著者

井上 義博 菊池 哲 小野寺 誠 藤野 靖久 秋冨 慎司 山田 裕彦 遠藤 重厚

出版者

日本蘇生学会

雑誌

蘇生 (ISSN:02884348)

巻号頁・発行日

vol.32, no.1, pp.23-28, 2013-03-28 (Released:2013-05-02)

参考文献数

4

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平成23年3月11日に発生した東日本大震災は,死者,行方不明者,災害関連死を含めると2万人を超える犠牲者を出した。発災から3月31日までの3週間に我々の施設に搬送された症例は23例で,内訳は溺水による呼吸不全3例,肺血栓塞栓症,うっ血性心不全,多発外傷が各2例,クラッシュ症候群,破傷風,熱傷,腸間膜動脈損傷,凍傷,脾動脈破裂が各1例,単独損傷7例であった。この内呼吸不全の3例はいずれも3週間以内に死亡したが,他の症例は救命された。津波肺は発症病態が生物学的(微生物),化学的(油脂が主体),物理学的(砂や泥)と複雑で,微生物も特殊なものに起因するため治療に難渋したものと思われた。

著者

高野 敦 森永 洋次 井上 登志夫

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集A編 (ISSN:18848338)

巻号頁・発行日

vol.79, no.800, pp.455-462, 2013 (Released:2013-04-25)

参考文献数

15

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Methods of evaluating the one-sided tolerance limit (A- and B-basis values) of unbalanced sample sets are derived. The A- and B-basis values are statistically calculated numbers that respectively indicate that at least 99 and 90 percent of the population is expected to equal or exceed the statistically calculated value with a confidence of 95 percent, and they are often used as strength tolerance limits in aerospace designs. The A- and B-basis values tend to be underestimated when the sample size is small and the conventional methods are used. Our novel methods improve the basis values by combining multiple sample sets from normally (Gaussian) distributed populations. We extended analysis of variance (ANOVA) to evaluate the A- and B-basis values by using non-central t-distribution under the condition of equality of variances. In addition, we derive coefficients for the basis values under the condition of non-equality of variances by using a Monte-Carlo method. Numerical examples show that both methods, i.e., equality and non-equality of variance cases, increase the A- and B-basis values.

著者

島田 長人

出版者

一般社団法人 日本プライマリ・ケア連合学会

雑誌

日本プライマリ・ケア連合学会誌 (ISSN:21852928)

巻号頁・発行日

vol.36, no.1, pp.50-57, 2013 (Released:2013-05-02)

著者

芝 祐輔 坂井 亮太 綿野 亮太 奥田 泰考 若林 宏海 荒川 昌史 中澤 寛仁 須藤 俊明 梶井 英治 長谷川 剛 岡山 雅信

出版者

一般社団法人 日本プライマリ・ケア連合学会

雑誌

日本プライマリ・ケア連合学会誌 (ISSN:21852928)

巻号頁・発行日

vol.36, no.1, pp.23-26, 2013 (Released:2013-05-02)

参考文献数

6

被引用文献数

1 1

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要 旨目的 : これまで長期災害支援の報告は数少ない. そこで今回我々が経験した東日本大震災の長期災害医療支援として巡回診療で得られた診療記録と処方箋から薬剤関連データを解析した. 方法 : 巡回診療で得られた診療記録と処方箋から患者数と医薬品の処方件数ならびに処方件数の多かった上位3位の医薬品使用量の推移について解析した. 結果 : 患者数は支援を開始した3/26から1週間後の166名/日 (中央値48.5名, 範囲14-166) をピークに減少し, 4/11以降は24名 (中央値)/日 (範囲0-47) であった. 医薬品の処方件数は感冒薬, 降圧薬, 抗アレルギー薬の順で多かった. また医薬品の使用量は感冒薬と降圧薬は時間経過とともに減少したが, 抗アレルギー薬は継続的に処方されていた. 結論 : 災害医療支援チームは被災地の医療機関の復興状況に応じて急性期だけでなく長期の支援を行うべきである. また支援の介入が早いほど, 急性疾患と慢性疾患の両方の治療薬を災害医療支援チームは必要とする.

著者

則武 正基 神谷 博昭 横井 基夫

出版者

JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.20, no.3, pp.125-129, 2001-12-01 (Released:2010-06-08)

参考文献数

20

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We often worry about oral lichen planus (OLP) with chronic inflammation, which is an intractable disease in the treatment. A study was carried out to evaluate the efficacy of allopurinol mouthwash (ALP) on OLP.We studied 9 cases (1 male and 8 females) of OLP that were clinically diagnosed in our ambulatory practice during the period from July 1996 to July 1997. The average age was 58.7, ranging from 23 to 82 years. The effect measurement was carried out after 4 weeks of administration, and there were 3 complete responses, 4 partial responses, and 2 minor responses.ALP was reported to be effective for prevention and treatment of the stomatitis, which develops during cancer chemotherapy. ALP can be easily used by gargling only, and no side effects were seen, so it seemed to be a useful drug.

著者

小俣 武志 井上 肇 瀬山 義幸 山下 三郎

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.93, no.3, pp.113-118, 1989 (Released:2007-02-20)

参考文献数

15

被引用文献数

1

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ラットの胃に酢酸潰瘍を作製し,2,10,40,80,180,365日目の時点で,その治癒過程における潰瘍部位と非潰蕩部位について,各種アミン含量とヒスチジンデカルボキシラーゼ(HDC)活性を比較検討した.その結果以下のことが明らかとなった,1)潰瘍部位のヒスタミン(HA)含量は非潰瘍部位と比較し,2,10日目で減少後,40日目で差がなくなり180日目で潰瘍部位ばかりでなく非潰瘍部位も正常対照群より増加した.2)セロトニン(5-HT)含量の変動はHAと同様であった.3)潰蕩部位のノルエピネフリン含量は非潰瘍部位と比較し,2,10,80,180日目で減少していた.4)潰瘍部位の HDC 活性は非潰瘍部位と比較し,2,10,40日目で減少し,180日目では正常対照群より減少したままであった.5)365日目に肉眼的に再燃,再発を確認したラットの潰瘍部位と非潰瘍部位のHA,5-HT含量は治癒したラットのその含量と差がなかったが,180日目と同様に高値を示していた.以上,胃粘膜中のHA,5-HT,HDC 活性の変動は慢性胃潰瘍の再燃,再発に係わる一因子となる可能性が推測された.

著者

庄 太郎

出版者

社団法人 大阪生活衛生協会

雑誌

家事と衛生 (ISSN:18836615)

巻号頁・発行日

vol.9, no.3, pp.64-68, 1933-03-01 (Released:2010-10-13)

出版者

一般社団法人 日本ペインクリニック学会

雑誌

日本ペインクリニック学会誌 (ISSN:13404903)

巻号頁・発行日

vol.20, no.1, pp.69-78, 2013 (Released:2013-03-22)

著者

関谷 亮 唐木田 一成 新井 俊弘 佐藤 佑介 坂本 由紀 金井 直樹 丸山 亮 金子 明寛

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.29, no.2, pp.69-76, 2010-08-01 (Released:2010-09-11)

参考文献数

13

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口腔感染症患者より分離した各種細菌およびCandida属菌株のbiofilm形成能をクリスタルバイオレット染色法で評価した結果,Prevotella intermedia,Porphyromonas gingivalis,Actinomyces odontolyticus,Streptococcus mitis,Candida albicansおよびCandida glabrataにおいてbiofilm形成能の高い菌株が見出された.これらの菌株を対象に各種抗菌薬または抗真菌薬のsub-MICにおけるbiofilm形成抑制作用を検討した.P. intermediaおよびP. gingivalisに対してlinezolid,azithromycinおよびclarithromycinのsub-MICでの作用によりbiofilm形成抑制効果が認められたが,検討した他の菌種のbiofilm形成に対する抑制効果は認められなかった.一方,C. albicansおよびC. glabrataに対しては,測定した抗真菌薬のうちmicafunginのみがsub-MICにおけるbiofilm形成抑制作用を示した.

著者

松田 源 吉村 安郎 原田 利夫 吉村 仁志 尾原 清司

出版者

特定非営利活動法人 日本口腔科学会

雑誌

日本口腔科学会雑誌 (ISSN:00290297)

巻号頁・発行日

vol.51, no.3, pp.171-177, 2002-05-10 (Released:2011-09-07)

参考文献数

16

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One hundred forty-six teeth on the fracture lines of mandibular fractures (85 patients) treated at the Department of Oral and Maxillofacial Surgery, Shimane Medical University Hospital, from 1980 to 1998, were clinicostatistically analyzed. The results were as follows:1. The age of patients was widely distributed. The peak incidence was the second and third decades (74.1%). The male and female ratio was 4 to 1.2. The cause of fracture was 26 cases (30.6%) in the traffic accident, 21 cases (24.1%) in falls, 17 cases (20.0%) in sports, 10 cases (11.7%) in beating, 9 cases (10.6%) in work accidents and 2 cases (2.4%) in others.3. Teeth on the lines of mandibular fractures were found in 35 teeth (20.4%) in the wisdom teeth and in 34 teeth (23.4%) in the canine teeth and in 77 teeth (56.2%) in the others.4. Seventy-three teeth (85.6%) out of all teeth were preserved without teeth extractions.5. Teeth on the mandibular fracture lines could be classified into four types (I-IV) according to our original classification ; type I was 19.2%, type II was 49.4%, type III was 19.2%, and type N was 12.2%.6. We investigated whether the teeth on the lines of the mandibular fractures were preserved or not after treatments-91.3% of the teeth had been preserved for more than one year after treatments.

著者

中村 國則

出版者

日本認知科学会

雑誌

認知科学 (ISSN:13417924)

巻号頁・発行日

vol.15, no.1, pp.174-187, 2008 (Released:2009-10-30)

参考文献数

27

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Verbal probability statements such as “very certain” or “impossible” are often used to communicate information regarding uncertainty. This study aims to investigate how people estimate the “informativeness” of verbal probability statements. With regard to numerical probabilities (e.g., “30%”), Keren and Teigen (2001) proposed the “search for definitive predictions” principle; according to this principle, relatively high or low probabilities are preferred to medium ones because high or low probabilities denote the occurrence or nonoccurrence of a single outcome more strongly than they do medium ones. However, whether people adhere to this principle when they estimate the informativeness of the verbal probability statement remains an unresolved issue. Through two empirical studies, this study establishes a quantitative relation between verbal probability statements and their “informativeness,” which is similar to the principle of Keren and Teigen (2001). In addition, this study shows that the directionality of verbal probability (Teigen & Brun, 1999) also affects the informativeness judgment. Finally, this study formalizes the judgment regarding the informativeness of probability statements in terms of the information theory and argues that the “search for definitive predictions” principle can be interpreted as rational information estimation under the rarity assumption (Oaksford & Chater, 1994).

著者

Yasuto Arakaki Hayaru Shouno Kazuyuki Takahashi Takashi Morie

出版者

Information and Media Technologies Editorial Board

雑誌

Information and Media Technologies (ISSN:18810896)

巻号頁・発行日

vol.7, no.4, pp.1480-1488, 2012 (Released:2012-12-15)

参考文献数

15

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For the detection of generic objects in the field of image processing, histograms of orientation gradients (HOG) is discussed for these years. The performance of the classification system using HOG shows a good result. However, the performance of using HOG descriptor would be influenced by the detecting object size. In order to overcome this problem, we introduce a kind of hierarchy inspired from the convolution-net, which is a model of our visual processing system in the brain. The hierarchical HOG (H-HOG) integrates several scales of HOG descriptors in its architecture, and represents the input image as the combinatorial of more complex features rather than that of the orientation gradients. We investigate the H-HOG performance and compare with the conventional HOG. In the result, we obtain the better performance rather than the conventional HOG. Especially the size of representation dimension is much smaller than the conventional HOG without reducing the detecting performance.

著者

平藤 彰 酒井 麻里 小出 洋子 日山 邦枝 池田 幸 村山 純一郎

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.30, no.1, pp.16-19, 2011-04-01 (Released:2011-06-21)

参考文献数

5

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After implementation of the new GCP, our hospital was staffed by clinical research coordinators (CRC) to smoothly conduct clinical trials of higher quality. At present, two pharmacists, two dental hygienists, and one nurse are working concurrently as CRCs in our hospital. An unique feature of CRC work at our hospital include 1) dental hygienists working as CRCs, and 2) CRCs of different specialities are coordinated on the same trial and contributing according to their specialties, participation of each clinical trial, one by one. Previously, in our hospital, clinical trials for medications had been allocated to nurse CRCs, while dental hygienist CRCs support for clinical trial of medical devices. However, a dental hygienist have participated as a CRC for the first time in a clinical trial for a medication in 2009, a pharmacist CRC cooperated the clinical trial with the dental hygienist CRC, and this trial was successfully completed. We anticipate that dental hygienist CRCs supporting clinical trials in dental practice will play an indispensable role in smoothly conducting clinical trials with high quality. In this report, we will present the current status of CRC work, which has been accomplished by cooperation with pharmacists and dental hygienists.

著者

小坂 和江 小西 吉裕 山下 佐知子 菊永 茂司

出版者

日本食生活学会

雑誌

日本食生活学会誌 (ISSN:13469770)

巻号頁・発行日

vol.23, no.4, pp.207-216, 2013-03-30 (Released:2013-04-30)

参考文献数

41

被引用文献数

5 2

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The purpose of this study was to examine two relationships; one between the serum zinc concentration and the intake of zinc, and the other between the serum zinc concentration and the hematological consistent associated with the serum zinc concentration in elderly patients in a health facility.  The estimations of the hematological consistent, physical index, and dietary survey were made based on an examination carried out on 15 disabled elderly patients (male=8, female=7, mean age 82±10 years) .  The obtained results from this study are summarized as follows:1) The subjects showed low levels of serum zinc, although the intake of zinc was close to the recommended dietary allowance (RDA) level.2) The ratio of the subjects of less than 66 μg/dl of the reference value of the serum zinc was 60% for men and 72% for female in the oral feeding, and also 100% of men and 83% of female in the enteral feeding.3) The three significant correlations was found between the serum zinc and the hematocrit, the serum zinc and total protein, and the serum zinc and albumin values.  As a high percentage of the subjects showed low levels of serum zinc, it is suggested that the nutritional zinc status for the subjects was not satisfactory.

著者

Yasushi Fujio Makiko Maeda Tomomi Mohri Masanori Obana Tomohiko Iwakura Akiko Hayama Tomomi Yamashita Hiroyuki Nakayama Junichi Azuma

出版者

The Japanese Pharmacological Society

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.117, no.4, pp.213-222, 2011 (Released:2011-12-15)

参考文献数

74

被引用文献数

24 36

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Postnatal cardiomyocytes have only limited capacity of proliferation. Therefore, the myocardium is intrinsically equipped with cardioprotective machineries and protects itself from pathological stresses. One of the most important cardioprotective systems is the signal network of autocrine/paracrine factors, including neurohumoral factors, growth factors, and cytokines. In this review, we focus on the roles of interleukin-6 (IL-6) family cytokines, also known as glycoprotein 130 (gp130) cytokines, in cardioprotection. These cytokines make a complex with their specific cytokine receptor α-subunits. The cytokine-receptor α-subunit complex binds to gp130, a common receptor of the IL-6 family, followed by the activation of JAK/STAT, ERK, and PI3 kinase/Akt pathways. In cardiomyocytes, signals through gp130 promote cell survival and angiogenesis through the JAK/STAT pathway. Activation of gp130 in cardiac stem cells induces their endothelial transdifferentiation, leading to neovascularization. Recently, accumulating evidence has revealed that altered JAK/STAT activity is associated with heart failure, suggesting that the JAK/STAT pathway is a therapeutic target against cardiovascular diseases. Interestingly, activation of the JAK/STAT pathway with interleukin-11 (IL-11) exhibits preconditioning effects in ischemia/reperfusion model. Moreover, IL-11 treatment after coronary ligation prevents cardiac remodeling through the JAK/STAT pathway. Since IL-11 is used for patients with thrombocytopenia, we propose that IL-11 is a candidate cytokine clinically available for cardioprotection therapy.

著者

菅野 敏夫 石井 武政 黒田 和男

出版者

公益社団法人 日本地下水学会

雑誌

日本地下水学会会誌 (ISSN:00290602)

巻号頁・発行日

vol.28, no.1, pp.25-32, 1986 (Released:2012-12-11)

参考文献数

11

被引用文献数

1 3

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Water level of Lake Kawaguchi in Yamanashi Prefecture had risen more than 3 m above the standard level after the heavy rainfalls in summer of 1983. On that opportunity the authors started to study the hydrogeological conditions around the lake with the use of long-term observation data of the lake water level, groundwater level, precipitation and others (Figs.4 and 5).The area is composed mainly of the Tertiary Misaka Group and the Quaternary volcanic rocks extruded from Fuji Volcano (Fig.1). The Misaka Group and the Kofuji Mud-flow Deposits, one of the effusive rocks of the volcano, constitute the hydrogeological impermeable bed rocks.Although Lake Kawaguchi has no natural mouth for surface discharge, the water is drained off through the man-made tunnels. On the other hand, it is likely that the water permeates through the volcanic rocks into the underground valley about 5 km south of the lake, judging from the contour line of the groundwater level (Fig.2). Figures 2 and 3 indicate that the hydrogeological watershed of the lake occupies only the northern part of the topographic watershed which extends southwards to the top of Mt. Fuji.The lake water is recharged from the surrounding mountains of the Misaka Group. The lake water remarkably rises after the 3 days rainfall reaches more than 200 mm (Figs.6 and 7). When the 3 days rainfall is less than 100 mm, it is invisible. Fluctuations of the lake water coincide with the rainfall pattern (Fig.4). The graph of the accumulation value of the rainfall variation is similar to the fluctuation of the lake water level.

著者

虎谷 秀穂

出版者

日本結晶学会

雑誌

日本結晶学会誌 (ISSN:03694585)

巻号頁・発行日

vol.34, no.2, pp.86-99, 1992-04-25 (Released:2010-09-30)

参考文献数

46

被引用文献数

2

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The first half of this chapter is devoted for describing: 1) a brief history of profile functions in both neutron and X-ray powder diffractions, 2) the relation between the Voigt and pseudo-Voigt functions and that between the pseudo-Voigt and Pearson VII functions, 3) the methods of asymmetrizing the symmetric profile function, and 4) the effect of profile-function truncation in powder pattern fitting. In the latter half of this chapter, the theory and application of the pattern decomposition method are described. Examples are pattern decompositions by using the individual profile fitting method and the Pawley method, The use of convolution function in pattern fitting derives the physically meaningful information from the profile shape. A sophisticated example of whole-powder-pattern fitting using a lattice-direction-dependent profile-width-model is given.

著者

宮 恒男 山木 誠 古谷 隆則 渡辺 俊英 横江 秀隆 丹沢 秀樹

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.45, no.8, pp.527-529, 1999-08-20 (Released:2011-07-25)

参考文献数

16

被引用文献数

1 1

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A case of eosinophilic granuloma of the soft tissue arising in the palate of a 65-year-old man is reported. It was an elastic hard lesion measuring about 10mm in diameter. The lesion was removed under a clinical diagnosis of fibroma. Histologically, the lesion was diagnosed as an eosinophilic granuloma of the soft tissue.Ultrastructurally, viruses similar to the herpes virus group, with a diameter of 100nm, were observed in the cytoplasm of histiocytes. These cells were positive for HSV (Herpes Simplex Virus)-Type I antibody on immunostaining. The findings indicate that the lesion was caused by Type I allergy due to HSV Type I infection.

著者

谷光 徳晃 久行 敦士 永澤 昌

出版者

耳鼻咽喉科展望会

雑誌

耳鼻咽喉科展望 (ISSN:03869687)

巻号頁・発行日

vol.45, no.5, pp.373-380, 2002-10-15 (Released:2011-03-18)

参考文献数

24

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軟部好酸球肉芽腫症, いわゆる木村病は, 全身の軟部組織, 特に顔面部に無痛性腫瘤を形成し, 末梢血好酸球及び, IgEの増加をみる原因不明の比較的稀な疾患である。今回我々は, この木村病の1例を経験したので, その診断, 治療について若干の文献的考察を加えて報告する。症例は52歳男性で, 主訴は約10年前からの右頬部, オトガイ下部の腫脹であった。緩慢な臨床経過, 末梢血好酸球及び血中IgEの著明上昇などの検査所見から木村病と診断し, ステロイドの内服及び手術を行った。本疾患はその存在を念頭におけば, 上記のような特徴的な臨床所見より診断は可能であると思われた。治療は最初にステロイド内服投与を行い, 腫瘤を退縮させた後, 抗アレルギー剤または, 非ステロイド性消炎鎮痛剤による維持療法を行う方法が第一選択であるが, 効果, その後の経過により, 手術, 放射線などの他の治療を適宜組み合わせていく必要があると思われた。

著者

西村 将人 折田 浩 津田 守 高橋 哲

出版者

耳鼻咽喉科展望会

雑誌

耳鼻咽喉科展望 (ISSN:03869687)

巻号頁・発行日

vol.37, no.6, pp.663-670, 1994-12-15 (Released:2011-08-10)

参考文献数

11

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木村病 (軟部好酸球性肉芽腫症) の2症例を経験したので報告した。症例1は17歳の男性で, 右顎下部に数個の境界不明瞭の腫瘤として摘出され, 病理組織診にて巨大濾胞や好酸球・形質細胞・リンパ球の多数の浸潤が見られ, 木村病と診断された。32ヶ月後に再発し, その直後には対側にも同様の小腫瘤が出現した。このため, 右側に対し再手術を施行したが, 顔面神経に近い部分は摘出できなかった。この後oxatomide内服にて経過観察しているが, 残存及び対側腫瘤は増大を見ていない。症例2は39歳の男性で, 右耳後部の掻痒感を主訴とし, 腫瘤触知より約3.5年が経過していた。摘出術を施行したところ同様の病理組織所見が見られ木村病と診断された。この症例もoxatornide投与にて術後3ヶ月時点で再発を見ていない。しかしこの疾患の再発時期は治療後長期後であることが多いので, 更に経過観察が必要である。