著者
飯田 啓治朗
出版者
サイコアナリティカル英文学会
雑誌
サイコアナリティカル英文学論叢 (ISSN:03866009)
巻号頁・発行日
vol.2000, no.21, pp.16-30, 2000 (Released:2011-03-11)
参考文献数
24

"Eros" and "Thanatos" mean "love" and "death" respectively in Greek. In Beyond the Pleasure Principle (1920), Sigmund Freud employed the ideas of "Eros" and the "death instinct" (which is generally called "Thanatos") as psychological concepts. "Eros, " the libidinal, sexual or life instinct, aims to form living substances into ever greater unities. "Thanatos" leads the living creatures to death and manifests itself as destructive or aggressive impulses. Romeo and Juliet dramatizes the romantic love and tragic death of the two young lovers. However, as the opening of scene 1, Act 1indicates, this drama is full of bawdy or sexual words, representing "Eros. " M. M. Mahood suggests that "the bawdy has always a dramatic function, " and this becomes clearer with reference to "Thanatos. " From the Prologue's first reference to "death-mark'd love, " this play abounds in the imageries of death, most of which are directed toward Romeo and Juliet. In addition these imageries are connected with the imageries of love. Freud first supposed a struggle between "Eros" and "Thanatos, "but in the course of time he allowed the fusion of these two instincts. In the final scenes where Romeo and Juliet kill themselves can be seen this fusion of "Eros" and "Thanatos. "
著者
Norio Suzuki Keisuke Kida Kengo Suzuki Tomoo Harada Yoshihiro J Akashi
出版者
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
pp.14-255, (Released:2015-02-27)
被引用文献数
2 12

Decreased Transthyretin (TTR) can be observed in heart failure patients with malnutrition evaluated by the Mini Nutritional Assessment (MNA). This study investigated whether a combination of different nutritional assessment methods would be useful for assessing prognosis in patients with acute decompensated heart failure (ADHF).This prospective study included 52 patients with ADHF (mean age, 71.1 ± 14.7 years; men 55.8%) who were admitted to our hospital between June 2012 and August 2013. On admission, nutritional status was evaluated according to levels of TTR and the MNA. Of 52 patients, 28 (53.8%) had TTR < 15 mg/dL, 39 (75.0%) had malnutrition or were at risk of malnutrition (MNA score ≤ 23.5), and 21 (40.4%) were categorized into group L (MNA score ≤ 23.5 and TTR < 15 mg/dL). Readmission due to worsening heart failure occurred in 12 patients (23.1%), and there were 4 (7.7%) allcause deaths. The 1-year event-free survival rates in group L and the remaining patients (group O) were 27.7% and 85.6%, respectively (P = 0.001). Using Cox multivariate analysis, group L also had a poorer prognosis (hazard ratio 4.35, 95% confidence interval 1.26–17.74, P = 0.020).MNA revealed that 75% of patients with ADHF had malnutrition or were at risk of malnutrition. The combination of low MNA and low TTR on admission can predict the prognosis of patients with ADHF.
著者
Takashi Watanabe Yuki Hayashi Akiko Aoki Shin Ishiguro Mikito Ueda Kazufumi Akiyama Kazuko Kato Yoshimasa Inoue Shoko Tsuchimine Norio Yasui-Furukori Kazutaka Shimoda
出版者
日本臨床精神神経薬理学会
雑誌
Clinical Neuropsychopharmacology and Therapeutics (ISSN:18848826)
巻号頁・発行日
vol.6, pp.5-15, 2015 (Released:2015-03-13)
参考文献数
39

Purpose: This study evaluated the impact of CYP2D6 polymorphism, and particularly CYP2D6*10 alleles, on the steady-state plasma concentrations of mirtazapine (MIR) and its metabolite N-desmethylmirtazapine (DMIR) in Japanese psychiatric patients.Patients and Methods: The subjects were 75 Japanese patients treated with racemic MIR. The steady-state plasma concentrations of MIR and DMIR were measured using liquid chromatography. The CYP2D6 genotypes were determined by polymerase chain reaction. Three subjects whose plasma levels of MIR and DMIR were below the limit of detection were regarded as non-adherent and excluded, and 4 subjects having the CYP2D6*5 allele (CYP2D6*1/CYP2D6*5 and CYP2D6*2/CYP2D6*5 (n = 3) and CYP2D6*5/CYP2D6*10 (n = 1)) were excluded from the analysis in order to eliminate the effect of the CYP2D6*5 allele. Accordingly, data from 68 subjects were subjected to analysis.Results: There were no significant differences in the plasma concentrations of MIR or DMIR (all corrected for dose and body weight) among different CYP2D6 genotypes. Multiple regression analysis also revealed that age affects MIR (corrected for dose and body weight) (p=0.079). Also, multiple regression analysis revealed that age correlated significantly to the plasma concentration of DMIR (corrected for dose and body weight) (p=0.026). Neither sex nor the number of CYP2D6*10 alleles were significant factors for either the plasma concentration of MIR (corrected for dose and body weight) or the plasma concentration of DMIR (corrected for dose and body weight).Conclusion: CYP2D6*10 polymorphism did not significantly affect the steady-state plasma levels of MIR and DMIR in Japanese patients, but age had a significant effect on the plasma levels of DMIR.
著者
川﨑 章司 田岡 久雄 長尾 泰気 大中 奎佑
出版者
一般社団法人 電気学会
雑誌
電気学会論文誌B(電力・エネルギー部門誌) (ISSN:03854213)
巻号頁・発行日
vol.135, no.2, pp.89-96, 2015 (Released:2015-02-01)
参考文献数
28
被引用文献数
1

Renewable energy sources such as photovoltaic generation (PV) have been promoted to be innovated. However, the output of PV is influenced by the weather condition and cause a steep fluctuation. So it is important to forecast the output of PV when an electric power company makes the power supply schedule for demand. In this paper, the authors proposed a forecasting method for amount of insolation closely related to the output of PV. In the proposed method, the amount of insolation is forecasted through the application of Genetic Algorithm which is one of the optimization method by using the past measured data. In addition, the correlation coefficients are analyzed with the weather data and measured insolation data. And, the correlation coefficients are used as the weight of observe value. The authors verify the validity and prediction accuracy of the proposed method. Moreover, we tried to improve the forecasting error by using the latest measured weather data and weather data of the other point.
著者
YOSHIKAZU SUZUKI TADASHI KAMIKAWA NOBORU YAMAZAKI
出版者
日本循環器学会
雑誌
JAPANESE CIRCULATION JOURNAL (ISSN:00471828)
巻号頁・発行日
vol.45, no.5, pp.552-559, 1981-05-20 (Released:2008-04-14)
参考文献数
38
被引用文献数
12 17

The effects of L-carnitine on ventricular arrhythmias were evaluated in dogs with acute myocardial ischemia and a supplement of excess free fatty acids (FFA). Acute myocardial ischemia was induced by ligation of left anterior descending coronary artery. After 80 minutes of coronary occlusion, high plasma FFA was induced by intravenous injection of heparin 200 u/kg and Intralipid(R) 5 ml/kg as a bolus. After additional 60 minutes, beating hearts were removed from animals and tissue levels of free carnitine, short and long chain acyl carnitine, FFA and adenosine triphosphate (ATP) were determined. L-carnitine 100 mg/kg was administered intravenously 5 minutes before coronary artery ligation. Electrocardiograms were recorded continuously by a Holter electrocardiographic recorder during the experiment and ventricular arrhythmias were quantified by an arbitrary scoring system. In ischemic and excess FFA supplemented myocardium, free carnitine and ATP decreased, whereas long chain acyl carnitine and FFA increased. And these metabolic changes tended to be reduced by L-carnitine. Pretreatment of L-carnitine also reduced the grade of ventricular arrhythmias induced both by acute myocardial ischemia and by supplement of excess FFA. These results suggest that the administration of L-carnitine may be beneficial to prevent serious arrhythmias in ischemic heart disease, presumably by restoring the impaired FFA oxidation.
著者
Yoshikazu SUZUKI Tadashi KAMIKAWA Noboru YAMAZAKI
出版者
Japanese Heart Journal Association
雑誌
Japanese Heart Journal (ISSN:00214868)
巻号頁・発行日
vol.22, no.2, pp.219-225, 1981 (Released:2008-12-09)
参考文献数
23
被引用文献数
7 11

The effect of L-carnitine on cardiac hemodynamics was evaluated in normal closed chest dogs. Extracorporeal circulation was produced to measure coronary blood flow in closed chest dogs. Coronay venous blood was introduced to the extracorporeal circuit through a polyethylene catheter wedged into the coronay sinus under fluoroscopic control and was returned to the animal through the left jugular vein. L-carnitine was infused intravenously at a constant rate of 80mg/Kg/min for 8min. Hemodynamic responses appeared within 1 to 3min of carnitine infusion and peak effects were observed nearly after 5min. Peak effects on cardiac hemodynamics after 5 to 8min of carnitine infusion were as follows. Heart rate decreased by 17% from control (p<0.05). Aortic and left ventricular pressure increased by 20% (p<0.05 and p<0.01 respectively) and peak positive left ventricular dp/dt increased by 35% (p<0.01), the mean rate pressure product as the index of myocardial oxygen consumption remained unchanged. Coronary blood flow increased by 60% (p<0.001) and coronary vascular resistance decreased by 25% (p<0.01). As the infusion of carnitine was discontinued, the effects promptly disappeared. These data suggest that L-carnitine has direct vasodilating and positive inotropic effects on cardiovascular system.
著者
三神 彩子 長尾 慶子 赤石 記子 久松 裕子 杉浦 淳吉 松葉口 玲子
出版者
一般社団法人 日本家政学会
雑誌
日本家政学会誌 (ISSN:09135227)
巻号頁・発行日
vol.66, no.3, pp.102-112, 2015 (Released:2015-03-07)
参考文献数
25

This research focuses on Eco-cooking, an environmentally-friendly way of cooking through shopping, cooking and cleaning. We analyze and quantify people's energy-saving behaviors, evaluate the effect of eco-cooking, and seek to clarify what kinds of energy-saving behaviors have or have not been promoted by energy-saving education. The three-year-research on third-year students in home economics teacher-training program shows reduction in gas, water usage and waste produced during cooking by 40% to 80%. CO2 emission amount also decreased by about 50%. Furthermore, survey shows people who sometimes or always perform energy-saving behaviors account for 75% of the total. In conclusion, Eco-cooking energy-saving education is generally effective in raising people's energy-saving awareness and inducing behavior change. In order to make limited energy-saving educational programs more effective, it is important to ponder upon the content that is suitable for such a program as well as what the program should focus on.
著者
羽山 順子 足達 淑子
出版者
日本行動医学会
雑誌
行動医学研究 (ISSN:13416790)
巻号頁・発行日
vol.12, no.1, pp.25-35, 2006 (Released:2014-07-03)
参考文献数
36

不眠者の行動観察から、いくつか仮説が提起されている。それは「不眠者は、不眠を補おうとして不眠を悪化させるような行動をとる、睡眠に対し過度の期待や思い込みのような不適応的な認知を持つ」というものであるが、日本ではまだこの仮説を検証した研究は少ない。また、生活習慣と不眠の関連は一定した結果が得られていない。本研究は以上の仮説と、生活習慣と不眠の関連を検証することを目的とした。保健所主催の睡眠改善セミナー参加者(以下不眠群)16名の睡眠に関連する生活習慣と睡眠に関する認知を、セミナー参加者と同じ地域の住民(以下一般群)73名と比較した。また、地域住民の中でも睡眠の良否で違いがあるかどうか確認するため、一般群について睡眠効率を基準に睡眠不良群18名と睡眠良好群55名に分け、生活習慣と睡眠に関する認知を比較した。不眠群と一般群を比較したところ、不眠群は一般群よりも入眠潜時は16.3分、要起床時間は50.4分長く、これは睡眠不足を補うための行動ではないかと考えた。睡眠に関連する生活習慣は、全体得点では傾向差がありやや不良であることがうかがわれたが、その内容を詳細に観察すると睡眠薬使用と寝室の環境以外は差が認められず、必ずしも不眠群の生活習慣が不良であるとはいえなかった。不適応的認知の保有数に差はなく、下位項目ごとに比較をしても、不眠群で「不安やイライラは不眠のせい」が多く見られたのみで、「不眠で身体や神経がまいる」はむしろ一般群の方が多い傾向にあった。その他の8下位項目に差はなかった。さらに睡眠不良群と睡眠良好群の比較では、睡眠不良群は睡眠良好群よりも、入眠潜時は58.4分、要起床時間は45.5分長く、睡眠効率は19.8%低いという不眠群同様の特徴が認められた。生活習慣は運動と就寝直前の活用の2項目で睡眠良好群よりも良好であり、不適応的認知については全ての項目において差がなかった。以上より、不眠を補う行動と睡眠効率についての仮説は不眠群も睡眠不良群もあてはまっていると考えられたが、生活習慣と不適応的認知に関しては、一概に不眠と関係があるということはできなかった。睡眠改善の指導はその人一人一人に適した指導が必要であると考えられた。また、睡眠の良否と生活習慣、睡眠に関する不適応的認知に関連がなかったことは、睡眠に関する一般的な知識が浸透していないためとも考えられ、睡眠に関する健康教育は、不眠者ばかりでなく、睡眠に問題がない者にも必要であると考えられた。
著者
永吉 実武
出版者
日本経営診断学会
雑誌
日本経営診断学会論集 (ISSN:18824544)
巻号頁・発行日
vol.12, pp.92-98, 2012 (Released:2013-06-29)
参考文献数
8

本論文では,小規模小売業の店舗数拡大時における業務改善事例を取り上げ,得られた効果を既存研究の理論に当てはめることにより,業務改革と効果獲得との間の因果関係メカニズムについて考察を行った。小規模企業が事業の拡大を行う際に,さまざまな課題や問題が発生し,それに対して,経営者は適切な対応策を講じていく必要がある。その際に業務改革や情報システムの導入を実施する企業が多いが,「プロセス志向」の醸成が重要である。これらは,業務改善に取り組む企業に有用な示唆を与えるだけでなく,既存理論が小規模小売業の店舗数拡大時の業務改善策が効果を獲得するに至る因果関係の考察にも有用であることを示すものである。