著者
飯塚 久夫
出版者
日経BP社
雑誌
日経コミュニケーション (ISSN:09107215)
巻号頁・発行日
no.513, pp.53-55, 2008-07-01

インターネット接続事業から,ブロードバンド広告,アプリケーション・サービス基盤へと事業の柱を増やしているNECビッグローブ。NGNでのサービス展開に向けた体制強化を図るとともに,2〜3年のうちに起こるIPv4アドレスの枯渇,情報通信法,アナログテレビ放送の停波といったイベントを前に,サービス・インフラの刷新を進めている。昨年夏に就任した飯塚久夫社長に聞いた。
著者
冨田 勝 AW WANPING AW Wanping
出版者
慶應義塾大学
雑誌
特別研究員奨励費
巻号頁・発行日
2015-11-09

In this year, we conducted a screening experiment using different food products (Manuka Honey, Rice Bran and Soy Beans) in the animal models that we have created in last year.Unfortunately, Manuka Homey and Soy Beans supplementation did not improve colitis. As such, we aimed to elucidate the molecular mechanisms of Oryza sativa, rice bran(RB) dietrary intervention on 2.0% dextran sulfate sodium (DSS)-included colitis C57BL/6L mice mode. Body weight loss, disease activity index, colon length and colon histopathology were improved in BR-fed mice. Time-course microbiome and metabolome results suggest that RB-related alterations of gut environment can prevent colitis via establishing gut homeostasis. Our approach is an important tool in developing new therapeutic applications of RB.
著者
中嶋 秀人
出版者
日本神経治療学会
雑誌
神経治療学 (ISSN:09168443)
巻号頁・発行日
vol.34, no.5, pp.495-499, 2018 (Released:2018-04-05)
参考文献数
22

Recent advances in the treatment of neurological infections are described based on reports published in 2016.According to the European cohort study of community–acquired bacterial meningitis, the incidence of adult bacterial meningitis has decreased substantially, which is partly explained by herd protection by pediatric conjugate vaccines. Also, adjunctive dexamethasone treatment was associated with substantially improved outcome. Streptococcus pneumonia is the most common pathogen in adult. Patients with active cancer, however, present with lower CSF leukocyte counts, are more likely to be infected with Listeria monocytogenes, and are at high risk of unfavorable outcome.The plasma–cell–depleting proteasome inhibitor bortezomib could be useful for severe and therapy–refractory cases of anti–NMDAR encephalitis. Bortezomib treatment showed clinical improvement or disease remission in 5 severely affected patients with anti–NMDAR encephalitis with resistance to standard immunosuppressive therapy (corticosteroids, IVIG, plasma exchange, immunoadsorption, rituximab, cyclophosphamide). Autoimmune encephalitis including anti–NMDAR encephalitis often poses a therapeutic challenge. The Korea study reported the efficacy and safety of rituximab treatment as a second–line immunotherapy treatment for autoimmune limbic encephalitis. Functional improvement occurred more frequently in the rituximab group compared to the control group, regardless of autoantibody status. In a prospective observational case control study, treatment effects of plasma exchange and immunoadsorption were evaluated in 21 patients with autoimmune encephalitis associated with NMDAR, LGI1, CASPR2, GAD, mGluR5 and Hu antibodies. Apheresis is well tolerated and effective also as first–line therapy in autoimmune encephalitis, particularly in patients with antibodies targeting neuronal surfaces.Cochrane Database Systemic Review reported the effect of adjuvant corticosteroid therapy in tuberculous meningitis. There is high quality evidence of the benefit of corticosteroids in preventing death in people with tuberculous meningitis. For HIV–positive people with TB meningitis, there is uncertainty about whether or not corticosteroids are beneficial due to the lack of direct evidence in this group. However, corticosteroids may not be associated with increased risk of adverse events. On the other hand, adjuvant corticosteroid therapy did not reduce mortality among patients with HIV–associated cryptococcal meningitis and was associated with more adverse events and disability than was placebo.
著者
Satoshi KAMEI Toshiaki TAKASU
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.39, no.11, pp.894-900, 2000 (Released:2006-03-27)
参考文献数
7
被引用文献数
26 29

Objective To estimate the annual prevalence of viral and other neurological infections at large hospitals in Japan during the period from 1989 to 1991. Methods A nationwide questionnaire survey on the numbers of inpatients with viral and other neurological infections was sent for completion to the chiefs of Departments of Internal Medicine, Neurology and Pediatrics at all hospitals with more than 200 beds. Results The average annual number of inpatients (and the number per 106 population) with encephalitis in large hospitals was estimated to be 2, 200±400 (17.7±13.2), while it was 32, 000±16, 000 (258±129) for meningitis, and 650±50 (5.2±0.4) for myelitis. Among the inpatients with encephalitis, meningitis, and myelitis, an unknown etiology was the most common (51.2% in encephalitis, 73.2% in meningitis, and 36.3% in myelitis), followed by a viral etiology for all three diseases. Conclusion The first estimate was made of the annual prevalence of viral and other neurological infections and their etiology in Japan.(Internal Medicine 39: 894-900, 2000)
著者
中嶋 秀人
出版者
日本神経治療学会
雑誌
神経治療学 (ISSN:09168443)
巻号頁・発行日
vol.33, no.2, pp.150-154, 2016 (Released:2016-08-10)
参考文献数
14

Meningitis and encephalitis are severe neurological infections that, if treated late and ineffectively, lead to poor neurological outcome or death. Since treatment is more efficient if given early, these conditions of meningitis and encephalitis should represent as a life–threatening neurological emergency. The management of patients with suspected meningitis or encephalitis begins with empiric treatments until the causal agent of infection is determined. However, the etiologic organism cannot always be distinguished. The goal is to identify those that are treatable, provide supportive care for those that are not, and, when possible, prevent the neurologic complications of these infections. In this article, the author will present some representative cases to describe the characteristic magnetic resonance imaging and spinal fluid analysis of bacterial meningitis, tuberculous meningitis, cryptococcal meningitis, herpes simplex encephalitis, and anti–NMDA receptor encephalitis, and discusses the choice of empirical treatments until the cause of infection is determined. Also the differential diagnosis of meningitis and encephalitis is reviewed, with an emphasis on infectious etiologies.
著者
山城 亘央 長坂 高村 高木 隆助 三輪 道然 新藤 和雅 瀧山 嘉久
出版者
日本神経学会
雑誌
臨床神経学 (ISSN:0009918X)
巻号頁・発行日
vol.55, no.2, pp.81-86, 2015 (Released:2015-02-20)
参考文献数
19
被引用文献数
1

症例は54歳の男性である.2010年12月歩行障害を発症し,2011年2月には記銘力低下も出現した.頭部MRIにて脳室周囲のT2高信号と脳室壁,脈絡叢の造影効果をみとめた.髄液は細胞数・蛋白上昇,糖低下をみとめ,クリプトコッカス抗原陽性から,クリプトコッカス脳室炎と診断した.リポゾーマル・アムホテリシンB,フルコナゾールにて治療を開始したが,副作用が出現したためボリコナゾール,フルシトシン,イトラコナゾールに変更した.本症例では頭部MRIにおける側脳室後角の隔壁形成をみとめ,脳室炎診断の一助となった.クリプトコッカス髄膜脳炎においてはまれながら脳室炎で発症するものがあることに留意すべきである.
著者
堀内 一宏 山田 萌美 白井 慎一 高橋 育子 加納 崇裕 金子 幸弘 秋沢 宏次 梅山 隆 宮崎 義継 矢部 一郎 佐々木 秀直
出版者
日本神経学会
雑誌
臨床神経学 (ISSN:0009918X)
巻号頁・発行日
vol.52, no.3, pp.166-171, 2012 (Released:2012-03-28)
参考文献数
17
被引用文献数
2 4

症例は37歳女性である.子宮頸癌術後,胸部CTにて腫瘤影をみとめ,クリプトコッカスを検出した.脳MRIで多発腫瘤影をみとめ脳,肺クリプトコッカス症と診断し,抗真菌薬を投与したが効果なく意識障害が出現した.抗真菌薬脳室内投与をおこない意識状態は改善,脳病変の縮小をみとめた.その後脳病変の再増大をみとめ,遅発性増悪と考えステロイドを投与し改善した.難治性経過のため菌株の同定検査をおこないCryptococcus gattii (VGI型)と判明した.C. gattii 感染症では強毒株による健常人症例も報告されている.難治性症例ではC. gattii の検索,ステロイド併用,脳室内投与をふくめた積極的な治療法を検討すべきである.
著者
沼畑 恭子 赤岩 靖久 吉澤 健太 乗峯 苑子 尾上 祐行 宮本 智之
出版者
日本神経学会
雑誌
臨床神経学 (ISSN:0009918X)
巻号頁・発行日
vol.59, no.4, pp.190-194, 2019 (Released:2019-04-25)
参考文献数
15
被引用文献数
1 2

症例は29歳男性,生来健康.頭痛と発熱が増悪し当院搬送.体温38.3°C,項部硬直著明,脳脊髄液検査で初圧500 mmH2O,細胞数増加,髄液糖/血糖比0.027,クリプトコッカス抗原陽性からクリプトコッカス髄膜脳炎と診断し抗真菌薬治療で症状改善を認めていた.第18病日に全身痙攣,右視野暗点を認め,頭部MRIで両側大脳皮質に散在性の病変が新たに出現した.脳脊髄液中のクリプトコッカス抗原価は低下したがIgG indexは上昇し,症状の増悪,病巣の拡大はクリプトコッカスの病勢悪化ではなく,免疫反応による遅発性増悪と考えステロイドパルス療法を施行し改善した.遅発性増悪に対してステロイド治療は有効である.
著者
伊藤 博隆 馬場 駿吉 高木 一平 大屋 靖彦 横田 明 伊藤 弘美 稲垣 光昭 小山 賢吾 北條 郷明 丸尾 猛 東内 朗 杉山 和子 河合 〓 森部 一穂 鈴木 賢二 柘植 勇人 板谷 純孝 鈴木 康夫
出版者
耳鼻咽喉科臨床学会
雑誌
耳鼻咽喉科臨床 補冊 (ISSN:09121870)
巻号頁・発行日
vol.1991, no.Supplement52, pp.107-118, 1991-12-25 (Released:2012-11-27)
参考文献数
17
被引用文献数
1 1

Mao-bushi-saishin-to extract capsules (6 caps. /day) were administered orally to 61 perennial nasal allergy patients presenting with nasal obstruction for 4 consecutive weeks to assess the overall efficacy, safety and utility of the drug. In the doctor's evaluation, the overall efficacy rate covering excellent and good responses was 38.3% at week 2 of treatment and 54.7% at week 4 of treatment. The utility rate covering useful and higher ratings was 60.7%.Nasal symptoms, viz, sneezing attack, nasal discharge, nasal obstruction, dysosmia and interference with daily living were all improved. Nasal obstruction, in particular, disappeared in many cases, thus generating a high improvement rate. Nasal mucosal findings, viz, swelling of inferior turbinal mucosa, watery secretion in nasal cavity, and nasal discharge eosinophil count showed good improvements.The time course of each nasal symptom i n terms of the average score according to allergy diaries, revealed significant reduction in nasal obstruction, dysosmia and interference with daily life in severity at and after week 2 and sneezing and nasal discharge were significantly alleviated at week 4 as compared with the findings obtained during the baseline period.As side effects, headache was reported in one case and stomachache in one case. These symptoms were relieved after discontinuation of treatment.
著者
安藤 一男 方違 重治
出版者
The Tohoku Geographical Association
雑誌
季刊地理学 (ISSN:09167889)
巻号頁・発行日
vol.49, no.4, pp.231-246, 1997-12-01 (Released:2010-04-30)
参考文献数
21
被引用文献数
6 8

ボーリングコアの珪藻分析, 14C年代測定および柱状図の解析結果に基づいて, 荒川低地上流域の古環境変遷を復元し, 縄文海進期の内湾最拡大期における海岸線付近の地形環境について検討した。本地域において最終氷期最盛期頃, 埋没立川段丘面を切り込んで谷幅2.5~3.5kmの埋没谷が形成され, その後, BGを基底として淡水成堆積物の形成が進行した。8,600y. B. P. を過ぎる頃から, 当地域は内湾化し海岸線が最も奥部に達したのは8,300y. B. P. 頃である。しぼらくこの状態が続いた後, 徐々に内湾の埋積が進み, 6,300~5,500y. B. P. 頃には当地域の陸化は完了した。珪藻遺骸群集に基づいて求められた内湾最拡大期の海岸線は, 荒川低地左岸の大宮台地側では台地に刻まれた支谷へ深く入り込んで位置していたのに対し, 右岸の武蔵野台地側では, 流入する入間川, 小畔川, 越辺川の影響により淡水域が広く分布することにより海岸線は低地中央付近に位置していた。このことは大宮台地の平方貝塚群がヤマトシジミ, カキ, ハイガイ, ハマグリを産出するのに対し, 武蔵野台地の小仙波貝塚は主淡であることとも調和的である。
著者
堀 雅彦
出版者
北海道大学宗教学インド哲学研究室
雑誌
北大宗教学年報 (ISSN:24343617)
巻号頁・発行日
vol.2, pp.26-32, 2019-08-31

本稿は、2018年12月に東京大学で行われた研究会―「宗教学生成期における哲学の位置」―での発表をもとにしたものである。堀の発表は、ウィリアム・ジェイムズ(William James 1842-1910)の哲学的(かつ神学的)営みとしての「宗教の科学」に注目し、その対象と方法の側面から、彼が描き出そうとした「宗教」の姿の再構成を試みるものであった。後日の考察を加えて行った北大宗教学研究会(2019年2月18日)での報告内容も含めて、以下、その概要を研究ノートとして記す。
著者
熊野 道子
出版者
一般社団法人 日本健康心理学会
雑誌
健康心理学研究 (ISSN:09173323)
巻号頁・発行日
vol.19, no.1, pp.56-66, 2006-06-25 (Released:2014-03-28)
参考文献数
31
被引用文献数
3 13

The purpose of this study is to determine the similarities and differences between ikigai and concepts similar to ikigai. University students (n=601) responded to a questionnaire using 3 scales related to ikigai and 6 scales related to concepts similar to ikigai: subjective well-being, psychological well-being and quality of life (QOL). A11 177 items were subjected to principal component analysis and categorized into 14 principal components. Elements central to ikigai were life-affirmation, goals/dreams, meaning of life, meaning of existence, sense of fulfillment, and commitment. Minor ikigai elements were environmental mastery, positive relations, autonomy, negative affect, personal growth, positive affect, physical health, and life enjoyment. Ikigai and concepts similar to it were represented in a figure consisting of circles drawn using an index of commonality of each element in each of the 9 scales. Results suggested that subjective well-being, psychological well-being, and QOL are not central elements of ikigai; but rather, are elements that differ from ikigai.
著者
Norihiro Yamada Yasushi Kokean Kazunobu Tsumura
出版者
Japanese Society for Food Science and Technology
雑誌
Food Science and Technology Research (ISSN:13446606)
巻号頁・発行日
vol.25, no.5, pp.751-754, 2019 (Released:2019-10-24)
参考文献数
26
被引用文献数
1

Ginger rhizome contains a number of proteases that possess milk clotting activity. It has been revealed that ginger rhizome juice acts as a coagulant to form milk gels. In this study, we investigated the gel forming conditions of soymilk using ginger rhizome juice. Soymilk gels were prepared by incubating a mixture of soymilk (prepared at different conditions) and a lyophilized powder suspension of ginger rhizome juice at 60 °C for 60 min. The strength of soymilk gels increased when the raw soymilk was heated above 90 °C prior to mixing with the ginger rhizome juice. At a high gel strength, decomposition of the glycinin fraction in soymilk was observed with SDS-PAGE analysis. These results suggest that decomposition of the glycinin fraction in soymilk plays an important role in gel formation.

1 0 0 0 OA 雨と植物

著者
木村 和義
出版者
The Society of Agricultural Meteorology of Japan
雑誌
農業気象 (ISSN:00218588)
巻号頁・発行日
vol.34, no.1, pp.23-30, 1978-06-15 (Released:2010-02-25)
参考文献数
25
被引用文献数
2