著者
Kamal Hassan Shadi Hassan Saab Anwar Armaly Zaher Rabia Edgem Fadi Hassan
出版者
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
vol.56, no.2, pp.186-191, 2015 (Released:2015-03-20)
参考文献数
30
被引用文献数
3 17

Cardiovascular complications are the main cause of morbidity and mortality in peritoneal dialysis (PD) patients. Left ventricular hypertrophy (LVH) is a major predictor of the development of cardiovascular events. This study aimed to identify risk factors that contribute to the development of LVH and to determine their cutoffs in patients on maintenance peritoneal dialysis.In this cross sectional study we evaluated the association of 23 variables including age, PD vintage, ultrafiltration, urine volume, residual renal function, mean daily SBP, mean daily DBP, fasting glucose, HbA1c, peritoneal glucose load index (PGLI), fluid overload (FO), plasma brain natriuretic peptide (BNP), plasma hsCRP and IL-6, serum albumin, white blood cell (WBC) count, hemoglobin, hematocrit, triglycerides, LDL-C (low density lipoprotein cholesterol), HDL-C (high density lipoprotein cholesterol), and PTH with LVH in 38 stable patients on maintenance PD ≥ 24 months.LVH was detected in 57.9% of patients. Logistic regression and receiver operating characteristics (ROC) analysis revealed that HbA1c, PGLI, FO, plasma BNP, hsCRP and IL-6 seem to be possible predictors of LVH. The cutoffs associated with the presence of LVH were: 7.5%, 3.2 g/kg/day, 1.7 L, 330 pg/mL, 7.5 mg/dL and 3.3 pg/mL for HbA1c, PGLI, FO, plasma BNP, hsCRP and IL-6, respectively (sensitivity 72.8 to 81.8% and specificity 75.0 to 93.8%).The results suggest that efforts should be made to reduce the peritoneal glucose load (PGL), to improve the hydration status, and to attenuate the inflammatory process in order to reduce the risk of the development of LVH among PD patients.
著者
遠田 晋次 三浦 大助 宮腰 勝義 井上 大栄
出版者
公益社団法人 日本地震学会
雑誌
地震 第2輯 (ISSN:00371114)
巻号頁・発行日
vol.52, no.4, pp.445-468, 2000-03-25 (Released:2010-03-11)
参考文献数
39
被引用文献数
1 3

The Itoigawa-Shizuoka Tectonic Line (ISTL) in central Japan is a complex 150km-long fault system consisting of north-trending east-dipping reverse, northwest-trending left-lateral strike-slip, and north-trending west-dipping reverse faults. To help to resolve segmentation and to estimate the magnitude of future shocks on the ISTL, we conducted four trench excavations across the Hakushu fault, the Shimotsuburai fault, and the Ichinose fault group in the southern part of the ISTL, where no paleoseismological data for the surface faulting had been available. On the trench walls at the Hakushu fault, we found the evidence for the most recent surface-rupturing event occurring sometime between 6, 650 and 7, 000cal. y. B. P. (BC 4700-BC 5050) with approximately one meter of coseismic slip. On the Shimotsuburai fault, we exposed evidence for three events at two trench sites. The low-angle thrust faults and associated sediments record the most recent and the penultimate events occurring between 1, 370 and 2, 500cal. y. B. P. (AD 580-BC 550), and between 7, 940 and 8, 430cal. y. B. P. (BC 5990-BC 6480), respectively. Vertically offset terrace gravels indicate the dip-slip rate of the Shimotsuburai fault to be about 0.5mm/yr during the past 22, 000 years. We also found evidence for the most recent two surface-faulting events on the scarp of the frontal fault of the Ichinose fault group. The most recent event, which accompanied a coseismic slip of 1.8-2.2m, is inferred to have occurred sometime between 3, 990 and 6, 270cal. y. B. P. (BC 2040-BC 4320). The penultimate event, which appears to have a coseismic slip of 2.1-3.0m, is constrained to have occurred between 9, 520cal. y. B. P. (BC 7570) and 10, 930y. B. P. The recurrence time and slip rate are roughly estimated as 5, 000 years and 0.5mm/yr, respectively. Regarding the long elapsed time since the most recent events, the Hakushu fault and the Ichinose fault group have accumulated enough strain to produce surface-rupturing earthquakes today. Based on such long recurrence times and lower slip rates on the southern ISTL relative to the central ISTL, we suggest that multiple segment ruptures of the central and southern ISTL are unlikely to have occurred during the past 10, 000years. However, partial synchronization of rupture timings for the central and southern ISTL might have occurred around 7, 000y. B. P. though. To evaluate the fault activity in the southern ISTL more precisely and to consider fault interaction with central ISTL, we still need to investigate other fault strands of the southern ISTL, and to gather more paleoseismic evidence.
著者
三浦 大助 幡谷 竜太 阿部 信太郎 宮腰 勝義 井上 大榮 二階堂 学 橘 徹 高瀬 信一
出版者
公益社団法人 日本地震学会
雑誌
地震 第2輯 (ISSN:00371114)
巻号頁・発行日
vol.55, no.1, pp.33-45, 2002-07-25 (Released:2010-03-11)
参考文献数
26
被引用文献数
3

Co-seismic faulting activity during the last three hundred thousands years of the Ichinose fault group, in the southern part of the 150km long Itoigawa-Shizuoka Tectonic Line active fault system, central Japan, was appraised. The Ichinose fault group consists of the mainly two distinct arcuate reverse fault traces bulged toward the east (frontal) and west (behind) directions. We conducted a trench excavation at the Nakano site across the behind fault, where the detailed geological and chronological information for the last ten thousands years was absent. The excavation resulted in evidences for the latest, at least two surface-rupturing events. The events were present sometimes between 665 and 1275 cal.y.B.P. and between 3355 and 4810 cal.y.B.P. The timing of the penultimate event is coincident with the previously estimated latest event on the frontal fault (3, 990-6, 270 cal.y.B.P.). The recurrence time and slip rate between these two events is approximately estimated as 3, 200 years and 0.9-1.8mm/yr in dip-slip, respectively. In comparison with a slip rate estimated from the geomorphological characteristics, the dip-slip rate from our excavation result is coincident well.A reappraisal of geomorphological reference deposits and a result of the seismic investigation study suggest that the total deformation rate of the Ichinose fault group is 3.5-3.7mm/yr (possibly up to 5.0mm/yr) and it becomes to increase in recent several ten thousands years. While the deformation rate suggests that the co-seismic faulting activity at the Ichinose fault group as a whole is ranked as the one of most active faults in Japan, however, it is smaller than that of 6.3-8.3mm/yr estimated previously from the gravimetric and numerical analyses.
著者
シュレスタアニシュマンシング 田湯 智 上野 修一
出版者
情報処理学会
雑誌
研究報告アルゴリズム(AL) (ISSN:18840930)
巻号頁・発行日
vol.2010, no.6, pp.1-7, 2010-11-12

It is known that the bandwidth problem is NP-complete for chordal bipartite graphs, while the problem can be solved in polynomial time for bipartite permutation graphs, which is a subclass of chordal bipartite graphs. This paper shows that the problem is NP-complete even for convex bipartite graphs, a subclass of chordal bipartite graphs and a superclass of bipartite permutation graphs. We provide polynomial-time approximation algorithms for convex bipartite graphs. We also provide a polynomial-time approximation algorithm for 2-directional orthogonal ray graphs which is a subclass of chordal bipartite graphs and a superclass of convex bipartite graphs.It is known that the bandwidth problem is NP-complete for chordal bipartite graphs, while the problem can be solved in polynomial time for bipartite permutation graphs, which is a subclass of chordal bipartite graphs. This paper shows that the problem is NP-complete even for convex bipartite graphs, a subclass of chordal bipartite graphs and a superclass of bipartite permutation graphs. We provide polynomial-time approximation algorithms for convex bipartite graphs. We also provide a polynomial-time approximation algorithm for 2-directional orthogonal ray graphs which is a subclass of chordal bipartite graphs and a superclass of convex bipartite graphs.
著者
Dwi Hilda Putri T Mirawati Sudiro Rina Yunita Ungke Anton Jaya Beti Ernawati Dewi Fithriyah Sjatha Eiji Konishi Hak Hotta Pratiwi Sudarmono
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
pp.JJID.2014.313, (Released:2015-03-13)
参考文献数
31
被引用文献数
2 8

The development of a dengue vaccine is a major priority. Several researchers are using Asian 1 and Asian 2 genotypes as vaccine candidates to develop a vaccine for dengue type 2 virus (DENV-2). However, in this study, we constructed a recombinant plasmid-based prM-E gene from the DENV-2 Cosmopolitan genotype as a dengue DNA vaccine candidate. The protein expression levels of recombinant plasmids in CHO cell lines were analyzed using an enzyme-linked immunosorbent assay, western blotting, and sucrose gradients. After immunizing ddY mice three times, DNA vaccine doses of 25 and 100 µg induced humoral immune responses. There was no difference in the neutralizing antibody titer (focus reduction neutralization test 50%) of mice immunized with 25 and 100 µg DNA vaccine doses. A challenge test using 3 × 105 FFU DENV-2 showed that immunized mice could raise anamnestic neutralizing antibody responses at day 4 and 8 post-challenge. An immunogenicity test with BALB/c mice showed that their antibody neutralization titers were lower than those of ddY mice. In addition, the antibodies produced after immunization and challenge test could also neutralize DENV-2 Asian 2 genotype (NGC strain). Thus, the DENV-2 Cosmopolitan genotype may be a DENV-2 vaccine candidate.
著者
Tomoe Shimada Tomimasa Sunagawa Kiyosu Taniguchi Yuichiro Yahata Hajime Kamiya Kumi Ueno Yamamoto Yoshinori Yasui Nobuhiko Okabe
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.68, no.2, pp.151-158, 2015 (Released:2015-03-23)
参考文献数
46
被引用文献数
1 7

This study reports the epidemiological characteristics of hospitalized cases of influenza A(H1N1)pdm09 infection analyzed on the basis of surveillance data collected from July 24, 2009, the date on which the hospital-based surveillance of influenza cases was implemented in Japan, to September 5, 2010. During the study period, 13,581 confirmed cases were reported. Among those cases with information regarding the reason for hospitalization, 39% were admitted to hospitals for non-therapeutic purposes such as medical observation and laboratory testing. The overall hospitalization rate was 5.8 cases per 100,000 population when cases hospitalized for non-therapeutic purposes were excluded. While those aged under 20 years accounted for over 85% of hospitalized cases, the largest proportion of fatal cases was observed in those aged over 65 years. The overall case fatality rate for all hospitalized cases was 1.5%. The year-round surveillance for hospitalized influenza-like illness cases was launched in 2011, and it was expected that this surveillance system could add value by monitoring changes in the epidemiological characteristics of hospitalized cases of seasonal influenza.
著者
土屋 研吾 鈴木 勝正 佐藤 三禄
出版者
一般社団法人 日本フルードパワーシステム学会
雑誌
日本フルードパワーシステム学会論文集 (ISSN:18803121)
巻号頁・発行日
vol.39, no.1, pp.7-12, 2008 (Released:2009-08-28)
参考文献数
8

A parallel link mechanism with six degrees of freedom using electrohydraulic servo cylinders has large rigidity and support power. This feature is widely used for a driving device with multi degrees of freedom that has a heavy load or needs a large driving force. In this research, basic characteristics are revealed by experiment and theory. In the 1st report, the characteristics of the hydraulic servo system was considered, and a detailed mathematical model was made. A transfer function was obtained by linear approximation, and the frequency response was presented. In the 2nd report, nonlinear simulation was executed based on the detailed mathematical model. The frequency response obtained from the simulation agreed well with the experimental result. The appearance of fluctuation in each part was presented, and the influence of nonlinear characteristics was clarified. From this research, the dynamic characteristics between the input and output of one link that comprises a parallel link mechanism were clarified. However, the parallel link mechanism comprises a so-called interaction system where the displacement of one link influences those of other links through the end effector. In this report, the interaction that each link receives from one link is examined by experiment and nonlinear simulation. The appearance of interaction is presented when the input is a rectangular wave or sinusoidal wave. The frequency response of the interaction that each link receives is presented. It is clarified that the amplitude of the reference value for a link and the load mass has a large influence on the frequency response of interaction. It is also presented that Coulomb friction has a big influence on the result.
著者
久保 健一郎
出版者
早稲田大学
雑誌
奨励研究(A)
巻号頁・発行日
1994

まず後北条氏関係文書約4500通の目録データベースを作成した。これには年月日・差出・充所等のほかにキーワードとして後北条氏における公儀を示す文言といわれる「大途」「公方」「公儀」を載せ、これらの使用者・使用対象・使用時期・使用方法等を検索できるようにした。「大途」文言の事例はおよそ120件、「公方」文言の事例はおよそ70件、「公儀」文言の事例はおよそ25件であった。これを基礎とした後北条氏関係文書の分析により、後北条氏における公儀の構造と機能を追究した。その結果、構造については当主ないし宗家のみが主体となる「大途」が支城主クラスの一族も主体となることができる「公方」「公儀」には見られない人格性・文書の発給主体・軍事的諸機能等の特徴を有していることを明らかにした。したがって「大途」は「公方」「公儀」に対して相対的に優位であり、「大途」を頂点とする公儀の構造を明らかにすることができた。特に「大途」の人格性は後北条氏における公儀の確立や維持に重要な規定を与えており、幕藩制国家における公儀に比して後北条氏の公儀の独自性を示していると考えた。この点は従来ほとんど追究されていないことであり、これを仮に公儀の人格的・イエ的構造と呼ぶことにした。機能については一般にいわれる訴訟→裁許や公共機能も再確認できたが、役賦課の正当性を示す機能や、上にも述べたように「大途」において見られる文書発給機能や軍事的諸機能をも見出すことができた。そしてこれらの必ずしも公共的でない機能が後北条氏の公儀においては重要な比重を占めていることを確認できた。なお毛利氏関係史料の調査・収集を行ったが、戦国期段階では公儀に類する文言はほとんど見出せなかった。後北条氏との大きな差異として留意し、今後追究したい。
著者
岡本 祐輝
出版者
日本建築学会
雑誌
日本建築学会計画系論文集 (ISSN:13404210)
巻号頁・発行日
vol.72, no.612, pp.115-122, 2007
被引用文献数
2 2

The Public Moral District "Fuki-chiku" which was provided for by Former City Planning Act (1919) was one of the Zoning measures to control the entertainment and amusement trades (such as bars, restaurants, etc.), the gay quarters or the red-light districts. However there was no "Fuki-chiku" district designated. In this paper, the auther tries to clarify the concept of "Fuki-chiku" and why it had not been designated. The provision of "Fuki-chiku" turning into a dead letter was caused by not only the defect of the law but also the political pressure and the social resistance.
出版者
日経BP社
雑誌
日経情報ストラテジ- (ISSN:09175342)
巻号頁・発行日
vol.13, no.8, pp.140-143, 2004-09

「お昼の人気テレビ番組で、風船がダイエットに効くと紹介されました」。平日の昼下がり、本部が配信した情報がレジに備え付けてある液晶ディスプレーに映し出されると、店員は売り場へと急ぐ。店舗で販売している風船をかき集めると目立つように陳列。POP(店頭販促)広告でも、テレビ番組で取り上げられたことを強調した。
著者
関 満博
出版者
日経BP社
雑誌
日経ベンチャ- (ISSN:02896516)
巻号頁・発行日
no.190, pp.68-70, 2000-07

戦争を身をもって経験した戦中派経営者の人間的圧力には、思わずたじろがされることが少なくない。原爆投下直後の広島の地獄絵を見た空研工業社長の楢木博氏(一九二四年生まれ)も、そうした気迫を感じさせる経営者の一人だ。 楢木氏は当時、広島工専の二年生。「逃げ場もなく、毎日、死にそうな目にあっていた。そんな中で、広島の原爆に遭遇した。
著者
佐原 玉恵
出版者
日本母性衛生学会
雑誌
母性衛生 (ISSN:03881512)
巻号頁・発行日
vol.48, no.1, pp.132-141, 2007-04
被引用文献数
1

本研究の目的は高校生の性に関する知識,価値観,行動について分析し四国A県の高校生の性の実態を調査することである。四国A県の高校6校に通学する高校生630名を対象に性交,避妊法,妊娠,人工妊娠中絶,性感染症についてアンケート調査を実施し565名から回答を得た。四国A県の高校生の性の実態調査の結果,知識面の特徴は,1.性に関する基礎的な知識が不足していた。価値観の特徴は,2.性交については全体の約6割の人が容認していた。3.人工妊娠中絶について全体の約8割が否定的な意見であった。行動の特徴は,4.女子の性交率は全国平均よりも高く,避妊率は低い結果であり,全国平均に比して女子は性行動が活発であるという特徴が示された。知識,価値観,行動の関係の特徴は,8.性に関する価値観と行動にはずれが生じていた。9.コンドームの使用法の知識について男女間の差はみられなかったがコンドームでの避妊の実施率は男子より女子が有意に低かった。以上のことより,性に関する基礎的知識の教育,女子に対する避妊法,避妊することを要求できる行動の教育が必要であると考えられた。
著者
瀧本 義彦 佐々木 功
出版者
京都大学農学部附属演習林
雑誌
京都大学農学部演習林報告 = BULLETIN OF THE KYOTO UNIVERSITY FORESTS (ISSN:0368511X)
巻号頁・発行日
vol.57, pp.258-267, 1986-01-31

振動障害の防止を目的として開発されたツインチェーンソーを実際に伐採現場で使用した場合, 機械としての耐久性と振動加速度値がどのように変化するかをしらべるため, 1984年6月から10月まで岐阜県の石原林材株式会社の伐採現場で広葉樹小中径木の伐倒・玉切り・枝払い作業, スギの間伐作業, ヒノキの伐倒作業等に使用していただき, 使用前・使用後の振動加速度値および使用上の問題点や故障個所について調査した。使用前と使用後の振動加速度の変化は, 常用回転数である7000 - 9000rpmではほとんど見られなかったが, 6000rpm以下では, 前ハンドル上下方向・後ハンドル上下方向と左右方向で増加が見られた。しかし, その値は小さく他の回転数での振動加速度値を超えるものではなかった。また, この期間での使用による防振ゴムの劣化による振動加速度値の変化ははっきりしなかった。使用中に, いくつかの故障が発生したが機械として致命的なものではなく, 簡単な修理でなおった。今後, 改良型のツインチェーンソーについても同様の試験を続けて行きたい。