑誌

中世文学 (ISSN:05782376)

巻号頁・発行日

vol.61, pp.58-67, 2016 (Released:2018-02-09)

著者

金子 正義

出版者

The Philosophy of Science Society, Japan

雑誌

科学哲学 (ISSN:02893428)

巻号頁・発行日

vol.1, pp.133-145, 1968-10-10 (Released:2009-05-29)

参考文献数

31

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In the finst place, I tried to make the meaning of the word dialectical "Contradiction" clear. It seems to me there are two usages of that term. The first, the contradiction in existence. The second, the contradiction in logical. It is my principal purpose in this two subject how we can get no contradiction.In my opinion, to find the contradiction in existence consists of Aristotle's principle of contradiction. As to the methodology of the expressional contradiction, for "Real Existence, " I took the cases of ideal dialectic and material dialectic, and analysed the relation between their expressional contradiction.

著者

寺澤 捷年

出版者

一般社団法人 日本東洋医学会

雑誌

日本東洋医学雑誌 (ISSN:02874857)

巻号頁・発行日

vol.67, no.1, pp.13-21, 2016-01-20 (Released:2016-05-27)

参考文献数

10

被引用文献数

7 7

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筆者は先に心下痞鞕と背部兪穴の関連を報告したところである。この報告において旁脊柱筋の硬結への施術によって心下痞鞕は消失するが,胸脇苦満は消失しないことを記した。そこで筆者は,改めて胸脇苦満と関連する背部諸筋の硬結を探索し,棘下筋の硬結が胸脇苦満と密接に関連することを発見した。またこの棘下筋硬結への施術が吃逆を改善することも見出した。棘下筋の硬結は肩こりなどでも現れるがその中に胸脇苦満と同時にあらわれるものがあることを明らかにした。本論文は棘下筋の硬結を手がかりに胸脇苦満が横隔膜の異常緊張と関連したものであることを具体的な2症例および15症例を基にその病態生理学的背景を明らかにしようと意図したものである。

著者

坪井 俊

出版者

一般社団法人 日本数学会

雑誌

数学 (ISSN:0039470X)

巻号頁・発行日

vol.45, no.2, pp.128-140, 1993-05-12 (Released:2008-12-25)

参考文献数

86

著者

浮ヶ谷 幸代

出版者

現代文化人類学会

雑誌

文化人類学研究 (ISSN:1346132X)

巻号頁・発行日

vol.23, pp.1-5, 2022 (Released:2023-01-28)

参考文献数

6

出版者

一般社団法人 日本透析医学会

雑誌

日本透析医学会雑誌 (ISSN:13403451)

巻号頁・発行日

vol.49, no.2, pp.127-135, 2016 (Released:2016-02-28)

参考文献数

68

著者

前田 保夫 山下 勝年 松島 義章 渡辺 誠

出版者

Japan Association for Quaternary Research

雑誌

第四紀研究 (ISSN:04182642)

巻号頁・発行日

vol.22, no.3, pp.213-222, 1983-11-30 (Released:2009-08-21)

参考文献数

20

被引用文献数

5 6

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A large shell mound called Mazukari shell-mound (YAMASHITA, 1978) was found in 1978 to be buried 12m under the ground surface, at Utsumi Town in the south part of the Chita Peninsula, Aichi Prefecture in Central Japan.Several hundred pieces of Kozanji-type pottery (the middle Earliest Stage of Jomon Age) are included in the collected remains. Tegillara granosa, dated at 8, 330±260y.B.P. (GaK-7950) occurred with these potteries. Many kinds of fossil shells, foraminifers as well as Akahoya Tephra (about 6, 300y.B.P.) were found in the Mazukari shell mound. These features and the 14C dating suggest that the sediments were formed by Jomon Transgression.There are Hayashinomine shell-mound, Shimizunoue shell-mound, Otofukudani remains and Shimobessho are near the Mazukari shell-mound. The following sea-level changes since 9, 000y.B.P. are deduced from the elevation of these remains and the upper limit of marine the sediments.ca. 9, 000y.B.P. ca-14mca. 7, 000y.B.P. ca+1mca. 6, 000y.B.P. ca+4.5-5.0mca. 4, 500y.B.P. ca+1mca. 3, 000y.B.P. ca+2m

著者

工藤 龍彦 首藤 裕

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

日本血栓止血学会誌 (ISSN:09157441)

巻号頁・発行日

vol.7, no.3, pp.239-243, 1996-06-01 (Released:2010-08-05)

参考文献数

10

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Patients on oral anticoagulant therapy present a clinical problem when they take large amounts of natto, because immoderate ingestion of natto results in reduction of the effect of warfarin so that thrombotest and PT-INR are adversely affected.We previously demonstrated an undesirable effect of immoderate ingestion of natto in a trial in patients given 100g of natto each. In the present study changes in blood levels of vitamins K were determined after the administration of reduced doses of 10 and 30g of natto.There was no change in blood levels of MK-4. Howevere, the blood levels of vitamin K1 increased from 0.53±0.26ng/ml to 0.72±0.25ng/ml at 4 hours after the administration of 10g of natto (p<0.001). After the administration of 30g of natto the blood level of vitamin K1 increased from 0.46±0.28ng/ml to 0.70±0.21ng/ml at 4 hours (p<0.001). The blood level of MK-7 increased from 0.58±0.15ng/ml to 2.43±0.77ng/ml at 4 hours, 1.66±0.69ng/ml at 24 hours, and 1.28±0.46ng/ml at 48 hours after the administration of 10g of natto (p<0.001).After the administration of 30g of natto the blood level of MK-7 increased from 0.57±0.18ng/ml to 7.24±2.92, 4.53±1.82, and 3.00±1.09ng/ml at the same time points as mentioned above, respectively (p<0.001).The results of this study suggest the wisdom of discouraging patients on anticoagulant therapy from taking natto, since it may reduce the effect of warfarin, be the amount ingested 30g or 10g insted of 100g.

著者

矢頭 卓児 手良村 知功 瀬能 宏

出版者

神奈川県立生命の星・地球博物館(旧神奈川県立博物館)

雑誌

神奈川県立博物館研究報告(自然科学) (ISSN:04531906)

巻号頁・発行日

vol.2022, no.51, pp.1-7, 2022 (Released:2022-03-29)

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ホウボウ科のミナミソコホウボウ(新称)Bovitrigla acanthomoplate Fowler, 1938 の1 標本が遠州灘から得られた。この種は日本初記録種であり、遠州灘における出現はこの種の北限記録となる。南シナ海産の10 個体と比較するとともに本種を詳細に再記載した。

著者

Kenichiro Ihara Hideko Onoda Masahiro Tanabe Etsushi Iida Takaaki Ueda Taiga Kobayashi Mayumi Higashi Marcel Dominik Nickel Hiroshi Imai Katsuyoshi Ito

出版者

Japanese Society for Magnetic Resonance in Medicine

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

pp.mp.2022-0137, (Released:2023-02-04)

参考文献数

20

被引用文献数

1

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Purpose: To evaluate the feasibility of breath-hold (BH) high-resolution (HR) T1-weighted gradient echo hepatobiliary phase (HBP) imaging using compressed sensing (CS) in gadoxetic acid-enhanced liver MRI in comparison with standard HBP imaging using parallel imaging (PI).Methods: The study included 122 patients with liver tumors with hypointensity in the HBP who underwent both HR HBP imaging with CS and standard HBP imaging with PI. Two radiologists evaluated the liver edge sharpness, hepatic vessel conspicuity, bile duct conspicuity, image noise, and overall image quality, as well as the lesion conspicuity on HR and standard HBP imaging and the contrast-enhanced (CE) MR cholangiography (MRC) image quality reconstructed from HBP images. As a quantitative analysis, the SNR of the liver and the liver to lesion signal intensity ratio (LLSIR) were also determined.Results: The liver edge sharpness, hepatic vessel conspicuity, bile duct conspicuity, and overall image quality as well as the lesion conspicuity and the LLSIR on HR HBP imaging with CS were significantly higher than those on standard HBP imaging (all of P < 0.001). The image quality of CE-MRC reconstructed from HR HBP imaging with CS was also significantly higher than that from standard HBP imaging (P < 0.001). Conversely, the SNR of liver in standard HBP was significantly higher than that in HR HBP with CS (P < 0.001).Conclusion: BH HR HBP imaging with CS provided an improved overall image quality, lesion conspicuity, and CE-MRC visualization when compared with standard HBP imaging without extending the acquisition time.

著者

Rabab A. Husseini Naoko Abe Tomoaki Hara Hiroshi Abe Kentaro Kogure

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.46, no.2, pp.301-308, 2023-02-01 (Released:2023-02-01)

参考文献数

46

被引用文献数

7

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mRNA vaccines have attracted considerable attention as a result of the 2019 coronavirus pandemic; however, challenges remain regarding use of mRNA vaccines, including insufficient delivery owing to the high molecular weights and high negative charges associated with mRNA. These characteristics of mRNA vaccines impair intracellular uptake and subsequent protein translation. In the current study, we prepared a minimal mRNA vaccine encoding a tumor associated antigen human gp10025–33 peptide (KVPRNQDWL), as a potential treatment for melanoma. Minimal mRNA vaccines have recently shown promise at improving the translational process, and can be prepared via a simple production method. Moreover, we previously reported the successful use of iontophoresis (IP) technology in the delivery of hydrophilic macromolecules into skin layers, as well as intracellular delivery of small interfering RNA (siRNA). We hypothesized that combining IP technology with a newly synthesized minimal mRNA vaccine can improve both transdermal and intracellular delivery of mRNA. Following IP-induced delivery of a mRNA vaccine, an immune response is elicited resulting in activation of skin resident immune cells. As expected, combining both technologies led to potent stimulation of the immune system, which was observed via potent tumor inhibition in mice bearing melanoma. Additionally, there was an elevation in mRNA expression levels of various cytokines, mainly interferon (IFN)-γ, as well as infiltration of cytotoxic CD8+ T cells in the tumor tissue, which are responsible for tumor clearance. This is the first report demonstrating the application of IP for delivery of a minimal mRNA vaccine as a potential melanoma therapeutic.

著者

村山 達也

出版者

東北哲学会

雑誌

東北哲学会年報 (ISSN:09139354)

巻号頁・発行日

vol.28, pp.1-13, 2012 (Released:2022-08-02)

著者

小畑 弘己 宮浦 舞衣

出版者

日本植生史学会

雑誌

植生史研究 (ISSN:0915003X)

巻号頁・発行日

vol.29, no.1, pp.3-14, 2021 (Released:2023-02-01)

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本野原遺跡は,宮崎市の中心部から 50 km 西に位置する,約 4300 ~ 3500 年前の九州地方の縄文時代で最も大きな集落の一つである。我々は,36 回にわたるこの遺跡での 179,135 点の土器の「圧痕法」による調査によって,マメ類を含む 500 点以上の種実や家屋害虫の圧痕を発見した。この調査以前には植物性食料資源と推定されるものは本遺跡ではコナラ属の堅果類のみであった。X 線機器を用いた追加調査の結果,九州地方で最も多数のダイズやアズキなどのマメ類圧痕を得るとともに,九州初の多量マメ類混入土器を検出することができた。これらの発見は九州地方における最も初期のマメ類栽培と栽培植物の豊作に対する精神と儀礼的行為の出現の可能性を示す。さらに,土器胎土中の高密度のマメ類種子はそれらの粘土中への意図的混入を強く示唆している。

著者

下萩原 勉

出版者

日本弁理士会

雑誌

別冊パテント (ISSN:24365858)

巻号頁・発行日

vol.74, no.26, pp.121-135, 2021 (Released:2021-11-18)

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データ駆動型社会への移行が予期される中,データの重要度や注目度はますます上昇している。本稿では,データ(構造)の特許法における保護に関して,審査基準や審査ハンドブックを整理するとともに,発明該当性による拒絶査定が取り消された審決事例(不服2018-2483)を取り上げ,検討する。

著者

田村 直俊 光藤 尚

出版者

日本自律神経学会

雑誌

自律神経 (ISSN:02889250)

巻号頁・発行日

vol.56, no.3, pp.162-169, 2019 (Released:2019-09-27)

参考文献数

50

被引用文献数

2

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脳脊髄液(CSF)減少症の原因は,潜在的な外傷によるCSF漏出と説明されているが.1970年代以前はCSF漏出の有無にかかわらず,CSFの産生低下によって生じると推定されていた.Hosemann(1909),Haug(1932)は腰椎穿刺後CSF減少症の原因として,現在でいう体位性頻脈症候群(PoTS)による代償性のCSF産生低下を考察した.Schaltenbrand(1938,40)は自然発生性CSF減少症におけるキサントクロミーの存在を強調し,CSFの蛋白量は血管周囲腔由来のCSFの方が脈絡叢由来のCSFより高値のため,本症の原因は脈絡叢のCSF産生低下であると主張した.Geller(1940)はCSF減少症患者の大多数が基礎疾患としてPoTSを有することを報告した.最近,CSF減少症とPoTSの共存が示唆されており(Grafら,2018),1970年代以前の研究を再評価する必要がある.

著者

益川 浩一

出版者

日本公民館学会

雑誌

日本公民館学会年報 (ISSN:1880439X)

巻号頁・発行日

vol.14, pp.50-57, 2017-11-30 (Released:2019-04-04)

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This paper constitutes an attempt to develop an interpretation at the general and abstract level of the text of Article 23 of Japan’s Social Education Act, which regulates “management policy for community learning centers (kominkan),” or stated in more concrete terms, so-called “usage restrictions” on community learning centers. The discussion gives particular attention to specific cases (e.g., examples in practice), in reference to the Article’s Paragraph 2, which states that such facilities “shall not support specific religions or otherwise assist any specific denominations, sects, or cults.” The following points are revealed through this discussion.Community learning centers are not permitted to “support specific religions or otherwise assist any specific denominations, sects, or cults.” Accordingly, it is understood that simply allowing such groups the use of community learning centers does not amount to “support” or “assistance,” and thus does not constitute a problem.·There are no arguments against recognizing the right of the public administration to allocate permission to use community learning centers (kominkan), and it is necessary to enact laws and regulations governing permissible and impermissible use.·When processing applications for permission to use community learning centers (kominkan), value judgements on the part of the facilities’ operators are not permitted. Rather, such operations must be performed in accordance with uniform and neutral standards (subject to the limitations of the law).·Regarding the refusal of permission for applications to use community learning centers (kominkan), the interests benefitted by granting permission, in terms of protecting fundamental human rights, such as freedom of assembly, must be compared with the interests disadvantaged by the foreseeable dangers of granting permission (balancing of interests).·Regarding the determination of dangers, the mere probability of a dangerous situation arising is insufficient; rather, there needs to be a “clear and present danger.”·Notably, constraints of spiritual freedoms like freedom of assembly must be carried out under strict criteria that go beyond constraints governing freedom of economic activity.·The blanket application of usage restrictions includes the danger of constraining “freedom of assembly” (Article 21 of the Constitution of Japan).