著者
浦井 教輝 奥中 大地 徳丸 正孝
出版者
日本知能情報ファジィ学会
雑誌
日本知能情報ファジィ学会 ファジィ システム シンポジウム 講演論文集 第28回ファジィシステムシンポジウム
巻号頁・発行日
pp.876-881, 2012 (Released:2013-07-25)

本論文では,衣服の感性検索のための類似画像検索を提案する. 感性検索はユーザの感性を用いて衣服を検索するシステムである. 感性検索システムには感性検索エージェントを用いている. 感性検索エージェントはユーザの感性を模倣しユーザが好む衣服を検索する. しかしながら,衣服の検索を行うには衣服画像の情報量が多いため感性検索エージェントの構造が複雑化してしまう問題点がある. したがって,感性検索システムには類似画像検索が必要である. 類似画像検索は感性検索エージェントが検索した衣服デザインを基に衣服画像を検索する. 衣服デザインは衣服が人に印象を与える要因から作成されるため,衣服画像と比べ情報量が少ない. また感性検索エージェントは衣服デザインを評価し,その評価によりユーザが好む衣服デザインを検索する. そのため,感性検索エージェントの複雑化を防ぐことができる. この研究において,類似検索の有効性を確認するために類似検索アプリケーションを作成した. 類似検索アプリケーションはユーザが選択した衣服デザインから衣服画像を検索する. その実行結果において,提案手法の類似画像検索は衣服デザインに類似した衣服画像を検索することができた.
著者
雨宮 正欣 長井 辰男
出版者
日本法科学技術学会
雑誌
日本鑑識科学技術学会誌 (ISSN:13428713)
巻号頁・発行日
vol.4, no.2, pp.95-98, 2000 (Released:2010-02-05)
参考文献数
14
被引用文献数
1 3

Though easiness and availability of a screening test are important factors, its correctness is most important for a drug abuser's arrest according to screening results. The use of Triage® in screening tests to detect stimulants was examined.   Abusers' urine samples contained methamphetamine at the concentration of which ranges from 1μg/ml to 479 μg/ml, and 66 μg/ml(n=68) on the average. Triage® showed negative reaction at 1000 μg/ml to 1500 μg/ml, even though there was a high concentration of methamphetamine. Triage® gives false negative result, even when there is a very high concentration of stimulant present in the urine. We should take this into consideration.
著者
Takanori Miyoshi Nobuhiro Misumi Mikako Hiraike Yuki Mihara Takashi Nishino Minako Tsuruta Yosei Kawamata Yoichi Hiraki Aki Kozono Masao Ichiki
出版者
公益社団法人日本薬学会
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.39, no.12, pp.2009-2014, 2016-12-01 (Released:2016-12-01)
参考文献数
42
被引用文献数
21

Cisplatin (CDDP) combination chemotherapy is widely administered to patients with advanced lung cancer. The dose depends on multiple factors, including whether the tumor is non-small-cell lung cancer (NSCLC) or small-cell lung cancer (SCLC). Although efficacy is limited by cisplatin-induced nephrotoxicity (CIN), little is known about the risk factors for this complication. The aim of this study was to identify the risk factors for CIN in patients with advanced lung cancer, both NSCLC and SCLC. We retrospectively reviewed clinical data for 148 patients who underwent initial chemotherapy including CDDP ≥50 mg/m2 per patient per day for the first course at Kyushu Medical Center between October 2010 and September 2013. All data were collected from the electronic medical record system. Nephrotoxicity was defined as an increase in serum creatinine concentration of at least grade 2 during the first course of CDDP chemotherapy, as described by the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. CIN was observed in nine patients. Univariate analysis revealed that cardiac disease and lower baseline serum albumin (Alb) values conferred a higher risk of nephrotoxicity (p<0.05). The cut-off value of Alb was 3.8 g/dL, calculated by receiver operating characteristics (ROC) curves. Multivariable logistic regression analysis revealed that cardiac disease (odds ratio=11.7; p=0.002) and hypoalbuminemia (odds ratio=6.99 p=0.025 significantly correlated with nephrotoxicity. In conclusion, cardiac disease and low baseline Alb values are possible risk factors for CIN.
著者
宮田 健
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.123, no.12, pp.987-1006, 2003 (Released:2003-11-29)
参考文献数
48
被引用文献数
3 6

Disturbance of the normal mucociliary clearance due to hyperproduction of mucus and modification of its physicochemical characteristics is a common finding in airway diseases. Drugs that affect airway secretion have been developed and used to cleanse the respiratory tract for many centuries and in many countries. On the basis of the mechanism of their actions, the mucoactive drugs are classified into several groups. Some mucoactive drugs have direct effects on the production or composition of airway secretions, resulting in increased effectiveness of mucociliary clearance. Other mucoactive drugs do not have a specific action on mucus, but have beneficial effects on airway structure and function, which lead to correction of the pathophysiologic mechanisms that result in abnormal secretions. However, since many drugs have overlapping effects, it is difficult to classify these drugs into groups based on their major actions. Taken together with previous findings on mucoactive drugs, it appears that an antioxidant effect is a common property of mucoactive drugs and that it is a crucial action to exert their effects against airway diseases. In light of this idea, we must use specific experimental models to simulate pharmacologic events in airway inflammation. The development of new techniques has made it possible to identify and measure the mucus components, measure the rheologic parameters more accurately, and evaluate mucociliary clearance precisely in animals and humans. Therefore, with modifications of methods, we have investigated airway-cleansing drugs from various points of view to reflect actions in inflammatory states for more than two decades. Here, I introduce the methods we have used to study many of the parameters involved in airway clearance, including cough reflex, and describe some of the mucoactive-antitussive drugs that we have studied recently. There is an increasing usage of traditional Chinese herbal medicines in clinics and hospitals, because they tend to have moderate side effects and sometimes remarkable efficacy. To renormalize overall defects in airway disorders, Chinese medicines may be adequate, because they are composed of various herbs with weak but ubiquitous pharmacologic activities. We have been investigating Bakumondo-to. Bakumondo-to has been used for the treatment of bronchitis and pharyngitis accompanying severe dry cough. We found that unlike codeine Bakumondo-to had a notable antitussive activity against the cough associated with bronchitis and the cough increased by angiotensin-converting enzyme inhibitors. Recently, we have found that, in alveolar type II cells, Bakumondo-to attenuated phosphatidylcholine secretion increased by oxygen radicals from activated PMNLS. In addition, we found that Bakumondo-to itself stimulated phosphatidylcholine secretion and increased β-adrenoceptor gene expression in rat alveolar type II cells. We studied the mechanism of action and clarified that Bakumondo-to increased glucocorticoid-sensitive promotor activity. The effect may contribute to its ubiquitous effectiveness in the treatment of airway diseases. Various parameters (chemical properties, physical properties, mucus production, surfactant phospholipid production, and mucociliary clearance) are considered to be important for the dynamics and mobilization of airway secretions. Pharmacologic investigation, with appropriate techniques, of the ability of an agent to modify these parameters can provide useful information about its mechanism of action. However, since these parameters are interconnected, it is very complicated to elucidate the precise mechanisms of action of mucoactive drugs. This means that the goal of treatment cannot always be achieved by the modification of a single parameter, but should, more realistically, be aimed at a renormalization of several parameters. On the basis of this idea, glucocorticoids are ideal mucoactive drugs because they exert various…
著者
山下 良子 神山 秀一 山本 明日香 加納 宏樹 結城 祥充 上田 晃 川本 由加里 後藤 仁和 山本 聡
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.136, no.12, pp.1641-1649, 2016 (Released:2016-12-01)
参考文献数
28
被引用文献数
6

The efficacy of cefepime (CFPM) is known to depend on the ratio of the time that the serum levels exceed the minimum inhibitory concentration (MIC) to the dosing interval (%T>MIC). The objective of this study was to clarify the relation between %T>MIC and clinical outcome of CFPM, and to identify the optimal dosage regimen. We investigated the outcome of CFPM treatment for febrile neutropenia (FN) patients with normal renal function. Treatment success was defined as the completion of FN therapy with CFPM only. And we calculated %T>MIC for each case based on population pharmacokinetic parameters. The MIC value for simulation was set as 8 μg/mL. In logistic regression analysis, treatment success was significantly associated with the elevation of %T>MIC in the group with persistent neutropenia, yielding a receiver operating characteristic curve with an optimal cutoff value of 73.1%. Next, we simulated %T>MIC for each case under various dosing regimens. For patients whose creatinine clearance (CLcr) exceeded 100 mL/min, it was found to be difficult to attain the objective under the current regimen. In contrast, it was calculated that treatment with 2 g three times a day (t.i.d.) could attain the objective for most of the patients with 3 h of infusion. These results suggest that CFPM treatment under the current regimen is ineffective for FN patients with normal or augmented renal function, and that 2 g t.i.d. is necessary in quite a lot cases, although such use is off-label.
著者
後藤 佐昌子 八軒 浩子 高田 充隆
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.37, no.1, pp.21-30, 2011 (Released:2012-04-27)
参考文献数
17
被引用文献数
4

To quantitatively investigate the history of medical pharmacy research in Japan,we analyzed the titles of articles in theJapanese Journal of Pharmaceutical Health Care and Sciences and the Japanese Journal of Hospital Pharmacy,the principalmedical pharmacy journals in Japan,by text-mining.All article titles (2884 articles) between 1975 and 2009 were collectedfrom article databases,and the text of titles was analyzed using the KH Coder,free software for quantitative textanalysis of the Japanese language.This software produces basic information on text data such as the rate of occurrence ofcertain words.Nine research categories were identified through multivariate analysis of frequently appearing words.Also,coding rules were created to assign article titles to these research categories,and the categorization results were analyzed quantitatively.Pharmaceutical investigation was the principal category in the 1970 s and 80 s,with the quality evaluation of drugs asthe major area of research.Articles assigned to this category accounted for 41.4% of all articles published during the period1980-1984.Articles assigned to the drug therapy category began to gradually increase in the 1990 s,and since 2000,drugtherapy has been the major area of medical pharmacy research in Japan.In addition,there has been an increase in investigationsassociated with the education of pharmacists and pharmacy students in recent yearsOur findings suggest that there has been a shift in the dominant research area of medical pharmacy in Japan from qualityevaluation of drugs to patient care.
著者
Yuki Nishikawa Masaki Satoh
出版者
(公社)日本気象学会
雑誌
SOLA (ISSN:13496476)
巻号頁・発行日
vol.12, pp.232-236, 2016 (Released:2016-08-31)
参考文献数
26
被引用文献数
3

As nonhydrostatic models have higher resolution, a topographical representation scheme is desirable as an alternative to the terrain-following approach, which is unstable for steep topography. We developed a conserved topographical representation scheme using a thin-wall approximation in z-coordinates (the CT scheme). This scheme is formulated by the flux-form finite-volume method with a flux limiter, so that the total integrals over the entire domain of prognostic variables are conserved: this is advantageous compared to the conventional thin-wall approximation method. The CT scheme is easily implemented for existing models that use the finite-volume method. We constructed the scheme to satisfy conservation of mass, horizontal momentum, and total energy. We compared the results of the CT scheme for an isolated mountain case with those of a step-mountain (SM) method. The CT scheme represents the propagation of gravity waves more accurately than the SM method. The upward flux of horizontal momentum becomes more vertically uniform for the CT scheme than for the SM method over time. In addition, the horizontal momentum budget shows that the total momentum is reduced by reaction force at the lower boundary with changes due to numerical damping in the upper layers and numerical filters in the free layers.
著者
山本 忠利 津久井 公平 大塚 徳勝
出版者
公益社団法人 日本アイソトープ協会
雑誌
RADIOISOTOPES (ISSN:00338303)
巻号頁・発行日
vol.31, no.8, pp.407-412, 1982-08-15 (Released:2010-09-07)
参考文献数
5

85Kr使用装置から漏れ出た放射性Krの回収と精製を目的として, 気密容器による閉じ込め方式をとり, その中に漏洩する放射性Krを回収, 精製できる装置を試作し, その特性試験を行った。85Kr使用装置を収納する気密容器内の放射性Kr濃度は0.3ppmまで低下し, そのときの回収率は99.976%に達した。さらに回収した放射性Krを精製することによって, その純度は99.9908%に達した。すなわち, 気密容器内に漏洩した放射性Krをほとんど100%近くまで回収可能であり, かつ回収した放射性Kr中のHeを100ppm以下まで除去することができる。
著者
Weiqing ZHENG Mingming LIU Paul Franck Adjou MOUMOUNI Xiaoqing LIU Artemis EFSTRATIOU Zhanbin LIU Yangqing LIU Huiying TAO Huanping GUO Guanbo WANG Yang GAO Zifen LI Aaron Edmund RINGO Charoonluk JIRAPATTHARASATE Haiying CHEN Xuenan XUAN
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.16-0484, (Released:2016-11-26)
被引用文献数
30

In this study, blood samples obtained from 162 dogs in Jiangxi, China, were employed in molecular screening of canine tick-borne pathogens by PCR and sequencing. Babesia spp. gene fragment was detected in 12 (7.41%) dogs. All samples were negative for Hepatozoon spp., Ehrlichia canis, Coxiella spp., Borrelia spp., Rickettsia spp. and Anaplasma platys. Species-specific PCR analysis further confirmed that 8 (4.94%) and 4 (2.47%) dogs were infected by Babesia canis vogeli and Babesia gibsoni, respectively. Based on our analyses, Babesia spp. infection in Jiangxi appeared not related to age, gender, breed, usage, activity and health status or tick infestation history of the dogs. This is the first molecular report of Babesia canis vogeli and Babesia gibsoni in dogs from Jiangxi, China.
著者
Yuka Watanabe Yuko Miyagoe-Suzuki
出版者
一般社団法人日本体力医学会
雑誌
The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
巻号頁・発行日
vol.4, no.1, pp.73-82, 2015-03-25 (Released:2015-03-23)
参考文献数
114
被引用文献数
2

Muscle mass and strength decline with age. When severe, the loss is called sarcopenia. Sarcopenia is drawing attention worldwide, especially in highly aged societies, as a disease that should be treated. At present, we have limited tools to combat sarcopenia (e.g. resistance training and nutritional intervention), but accumulating knowledge of the molecular and cellular mechanisms of sarcopenia is accelerating the development of pharmacological therapies for sarcopenia. Because sarcopenia is a complicated pathological condition caused and modified by many aging-related factors, such as inactivity, loss of motor neurons, poor nutrition, decline of anabolic hormones, chronic inflammation, oxidative stress, impaired stem cell function, and comorbidity, the proposed target molecules or pathways for pharmacological intervention are diverse. Here we review recent progress in drug development with emphasis on small-molecule compound-based therapies and review the literature to identify new therapeutic targets to prevent, delay, or reverse sarcopenia.
著者
木島 明博 藤尾 芳久
出版者
公益社団法人 日本水産学会
雑誌
日本水産学会誌 (ISSN:00215392)
巻号頁・発行日
vol.45, no.3, pp.287-295, 1979-03-25 (Released:2008-02-29)
参考文献数
9
被引用文献数
1 4

The chum salmon populations collected from 21 rivers in Japan were analyzed by using as markers the three genes, Idh-A2, Idh-B2, and Ldh-Al, controlling IDH and LDH isozymes. (1) No differences in gene frequencies at the three loci were found between the sexes or between the years of catch. (2) Any two of the 21 river populations showed clear differences of gene frequencies, indicating that they are independent of each other. (3) The chum salmon populations in Japan could be divided into at least 3 groups: Hokkaido group, and the Pacific Ocean and Japan Sea groups of Honshu. (4) A geographical cline of gene frequencies was observed in each of the Pacific Ocean and Japan Sea groups of Honshu, the phenomenon suggests that there has been a mixing of chum salmon individuals between neighboring rivers, though on a small scale.
著者
小橋 昌司 諸岡 孝俊 奥野 真起子 森本 雅和 吉矢 晋一 相河 聡
出版者
公益社団法人 日本生体医工学会
雑誌
生体医工学 (ISSN:1347443X)
巻号頁・発行日
vol.54Annual, no.26PM-Abstract, pp.S123-S123, 2016 (Released:2016-11-19)

Total knee Arthroscopy (TKA) is an operation which replaces the damaged knee with an artificial knee implant. There are some kinds of TKA procedures, and various kinds of prosthesis. Thus, it becomes a tough work for surgeons to select an appropriate procedure and prosthesis for individual patients. This study proposes a prediction method of post-operative implanted knee kinematics. It predicts the post-operative kinematics from only pre-operative kinematics using a machine learning method with clinical big data. In 46 TKA subjects, the method predicts the post-operative anterior-posterior translation with a correlation coefficient of 0.77 and a root-mean-squared error of 0.7mm.
著者
村上 宣寛
出版者
一般社団法人 日本教育心理学会
雑誌
教育心理学研究 (ISSN:00215015)
巻号頁・発行日
vol.28, no.3, pp.183-191, 1980-09-30 (Released:2013-02-19)
参考文献数
38
被引用文献数
1 2

音象徴の研究には2つの流れがあり, 1つはSapir (1929) に始まる, 特定の母音と大きい-小さいの次元の関連性を追求する分析的なものであり, もう1つはTsuru & Fries (1933) に始まる, 未知の外国語の意味を音のみから推定させる総合的なものであった。本研究の目的は音象徴仮説の起源をプラトンのテアイテトス (201E-202C) にもとめ, 多変量解析を用いて日本語の擬音語・擬態語の音素成分を抽出し, それとSD法, 連想語法による意味の成分との関連を明らかにするもので, 上の2つの流れを統合するものであった。刺激語はTABLE1に示した65の擬音語・擬態語であり, それらの言葉から延べ300人の被験者によって, SD評定, 名詞の連想語, 動詞の連想語がもとめられた。成分の抽出には主因子法, ゼオマックス回転が用いられた。なお, 言葉×言葉の類似度行列作成にあたって, 分析Iでは言葉に含まれる音をもとにした一致度係数, 分析IIでは9つのSD尺度よりもとめた市街模型のdの線型変換したもの, 分析IIIでは6803語の名詞の反応語をもとにした一致度係数, 分析IVでは6245語の動詞の反応語をもとにした一致度係数を用いた。分析Vの目的は以上の4分析で抽出した成分の関係を調べるもので, Johnson (1967) のMax法が用いられた。分析1の結果はTABLE2に示した。成分I-1は/n/と/r/, I-2は/r/と/o/, I-3は/a/と/k/, I-4は促音, I-5は/o/, I-6は/a/, I-7は/i/, I-8は/p/, I-9は/u/, I-10は/b/, I-11は/k/, I-12は/t/に関連していた。分析IIの結果はTABLE3に示した。成分II-1はマイナスの評価, II-2, II-4はダイナミズム, II-3は疲労, に関連していた。分析IIIの結果はTABLE4に示した。成分III-1は音もしくは聴覚, III-2は歩行, III-3は水, III-4は表情, III-5は不安, III-6は液体, III-7は焦りに関連していた。分析IVの結果はTABLE5に示した。成分IV-1は活動性, IV-2は不安, IV-3は表情, IV-4は音もしくは運動, IV-5はマイナスの評価もしくは疲労, IV-6は液体, IV-7歩行, IV-8は落着きのなさに関連していた。分析Vの結果はTABLE6とFIG. 1に示した。音素成分と意味成分の関係として, I-5 (/o/) とIV-8 (落着きのなさ), I-7(/i/)とIII-7 (焦り), I-10 (/b/) とIII-6 (液体) が最も頑健なものであった。さらに, I-8 (/p/) とIII-2 (活動性), I-9 (/u/) とIII-5 (不安) 及びIII-6 (液体), I-12 (/t/) とIII-2 (歩行) 及びIV-8 (落着きのなさ) も有意な相関があった。日本語の擬音語・擬態語の限定のもとで, 音象徴の仮説が確かめられた。/o/が落着きのなさを, /i/が焦りを, /b/が液体を象徴するという発見は新しいものでありその他にも多くの関係があった。また, SD法によってもたらされた成分は狭い意味の領域しかもたらさず, 意味の多くの側面を調べるには不十分であり, 擬音語と擬態語の区別は見出されなかった。
著者
郷田 兼則
出版者
The Japan Society of Naval Architects and Ocean Engineers
雑誌
造船協會會報 (ISSN:18842054)
巻号頁・発行日
vol.1939, no.64, pp.165-182, 1939-09-15 (Released:2009-09-04)

In oil-tankers of Japan, it is very rare to have steam plants. “Kuroshio-Maru” which was recently completed has three main boilers of such a modern forced-circulating type as never been found formerly in our country. The steam condition of these boilers is 21 kg/cm2 G and 350°C. Each boiler generates steam 17, 000 kg/h at normal and 22, 000 kg/h at maximum. They are of the Kawasaki La-Mont marine water tube type and each has heating surface of 333 square metres excluding air-preheater, and is equipped with five oil burners, La-Mont water wall, superheater, economizer and tubular air-preheater. These boilers were adopted for the purpose to save space and to improve the.whole plant efficiency. One of these boilers was tested on land and obtained the efficiency of 87.29%.
著者
黒須 明 木戸 雅人 長井 敏明 徳留 省悟
出版者
公益財団法人 日本心臓財団
雑誌
心臓 (ISSN:05864488)
巻号頁・発行日
vol.38, no.Supplement3, pp.61-65, 2006-08-30 (Released:2013-05-24)
参考文献数
8

1953年から2003年までの50年間の東京23区内における自動車運転中の突然死629例(男性623例,女性6例)について東京都監察医務院の症例から抽出し検討を行った.年齢別では40歳未満99例(15.7%),40~64歳450例(71.5%),65歳以上80例(12.77%)であった.車種別では大型車が51例(8.1%),普通自動車が402例(63.9%),軽自動車が32例(5.1%),二輪車が47例(7.4%)であり,タクシーの率が高く135例(21.5%)を占めた. 死因別では心血管系が379例(60.3%),脳血管障害が200例(31.8)%であった.事故の有無については,構造物あるいは他車との衝突があった事故が169例(26.9%),無事故が460例(73.1%)であった.
著者
橋爪 伸子
出版者
日本調理科学会
雑誌
日本調理科学会大会研究発表要旨集 平成21年度日本調理科学会大会
巻号頁・発行日
pp.1034, 2009 (Released:2009-08-28)

【緒言】地域固有の歴史を背景とする食文化史の研究は、現代の地域活性化事業に有用な情報を提供し、ひいては地域アイデンティティ確立の一端を担うことができると考える。本報では、熊本城築城400年記念事業で監修を担当した、近世熊本の食史料の再現三事例を検証し、食文化史研究の現代への活用について、可能性、課題などを考えてみたい。【方法】再現の典拠とした主な史料は、熊本藩士による飲食物製法記録「料理方秘」(都立中央図書館加賀文庫蔵)、「歳時記」(熊本県立大学文学部蔵)、同藩における献立記録「御入国御拝任御祝」(熊本市歴史文書資料室蔵)である。これらの解読および翻字に加え、それぞれの活用の目的に応じて食素材や調理法などの具体的な調査研究を行った。【結果】1飲食物製法記録をもとに、所収の料理を再現できる料理書『熊本藩士のレシピ帖』を刊行した。県内主要書店、熊本城売店にて販売され、県内外から需要を受けている。また県内料理店、宿泊施設などでは、同書を参考にした再現料理が、肥後熊本の古料理等と称され活用されている。2献立記録をもとに、万延元年(1860)熊本藩主初入国の御祝御能で供された本膳料理二汁七菜を、レプリカによって再現した。それは同事業で復元した本丸御殿内大御台所に常設展示されている。食記録の模型化により、近世の食を視覚でより具体的に印象づけることが可能となるが、一方で有形化に際し根拠の不足という問題も生じた。3上記史料や2で模型化した一部の料理再現を中心とした「本丸御膳」が、2の展示される大御台所で、同市の郷土料理店により提供されている。再現料理の食体験として、季節ごとに献立を変えながら継続される予定である。