著者

柳本 卓 北村 徹 TAKASHI YANAGIMOTO TORU KITAMURA 北海道区水産研究所 日本エス・ユー・エス株式会社 Groundjish Biology Section Subarctic Fisheries Resources Division Hokkaido National Fisheries Research Institute Laboratory of Environmental Biology Japan NUS Co. Ltd.

出版者

The Japanese Society of Fisheries Science

雑誌

日本水産学会誌 = Bulletin of the Japanese Society of Scientific Fisheries (ISSN:00215392)

巻号頁・発行日

vol.68, no.6, pp.893-899, 2002-11-15

参考文献数

21

被引用文献数

7 4

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タラ科3種(スケトウダラ,マダラ,コマイ)の成魚の筋肉から抽出した粗DNAを用いPCR法にて増幅したシトクロームb領域の塩基配列を決定した。塩基配列からDpnII,HaeIII, RsaIおよびTaqIの4種類の制限酵素により,タラ科3種の種判別ができることが明らかになった。また,種特異的なプライマーを設計して,増幅した断片の長さの違いで3種を識別する方法を確立した。これらの手法により,形態的な差異だけでは困難なタラ科仔稚魚の種判別が可能になった。Mitochondrial DNA sequences of the cytochrome b gene (1161bp) were obtained from three gadoid species (Theragra chalcogramma, Gadus macrocephalus, and Eleginus gracilis) near Hokkaido, Japan. Four restriction enzymes (DpnII, HaeIII, RsaI and TaqI) were diagnostic to identify these three species. Species specific internal primers were designed based upon the characteristic nucleotide substitutions in each species, which allowed discrimination among these three species by amplicon size.

著者

Futoshi KOMINE Shingo KAMIO Hiroki TAKATA Shogo YAGAWA Serina TAGUCHI Kohei TAGUCHI Akiko HASHIGUCHI Hideo MATSUMURA

出版者

日本歯科理工学会

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2017-057, (Released:2017-09-07)

参考文献数

41

被引用文献数

3

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This study evaluated the effect of zirconia framework design on fracture load of implant-supported zirconia-based prostheses after thermal cycling and mechanical loading. Three different zirconia framework designs were investigated: uniform-thickness (UNI), anatomic (ANA), and supported anatomic (SUP) designs. Each framework was layered with feldspathic porcelain (ZAC group) or indirect composite material (ZIC group). The specimens then underwent fracture load testing after thermal cycling and cyclic loading. In the ZAC group, mean fracture load was significantly lower for UNI design specimens than for the other framework designs. In the ZIC group, there was no significant difference in mean fracture load between ANA design specimens and either UNI or SUP design specimens. To improve fracture resistance of implant-supported zirconia-based prostheses after artificial aging, uniformly thick layering material and appropriate lingual support with zirconia frameworks should be provided.

著者

内田 直樹 小林 秀行 戸嶋 洋和 三邉 武彦 小林 真一

出版者

The Japanese Society of Clinical Pharmacology and Therapeutics

雑誌

臨床薬理 = Japanese journal of clinical pharmacology (ISSN:03881601)

巻号頁・発行日

vol.43, no.2, pp.57-64, 2012-03-31

参考文献数

13

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MSG203 was developed by Meiji Seika Pharma Co., Ltd. as a generic drug of paroxetine hydrochloride hydrate (Paxil^® Tablets). Paroxetine is mainly metabolized by CYP2D6.Therefore, in addition to the evaluation of bioequivalence between MSG203 and Paxil^®, the effects of CYP2D6 polymorphism on the pharmacokinetic (PK) parameters of plasma paroxetine were also investigated.<BR>Ninety-six Japanese healthy subjects aged 20-35 years participated in the study. The study was performed in 3 different groups: MSG5 group compared 2 tablets of MSG203 5 mg versus 1 tablet of Paxil^® 10 mg; MSG10 group compared 1 tablet of MSG203 10 mg versus 1 tablet of Paxil^® 10 mg; and MSG20 group compared 1 tablet of MSG203 20 mg versus 1 tablet of Paxil^® 20 mg. Bioequivalence between MSG203 and Paxil^® was confirmed in all three groups. The safety profiles of both drugs were also similar. The PK parameters after a single oral dose of MSG203 20 mg in subjects with different CYP2D6 phenotypes were as follows. Mean C_max (ng/mL) of paroxetine was 0.78 in ultra-rapid metabolizers (UM; n=1), 5.82 in extensive metabolizers (EM; n=24), and, 18.60 in intermediate metabolizers (IM; n=4). Mean AUC _t (ng•h/mL) was 7.93 in UM, 88.52 in EM, and 495.61 in IM. Similar PK profiles in these phenotypes were confirmed after a single oral dose of Paxil^®.<BR>In this study, plasma concentrations of paroxetine were very low because of the high clearance profile in UM subjects. Generally, inadequate treatment would occur in patients with the UM phenotype of CYPs. However, information on the PK profiles in different CYP phenotypes is insufficient. Evaluation of the PK profiles of drugs in different CYP phenotypes provides valuable information for clinical use of drugs that are metabolized by polymorphic enzymes.

著者

宋 浣範

出版者

東京大学大学院人文社会系研究科・文学部日本史学研究室

雑誌

東京大学日本史学研究室紀要

巻号頁・発行日

no.7, pp.77-94,図巻頭2p, 2003-03

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論文Articles

出版者

日経BP社

雑誌

日経エレクトロニクス (ISSN:03851680)

巻号頁・発行日

no.1137, pp.40-43, 2014-06-23

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Pur3社のEspruinoは、マイクロコントローラーで動作する軽量なJavaScriptインタープリターを開発したGordon Williams氏が、2013年8月にクラウドファンディングのサイト「Kickstarter」でプロジェクトを立ち上げたのが始まりだ。2万ポンドを目指した同プロジェクトには、1カ月…

出版者

日経BP社

雑誌

日経コミュニケーション (ISSN:09107215)

巻号頁・発行日

no.464, pp.76-79, 2006-06-15

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企業の内線機能を代替するIPセントレックス・サービスが始まってから3年あまり。当初注目を集めた割には,導入がそれほど進んでいない。そこで通信事業者は,「ワンナンバー・サービス」をメニューに加えるなどサービスの強化を進め,新しいニーズの掘り起こしに取り組んでいる。

著者

小山 由紀江

出版者

名古屋工業大学共通教育・英語

雑誌

New directions (ISSN:18810349)

巻号頁・発行日

no.28, pp.13-25, 2010

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This paper first describes the history of testing, especially that of language testing, in order to provide a background to Computer Based Testing and Computerized Adaptive Testing. Secondly, the paper introduces an implementation of CAT, whose content is English for general science and Technology,along with a description of its construction and results. The results indicate that the CAT is more efficient than TOEIC and final examinations at NIT in terms of time consumed and the number of items answered. The result has relatively high correlation coeffcients bothwith TOEIC and the final examination, which suggests that the CAT could be reliable and valid substitute for other tests. However, the termination condition and the difficulty level of items should be carefully considered in order to further increase to the validity and reliability of CAT. In addition, the quality and the quantity of the item-bank is crucial.

著者

土屋湧暉 勝間亮

雑誌

マルチメディア、分散協調とモバイルシンポジウム2014論文集

巻号頁・発行日

vol.2014, pp.1071-1076, 2014-07-02

著者

伊藤 嘉規

出版者

富山大学経済学部

雑誌

富山大学紀要.富大経済論集 (ISSN:02863642)

巻号頁・発行日

vol.61, no.3, pp.265-306, 2016-03

著者

並木 政人 中村 壮亮 橋本 秀紀

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌D(産業応用部門誌) (ISSN:09136339)

巻号頁・発行日

vol.136, no.7, pp.485-493, 2016

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Recently, wireless charging via magnetic resonance coupling has gained attention because it has the potential of efficient midrange wireless charging. Here, functions such as sensing at the transmitter and wireless communication from the target are the essential elements to realize a standard wireless charging system. Currently, the sensing and communication protocol of the hardware (i.e., the high-frequency power source and antenna configuration) compatible with wireless charging is gaining attention in terms of its cost and space reduction due to the use of common components for multiple functions. However, this protocol has the problem of narrow effective areas due to the fact that the sensing range depends on the fixed Q factor of the antenna. To overcome this problem, the concept of wide-area sensing based on a Q controllable antenna is proposed, and the effectiveness is verified through a theoretical analysis and an experiment. As a result, it is clarified that the effective area can be expanded up to a ratio of the distance g between the transmitting and receiving antennas to the inner diameter d of the antenna g/d =5.0.

著者

一勇斎国芳

出版者

伊場仙

雑誌

東錦絵百人一首

著者

長谷川 達人 越野 亮 木村 春彦

雑誌

研究報告モバイルコンピューティングとユビキタス通信(MBL)

巻号頁・発行日

vol.2015, no.8, pp.1-7, 2015-02-23

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現在,スマートフォンは世界中で多くの人々に利用されている.携帯電話の様々な機能が日々発展している中,音量設定に関しては依然として物理ボタンで手動設定が行われている.利用者は毎日通勤前にマナーモードを設定し,帰宅後は元に戻すなどの設定を行う必要があるため,それが手間で,常にマナーモードに設定している利用者も少なくないだろう.それでも,必要な連絡をとり逃してしまうことや,音楽が聞きたいときにはわざわざ音量を設定する必要があるなどの不便は残る.我々はこれらの課題を解決するためにインテリジェントな音量変更手法を開発している.その実現に向け,本稿では多数の被験者による実際の操作ログを収集する実験を行った.本稿では,利用者属性や音量変更を行うタイミングなどに関する考察を行った結果を報告する.Nowadays, many people use a smartphone in the world. Although many functions are improved step by step, users still manually adjust the suitable volume with hard buttons. Users set their smartphone to vibrate mode before commuting and ring mode after getting their home every day. Therefore, quite a few people always set their smartphone to vibrate mode. However, inconvenience still remains, such as to miss a necessary phone call, or to raise sound volume when the user would like to listen to music. We develop an intelligent volume adjustment method to improve such inconvenience. Towards implementation of this method, we gathered operation log of actual use by many participants. In this paper, we described the results of considerations such as considering user attributes and the right time to change sound volume.

著者

浜口 惠治

出版者

高知大学

雑誌

高知大学学術研究報告. 人文科学 (ISSN:03890457)

巻号頁・発行日

vol.53, pp.11-21, 2004-12-31

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The Lipps XY figure (Figure 2) was decomposed six line elements. Thirty two Lipps variation figures (Figure 3) contained the principal line x in the refracting line X were constructed. The apparent directions of x in these figures were estimated with parallel matching method by ten university students. The assimilation illusory effects of the accessory lines attached to x were found. These results were discussed in relation to the Metzger's theory, the apparent direction of the principal lines in the refracting lines are assimilated by the direction of the accessory lines attached to the principal lines.

著者

浅野長祚

出版者

写

巻号頁・発行日

vol.[2],

著者

GODLEY BF.

雑誌

Brain Res

巻号頁・発行日

vol.452, pp.393-395, 1988

被引用文献数

1 86

著者

Ito Yukako Kojima Osamu Kita Takashi Shim YongGu

出版者

The Physical Society of Japan

雑誌

Journal of the Physical Society of Japan (ISSN:00319015)

巻号頁・発行日

vol.86, no.9, 2017-08-31

被引用文献数

1

著者

古賀 義昭 永松 土巳

出版者

九州大学

雑誌

九州大學農學部學藝雜誌 (ISSN:03686264)

巻号頁・発行日

vol.23, no.2, pp.43-48, 1967-07

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During 5 years from 1959 to 1963, many reciprocal pollinations between diploid and autotetraploid rice plants using Japanese and foreign varieties were artificially carried on by hot water emasculation method, and results were as follows (Tables 2 and 3). From these crossings, besides plumply, well developed seeds, many shriveled and ill-developed seeds which contained no endosperm and were very light, 1/10~1/20 of normal seed in weight, were obtained. For convenience' sake, they were called perfect and imperfect seeds respectively. The perfect seeds set in very low percentage, that is about 1%, but they germinated well and grew to maturity. From the cytological observations, it was found that almost all of them were selfed seeds of female plants. As to the imperfect seeds, seed setting ratio was comparatively high, but they germinated in low percentage and if germinated they could not grow to seedlings. For the question whether these imperfect seeds were true hybrid seeds or parthenocarpically developed ones, some knowledges were already given in the first report. When diploid and tetraploid plants were castrated by hot water emasculation method and not pollinated afterwards, imperfect seeds did not set on diploid plants, and on tetraploid plants only 1.1% were set. This ratio was very low compared with the crossed results as shown in Tab. 2 and 3, so that the greater part of imperfect seeds in crossed case were seemed to be true hybrid seeds. Degree of seed set was typically different between reciprocal crossings, and some differences were also found between varieties. In Japanese varieties, when diploid was used as female parent imperfect seeds were less easily obtained, but in reversed crossings they were more easily obtained and more heavy in weight and germinable. On the other hand, in foreign varieties imperfect seeds were more easily obtained in the crossing 2X×4X than in reversed crossings. This tendency was very striking in the varieties O. sativa f. spontanea and Ba Thut Nuho T. T. B., but in the crosses with O. sativa f. spontanea germination was better than that in 4X×2X cross as in Japanese varieties. In foreign varieties, Ba Thut Nuho T. T. B. and Songa T. T. B. belong to the so-called Indica type, and O. sativa f. spontanea belongs to wild species. So that they were genetically different from Japanese varieties. From above facts, it was considered that the tendency of seed setting was not constant within varieties, and that this phenomenon was affected by genetic differences.1) イネの3倍体を作出することを目的として,日本稲および外国稲を用い,2倍体および同質4倍体間に相反交配を行ない,交配種子の着生について観察した. 2) 交配の結果,良く充実した完全種子は低率で約1%しか着生しなかつたが,発達が劣る不完全種子は多量に着生した. 3) 完全種子は大部分が母本の自殖種子であり,不完全種子が真正の雑種種子と考えられたので,不完全種子により相反交配および品種間の交雑成功度を検討した. 4) 交配種子の着生率は相反交配により異なり,日本稲では4x×2xが逆交配より高く,また種子重,発芽率とも大であつたが,外国稲では2x×4xの方が多く着生し,種子重には差が見られなかつた.しかし発芽率は4x×2xの方が良いようであつた.

出版者

写

著者

中野 治郎 石井 瞬 福島 卓矢 夏迫 歩美 田中 浩二 橋爪 可織 上野 和美 松浦 江美 楠葉 洋子

出版者

日本緩和医療学会

雑誌

Palliative Care Research (ISSN:18805302)

巻号頁・発行日

vol.12, no.3, pp.277-284, 2017 (Released:2017-09-08)

参考文献数

21

被引用文献数

1

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【目的】本研究の目的は,化学療法実施中に低強度の運動療法を適用した造血器悪性腫瘍患者における運動機能,倦怠感,精神症状の状況を把握することである.【方法】対象は化学療法実施中に低強度の運動療法を適用した入院中の造血器悪性腫瘍患者 62名とし,運動療法の介入時と退院時の握力,膝伸展筋力,歩行速度,日常生活動作能力,全身状態,倦怠感,痛み,不安,抑うつを評価した.そして,各項目の介入時から退院時への推移を検討した.【結果】介入時と退院時を比較すると,膝伸展筋力は一部の患者では低下していたが,歩行速度,ADL能力,全身状態は9割以上の患者で維持・改善されていた.また,女性では倦怠感,不安,抑うつの改善傾向が認められたが,男性では認められなかった.【結論】化学療法実施中に低強度の運動療法を適用した造血器悪性腫瘍患者の運動機能は維持・改善しており,倦怠感,不安,抑うつの変化には性差が認められた.

著者

西﨑 久純 石川 奈津江 平山 英幸 宮下 光令 中島 信久

出版者

日本緩和医療学会

雑誌

Palliative Care Research (ISSN:18805302)

巻号頁・発行日

vol.12, no.3, pp.271-276, 2017 (Released:2017-09-08)

参考文献数

10

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【目的】在宅診療を受けているがん末期患者における褥瘡の予測危険因子を明らかにすることを目的とした.【方法】在宅診療を専門としている施設において,在宅のまま死亡にて診療終了となるまで施設入居者を含む在宅診療を受けていたがん末期患者95例について,後ろ向き研究を行った.【結果】褥瘡ができた患者は31名で,できなかった患者は64名であった.二変量解析の結果,統計学的に有意であった変数は,大浦・堀田スケール(以下,OHスケール)(P=0.02),過活動型せん妄(P=0.005),拘縮(P=0.008),ヘモグロビン値(P=0.02)で,多変量ロジスティック解析で有意であった変数は,拘縮(OR=16.55 P=0.0002) と,過活動型せん妄(OR=4.22 P=0.008)が独立した褥瘡のリスク因子として同定された.【考察】在宅診療を受けているがん末期患者においては,褥瘡の予測危険因子として過活動型せん妄についても考慮すべきである.