著者

碇 直樹 松山 悟 下西 智徳 那須 賢司 大田 準二

出版者

日本臨床外科学会

雑誌

日本臨床外科学会雑誌 (ISSN:13452843)

巻号頁・発行日

vol.70, no.4, pp.1095-1098, 2009 (Released:2009-10-05)

参考文献数

24

被引用文献数

1

---

症例は62歳,男性.2007年1月27日(土)心窩部痛,右下腹部痛を主訴に夜間外来を受診した.30年前虫垂炎の診断で開腹されたがドレナージのみで治療され未切除だった.血液検査で炎症所見を認め,US施行されたが診断は困難であったため,CTを施行し当直医は急性腸炎と診断し外来で抗菌薬加療を開始した.翌日,圧痛を右季肋部に認めた.翌々日,症状及び炎症所見は改善傾向であったが,放射線科医によるCT再読影で,盲腸の頭側偏位と腫大した虫垂,糞石を認め,移動盲腸を伴う急性虫垂炎と診断された.虫垂根部の処理を考え右上腹部傍腹直筋切開で開腹すると盲腸・上行結腸周囲は右側腹部,右上腹部で強固に癒着しており,これを剥離し盲腸壁の一部を含め虫垂を切除した.移動盲腸は稀ではなく,急性腹症の診断においては念頭に置く必要がある.今回,CTで移動盲腸に伴う急性虫垂炎と診断し,適切な皮膚切開での病変切除が可能であった.

著者

千須和 寿直 田内 克典 大森 敏弘 森 周介 岸本 浩史 小池 秀夫 樋口 佳代子 宮澤 正久

出版者

日本臨床外科学会

雑誌

日本臨床外科学会雑誌 (ISSN:13452843)

巻号頁・発行日

vol.69, no.10, pp.2462-2467, 2008 (Released:2009-04-07)

参考文献数

18

被引用文献数

4 2

---

目的:急性虫垂炎の診断におけるCTを重視したプロトコールの正確性と虫垂径の測定の有用性の評価.対象と方法:2002年1月から2004年6月の間に急性虫垂炎と診断した連続した239人を検討した.CTでの診断基準は6mm以上の虫垂径または2次性の炎症変化とした.病理学的な診断基準は筋層以上の炎症細胞浸潤とした.結果:239人のうち235人がCTを受けていた.222人が虫垂切除術を受け,205人が病理学的に急性虫垂炎と診断された.CTで虫垂径が6mm以上あった200人中193人が病理学的に急性虫垂炎と診断された.手術症例の陽性的中率は92.3%(205/222)で,CTで虫垂径が6mm以上あった手術症例の陽性的中率は96.5%(193/200)であった.また保存的治療症例の35.3%(6/17)が再発し,10mm以上で再発率が50%(5/10)と高かった.結論:CTは急性虫垂炎の診断に有用である.

著者

Eun-Joo Shin Wan Kyunn Whang Sungun Kim Jae-Hyung Bach Jin-Man Kim Xuan-Khanh Thi Nguyen Thuy-Ty Lan Nguyen Bae Dong Jung Kiyofumi Yamada Toshitaka Nabeshima Hyoung-Chun Kim

出版者

(公社)日本薬理学会

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.113, no.4, pp.404-408, 2010 (Released:2010-08-18)

参考文献数

15

被引用文献数

11 25

---

Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5HT1A–receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A–agonist activity in a 8-OH-DPAT–stimulated [35S]GTP-γS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors.

著者

Vu Thu TRANG Vu Hong SON Lam Xuan THANH Samira SARTER Tomoko SHIMAMURA Hiroyuki UKED Hiroaki TAKEUCHI

出版者

社団法人 日本食品科学工学会

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.19, no.5, pp.833-841, 2013 (Released:2013-11-20)

参考文献数

30

被引用文献数

6

---

Antimicrobial activities of aminoreductone (AR), a product formed in the initial stages of the Maillard reaction, were investigated using eight clinical isolates of antibiotic-susceptible/resistant pathogenic bacteria: four Pseudomonas aeruginosa, one multi-drug-resistant Pseudomonas aeruginosa (MDRP), one Escherichia coli, one methicillin-susceptible Staphylococcus aureus, and one methicillin-resistant Staphylococcus aureus (MRSA). AR showed advanced growth inhibition effects compared to antibiotics (amikacin, ciprofloxacin, imipenem and levofloxacin) frequently used for the treatment of infectious diseases, and worked synergistically with these antibiotics. The minimum inhibitory concentrations (MIC) of AR ranged from 13 to 20 mM. The bactericidal activity of AR was dose and time dependent. The minimum bactericidal concentration (MBC) was lower for Gram-negative bacteria (32 to 40 mM). These findings suggest that AR, a naturally formed antimicrobial agent present in thermally processed foods, has promising potential for health promotion and for use in medical practices.

著者

Michiyasu Sakagami Takahiro Sasamori Heisuke Sakai Yukio Furukawa Norihiro Tokitoh

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

vol.86, no.10, pp.1132-1143, 2013-10-15 (Released:2013-10-15)

参考文献数

62

被引用文献数

27

---

1,2-Bis(ferrocenyl)dipnictenes bearing a Pn=Pn π-spacer (Pn: P (1), Sb (2), and Bi (3)) between two ferrocenyl units have been synthesized as stable compounds. Not only their molecular structures and fundamental properties but also their redox behavior have been systematically disclosed. Interestingly, in the reduction region, the dipnictenes showed two pseudo-reversible one-electron redox couples at low temperature, suggesting possible generation of the corresponding radical anion and dianion species. On the other hand, they showed three-step one-electron oxidation processes in the oxidation region. The first two oxidation steps would correspond to those of the two ferrocenyl moieties, while the third step would be that of the Pn=Pn π-spacer moiety, respectively. Thus, these 1,2-bis(ferrocenyl)dipnictenes with a Pn=Pn π-spacer should be stable multiredox systems reflecting unique properties of a double bond between heavier 15 group elements. As a result, all Pn=Pn units (Pn: P, Sb, and Bi) were found to work as a more effective π-spacer than those of 2nd row elements such as C=C and N=N.

著者

林 礼子

出版者

日本言語学会

雑誌

言語研究 (ISSN:00243914)

巻号頁・発行日

vol.1995, no.107, pp.129-152, 1995-03-25 (Released:2007-10-23)

参考文献数

34

著者

奥田 道大

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.56, no.2, pp.559-563, 2005-09-30 (Released:2009-10-19)

参考文献数

14

著者

久米 道之 小野 さとみ 大澤 松夫

出版者

一般社団法人 表面技術協会

雑誌

表面技術 (ISSN:09151869)

巻号頁・発行日

vol.42, no.8, pp.854-855, 1991-08-01 (Released:2009-10-30)

参考文献数

2

被引用文献数

1

著者

審良 静男

出版者

日本炎症・再生医学会

雑誌

炎症・再生 (ISSN:13468022)

巻号頁・発行日

vol.23, no.4, pp.211-217, 2003 (Released:2006-12-01)

参考文献数

26

被引用文献数

1 2

---

Toll-like receptors (TLRs) play a critical role in the detection of invading pathogens and subsequent immune response against them. Individual TLRs recognize distinct microbial components. The TLR is a type 1 transmembrane receptor that is composed of an extracellular leucine-rich repeat (LRR) domain and cytoplasmic domain homologous to that of the IL-1R family. Therefore, TLR and IL-1R family use the same signaling molecules. Cytokine production in response to each TLR ligand is completely abolished in MyD88-deficient cells, indicating that MyD88 is an essential signaling molecule shared among IL-1R/Toll family. However, accumulating evidence indicates that differential utilization of adaptors including MyD88, TIRAP, and TRIF may activate overlapping as well as distinct signaling pathways, and finally give rise to distinct biological effects exerted by individual TLR family.

著者

北垣 邦彦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.12, pp.1309-1314, 2013 (Released:2013-12-01)

参考文献数

4

被引用文献数

2 1

---

World Health Organization (WHO) indicated that recognition of the responsibility of individuals for their own health and awareness that professional care for minor ailments is often unnecessary were important points of view for “Self-Medication” in “Guidelines for the Regulatory Assessment of Medicinal Products for Use in Self-Medication” published in 2000. In Japan, educational curriculum in each school is formulated by “the Courses of Study”. Education for health at junior and senior high school is mainly carried out in “Health and Physical Education” class. The objectives are to enable students to develop qualities and abilities to appropriately manage and improve their health throughout their lives through understanding of health and safety in personal and social life. This idea is common with self-medication at a basic concept level. The previous Courses of Study were revised in 2008 and 2009. They described about medicine for senior but not junior high school. The interim report of “The Central Council for Education” in 2005 pointed out that understanding about effects/side effects by medicines, and abilities to use them appropriately are one of minimal qualities that all children must acquire. Due to revision of the Pharmaceutical Affairs Law in 2006, the necessity of endeavoring to widespread knowledge and enlighten about proper use of medicines in school education was considered. Since the new Courses of Study in the junior high school shows content that medicines should be used properly, it is thought that educational frame of medicines for children is going into new era in Japan.

著者

兪 文偉 横井 浩史 嘉数 侑昇

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌C(電子・情報・システム部門誌) (ISSN:03854221)

巻号頁・発行日

vol.117, no.9, pp.1300-1307, 1997-08-20 (Released:2008-12-19)

参考文献数

14

---

In this paper, we propose the State Grouping scheme for coping with the problem of scaling up the Reinforcement Learning Algorithm to real, large size application. The grouping scheme is based on geographical and trial-error information, and is made up with state generating, state combining, state splitting, state forgetting procedures, with corresponding action selecting module and learning module. Also, we discuss the Labeling Based Evaluation scheme which can evaluate the opportunity of the state-action pair, therefore, use better experience to guide the exploration of the state-space effectively. Incorporating the Labeling Based Evaluation and State Grouping scheme into the Reinforcement Learning Algorithm, we get the approach that can generate organized state space for Reinforcement Learning, and do problem solving as well. We argue that the approach with this kind of ability is necessary for autonomous agent, namely, autonomous agent can not act depending on any pre-defined map, instead, it should search the environment as well as find the optimal problem solution autonomously and simultaneously. By solving the large state-size 3-DOF and 4-link manipulator problem, we show the efficiency of the proposed approach, i.e., the agent can achieve the optimal or sub-optimal path with less memory and less time.

著者

東 政明

出版者

(社)日本蚕糸学会

雑誌

日本蚕糸学雑誌 (ISSN:00372455)

巻号頁・発行日

vol.64, no.1, pp.1-18, 1995-02-27 (Released:2010-07-01)

参考文献数

81

被引用文献数

1

著者

村田 伸 津田 彰 中原 弘量

出版者

理学療法科学学会

雑誌

理学療法科学 (ISSN:13411667)

巻号頁・発行日

vol.20, no.3, pp.213-217, 2005 (Released:2005-09-02)

参考文献数

29

被引用文献数

2 2

---

本研究は,健常成人16名(男性7名,女性9名,平均24.8±3.7歳)を対象に,音楽聴取と精神作業負荷(数字の逆唱と果物の想起課題)が重心動揺に及ぼす影響を検討した。重心動揺の指標とした総軌跡長と外周面積は,3条件間で有意に異なり,精神作業負荷条件での重心動揺が統制条件(無音状態)での重心動揺より有意に大きかった。音楽聴取条件での重心動揺については,有意差が認められなかった。これらの知見より,受動的音楽聴取以上に精神作業負荷が,身体動揺の増加を惹起することが明らかとなった。

著者

渡部 昭男

出版者

一般社団法人 日本教育学会

雑誌

教育学研究 (ISSN:03873161)

巻号頁・発行日

vol.46, no.4, pp.314-323, 1979-12-30 (Released:2009-01-13)

参考文献数

53

著者

楠美 順理 ニラシュ アグネス

出版者

一般社団法人 日本環境教育学会

雑誌

環境教育 (ISSN:09172866)

巻号頁・発行日

vol.21, no.3, pp.3_56-63, 2012-03-31 (Released:2013-11-30)

参考文献数

3

著者

松岡 憲知

出版者

公益社団法人 東京地学協会

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.121, no.2, pp.v-vi, 2012-04-25 (Released:2012-05-29)

参考文献数

3

著者

Naotaka SAGA Yoshifumi KIMURA Masahide TERAZIMA Noboru HIROTA

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences/Supplements

巻号頁・発行日

pp.s234-s236, 2002 (Released:2007-03-13)

著者

森田 利文

出版者

公益社団法人 高分子学会

雑誌

高分子 (ISSN:04541138)

巻号頁・発行日

vol.12, no.8, pp.592-597,607, 1963-07-20 (Released:2011-09-21)

参考文献数

79

著者

岡沢 精茂 並木 満夫 高田 君枝 松山 晃

出版者

公益社団法人 日本農芸化学会

雑誌

日本農芸化学会誌 (ISSN:00021407)

巻号頁・発行日

vol.36, no.8, pp.680-684, 1962 (Released:2008-11-21)

参考文献数

16