著者

笹山 啓 ササヤマ ヒロシ SASAYAMA Hiroshi

出版者

東京外国語大学総合文化研究所

雑誌

総合文化研究 (Trans-Cultural Studies) (ISSN:18831109)

巻号頁・発行日

no.19, pp.255-258, 2016-03-12

著者

金田 英宏 芝井 広 尾中 敬 The SPICA Team Kaneda Hidehiro Shibai Hiroshi Onaka Takashi The SPICA Team

出版者

宇宙航空研究開発機構(JAXA)

雑誌

宇宙航空研究開発機構特別資料 = JAXA Special Publication: The Cosmic Wheel and the Legacy of the AKARI archive: from galaxies and stars to planets and life (ISSN:24332232)

巻号頁・発行日

no.17, pp.53-58, 2018-03-09

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第4回「あかり」国際会議 (2017年10月17-20日. 東京大学), 文京区, 東京形態: カラー図版あり資料番号: AA1730026007レポート番号: JAXA-SP-17-009E

著者

青木 良尚 浜本 滋 神田 宏 佐藤 衛 木村 毅 西島 寛典 Aoki Yoshihisa Hamamoto Shigeru Kanda Hiroshi Sato Mamoru Kimura Takeshi Nishijima Hironori

出版者

宇宙航空研究開発機構(JAXA)

雑誌

宇宙航空研究開発機構特別資料: 第86-第90回風洞研究会議論文集 = JAXA Special Publication: Proceedings of the Wind Tunnel Technology Association 86th-90th meeting (ISSN:1349113X)

巻号頁・発行日

vol.JAXA-SP-14-011, pp.1-6, 2015-03-25

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第86回風洞研究会議 (2011年5月19日-20日)

著者

鈴木 宏 Hiroshi Suzuki

巻号頁・発行日

vol.21, pp.11-16, 2014-03-31

著者

石黒 洋 山本 明子 中莖 みゆき 衣 蘭娟 石黒 真理子 山口 誠 近藤 志保 持丸 由香 Ishiguro Hiroshi Yamamoto Akiko Nakakuki Miyuki Yi Lanjuan Ishiguro Mariko Yamaguchi Makoto Kondo Shiho Mochimaru Yuka

出版者

名古屋大学総合保健体育科学センター

雑誌

総合保健体育科学 (ISSN:02895412)

巻号頁・発行日

vol.35, no.1, pp.9-15, 2012-03-30

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Excretion of hypotonic sweat by eccrine sweat gland is achieved by re-absorption of NaCl by sweat duct which is an important function to prevent the salt loss and heat prostration. The Cl– transport by sweat duct is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. CFTR is the causative gene for cystic fibrosis, an autosomal recessive genetic disease. CFTR functions as a cAMP-dependent anion channel localized in the apical membrane of various epithelia. Loss of function due to severe mutations in both alleles causes typical cystic fibrosis characterized by dehydrated, thick, and viscous luminal fluid/mucus in the respiratory and gastrointestinal tract, pancreatic duct, and vas deferens. Cystic fibrosis is the most common genetic disease in Caucasians (1 per ~3,000 births) but it is rare in the Asian population including Japanese (1 per ~1.5 million). A compound heterozygote of mutations/polymorphisms (causing a mild dysfunction of CFTR) involves a risk of developing CFTR-related diseases (or atypical cystic fibrosis) such as chronic pancreatitis and male infertility due to congenital bilateral absence of the vas deferens (CBAVD). Recent studies suggest that CFTR mutations/polymorphisms are frequently found in Japanese patients with chronic pancreatitis, CBAVD and diffuse panbronchiolitis. Cl– concentration in the sweat is a useful measure of CFTR function in human. The sweat [Cl–] in healthy subjects is correlated with ages. High levels (>60 mM) of sweat [Cl–] suggest the dysfunction of CFTR.

著者

Hiroshige Tateuchi Toshihiko Yoneda Takahiro Tanaka Hitoshi Kumada Masahiro Kadota Hiroshi Ohno Kazunari Tanaka Jun Yamaguchi

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.18, no.1, pp.49-55, 2006 (Released:2006-07-26)

参考文献数

22

被引用文献数

4 5

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The purpose of this study was to clarify the postural control of the initiation of lateral step and step-up motions in healthy young adults (24.3 ± 1.8 years: mean ± SD). The tasks involved the lateral step (step lengths, 10 cm and 20 cm) and lateral step-up motions (10-cm high stool; step lengths, 10 cm and 20 cm). The variables for analysis included motion duration (weight-shift phase and swing phase), shifts of the center of pressure (CoP) and the center of gravity (CoG), displacement and inclination of the shoulder and the pelvis, and root mean square electromyographic amplitude of the erector spinae, gluteus medius (GM) and adductor longus (AL) bilaterally. The CoP shift toward the stepping side was larger in the step-up task than in the step task, and it was smaller when both tasks were performed in the long lengths. The CoG shift toward the supporting side and the displacements of the shoulder and pelvis were larger in the step-up task than in the step task. However, the magnitude of GM activity of the supporting leg was larger in the step task than in the step-up task, and increased when both tasks were performed in the long lengths. In the stepping leg, the magnitude of AL activity was larger in the step-up task than in the step task, and decreased when both tasks were performed in the long lengths. These results suggest that GM activity of the supporting leg and AL activity of the stepping leg control the shift of CoG in the frontal plane. Our results indicate that the increase in GM activity does not depend on the height of stepping but on the length of stepping in lateral step and step-up motions.

著者

市瀬 晶子 引土 絵未 李 善惠 大倉 高志 山村 りつ 全 海元 高 仙喜 倉西 宏 尾角 光美 木原 活信 Akiko Ichinose Emi Hikitsuchi Sunhye Lee Takashi Okura Ritsu Yamamura Haewon Jun Sun Hui Ko Hiroshi Kuranishi Terumi Okaku Katsunobu Kihara

雑誌

人間福祉学研究 = Japanese Journal of Human Welfare Studies (ISSN:18832741)

巻号頁・発行日

vol.7, no.1, pp.115-127, 2014-12-31

著者

Yano Hiroshi Shinkawa Yuya Ishii Kazuo

雑誌

DPレポート = DP Report

巻号頁・発行日

no.10015, pp.1-9, 2020-12-07

著者

及川 和美 荒金 圭太 倉藤 利早 斎藤 辰哉 松本 希 高木 祐介 河野 寛 藤原 有子 白 優覧 小野寺 昇 Oikawa Kazumi Arakane Keita Kurato Risa Saito Tatsuya Matsumoto Nozomi Takagi Yusuke Kawano Hiroshi Fujiwara Yuko Baik Wooram Onodera Sho

雑誌

川崎医療福祉学会誌 = Kawasaki medical welfare journal

巻号頁・発行日

vol.20, no.2, pp.453-456, 2011

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本研究は,「水中だるまさんがころんだ」運動時の心拍数と酸素摂取量の変化から水中運動としての「だるまさんがころんだ」の特性を明らかにすることを目的とした.被験者は,健康成人男性8名(年齢 : 21±2歳,)とした.被験者は,鬼が「だるまさんがころんだ」と発声している時に最大努力で水中を移動し,声が止んだ時に静止した.鬼までの距離を20mとした.鬼に到着するまでを1セットとし,3セット繰り返した.セット間には,3分間水中立位安静を行った.測定項目は,心拍数と酸素摂取量とした.運動後の心拍数および酸素摂取量は,1セット目の運動時と比較して,1セット目以降の運動時が,同等あるいはそれ以上の値を示した.水中でも陸上の「だるまさんがころんだ」と同様にインターバルトレーニング様の心拍数と酸素摂取量変化を示した.運動生理学的な分析から「水中だるまさんがころんだ」が身体トレーニングの要素を持つことが明らかになった.

著者

UBARA Ayaka SUMI Yukiyoshi ITO Kazuki MATSUDA Arichika MATSUO Masahiro MIYAMOTO Towa KADOTANI Hiroshi 乳原 彩香 角 幸頼 伊藤 一樹 松田 有史 松尾 雅博 宮本 都和 角谷 寛

出版者

MDPI AG

雑誌

International Journal of Environmental Research and Public Health

巻号頁・発行日

vol.17, no.23, pp.8971, 2020-12-02

被引用文献数

11

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We aimed to analyze (a) the changes in depression, sleepiness, insomnia, and sleep habits in relation to the degree of self-isolation and (b) the effects of changes in sleep habits and social interactions on depression, insomnia, and sleepiness during the coronavirus disease 2019 (COVID-19) pandemic. We enrolled 164 patients who visited the sleep outpatient clinic in Shiga University of Medical Science Hospital. We compared the sleep habits, depression (Patient Health Questionnaire-9: PHQ-9), insomnia (Athens Insomnia Scale: AIS), and sleepiness (Epworth Sleepiness Scale: ESS) of patients during the period from April to July 2019 vs. May 2020 (a period of self-isolation due to COVID-19). A Wilcoxon signed-rank test indicated no significant differences in PHQ-9, ESS, and AIS scores between 2019 and 2020 within both the strong self-isolation group and no/little self-isolation group. With respect to sleep habits, earlier bedtime (p = 0.006) and increased sleep duration (p = 0.014) were found in the strong self-isolation group. The former (p = 0.009) was also found in the no/little self-isolation group, but we found significant differences in sleep duration between the no/little self-isolation group and the strong self-isolation group (p = 0.047). Therefore, self-isolation due to COVID-19 had relatively small one-year effects on depression, sleepiness, and insomnia in a clinical population.

著者

Eiichi Araki Atsushi Tanaka Nobuya Inagaki Hiroshi Ito Kohjiro Ueki Toyoaki Murohara Kenjiro Imai Masataka Sata Takehiro Sugiyama Hideki Ishii Shunsuke Yamane Takashi Kadowaki Issei Komuro Koichi Node on behalf of the Directors of the JCS and JDS

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.85, no.1, pp.82-125, 2020-12-25 (Released:2020-12-25)

参考文献数

293

被引用文献数

16

著者

Kyohei MATSUI So TANABE Shuyi SUN Dung NGUYEN Takamasa KINOSHITA Yojiro YAMAMOTO Hiroshi SHIIGI

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.36, no.12, pp.1461-1465, 2020-12-10 (Released:2020-12-10)

参考文献数

31

被引用文献数

5

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Enzyme-linked immunosorbent assay (ELISA) is a widespread analytical biochemistry assay. In this work, a direct ELISA method using a metallic nanoparticle (NP)-immobilized 96-well plate was developed for high-throughput, highly sensitive fluorescence analysis. Immobilization of metallic NPs on a 96-well plate effectively amplified fluorescence signals of the assay. The silver (Ag) NP-immobilized plate showed the best fluorescence enhancement effect of all the metal-immobilized plates tested. We used the Ag NP-immobilized plate to detect biomolecules and bacteria and found that both the fluorescence intensity and the limit of detection (LOD) were strongly enhanced by more than 100 times compared with those of the unmodified 96-well plates. Quantitative and qualitative considerations for target bacteria regarding the impact of autofluorescence on detection were successfully obtained for several strains. Our results demonstrate the potential of applying Ag NPs for enhancing the efficiency of direct and indirect ELISA assays.

著者

Hiroshi Kobe Akihiro Ito Hiroki Hayata Keisuke Nishimura Yasunori Ueda Tadashi Ishida

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.60, no.1, pp.131-136, 2021-01-01 (Released:2021-01-01)

参考文献数

22

被引用文献数

2

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A 76-year-old woman with dermatomyositis was being treated with prednisolone, tacrolimus, and mycophenolate mofetil. There was a solitary lung nodule in the right middle lobe on chest computed tomography at a routine follow-up examination. A transbronchial lung biopsy was performed, and the histopathologic findings indicated diffuse large B-cell lymphoma. An immunodeficiency-associated lymphoproliferative disorder was suspected, and mycophenolate mofetil was stopped without adding any other therapy. Nine months later, the pulmonary nodule had disappeared on chest computed tomography.

著者

Hiroshi Fujimoto Koichi Sakata

出版者

The Institute of Electrical Engineers of Japan

雑誌

IEEJ Journal of Industry Applications (ISSN:21871094)

巻号頁・発行日

vol.3, no.3, pp.270-276, 2014 (Released:2014-05-01)

参考文献数

17

被引用文献数

3 6

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Motion control techniques are employed for nanoscale positioning in industrial equipment such as numerical control (NC) machine tools and exposure systems. The advanced motion control techniques are based on precise current control. However, speeding up the precise current response causes a serious limitation owing to the carrier period of the inverter. In addition, the position response has to be slower than the current response. In a previous paper, we designed and fabricated an experimental precision stage, achieving novel ultrahigh-speed nanoscale positioning based on multirate pulse width modulation (PWM) control. However, it was difficult to achieve faster and more precise positioning because of the resonance modes of the stage. In this paper, we propose a multirate PWM control in which the resonance mode is considered. Simulations and experiments are performed to demonstrate the advantages of the proposed method.

著者

Hitoshi NAKANO Yuki KAMEO Hiroshi SATO Masami MOCHIZUKI Mayumi YOKOYAMA Shigehiko UNI Takahiro SHIBASAKI Ken MAEDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.71, no.12, pp.1661-1663, 2009 (Released:2009-12-31)

参考文献数

16

被引用文献数

11 12

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Canine distemper virus (CDV) causes a lethal disease among members of the Carnivora. To clarify the distribution of CDV in wild animals, we examined 106 raccoon sera collected from two prefectures in Japan, Hyogo and Osaka, from 2005 to 2007. Among them, 34 raccoons (32.1%) possessed a virus-neutralizing (VN) antibody to KDK-1 strain (genotype Asia-1). There was no significant difference in seroprevalence of CDV regardless of places, gender, and body weights. In Hyogo, a geometric mean of VN titers to KDK-1 was significantly higher than that to Onderstepoort (vaccine strain), indicating that KDK-1-like CDV different from vaccine strain might have spread among raccoon population in Hyogo. In conclusion, CDV is epidemic among feral raccoons in Japan, suggesting that CDV might have been spreading among Japanese wild animals.

著者

Hiromi Nabeshi Tomoaki Tsutsumi Masaaki Imamura Yoshinori Uekusa Akiko Hachisuka Rieko Matsuda Reiko Teshima Hiroshi Akiyama

出版者

Food Safety Commission, Cabinet Office, Government of Japan

雑誌

Food Safety (ISSN:21878404)

巻号頁・発行日

vol.8, no.4, pp.97-114, 2020 (Released:2020-12-25)

参考文献数

28

被引用文献数

7

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Radionuclide contamination in foods has been a great concern after the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident. To estimate time trends of daily intake and annual committed effective dose of radionuclides after the accident, radioactive cesium (r-Cs; 134Cs and 137Cs) and potassium-40 (40K) in market basket (MB) samples prepared at 6-month intervals in periods from September 2013 to March 2019 in 15 regions of Japan were analyzed using γ-ray spectrometry. The annual committed effective dose of r-Cs, calculated at non-detected radionuclide levels assumed to be half the limit of detection (LOD), appeared to decrease gradually in 11 regions close to the FDNPP that were more likely to be affected by the accident. Differences in doses among the 15 regions were large just after the accident, but gradually decreased. In particular, 134Cs has not been detected in any MB sample in any region since September 2018, and annual committed effective dose from 134Cs in all regions was mostly constant at around 0.3 μSv/year (given the respective LODs). The maximum annual committed effective dose of r-Cs in this study was decreased from 2.7 μSv/year in September 2013 to 1.0 μSv/year in March 2019. In contrast, the range of annual committed effective dose of 40K varied from approximately 150 to 200 μSv/year during that time frame and did not change much throughout the period of this study. Although annual committed effective doses of r-Cs in regions close to the FDNPP appeared to be higher than in regions far from the FDNPP, doses in all regions are remaining at a much lower levels than the intervention exemption level, 1 mSv/year, in foods in Japan.

著者

Hidefumi Inaba Hiroyuki Ariyasu Hiroshi Iwakura Chiaki Kurimoto Ken Takeshima Shuhei Morita Hiroto Furuta Muneki Hotomi Takashi Akamizu

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ20-0371, (Released:2020-10-03)

被引用文献数

24

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Immune-related adverse events in the thyroid glands (thyroid irAEs) during treatment with immune-checkpoint inhibitors (ICIs) are most frequent endocrine irAE. Thyroid irAE can be divided into that requiring continuous therapy for thyroid dysfunction (P-THY), and that requiring only temporal treatment (T-THY). However, predictive factors for those differential outcomes are unknown, and susceptibility of human leukocyte antigen (HLA) to thyroid irAE has never been investigated. This study aimed to elucidate clinical courses and prognosis of P-THY in comparison with T-THY in the aspect of thyroid immunity and HLA. Patients with P-THY (n = 15) that required L-T4 supplemental therapy for hypothyroidism for more than 3 months, and patients with T-THY who required no therapy or therapy within 1 month were enrolled in the study. Lower-value of TSH, higher-value of FT4, and lower value of TSH/FT4 were thought to be predictive markers to estimate P-THY. In addition, anti-thyroglobulin antibody (TgAb) levels were significantly higher in patients with P-THY than those in patients with T-THY. HLA-DPA1*01:03 and HLA-DPB1*02:01 allele, and their haplotype frequencies were significantly higher in patients with P-THY than those in controls. P-THY had better survival rate than T-THY. Pre-existing thyroid autoimmunity, the extent of thyroid dysfunction, and predisposing HLA were associated with the differential course of thyroid irAEs. It was suggested that thyroid function tests, TgAb, and HLA typing tests are useful for prediction of clinical course in thyroid irAEs.

著者

HIROSHI NISHIURA MASAYUKI KAKEHASHI

出版者

Japanese Society of Tropical Medicine

雑誌

Tropical Medicine and Health (ISSN:13488945)

巻号頁・発行日

vol.33, no.3, pp.127-132, 2005 (Released:2005-12-03)

参考文献数

32

被引用文献数

1 1

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To estimate the time-dependent transmission potential of primary pneumonic plague (PPP), we analyzed historical records from six outbreaks. Based on contact investigation information (source of infection information) of three outbreaks, we generalized the probability density function of the serial interval with a Gamma distribution using maximum likelihood estimations. Furthermore, we used a likelihood-based approach to estimate effective reproduction numbers at time t, Rt, incorporating records from the remaining three outbreaks by assuming independence within unknown contact networks. According to our estimates, the Rt of PPP during the initial phases of each epidemic were roughly in the order of 1.3 (95% confidence interval (CI): 0.0-4.3) in Oakland, 1.4 (0.0-4.6) in Rangoon and 6.5 (0.0-16.0) in Ecuador. The expected values of Rt were shown to slightly exceed unity, even in latter stages. While declining trends in Rt were observed in Oakland and Ecuador, no such trend was observed in Rangoon. The findings suggest that the three outbreaks investigated could have been accompanied by demographic stochasticity. The statistical usefulness of the transformation procedure, even with a small number of recorded cases available, was demonstrated, and the expected responses to bioterrorism using Yersinia pestis were discussed.

著者

Gen Inoue Takashi Kaito Yukihiro Matsuyama Toshihiko Yamashita Mamoru Kawakami Kazuhisa Takahashi Munehito Yoshida Shiro Imagama Seiji Ohtori Toshihiko Taguchi Hirotaka Haro Hiroshi Taneichi Masashi Yamazaki Kotaro Nishida Hiroshi Yamada Daijiro Kabata Ayumi Shintani Motoki Iwasaki Manabu Ito Naohisa Miyakoshi Hideki Murakami Kazuo Yonenobu Tomoyuki Takura Joji Mochida

出版者

The Japanese Society for Spine Surgery and Related Research

雑誌

Spine Surgery and Related Research (ISSN:2432261X)

巻号頁・発行日

pp.2020-0083, (Released:2020-11-20)

被引用文献数

2

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Introduction: Chronic low back pain (CLBP) is a leading cause of disability, yet there is limited high-quality evidence to identify the most suitable pharmacological therapy. The purpose of this Japanese nationwide, multicenter, prospective study was to compare the effectiveness of four representative drug therapies—acetaminophen, celecoxib, loxoprofen, and a tramadol and acetaminophen (T+A) combination drug—to establish evidence for a drug of choice for CLBP.Methods: Patients with CLBP (N = 471) received one of the four treatments and were evaluated, prospectively and comprehensively, once every month for six months using a visual analog scale (VAS) for LBP, the Japanese Orthopedic Association (JOA) score, the JOA Back Pain Evaluation Questionnaire (JOABPEQ), the Roland–Morris Disability Questionnaire (RDQ), the EuroQol five-dimensions three-levels (EQ-5D-3L), and the Short Form-8 item health survey (SF-8). We conducted multivariable linear regression analyses of the four drugs at 1 and 6 months after drug allocation. Differences with P < 0.05 were considered statistically significant.Results: Patients who received acetaminophen showed a significant improvement from baseline in the mental health subscale of the JOABPEQ at one month (P = 0.02) and the JOA score at six months (P < 0.01). None of the other outcome measures among the four drugs differed significantly. Across groups, all outcome measures, except the mental component summary (MCS) score of the SF-8, improved equivalently, although most measurements showed no obvious cumulative effect over six months. The MCS score of the SF-8 decreased gradually over six months in all groups.Conclusions: Most of the outcome measures among the treated groups were not significantly different, indicating similar treatment effects of the four drugs for CLBP. Our study indicated the limit of each outcome measure for evaluating the patient status, suggesting that a single outcome measure is insufficient to reflect treatment effectiveness.

著者

Hiroshi Sawamura

出版者

The Japan Institute of Metals

雑誌

Transactions of the Japan Institute of Metals (ISSN:00214434)

巻号頁・発行日

vol.13, no.4, pp.225-230, 1972 (Released:2007-06-01)

参考文献数

10

被引用文献数

2 5

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The present investigation has been carried out in order to revise the results of the present author’s previous investigation. For this purpose, the new data about the heat of fusion of most metallic elements have been used.Almost the same results as those of the previous investigation have been obtained. In the present investigation, however, a new fact has been found that the relation in question in metallic elements belonging to CPHex should be considered in two different regions separately, the one being the region of the lower melting temperature and the other the region of the higher melting temperature.The following predictions have been deduced from the present investigation :(1) The structures of the liquid phases in equilibrium with the solid metallic elements (except Al) belonging to FCC at their melting temperatures will be the same with each other, independently of the species of metallic element, because the relation between the entropy of fusion or the heat of fusion of these metallic elements and their melting temperature is represented exactly by a straight line or a smooth curve. The same thing will be said about the metallic elements belonging to other types of space lattice.(2) Though the space lattice of the following metallic elements is considered to be BCC at present, most of them belong probably to FCCZr, V, Ti, Mn, Eu.(3) Though the crystal structure of the following metallic elements is unknown at present, they belong probably to FCC or CPHexPa, Ac, U, Sm, Pm, Nd, Pr, La, Ce, Ra.