著者

山本 吉章 家田 直幸 三島 信行 松田 一己 高橋 幸利 賀川 義之

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.7, pp.411-418, 2011 (Released:2012-08-30)

参考文献数

25

被引用文献数

1

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This study was designed to evaluate the persistence and safety of topiramate therapy in children and adults with epilepsy. It was a retrospective cohort study undertaken from October 2007 in which we analyzed the clinical records of 726 patients (216 children and 510 adults) who received topiramate for the treatment of epilepsy at the National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders. Factors associated with discontinuation of topiramate therapy determined from the results of the log-rank test (p<0.1) were subjected to multivariate Cox regression analysis in order to calculate hazard ratios and 95% confidence intervals (95% CI).Suspension (Discontinuation) or dose reduction of topiramate were necessary due to adverse effects in 85 children (39%), of which the major ones were drowsiness (16.2%), anorexia (10.7%), hypohidrosis (4.7%), and irritability (4.2%). There was a higher incidence of hypohidrosis and a lower incidence of speech disorders in children as compared with adults (both p < 0.05). According to Cox proportional hazards analysis, the adjusted hazard ratio for discontinuation of topiramate therapy in children was 0.92 (95% CI : 0.75-1.23 ; p=0.76). In conclusion, this comparative study showed that the persistence and safety of topiramate therapy were similar in children and adults.

著者

菅原 慎悦 城山 英明

出版者

公益社団法人 土木学会

雑誌

土木学会論文集D3(土木計画学) (ISSN:21856540)

巻号頁・発行日

vol.67, no.4, pp.441-454, 2011 (Released:2011-11-18)

参考文献数

47

被引用文献数

1

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本研究では,フランス地域情報委員会(CLI)関係者へのインタビュー調査に基づき,原子力施設をめぐる日本とフランスの自治体関与のあり方を整理した上で両国の比較分析を行い,フランス事例の日本への示唆となる点を指摘する.その結果,両国ではローカル・コンテクストの差が大きいものの,それを考慮した上でなお参照に値する示唆として,(1)原子力規制体系への自治体の位置づけの明確化,(2)事業者及び規制機関と自治体との双方向コミュニケーションの回路の確保,(3)規制目的としての「透明性確保」の明示化,という3点を得た.

著者

川本 盛四郎

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.25, no.4-6, pp.68-74, 1949-11-20 (Released:2012-09-24)

参考文献数

14

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I investigated the form, the speed of Capillary stream, the changes of subpapillar venous plexus, and the pigmentation of the basilar part in Sulcus subungualis on left ring finger.I measured the width and the lengh of Capillary by ocular Micrometer, Adrenalin was used locally as a solution of 1: 2000 or 1: 5000 Adrenalin Glycerin, and subcutaneously as 0.1cc of 1: 1000 HCl-Adrenalin per kilo-gram body weight, The result was as follows.By the treatment of adrenalin, venous and arterial capillaries of skin contracted, the speed of blood stream became slow and the pigmentation of basilar part became lighter. These changes were proportional to concentration of adrenalin, and were stronger in subcutaneous application than in local application.The reaction of adrenalin was stronger in man than in woman.

著者

山越 健弘 田中 直登 山越 康弘 松村 健太 ROLFE Peter 廣瀬 元 高橋 規一

出版者

公益社団法人 日本生体医工学会

雑誌

生体医工学 (ISSN:1347443X)

巻号頁・発行日

vol.48, no.5, pp.494-504, 2010-10-10 (Released:2011-05-27)

参考文献数

19

被引用文献数

1

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Motor racing athletes in the closed-cockpit category are always facing life-threatening situations caused by heat stroke, especially in hot weather. We report here the development of a novel infrared-radiation-type eardrum thermometer, with a built-in earphone, which can be used for continuous measurement in GT car racing. We examined the accuracy of the system for core body temperature monitoring in 10 healthy volunteers (21.8 ± 1.0 (S.D.) yrs) using a temperature controlled water bath. In addition, we assessed the usefulness of the system under real racing conditions with 2 professional drivers in the practice session of 2010 SUPER GT International Series Round 4 MALAYSIA being held at the Sepang International Circuit. To examine accuracy two thermistor probes, one inserted into the ear canal and the other beneath the tongue, were used for measurements of eardrum and sublingual temperatures respectively. An infrared eardrum thermometer was inserted into the contra-lateral ear canal. The measured temperatures were recorded at 30-s intervals. The results showed good correlation between the infrared eardrum temperature and both the direct eardrumtem temperature (r = 0.994, n = 1119, p < 0.001) and the sublingual temperature (r = 0.972, n = 1119, p < 0.001). The mean difference between these temperatures was + 0.09 °C, - 0.08 °C, and 1.96 S.D. was 0.21 °C, 0.44 °C, respectively. As for the field test, the system functioned satisfactorily during real racing conditions performed on the racing circuit. These results suggest that our new system can be used in a race setting as a reliable core temperature monitor and could help to improve safety of motor sports.

著者

志賀 弘典

出版者

一般社団法人 日本数学会

雑誌

数学 (ISSN:0039470X)

巻号頁・発行日

vol.38, no.2, pp.116-132, 1986-05-09 (Released:2008-12-25)

参考文献数

33

著者

河内 了輔 新川 拓也 河原崎 景太 藤川 智彦 武井 安津子 湊 小太郎

出版者

公益社団法人 日本生体医工学会

雑誌

生体医工学 (ISSN:1347443X)

巻号頁・発行日

vol.50, no.6, pp.564-570, 2012-12-10 (Released:2013-07-31)

参考文献数

12

被引用文献数

1

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In this study, we developed a point-contact force sensor, and this sensor was used to develop a measurement system that was shaped in the form of a feeding bottle. Unlike in a cantilever force sensor, in the proposed force sensor, the point of force measurement does not move. Thus, the force sensor can measure a force at a specified point. The force sensor consists of a pressure transducer and a steel ball with a diameter of 3 mm. Any force applied to the artificial nipple is transmitted to the pressure transducer, which is in point contact with the steel ball. The force sensor is linear up to a load of 3.92 N, has a hysteresis of 1%, and has a response time of 4 ms. The force is measured at distances of 8 mm (channel 1) and 14 mm (channel 2) from the tip of the nipple. In the measurement system, the sensor signals are converted (A/D) at a sampling rate of 100 Hz and a quantization resolution of 10 bits. After the A/D conversion, the force signals are transferred to a data indicator and a data logger for real-time display on an LCD and for storage ona micro SD card, respectively. Using this system, we performed measurements on four infants. A signal peak was observed from channel 2 and then from channel 1. This result could be attributable to the peristaltic movements of the infant's tongue. The same result was observed for all subjects. These results indicate that the proposed system can be used to measure any force that is applied to an artificial nipple. Moreover, the mother of a subject also performed measurements using the system. This confirmed that the system was easy to operate and that measurements could be performed in a normal feeding posture.

著者

Hong-Li REN Fei-Fei JIN Malte F. STUECKER Ruihuang XIE

出版者

(公社)日本気象学会

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.91, no.6, pp.835-842, 2013 (Released:2014-01-10)

参考文献数

30

被引用文献数

8 37

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During the late 1970s, the El Niño-Southern Oscillation (ENSO) experienced a notable regime change, manifested by a change in amplitude, dominant ENSO period, and sea surface temperature anomaly (SSTA) propagation characteristics. The present study shows that these features of the ENSO regime change are associated with property changes of the canonical ENSO, i.e., cold-tongue (CT) type ENSO. Another signature of the ENSO regime change is manifested in the frequent occurrence of a warm-pool (WP) type ENSO that accompanies SSTAs centered over the central Pacific near the WP edge and exhibits characteristics differing from those of the CT ENSO. The distinct manifestations of the two types of ENSO detected in this ENSO regime change are clearly identifiable with the removal of the strong background decadal signal. Since the late 1970s, the WP ENSO has featured a weak eastward (westward) propagation of the SSTA center in the developing (decaying) phase, which makes no net contribution to the observed eastward propagation, and a 2-3 yr period compared to the 4-5 yr period of the CT ENSO. Observations strongly suggest that the WP and CT ENSO are independent quasi-biennial and quasi-quadrennial modes, respectively, of the tropical Pacific climate variability. Our observations also suggest that these two ENSO modes have coexisted actively since the late 1970s when either El Niño or La Niña can be separated into the two types.

著者

Muhammad AAMIR Mustafa Ali ZAIDI

出版者

東北大学大学院情報科学研究科ジャーナル編集委員会

雑誌

Interdisciplinary Information Sciences (ISSN:13409050)

巻号頁・発行日

vol.19, no.2, pp.173-200, 2013 (Released:2013-11-22)

参考文献数

157

被引用文献数

1 22

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Distributed Denial of Service (DDoS) attacks exhaust victim's bandwidth or services. Traditional architecture of Internet is vulnerable to DDoS attacks and an ongoing cycle of attack & defense is observed. A recent attack report of year 2013 –- `Quarter 1' from Prolexic Technologies identifies that 1.75 percent increase in total number of DDoS attacks has been recorded as compared to similar attacks of previous year's last quarter. In this paper, different types and techniques of DDoS attacks and their countermeasures are surveyed. The significance of this paper is the coverage of many aspects of countering DDoS attacks including new research on the topic. We survey different papers describing methods of defense against DDoS attacks based on entropy variations, traffic anomaly parameters, neural networks, device level defense, botnet flux identifications, application layer DDoS defense and countermeasures in wireless networks, CCN & cloud computing environments. We also discuss some traditional methods of defense such as traceback and packet filtering techniques, so that readers can identify major differences between traditional and current techniques of defense against DDoS attacks. We identify that application layer DDoS attacks possess the ability to produce greater impact on the victim as they are driven by legitimate-like traffic, making it quite difficult to identify and distinguish from legitimate requests. The need of improved defense against such attacks is therefore more demanding in research. The study conducted in this paper can be helpful for readers and researchers to recognize better techniques of defense in current times against DDoS attacks and contribute with more research on this topic in the light of future challenges identified in this paper.

著者

廣瀬 圭 土岐 仁 近藤 亜希子

出版者

日本スポーツ産業学会

雑誌

スポーツ産業学研究 (ISSN:13430688)

巻号頁・発行日

vol.22, no.2, pp.255-262, 2012 (Released:2012-11-16)

参考文献数

12

被引用文献数

3 10

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This paper proposes a measurement system and computation method for 3D motion analysis in sports. The measurement system that consists of inertial and magnetic field sensors is able to measure 3-axis angular velocity, 3-axis acceleration and 3-axis magnetic field. We can easily perform the experiment in sports because this system is directly attached to the body. Introducing the sensor fusion algorithm using Kalman filter, we can avoid storage error by the drift of the gyro sensor. The computation method provides the angles by compensation of centrifugal and tangential acceleration and sensor fusion.     In order to confirm the accuracy of this proposed system and computation method, we compared the value obtained by this system with the value obtained by a rotary encoder. It was found that the measurement system and computation method provided the accurate value. It is shown that the proposed method can be used for motion analysis in sports.

著者

秋葉 澄伯

出版者

公益財団法人 日本学術協力財団

雑誌

学術の動向 (ISSN:13423363)

巻号頁・発行日

vol.18, no.7, pp.7_10-7_17, 2013-07-01 (Released:2013-11-01)

参考文献数

23

著者

Kensuke Nakamura Ryota Inokuchi Kent Doi Tatsuma Fukuda Kurato Tokunaga Susumu Nakajima Eisei Noiri Naoki Yahagi

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.53, no.10, pp.1071-1073, 2014 (Released:2014-05-15)

参考文献数

20

被引用文献数

3 10

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Various unmeasured anions other than lactate appear in the blood of septic patients, including ketones. However, the occurrence of sepsis-induced ketoacidosis without diabetes mellitus has not been reported to date. We herein describe severe ketoacidosis in a patient with septic shock despite the absence of diabetes, alcohol and starvation. A 76-year-old woman presented with septic shock due to acute obstructive cholangitis. She exhibited ketoacidosis and a remarkably strong ion gap, except for ketones. Sepsis alone may lead to ketoacidosis in patients without diabetes under specific conditions. The accumulation of ketones and other strong anions can occur in cases involving a decreased metabolic function. There may be a pathological condition called septic ketoacidosis.

著者

Ahmad N. Mohammed Megat Azmi Megat Johari Abdullah M. Zeyad Bassam A. Tayeh Moruf O. Yusuf

出版者

Japan Concrete Institute

雑誌

Journal of Advanced Concrete Technology (ISSN:13473913)

巻号頁・発行日

vol.12, no.4, pp.127-137, 2014-04-24 (Released:2014-04-24)

参考文献数

34

被引用文献数

7 72

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Ground treated ultrafine-POFA obtained from palm oil industry was heat-treated to remove excess carbon. The varied proportion (17%, 30% and 40%) of UPOFA was incorporated into the ultra-high strength concrete (UHSC) to study its effects on the UPOFA-UHSC (Ux-UHSC) in comparison with OPC-UHSC (U0-UHSC) engineering and transport properties. The Ux-UHSC has an increasing workability tendency with a retarded setting times as compared to U0-UHSC. Besides, Ux-UHSC registered higher compressive strength than the U0-UHSC. The 90-d strength of 156 MPa was achieved in U17-UHSC which was 4.7%, 7.5% and 12.2% higher than the values obtained for U30-UHSC, U40-UHSC and U0-UHSC, respectively. The U40-UHSC exhibited the greatest improvement at 90 days in transport properties such as porosity, water absorption, initial surface absorption, rapid chloride permeability, gas permeability and water permeability while the highest strength was recorded with U17-UHSC. Thus, the pozzolanic UPOFA is capable of improving the engineering and transport properties of UHSC.

著者

橋本 禅 有田 博之 保高 徹生 岩崎 有美

出版者

公益社団法人 農業農村工学会

雑誌

農業農村工学会論文集 (ISSN:18822789)

巻号頁・発行日

vol.81, no.2, pp.153-162, 2013-04-25 (Released:2014-04-25)

参考文献数

28

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本稿では,(1)除染における地域指定や優先順位の方針の整理を通じて,(2)除染において農村地域がどのように序列化されるかを明らかにすると共に,(3)農村地域の除染と生活再建においてどのような影響が想定されるか,また(4)それら影響に対する対応策の提案を行なった.国が示す除染の優先順位付けの方針は,結果的に農村地域の除染対応の遅れを引き起こす可能性が高い.仮置き場の確保や同意取得の難航は本状況を更に深刻なものとすると懸念される.また,除染の効果にも限界があり,空間線量の高い地域では除染の遅延と相まって住民の避難生活の長期化が予測される.自治体の住民意向調査からは,避難が長期化した場合,帰還率のさらなる低下が見込まれることが示唆されており,除染や復興への戦略的対応が求められる.本稿ではこれに対応する方策として,急激な人口の流出を前提としつつも除染対応を地域再編の契機として捉えた,地区レベルでの復興構想の策定を提案した.

著者

松永 久 富永 忠男 王寺 睦満 田中 英夫

出版者

一般社団法人 日本鉄鋼協会

雑誌

鉄と鋼 (ISSN:00211575)

巻号頁・発行日

vol.63, no.13, pp.1945-1952, 1977-11-01 (Released:2010-02-22)

参考文献数

36

被引用文献数

1

著者

Teppei J. Yasunari K.-M. Lau Sarith P. P. Mahanama Peter R. Colarco Arlindo M. da Silva Teruo Aoki Kazuma Aoki Naoto Murao Sadamu Yamagata Yuji Kodama

出版者

(公社)日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.10, pp.50-56, 2014 (Released:2014-04-23)

参考文献数

44

被引用文献数

5 14

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The snow darkening module evaluating dust, black carbon (BC), and organic carbon (OC) depositions on the mass of snow impurities and albedo has been developed for the NASA Goddard Earth Observing System, Version 5 (GEOS-5) Earth System Model, as the GOddard SnoW Impurity Module (GOSWIM). GOSWIM consists of the updated snow albedo scheme from a previous study (Yasunari et al. 2011) and a newly developed mass concentration calculation scheme, directly using aerosol depositions from the chemical transport model (GOCART) in GEOS-5. Compared to observations at Sapporo, the off-line simulations, forced by observation-based meteorology and aerosol depositions from GOES-5, reasonably simulated the seasonal migration of snow depth, albedos, and impurities of dust, BC, and OC in the snow surface. However, the simulated dust and BC mass concentrations in snow were especially underestimated except for the BC in the early winter, compared to the observations. Increasing the deposition rates of dust and BC could explain the observations. Removing BC deposition could possibly lead to an extension of snow cover duration in Sapporo of four days. Comparing the off-line GOSWIM and the GEOS-5 global simulations, we found that determining better local precipitation and deposition rates of the aerosols are key factors in generating better GOSWIM snow darkening simulation in NASA GEOS-5.

出版者

日本地図学会

雑誌

地図 (ISSN:00094897)

巻号頁・発行日

vol.29, no.2, pp.AP1-AP1, 1991-06-30 (Released:2011-07-19)

著者

大木 知彦 森田 寿郎

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集C編 (ISSN:18848354)

巻号頁・発行日

vol.79, no.804, pp.2758-2768, 2013 (Released:2013-08-25)

参考文献数

32

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Wheels have high movement efficiency, simple structures and low cost. So various wheeled mechanisms are used in the living space. However, wheels have low traveling performance. Therefore, there are areas that wheeled mechanism can't move in. In order to solve this problem, various movement mechanisms are developed. Yet, they have many problems. For example, complicate, heavy, large, expensive, and so on. Because of these reasons, the spread of these movement mechanisms are blocked. Then, we propose TFW that have high performance of driving on level surface and traveling over a single step. Movement mechanisms that are equipped with TFW can travel over steps that conventional wheeled vehicle can't travel over. Consequently, we showed that TFW have high performance movement mechanism of level running and traveling over steps by experiments with a vehicle “SRIDER-II”.

著者

寺尾 元康

出版者

一般社団法人 映像情報メディア学会

雑誌

映像情報メディア学会誌 (ISSN:13426907)

巻号頁・発行日

vol.51, no.7, pp.947-951, 1997-07-20 (Released:2011-03-14)

参考文献数

7

著者

高柳 栄子 中山 裕樹 石川 剛志 永石 一弥 井龍 康文

出版者

一般社団法人 日本地質学会

雑誌

地質学雑誌 (ISSN:00167630)

巻号頁・発行日

vol.116, no.4, pp.237-240, 2010 (Released:2010-10-13)

参考文献数

14

被引用文献数

3

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We present strontium (Sr) isotope data for island-surface dolomites at Kita-daito-jima, northern Philippine Sea. The 87Sr/86Sr ratios of 50 samples fall within a wide range from 0.709037 to 0.709079, corresponding to 4.9-2.1 Ma. This wide range in Sr ages reflects the fact that the island-surface dolomites comprise variable mixtures of geochemically distinct, diachronous, dolomite crystal phases. Our results indicate that the Sr isotope ages of multi-generational dolomites on carbonate islands such as Niue and Little Bahama Bank, as well as Kita-daito-jima, should be re-examined employing a new method that determines the Sr isotope ratio of individual crystal phases.

著者

森本 肇

出版者

日本動物心理学会

雑誌

動物心理学年報 (ISSN:00035130)

巻号頁・発行日

vol.6, pp.91-97, 1956-04-25 (Released:2009-10-14)

参考文献数

13

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一般にandrogenは優位性を高め, estrogenは攻撃性を弱めるか, または影響しないことが認められているようである (1) 。魚類での性ホルセンと行動についての研究はただツルギメダカXiphophorus helleriで行われているだけのようである (1) 。メダカOryzias latipesの行動については色々な実験が行われている (2, 6, 8, 9, 10, 11, 12, 13) が, その行動に及ぼすホルモンの効果の研究は, まだ行われていない。そこで筆者は, メダカの2個体社会の行動に及ぼす去勢の影響について実験的分析を企てた。