著者
Kent R. Walters Jr. S. Indu Rupassara R.J. Cody Markelz Andrew D.B. Leakey William M. Muir Barry R. Pittendrigh
出版者
日本毒性学会
雑誌
The Journal of Toxicological Sciences (ISSN:03881350)
巻号頁・発行日
vol.37, no.4, pp.773-790, 2012-08-01 (Released:2012-08-01)
参考文献数
55
被引用文献数
1 9 1

Methamphetamine (MA) appears to produce neurotoxic effects, in part, through disruptions of energy metabolism. A recent study of the whole-body proteome of Drosophila melanogaster showed many changes in energy metabolism-related proteins, leading us to hypothesize that MA toxicity may cause whole-body disruptions of energy metabolism. To test this, we monitored the response of energy reserves and other metabolites to MA-exposure with and without the addition of dietary glucose. We also monitored changes in feeding behavior, locomotor activity and respiration rates associated with MA-exposure to investigate how MA affects energy balance. We observed that glycogen and triglyceride levels decreased dramatically within 48 hr of MA-exposure, indicating a strongly negative caloric balance. Behavioral assays revealed that MA-treated flies decreased food consumption by 60-80% and exhibited a 2-fold increase in locomotion. Caloric expenditure decreased with MA-exposure, apparently due to a compensatory decrease in resting metabolism, showing that anorexia was the primary driver of the negative caloric balance. Additionally, we observed that glucose supplementation of MA-containing diet increased glycogen reserves by 44% at 48 hr, leading to a commensurate increase in survivorship. We conclude that dietary sugar supplementation enhances survivorship by partially compensating for decreased caloric intake resulting from MA-induced anorexia. The observation that MA produces similar behavioral changes in Drosophila and humans, i.e. increased locomotor activity and anorexia, further supports the use of Drosophila as a model organism for the study of the effects of MA.
著者
柳沢 史明
出版者
美学会
雑誌
美學 (ISSN:05200962)
巻号頁・発行日
vol.58, no.3, pp.14-27, 2007-12-31

Les arts chez Georges Bataille sont souvent lies a la conception ontologique et existentielle d' "angoisse". L'angoisse, pour Bataille, est le sentiment d'un danger qui visite l'homme qui s'affronte a la mort. Par ailleurs, en eveillant les attentions sur la mort habituellement cachee, elle est aussi le sentiment de l'attente de franchir la vie quotidienne et "un monde avare". Toutefois, bien que l'intention d'introduire les elements de mort (i.e., l'angoisse, la souffrance et la douleur) soit cruciale dans la vie quotidienne, il faut eviter que la vie soit menacee excessivement. Et alors, pour raison d'equilibre entre la vie et la mort, Bataille dit qu'on doit recourir aux "tricheries", c'est a-dire, aux arts. Selon Bataille, le pouvoir de l'art concerne l'effet d'evocation. Compte tenu de l'usage de (revocation), qui autrefois principalement signifiait "appeler les morts par la magie", Bataille considere l'evocation comme une apparition intime de ce qui n'est ni substantiel ni accessible. La mort en est un exemple. Par l'evocation, qui est un procede indirect mais done assure la vie, l'art permet aux hommes l'acces inacheve a la mort. activement et volontairement.
著者
黄 孔良
出版者
新潟大学
雑誌
新潟医学会雑誌 (ISSN:00290440)
巻号頁・発行日
vol.117, no.12, pp.744-750, 2003-12-10

黙読には,視覚的に呈示された情報を音情報に変換し,音声言語と融合する過程が含まれる.本研究の目的は,黙読時に行われる音韻変換の脳内過程を,意味判断などの他のプロセスをなるべく介在させない状態で,事象関連電位と反応時間の計測により明らかにすることである.読めないハングル文字を注意して見る課題をコントロール課題とし,意味を持たない平仮名3文字を黙読する黙読課題を行って,事象関連電位を記録した.反応時間の計測は事象関連電位と別のブロックで行い,1文字目と3文字目を黙読する時点を,それぞれ,黙読開始時刻の指標となるRT1と黙読終了時刻の指標となるRT2として計測した.この結果,RT1が673±169msで,RT2が1376±238msであった.事象関連電位の結果では,黙読課題で頂点潜時を約590msとする持続的な陰性電位が,後側頭部から後頭部にかけて左半球優位に観測された.この陰性電位はコントロール課題では観測されず,また,反応時間から推測された黙読の時間帯にほぼ一致して観測されたことから,黙読時の音韻変換過程に関連した脳活動を反映したものと推定した.
著者
奥野 孝英 森 光司 堀尾 喜彦
出版者
一般社団法人電子情報通信学会
雑誌
電子情報通信学会技術研究報告. NLP, 非線形問題 (ISSN:09135685)
巻号頁・発行日
vol.103, no.741, pp.23-28, 2004-03-19

スイッチト・キヤパシタ(SC)カオスニューロン回路を用いた,400ニューロンカオスニューロコンピュータを構築し,400ニューロンシステムに動的連想記憶を実装する.連想記憶におけるカオス的振る舞いは,実数の複雑さによってもたらせる.カオスニューロコンピュータに実装されているSCニューロン回路は,アナログ回路で構成されている.アナログ回路は,状態変数が連続値であるため,実数値を扱うことができる.従って,カオス的振る舞いを忠実に再現することができる.一方,デジタル計算機は,実数を扱うことが原理的に不可能である.本稿では,400ニューロンシステムの動作検証結果を報告するとともに,400ニューロン動的連想記憶におけるカオスニューロコンピュータハードウェアとデジタル計算機によるコンピュータシミュレーションの結果から,ネットワークの挙動の違いについての比較・検討を試みる.また,コンピュータシミュレーションでは,ハードウェアの特性を考慮して行う.
著者
豊口 真衣子
出版者
日本建築学会
雑誌
日本建築学会計画系論文集 (ISSN:13404210)
巻号頁・発行日
vol.70, no.594, pp.223-229, 2005
被引用文献数
1

The purpose of this study is to analyze the cult of ruins in the Picturesque movement in architecture, gardens and landscape during eighteenth-century England. The ruin-mania and the heightened interest in landscape gardening produced a number of artificial ruins. The leading architect of such artificial ruins was Sanderson Miller. In this study, the ruins at Radway Grange and Hagley Park and his original design for Wimpole Castle will be analyzed as case studies. Through the analysis of artificial ruins, this study aims to clarify the historical meaning of the cult of ruin in term of the Picturesque and Gothic Revival.
著者
浜田 幸一 井坂 和実 土居 大治 米満 善久 岩崎 信吾
出版者
社団法人日本鉄鋼協会
雑誌
鐵と鋼 : 日本鐡鋼協會々誌 (ISSN:00211575)
巻号頁・発行日
vol.88, no.2, pp.66-72, 2002-02

Clad steel sheet is formed by cladding different metals and used for the functional material, which has convenient characteristics of each metal. Especially, a lot of stainless steel/aluminum clad strip is produced for electromagnetic rice cookers which are in demand because of the higher thermal conductivity, having magnetism and corrosion resistance. For the demand, continuous cladding technology of the wide width stainless steel/aluminum strip has been developed by warm rolling after the rapid heating process. Recently, much higher uniformity for peeling strength is required as the market grows. So, a new heating process, in which uniform heat generation is achieved by the electric resistance of metals and the directly applied current, is developed in place of the conventional process of induction heating. After solving some technical problems about sparks and temperature uniformity, direct resistance heating equipment have installed in the manufacturing line. As the result, high-quality clad steel sheets, which have the uniform peeling strength, can be produced by the improvement of temperature deflection on rolling.

3 0 0 0 OA 讃岐名勝栞

著者
矢原理平 編
出版者
日柳活版所
巻号頁・発行日
1907

3 0 0 0 OA 体育演武必携

著者
隈元実道 著
出版者
静思館
巻号頁・発行日
1897
著者
北山 夏季
出版者
人間環境学研究会
雑誌
人間環境学研究 (ISSN:13485253)
巻号頁・発行日
vol.10, no.1, pp.17-24, 2012 (Released:2012-06-30)
参考文献数
17
被引用文献数
1

In recent years, there have been more arguments on the importance of educating children not only in Japanese but also in their mother language from different viewpoints and backgrounds because the number of children who have foreign roots has rapidly increased in Japan. Some argue that it is important to involve parents as a support system for learning in their mother language in public schools but it is not necessarily easy due to a lack of understanding of Japanese education by parents, "the wall standing between school and parents", etc. This research, basing on hypothesis that to remove "the wall", setting classes for learning in their mother language in public schools is effective and involving parents in those classes encourages parents to participate in school education and children to study their language and their culture as well, considered how parents were involved in schools and classes for learning in their mother language and what influence did that had on learning attitude and motivation of children by actual setting of those classes from the data gained there. As a result, the following are revealed: 1) The significance of setting classes for learning in their mother language to parents: This research also confirmed that it is difficult to involve Vietnamese parents. 2) The relationship between children's motivation toward learning mother language and culture and involvement of parents: Children who had shown positive learning attitude in classes for learning in their mother language in the lower grades began to show defiant attitude in the fourth grade, which is said to be the time developmental stage changes greatly. It was considered that bringing in lion dance affected the improvement of motivation to take part in classes for learning in their mother language significantly in the time of overcoming this great change in developmental stage after the fourth grade. This enhanced willingness toward lion dance was thought to be the result of children themselves having recognized and been aware that their Vietnamese parents were involved in this lion dance. This positive attitude toward lion dance study also had a good effect on the motivation in the entire activity of classes for learning in their mother language and seemed to lead children to find the significance of those classes, "learning for their family".