著者
濱崎 雅孝
出版者
日本基督教学会
雑誌
日本の神学 (ISSN:02854848)
巻号頁・発行日
vol.2006, no.45, pp.108-125, 2006-09-21 (Released:2009-10-23)
参考文献数
20
著者
Srinuan SOMROOP Noritoshi HATANAKA Sharda Prasad AWASTHI Kentaro OKUNO Masahiro ASAKURA Atsushi HINENOYA Shinji YAMASAKI
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.16-0654, (Released:2017-02-16)
被引用文献数
3

Cytolethal distending toxin (CDT) consisting of CdtA, CdtB and CdtC has been reported to be a possible virulence factor of campylobacters including C. upsaliensis. In our previous study, the cdtB gene-based PCR-restriction fragment length polymorphisms (RFLP) assay for detection and differentiation of 7 Campylobacter species yielded 3 different RFLP patterns (Cu-I to Cu-III). In this study, entire cdt (Cucdt) genes of each pattern were sequenced to see whether there are any differences in cdt genes, its amino acid sequences and biological activity of CuCDT. We found that all 3 representative strains harbor the entire Cupcdt genes and homology between prototype and newly determined Cucdt genes was 94 to 98% with cdtA, 93 to 94% with cdtB and 92 to 93% with cdtC, while that between amino acids of CuCDT was 95 to 99% with CdtA, 97 to 98% with CdtB and 92 to 93% with CdtC. Furthermore, CDT activity produced by C. upsaliensis strains was examined by cytotoxicity assay with HeLa cells. Interestingly, C. upsaliensis produced 64 to 2,340 times higher CDT titer in comparison to other campylobacters did. In addition, Cu-III showed 64 times higher CDT titer than Cu-II, although CDT production level was almost the same by western blotting. These data suggest that CDT produced by C. upsaliensis might contribute more to human diseases in comparison to that produced by other campylobacters and Cu-III CDT seems to be more toxic to HeLa cells in comparison to Cu-I and Cu-II CDTs.
著者
原田 昌和
出版者
日本私法学会
雑誌
私法 (ISSN:03873315)
巻号頁・発行日
vol.2005, no.67, pp.143-150, 2005-04-30 (Released:2012-02-07)
著者
Naomi OSAKABE Chiaki SANBONGI Megumi YAMAGISHI Toshio TAKIZAWA Toshihiko OSAWA
出版者
(社)日本農芸化学会
雑誌
Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)
巻号頁・発行日
vol.62, no.8, pp.1535-1538, 1998 (Released:2005-03-25)
参考文献数
26
被引用文献数
35

The antiulcer activity of cacao liquor water-soluble crude polyphenols (CWSP) was examined.   CWSP, α-tocopherol, sucralfate (500 mg/kg), and cimetidine (250 mg/kg) were orally administerted to male SD rats 30 minutes before ethanol treatment. 5 ml/kg of ethanol given intragastrically caused lesions in mucosa of the glandular stomach. CWSP caused a reduction of such hemorrhagic lesions as well as cimetidine and sucralfate which are typical antiulcer drugs, but α-tocopherol was less effective. Thiobarbituric acid reactive substances in gastric mucosa significantly increased with ethanol administration. CWSP treatment significantly reduced this change. The administration of ethanol extensively increased myeloperoxidase (MPO) but not xanthine oxidase (XOD) activity. CWSP reduced the activities of both enzymes; they were considered the main sources of oxygen radicals. According to an in vitro study, CWSP directly reducted XOD but not MPO. These results suggest that the antiulcer mechanism of CWSP was not only radical scavenging but also modulation of leukocyte function.
著者
野田 文雄
出版者
公益財団法人 日本醸造協会
雑誌
日本醸造協会誌 (ISSN:09147314)
巻号頁・発行日
vol.88, no.7, pp.531-536, 1993-07-15 (Released:2011-09-20)
参考文献数
7
被引用文献数
2 1

いま, 醤油業界はじめ多くの食品業界では, 魚醤の製造が注目されている。著者は, キッコーマン社のシンガポール工場建設のため, 約6年間にわたる現地の生活の中で, 本場の魚醤と接して来られた。従って通り一遍の現地調査とは趣きの異なった, 深みのある解説をしていただいた。
著者
金子 秀雄 木庭 知美 徳永 理紗
出版者
理学療法科学学会
雑誌
理学療法科学 (ISSN:13411667)
巻号頁・発行日
vol.31, no.6, pp.799-804, 2016 (Released:2016-12-22)
参考文献数
30

〔目的〕本研究は,女子学生における非特異的慢性腰痛の有無による呼吸機能の違いを検証することを目的とした.〔対象と方法〕非特異的慢性腰痛のある女子学生17名(腰痛群)と健常な女子学生17名(健常群)を対象とした.呼吸機能として努力性肺活量(対標準努力性肺活量),呼吸筋力(最大吸気圧,最大呼気圧),胸腹部可動性(呼吸運動評価スケール)を測定した.〔結果〕腰痛群の努力性肺活量(対標準努力性肺活量),上部および下部胸郭スケールと下肢挙上位での腹部スケールは,健常群より有意に低値であった.〔結語〕女子学生における非特異的慢性腰痛は,胸腹部可動性に関連した努力性肺活量低下を招く可能性が示された.
著者
森永 実 藤田 淳一 松井 真二 清水 富士夫
出版者
公益社団法人 応用物理学会
雑誌
応用物理 (ISSN:03698009)
巻号頁・発行日
vol.65, no.9, pp.912-918, 1996-09-10 (Released:2009-02-05)
参考文献数
11

レーザー冷却法と微細加工技術の発展により原子をホログラフィックな手法で制御することが可能になった.任意の距離に任葱の像を酉生す一る原子線ホログラムのバイナリパターンの設計法について解説し,最近の原子線ホログラフィーの実験の紹介をする.また原子線ホログラフィーの将来の可能性についても検討する.
著者
廣川 明日菜
出版者
公益社団法人 日本表面科学会
雑誌
表面科学 (ISSN:03885321)
巻号頁・発行日
vol.37, no.5, pp.235-237, 2016-05-10 (Released:2016-05-31)
参考文献数
16

国立国会図書館は,納本制度に基づき国内出版物の網羅的収集・保存を行う国内唯一の国立図書館である。技術革新に伴い,図書館が取り扱う情報媒体も多様化が進む中,資料の長期保存には様々な課題がある。本稿では当館の取組みを事例に,資料保存の重要性とその課題について整理したい。
著者
吉村 亜希子
出版者
農村計画学会
雑誌
農村計画学会誌 (ISSN:09129731)
巻号頁・発行日
vol.17, no.3, pp.238-239, 1998-12-30 (Released:2011-04-13)
参考文献数
6
著者
土居 養二 寺中 理明 与良 清 明日山 秀文
出版者
日本植物病理学会
雑誌
日本植物病理学会報 (ISSN:00319473)
巻号頁・発行日
vol.33, no.4, pp.259-266, 1967-09-30 (Released:2009-02-19)
参考文献数
42
被引用文献数
184 490

1. クワ萎縮病の罹病新梢の茎葉を電子顕微鏡観察したところ,既知の植物ウイルス粒子様のものは見出されなかつたが,篩管,ときに篩部柔細胞内に,大小(80∼800mμ)多数の球∼不斉楕円形のMycoplasma様あるいはPLT様の粒子が見出された。これらは2層の限界膜(約8mμ)に包まれ,細胞壁はなく,小形(100∼250mμ)の粒子は概ね球形でribosome様顆粒(径約13mμ)で充たされ,ときに核質様の繊維状領域を示すものもあり,大形(300mμ以上)の粒子は中心が空虚で僅かに核質様の繊維が認められ,顆粒は周辺に偏在する。大小粒子が篩管内に混在する点からみて,小形粒子が生長して大形粒子となるらしく,またときに大形粒子が一部くびれて小形粒子ができるごとき像,小形粒子が大形粒子の内部に数個生じ大形粒子が崩解するような像も認められた。健全植物にはこのような粒子は見出されない。なお,テトラサイクリンで萎縮病から回復したクワ茎葉からはこの粒子は見出されなくなつた。2. ジャガイモてんぐ巣病の罹病茎葉篩部にも大形粒子がやや多いが,同類の大小粒子が見出された。異常肥大した篩部柔細胞の細胞質には大形粒子が充満する例がしばしば認められた。3. Aster yellows感染で叢生萎黄症状を示したペチュニア茎葉篩管部にも前2者と同類の大小粒子が見出された。4. 典型的なてんぐ巣症状を示すキリの側生枝茎葉の篩管内にもクワ萎縮病と同類の大小粒子が見出された。症状の著しい場合は多くの粒子が見出される傾向がある。5. 4種の“叢生萎黄”グループに属する植物病で茎葉篩部に共通して見出された同類の粒子は植物寄生では未報告であるが,それらの形状,構造,所在様式などから,Mycoplasmaに近い寄生微生物であるとの結論に達したので,さらにそれらの病原的意義について若干の考察を行なつた。
著者
吉田 和男
出版者
公共選択学会
雑誌
公共選択の研究 (ISSN:02869624)
巻号頁・発行日
vol.1983, no.3, pp.39-55, 1983-12-10 (Released:2010-10-14)
参考文献数
48

This paper is a study of social optimal control rules of enterprise behavior in the framework of optimal control theory. In the neoclassical theory, enterprise are treated as a mere taker of the price given by the market under the principle of profit maximization. But, in the real economic world, enterprises have power to determine prices and the volume of production. Futhermore enterprise behavior must be alalyzed in the feed back system with factor markets as endogeneous variables. And, we must recognize that the real economy is typically disequilibrium.Based on these premises, it is more proper to formulate enterprise behavior as maximizing the following utility functionJ (X, p) =pX-C (X) -μ (X-D (p) ) 2p: price, X : the volume of production, C: cost function, D: demand function, μ: unit penaltyIn the real economy, enterprises do not maximize their utility function in the sense of global optimality, and seem to approach the true optimal point through quadratic optimization. Thus, it may be formulated by Newton method.[Xp]=[∇2J]-1∇JThis system of equations has a locally stable solution. But, when endogeneous factor prices, wage and interest rate, are considered, the system does not always stable solution. If the system is unstable, the feed back control using fiscal and monetary policy would be required. But negative feed back system does not always produce stable conditions. It means that sometimes discretionary fiscal and monetary policy could make the economy more unstable and produce situations such as stagflation. The system must be controled by optimal control rule. In this paper, it is shown by Pontryagin's maximization principle in linear system.But the real economy is typically nonLinear. When the government controls the economy using a linear economic model, adjustment must be made on the nonlinear factor. It may be made by adaptive control rule.In this paper, Model Refference Adaptive Control System Theory, which is a feed back system (optimal control) ajusted by errors between realized values and estimations by linear model, is introduced. The control of system stability theory.Then, general control rules of enterprise activity are shown.
著者
Shigeo Godo Yoshitaro Yoshida Motoo Fujita Daisuke Kudo Ryosuke Nomura Hiroaki Shimokawa Shigeki Kushimoto
出版者
一般社団法人 日本内科学会
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.56, no.4, pp.455-459, 2017-02-15 (Released:2017-02-15)
参考文献数
21
被引用文献数
6

Biguanides are a drug of choice for the treatment of type 2 diabetes mellitus. Although they can cause lactic acidosis in susceptible patients with predisposing risk factors, the incidence of lactic acidosis is reported to be very low when they are used properly. We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency. Diabetic patients taking biguanide may be predisposed to thiamine deficiency, even when there is no evidence of risk factors, and the high-dose administration of thiamine may be essential in the treatment of this otherwise under-recognized disorder.
著者
鶴 清 広瀬 茂男
出版者
一般社団法人 日本ロボット学会
雑誌
日本ロボット学会誌 (ISSN:02891824)
巻号頁・発行日
vol.30, no.6, pp.639-647, 2012 (Released:2012-08-15)
参考文献数
12
被引用文献数
2 3

Wall-climbing robots having holonomic and omni-directional mobility would enhance the manipulation performance of the mounted arm and enable it to execute various tasks on the surface of large structures. This study focuses on the wall-climbing robots having permanent magnet attractive units to stick to the surface of iron structure such as atomic reactors and discuss the development of a specific holonomic and omni-directional wall-climbing mechanisms. Basic driving mechanism of the wall-climbing robot is based on our former invention named Omni Disk which consists of multiple rollers attached to one side of a rotating disk and having a mechanism to direct the rollers to the same direction. We firstly discuss about the mechanical improvements of the Omni Disk to make it lightweight and low cost. We next discusses about four types of methods to attach permanent magnets to the wall-climbing robot and generates attractive force on the iron wall and select the best type based on the motion experiments about the constructed models. As the result of these considerations, we developed a holonomic and omni-directional wall-climbing robot named Vmax III which consists of three Omni Disks having permanent magnet at their center having the function to change the magnetic attractive force. By using the Vmax III, we studied about the relation among the magnetic attractive force of three Omni Disks, posture of the Vmax III and inclination angle of the iron wall and clarified the optimized distribution of the magnetic attractive force of the Omni Disks in different inclination of the iron wall.