著者

森本 和滋 川崎 聡子 吉田 易範

出版者

日本薬史学会

雑誌

薬史学雑誌 (ISSN:02852314)

巻号頁・発行日

vol.50, no.1, pp.64-77, 2015 (Released:2020-12-03)

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For 20 years, the Ministry of Health, Labour and Welfare (MHLW, formerly Ministry of Health and Welfare (MHW)) has been trying to increase transparency of the review process for approving reports in order to promote the rational use of newly approved drugs and medical devices. The first Summary Basis of Approval (SBA) was published by MHW in 1994. In 1999, evaluation reports were prepared by MHW and the Pharmaceuticals and Medical Devices Evaluation Center to make them available to the public. In 2005, a notice from the Chief Executive of the Pharmaceuticals and Medical Devices Agency (PMDA) made procedures for public release of information on reviewing applications for new drugs. In 2006, 90 review reports of newly approved drugs and eight medical devices were revealed on PMDA websites. The dissemination of information by the United States Food and Drug Administration (FDA) and that of the European Medicines Agency (EMA) were studied and compared with that of the MHLW and PMDA. While common technical documents (CTD) for new drugs and summary technical documents (STED) for new medical devices have been released by PMDA, such documents are not released by the FDA and EMA. The European Public Assessment Report (EAPR) summary for the public is an interesting questionnaire approach that uses the What, How and Why format. Finally, future proposals for the next decade are also outlined. PMID: 26427100 [Indexed for MEDLINE]

著者

森 毅

出版者

一般社団法人 日本数学会

雑誌

数学 (ISSN:0039470X)

巻号頁・発行日

vol.12, no.4, pp.210-225, 1961-05-20 (Released:2008-12-25)

参考文献数

62

著者

小森 宏美

出版者

独立行政法人 日本貿易振興機構アジア経済研究所

雑誌

アジア経済 (ISSN:00022942)

巻号頁・発行日

vol.62, no.1, pp.77-82, 2021-03-15 (Released:2021-03-25)

参考文献数

9

著者

島森 哲男

出版者

宮城教育大学

雑誌

宮城教育大学紀要 = Bulletin of Miyagi University of Education (ISSN:13461621)

巻号頁・発行日

vol.51, pp.242-270, 2017-01-31

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戦国武将、直江兼続は漢詩を二十三首残している。本稿はその校訂、注釈、現代語訳である。これらの注釈作業を通じて、我々は直江兼続の中国文学に関する深い造詣と、日本の王朝文学の流れを汲む伝統的な花鳥風月の美意識、そして漢詩を通じての交友関係の跡を知ることができる。

著者

山森 邦夫 松居 隆 河原 栄二郎 天野 勝文

出版者

北里大学

雑誌

基盤研究(B)

巻号頁・発行日

1997

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タイ国ではカブトガニ類の卵巣を食べる習慣があり、これに伴う食中毒死事件がたまに起こる。原因毒はフグ毒(TTX)や麻痺性貝毒(PSP)などの麻痺性毒である。カブトガニ類は原始的な節足動物であり、世界には3属4種が現存している。アメリカカブトガニ、カブトガニ、ミナミカブトガニ、マルオカブトガニである。タイには後2者が生息しているが、食中毒はもっぱらマルオカブトガニによるものであり、ミナミカブトガニによる中毒例はない。そこで本研究ではマルオカブトガニの毒化機構を明らかにする研究の一部として、カブトガニ類のTTXおよびサキシトキシン(STX)に対する抵抗性を調べ、比較検討した。TTX投与時の最小致死量は、ミナミカブトガニ成体では60〜150MU/20g 体重、アメリカカブトガニ幼体では50〜100MU/20g体重のかなり高い抵抗性を示したが、マルオカブトガニ成体では約900MU/20g体重、幼体では3600MU/20g体重以上となり、前2者を大きく上回った。一方、STXに対する抵抗性はマルオカブトガニ幼体およびアメリカカブトガニ幼体のいずれにおいても100〜200MU/20g体重とかなり高いが、差はなかった。TTX結合タンパク質がクサフグの血漿からDEAEセルロース処理、硫酸アンモニウム分画、Sephad exゲル濾過,Sephacryl S-200とCellulofine A-500によるカラムクロマトグラフィーを経て精製された。TSK G-3000SLカラムを用いた高速液体クロマトグラフィーによる最終精製物は単一のタンパク質ピークを示した。そのタンパク質の分子量はSDS-PAGEおよびmass spectrometryで、それぞれ、116,000および96,000と推定された。精製されたタンパク質のアミノ末端側アミノ酸配列はAla-Pro-Ser-Pro-?-?-?-His-?-Leu-The-Lys-Pro-Val-と推定された。

著者

森 耕平

出版者

一般社団法人 システム制御情報学会

雑誌

システム/制御/情報 (ISSN:09161600)

巻号頁・発行日

vol.66, no.7, pp.276, 2022-07-15 (Released:2023-01-15)

著者

眞子 裕友 小針 統 一宮 睦雄 小森田 智大 幅野 明正 東 隆文 久米 元

出版者

日本プランクトン学会

雑誌

日本プランクトン学会報 (ISSN:03878961)

巻号頁・発行日

vol.69, no.2, pp.93-101, 2022-08-25 (Released:2022-09-17)

参考文献数

53

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It has been thought that food availability for fish larvae was poor in the Kuroshio because of the low standing stocks of plankton in the oligotrophic conditions under thermal stratification throughout the year. Despite a potential risk or disadvantage for larval survival and growth, Kuroshio and its neighbouring waters are nursery grounds for the early life stages of various fishes. Here, we compared the growth activity of fish larvae among 15 taxonomic groups, including 11 families in the Kuroshio and its neighbouring waters, based on protein synthetase activity and protein contents. Protein-specific (spAARS), individual-based aminoacyl tRNA synthetase activities (iAARS), and protein contents (PRO) of fish larvae ranged from 2 to 232 nmol PPi mg protein−1 h−1, from 1 to 21 μmol PPi ind−1 d−1, and from <1 to 26 mg ind−1, respectively. spAARS, iAARS and PRO were variable among the taxonomic groups and were not classified between mesopelagic groups and the others. Compiling these measurements among all taxonomic groups, a significant negative correlation was found for spAARS to PRO. The correlation showed no significant difference between the Kuroshio and its neighbouring coastal waters, indicating that growth activities to fish larvae body mass were comparable in the Kuroshio and its neighbouring waters. Based on nonmetric multidimensional scaling on spAARS, iAARS and PRO among 15 taxonomic groups, two different groups were classified for fish larvae, represented by the high iAARS under the high PRO but low spAARS (Group 1) and the low iAARS under the low PRO but high spAARS (Group 2), representing the different life strategies for larval growth among the taxonomic groups. The present findings suggest that these biochemical indices are useful for evaluating the growth activity of fish larvae among various taxonomic groups and that food availability is not poor enough to support larval growth in the Kuroshio and its neighbouring waters.

著者

城下 慧人 小森 政嗣 横山 卓未

出版者

ヒューマンインタフェース学会

雑誌

ヒューマンインタフェース学会論文誌 (ISSN:13447262)

巻号頁・発行日

vol.24, no.1, pp.53-62, 2022-02-25 (Released:2022-02-25)

参考文献数

14

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This study aimed to estimate psychological utility functions that convert product design into impressions using preference learning methodology, and to construct product shapes that match product concepts based on the estimated functions. Using Elliptic Fourier descriptors (EFDs), we converted the contours of 26 shampoo bottle shapes into Fourier coefficients and performed a Principal Component Analysis (PCA) on the coefficients to construct shape space. Twelve persons participated in five experimental sessions corresponding to five different product concepts. For each session, participants were presented with a pair of randomly generated images of shampoo bottles from the shape space. They were asked to choose the one that matched a given product concept for 100 trials. The bottle shapes conforming to the product concepts were synthesized based on the average utility functions estimated by using Gaussian process preference learning. The synthesized bottle shapes were assessed to determine if they conveyed the intended product concepts. The results suggested that our approach is an effective way to reflect the product concept in the shape design.

著者

濵田 秀行 秋田 喜代美 藤森 裕治 八木 雄一郎

出版者

日本読書学会

雑誌

読書科学 (ISSN:0387284X)

巻号頁・発行日

vol.58, no.1, pp.29-39, 2016-03-31 (Released:2017-01-12)

参考文献数

10

被引用文献数

2

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This study investigates the effects of childhood reading experiences on adult consciousness, motivations and activities through structural modeling of their relations as mediated by individual annual income. Adult respondents (N=5,258, age range=20-69 years) completed a questionnaire and the results of analyses conducted for 2,589 respondents for whom annual income information was obtained suggest that childhood reading experiences have a relatively stronger influence on adult consciousness, motivations and activities than individual annual income. Moreover, the results of multiple population analysis conducted for 1,070 adults with less than ten years of work experience and 1,204 adults with more than ten years work experience indicate that (1) childhood reading experiences had strong influences on adult consciousness, motivations and activities in both populations, and (2) childhood reading experiences only had a significant effect on annual incomes for the group with more than 10 years of work experience. These results suggest that childhood reading experiences are important variables that impacts on the psychological fulfillment of adults. Thus, this study concludes that childhood reading experiences are strongly associated with adulthood consciousness, motivations and activities.

著者

平森 大規

出版者

国際基督教大学ジェンダー研究センター

雑誌

Gender and sexuality : journal of Center for Gender Studies, ICU (ISSN:18804764)

巻号頁・発行日

no.10, pp.91-118, 2015

著者

山森 宙史

出版者

日本マス・コミュニケーション学会

雑誌

マス・コミュニケーション研究 (ISSN:13411306)

巻号頁・発行日

vol.82, pp.153-172, 2013-01-31 (Released:2017-10-06)

参考文献数

51

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This study aims to reexamine the historical perceptions of the Japanese comic book medium, particularly the "magazine culture" which began in the late I960s, by tracing the historical process of creating "Shinshoban comics" during the 1960s and 1970s. Prior historical studies of postwar manga have not fully examined manga comic magazines, and manga has usually been defined as one type of comic magazine, not as its own independent form of media. Accordingly, in this article, I focus on the "Shinshoban comics" that predated present-day manga comics in order to understand the transformations in the comic industry during the late 1960s and early 1970s. Unlike the manga comics of today, due to the lack of modern industry and marketing systems, Shinshoban comics were very marginalized and crossed over various manga publishing borders. However, as series of Shinshoban comics based on particular comic magazines became the dominant publication style of manga comics, they were gradually perceived to be one type of comic magazine in the comic industry. Moreover, in the political and cultural climate of that time, the publication of some Shinshoban comics was delayed while others were screened out. Some of the works filtered out of the major public companies were published by small publishers as well as Kashihon publishers, which published for book-lending shops. As a result, though Shinshoban comics were subsumed by the comic publishing industry as a part of magazine culture, they were also relatively independent and established themselves as an original publishing medium. Therefore, an investigation of the historical process of creating Shinshoban comics clarifies that the industrialization centering around comic magazines produced by the major publishers beginning in the late 1960s contained within it a complexity that gave rise to an "independent" or "derivative" media culture.

著者

荻野 均 善甫 宣哉 松田 均 湊谷 謙司 東 信良 古森 公浩 大北 裕 本村 昇 志水 秀行 藤吉 俊毅

出版者

東京医科大学

雑誌

基盤研究(C)

巻号頁・発行日

2020-04-01

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突然に発症し致死率の高い急性大動脈解離に関して、全国規模の診療データベースがなく、診療エビデンスも少ない。本研究においては、心臓血管外科に関する全国規模の悉皆性データベースであるNCD内のJCVSDと血管外科データベースに期間限定で追加項目を設定し、さらにステントグラフト実施基準管理委員会のデータも加え、急性大動脈解離の外科治療に特化したデータベースを作成し外科診療の実態を把握する。重篤かつ致死的な急性大動脈解離の克服のための全国規模の網羅的診療基盤データとして初めての試みであり、「脳卒中・循環器対策基本法」の対象疾患である急性大動脈解離の救急診療体制作りの基礎データとして有用と考える.

著者

天野 晃滋 森田 達也

出版者

日本緩和医療学会

雑誌

Palliative Care Research (ISSN:18805302)

巻号頁・発行日

vol.13, no.2, pp.169-174, 2018 (Released:2018-04-27)

参考文献数

25

被引用文献数

1

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がん悪液質の病態に基づく患者と家族の食に関する苦悩への関わり方の解明は不十分だが,その要点は,1)患者と家族の食に関する苦悩に注意を向ける,2)がん悪液質の影響を抑制できれば患者と家族の食に関する苦悩は軽減できる,3)患者と家族の食に関する苦悩の主な原因はがん悪液質についての理解不足・体重増加の失敗体験・死の予兆としての認識,そして患者と家族の食に関する感情の衝突である,4)患者と家族にがん悪液質の病態と食に関する苦悩の要因を説明し付随する問題の対処についてアドバイスする,5)がんの進行にともない患者と家族の食に関する苦悩は増強するので個々の患者と家族にあった緩和ケアと栄養サポートを検討する,にまとめられる.がん悪液質に起因する食に関する苦悩には患者と家族で固有のものもあれば双方の関係で生じるものもある.それら苦悩の要因と過程をふまえた緩和ケアと栄養サポートが求められる.

著者

山川 香織 木村 司 伏田 幸平 森本 文人 井澤 修平 木村 元洋 手塚 洋介 入戸野 宏

出版者

日本生理心理学会

雑誌

生理心理学と精神生理学 (ISSN:02892405)

巻号頁・発行日

pp.2217rp, (Released:2023-02-07)

参考文献数

48

著者

谷岡 健資 上阪 彩香 山下 陽司 大森 崇 寒水 孝司

出版者

日本計量生物学会

雑誌

計量生物学 (ISSN:09184430)

巻号頁・発行日

vol.35, no.2, pp.95-105, 2015-01-31 (Released:2015-03-23)

参考文献数

13

被引用文献数

1 1

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Few studies have investigated the content of introductory statistics classes for medical school students in Japan. Yet, to assure the quality of university statistics courses and develop a standard curriculum for them, it is necessary to assess the current condition of statistics education.Therefore, we collected data on the type of course (i.e., course title and targeted year for the students), field of specialty of the lecturer, course contents, and which textbooks were pre-specified for the lecture by analyzing the syllabi of statistics courses published on university websites. Next, the result of the survey is summarized. Of the 80 universities surveyed, 45 universities provided the online sylabi for the introductory statistics course. We identified 26 different course titles for statistics classes. Thirty courses (73.3%) were intended for first-year students. Eightteen courses (54.5%) provided two credits. The most common field of specialty for statistics lecturers was mathematics (43.2%). Further, we found that the course contents included various subjects related to mathematics. A total of 35 textbooks were specified. Finally, the conclusion is that mathematical concepts seem to be taught more often than statistical practice in introductory statistics classes. Further, there were large variations in each item of analysis except the target year.

著者

榎森 進

出版者

東北学院大学東北文化研究所

雑誌

東北学院大学東北文化研究所紀要 (ISSN:03854116)

巻号頁・発行日

no.45, pp.1-22, 2013-12

著者

森田 哲夫

出版者

日本哺乳類学会

雑誌

哺乳類科学 (ISSN:0385437X)

巻号頁・発行日

vol.35, no.1, pp.1-20, 1995 (Released:2008-07-30)

被引用文献数

1

著者

森本 尚之

出版者

情報処理学会

雑誌

情報処理

巻号頁・発行日

vol.64, no.1, pp.10-13, 2022-12-15

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三重大学では,2018年度に学部入学生のノートPC必携制度が始まった.筆者は2017年から総合情報処理センターの教員として全学的な必携制度の推進に従事したのち,2021年度からは工学研究科の教員として,立場を変えながら必携制度と向き合ってきた.本稿では三重大学の必携制度の5年間とこれからについて,全学からの視点と学部教員の視点の両方から考察する.特に,ノートPCのスペック,サポート体制,必携PCの活用を念頭に開設した施設である数理・データサイエンス館(CeMDS),学部の研究室でのPC活用,そして必携制度のこれからに焦点を当てる.

著者

眞子 裕友 小針 統 久米 元 兵藤 不二夫 野口 真希 一宮 睦雄 小森田 智大 河邊 玲 中村 乙水 米山 和良 土田 洋之

出版者

日本プランクトン学会

雑誌

日本プランクトン学会報 (ISSN:03878961)

巻号頁・発行日

vol.69, no.1, pp.18-24, 2022-02-25 (Released:2022-03-06)

参考文献数

38

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The prey of whale sharks (Rhincodon typus) visiting the northern Satsunan area (western North Pacific Ocean) was investigated using microscopic and metabarcoding analysis of their faecal pellets. The stable isotope ratios of the dorsal fin and faecal pellets from the whale sharks were compared with those of their potential prey (plankton and fish larvae). Microscopic analysis identified protozoans (foraminifera) and metazoans (copepods, ostracods, and amphipods) but unclassified material was predominant in their faecal pellets. Metabarcoding analysis detected metazoans in the faecal pellets, represented by copepods, ostracods, amphipods, hydrozoans, and tunicates. Comparison of stable isotope ratios (δ13C and δ15N) from their dorsal fin and faecal pellets with those of zooplankton in the northern Satsunan area showed different feeding histories for the whale sharks appearing in the northern Satsunan area.

著者

森脇 真一

出版者

大阪医科大学

雑誌

基盤研究(C)

巻号頁・発行日

2009

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光線(LED IPL疑似光源)照射による紫外線性DNA損傷の修復能、酸化的DNA損傷の修復能、さらに細胞増殖能、ヒアルロン酸産生能、メラニン産生抑制能の定量的変化を種々の正常ヒト皮膚由来培養線維芽細胞、ヒト皮膚3次元モデルを用いて解析した。その結果赤、黄、青色LEDが細胞内酸化的DNA損傷、青色LEDが紫外線性DNA損傷の修復能を高め、また赤色、青色LEDはともに細胞増殖能亢進作用、ヒアルロン酸産生亢進作用、さらに組織を損傷することなくメラニン産生抑制作用を持つことが判明した。これらの所見はLED光には皮膚の抗老化作用があることを示唆する。