著者

Masako Miyashita Masahiro Kikuya Chizuru Yamanaka Mami Ishikuro Taku Obara Yuki Sato Hirohito Metoki Naoki Nakaya Fuji Nagami Hiroaki Tomita Hideyasu Kiyomoto Junichi Sugawara Atsushi Hozawa Nobuo Fuse Yoichi Suzuki Ichiro Tsuji Shigeo Kure Nobuo Yaegashi Masayuki Yamamoto Shinichi Kuriyama

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.237, no.4, pp.297-305, 2015 (Released:2015-12-02)

参考文献数

32

被引用文献数

1 22

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After the Great East Japan Earthquake of 2011, there has been a concern about health problems among children. Therefore, we investigated the prevalence of wheeze and eczema symptoms and associated factors among children in areas primarily affected by the disaster. From 2012 to 2014, we distributed the parent-administered questionnaire to 25,198 children in all 233 public schools in the 13 municipalities of Miyagi Prefecture in northeast Japan. A total of 7,155 responses (mean age 10.5 ± 2.2 years) were received (response rate: 28.4%). The prevalence of allergic symptoms according to the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire in 2nd, 4th, 6th, and 8th graders was 12.4%, 9.9%, 9.3%, and 5.6% for wheeze, and 20.1%, 18.0%, 14.0%, and 12.4% for eczema. In multivariate logistic analysis, younger age, history of hospitalization, and difficulties in children’s daily lives as assessed by the Strengths and Difficulties Questionnaire (SDQ), were significantly and consistently associated with both allergic symptoms (both P < 0.05). Living in a coastal municipality was also associated with eczema symptoms (P = 0.0278). The prevalence of eczema symptoms in the 2nd (20.1%) and 8th (12.4%) grades was significantly higher than previously reported in Japan. Living in a coastal municipality was independently associated with eczema symptoms, and psychometric properties were also closely linked to allergic symptoms. These findings are clinically important for understanding the risks of allergic disorders after natural disasters.

著者

千葉 達朗

出版者

一般社団法人 日本写真測量学会

雑誌

写真測量とリモートセンシング (ISSN:02855844)

巻号頁・発行日

vol.54, no.1, pp.2-3, 2015 (Released:2016-03-01)

参考文献数

4

著者

林 上

出版者

公益社団法人 東京地学協会

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.106, no.6, pp.794-798, 1997-12-25 (Released:2009-11-12)

被引用文献数

1 1 1

著者

Ayaka Sunami Kazuto Sasaki Yoshio Suzuki Nobuhide Oguma Junko Ishihara Ayumi Nakai Jun Yasuda Yuri Yokoyama Takahiro Yoshizaki Yuki Tada Azumi Hida Yukari Kawano

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20150104, (Released:2016-02-20)

参考文献数

39

被引用文献数

26

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Background: Food frequency questionnaires (FFQs) have been developed and validated for various populations. To our knowledge, however, no FFQ has been validated for young athletes. Here, we investigated whether an FFQ that was developed and validated to estimate dietary intake in middle-aged persons was also valid for estimating that in young athletes.Methods: We applied an FFQ that had been developed for the Japan Public Health Center-based Prospective Cohort Study with modification to the duration of recollection. A total of 156 participants (92 males) completed the FFQ and a 3-day non-consecutive 24-hour dietary recall (24hDR). Validity of the mean estimates was evaluated by calculating the percentage differences between the 24hDR and FFQ. Ranking estimation was validated using Spearman’s correlation coefficient (CC), and the degree of miscategorization was determined by joint classification.Results: The FFQ underestimated energy intake by approximately 10% for both males and females. For 35 nutrients, the median (range) deattenuated CC was 0.30 (0.10 to 0.57) for males and 0.32 (−0.08 to 0.62) for females. For 19 food groups, the median (range) deattenuated CC was 0.32 (0.17 to 0.72) for males and 0.34 (−0.11 to 0.58) for females. For both nutrient and food group intakes, cross-classification analysis indicated extreme miscategorization rates of 3% to 5%.Conclusions: An FFQ developed and validated for middle-aged persons had comparable validity among young athletes. This FFQ might be useful for assessing habitual dietary intake in collegiate athletes, especially for calcium, vitamin C, vegetables, fruits, and milk and dairy products.

著者

西田 清一郎 佐藤 広康

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.140, no.2, pp.58-61, 2012 (Released:2012-08-10)

参考文献数

13

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未病は,古来より東洋医学において重要なテーマとして掲げられている.未病ははっきりとした病が現れる前から体の中に潜む病態(状)を意味しており,まだ病ではない状態を意味しているのではない.未病は病を発生させる根本的な異常を意味し,東洋医学的には「〓血(おけつ)」と深いかかわりがあると考えられている.我々は,未病を現代医学的に解釈した場合,その病態は酸化ストレスの蓄積が一つの原因であると考えている.〓血に対して処方される駆〓血剤は,酸化ストレスの蓄積を抑制し,すなわち未病の進展を遅延,または阻害すると推察されている.駆〓血剤である桃核承気湯(とうかくじょうきとう)と桂枝茯苓丸(けいしぶくりょうがん)には,抗酸化作用があることが知られていた.酸化ストレスは血管緊張に変化を与えるが,これらの漢方薬は酸化ストレス負荷条件下で,血管の収縮を抑制し弛緩作用を増強した.駆〓血剤をはじめとする漢方薬は,酸化ストレスに対して,抗酸化剤として緩和作用だけではなく,状況に応じて酸化促進剤として血管収縮作用を表す.つまり,酸化ストレスをうまく制御して生体機能の調節作用をするものと考えられる.この酸化ストレス緩和作用は,酸化ストレスによる障害を和らげ,未病の進展を抑制していると思われる.

著者

藤波 直人 西内 一 渡辺 哲也 都築 英明 伊吹 勝藏

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.32, no.3, pp.305-311, 1997 (Released:2010-02-25)

参考文献数

16

被引用文献数

1 1 2

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In order to examine the dispersion of tritium released from the Takahama nuclear power plant into Uchiura Bay, seawater was sampled at three stations off the release point every two months. Tritium concentrations in these samples were determined. Simultaneously, the surface temperature of the seawater was also recorded at 25 points around the sampling stations. Observed data indicated that on those occasions when the sampling coincided with the release of tritium from the plant, the contribution of released tritium could be temporarily detected within the dispersion area of thermal effluent.

著者

Makiko OZAWA James K. CHAMBERS Kazuyuki UCHIDA Hiroyuki NAKAYAMA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0624, (Released:2016-02-27)

被引用文献数

35

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Canine cognitive dysfunction (CCD) is a syndrome that manifests itself in abnormal behaviors, such as disorientation and wandering. β-amyloid deposition in the brain, including the senile plaque (SP) and cerebral amyloid angiopathy (CAA), has been suggested as a major cause of the syndrome. However, the pathological significance of β-amyloid deposition in CCD dogs remains unclear. The present study was conducted using 16 dogs aged 10 years or older to clarify the relationship between the age-related histopathological lesions, such as β-amyloid deposition, in the brain and the clinical symptoms of CCD as evaluated in a questionnaire previously established in a large survey. In addition, age-related brain lesions were assessed in 37 dogs. The pathological lesions were evaluated by the severity of β-amyloid deposition (SP and CAA), the amount of ubiquitin-positive granules (UBQ), GFAP-positive astrocytes, Iba-1-positive microglia and Nissle stain-positive nerve cells. The results revealed that there was no significant correlation between the severities of canine SP and CCD. The SP increased until 14 years old, but decreased thereafter, although the incidence of CCD is high at these ages. The CAA consistently increased with age, but did not correlate greatly with the CCD score. In contrast, the increases of UBQ, astrocytes and microglia were significantly correlated with CCD. Thus, the impairment in the synapse and/or myelin suggested by increased UBQ and glial activation might be involved in CCD pathogenesis, but β-amyloid deposition, especially SP, is not a direct pathogenic factor of CCD.

著者

豊田 秀樹 拜殿 怜奈 久保 沙織 池原 一哉 磯部 友莉恵

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

vol.86, no.6, pp.535-544, 2016 (Released:2016-02-25)

参考文献数

30

被引用文献数

1

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The purpose of this study is to propose a method of factor analysis for analyzing contingency tables developed from the data of unlimited multiple-choice questions. This method assumes that the element of each cell of the contingency table has a binominal distribution and a factor analysis model is applied to the logit of the selection probability. Scree plot and WAIC are used to decide the number of factors, and the standardized residual, the standardized difference between the sample, and the proportion ratio, is used to select items. The proposed method was applied to real product impression research data on advertised chips and energy drinks. Since the results of the analysis showed that this method could be used in conjunction with conventional factor analysis model, and extracted factors were fully interpretable, and suggests the usefulness of the proposed method in the study of psychology using unlimited multiple-choice questions.

著者

藤垣 裕子 立石 裕二

出版者

社会学研究会

雑誌

ソシオロジ (ISSN:05841380)

巻号頁・発行日

vol.57, no.1, pp.159-167, 2012-06-30 (Released:2015-05-13)

著者

ニシオ ハリー・K 竹中 和郎

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.20, no.1, pp.73-90,131, 1969-07-30 (Released:2010-05-07)

参考文献数

36

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The social sciences, sociology in particular, have aimed to develop an empirically-verifiable body of theory through application of the structural-functional analysis of social action in general. Functional sociologists, whether they be the Grand Theorists or Middle-range Theorists, have therefore concerned themselves with “objective” and “scientific” investigation of phenomena, rejecting metaphysical as well as positivistic interpretations of social reality. While the voluntaristic theory of social action caught the imagination of sociologists articulating the theoretical position of sociology vis-a-vis social idealism, radical utilitarianism and Social Darwinism, a new, though somewhat “off-beat” sociological approach has begun to appear, challenging the theoretical foundation of systematic sociology in general. Ethnomethodology is one of such challenges posed upon against the Orthodox Sociology.Ethnomethodology finds its origin in the work of Alfred Schutz, an Austrian sociologist who wrote a three-volume work titled Collective Papers, in which most of his ideas are contained. His “subjective” approach to social action, tied with his interest in phenomenology, appealed to social scientists in New York and California. Included in this group of ethnomethodologists are Harold Garfinkel, Aron Cicourel, Peter Mcllugh, Marvin Scott and many young sociologists.What these sociologists aim to accomplish may be summarized in the following : 1) in the process of scientific enquiries, a priority should be given to the subjective aspect of social interaction based on mutual understanding and on the accepted “rules of the game”, 2) instead of developing generalized rules arbitarity constructed by scientists, ethnomethodologists, by taking the position of social actors, attempt to understand not only the expressed symbolic interaction but also more subtle, unstated, unpredictable definitions of situations, 3) the ethnomethodologists treat the acting individuals not merely as “actors” but as “theorists” capable of defining the situation, impressing others in ways they desire and to some extent manipulating the given social structure to their advantage, and 4) in this type of observation, it is indispensable for the observer to react with those whom he analyses so as to enable him to identify the processes by which new shared knowledge and group experiences emerge and become sanctioned. In ethnomethodology, however, emphasis is upon culturally unstated social facts, rather than those formally institutionalized or stated. Because of this interest, ethnomethodologists tend to preoccupy themselves with many unusual, off-beat topics such as homosexuality, the social system of gamblers, social interaction in horse racing, etc. They are convinced that orthodox sociology is able to deal with only a very small portion of social reality which appears above the surface while a gigantic mass of unstated social interaction remaining beneath totally untouched. With this approach, E. Goff man attempts to analyse the communication processes which are primarily being “give-off” by the social performers. He uses a dramaturgical approach and cynically examines social interaction in terms of the performance that takes place in front or back of the curtain in relation to the audience. Aron Cicourel, articulating the theory of Harold Garfinkel, attempts to develop the theory-methodology of Ethnomethodology in his recent work by pointing out the theoretical, methodological shortcomings of the conventional survey methods.Ethnomethodology is still theoretically ambiguous and methodologically unclear to many. For one thing, where should we draw a line between ethnomethodology and social interactionist approach?

著者

Hiroe Sato Junichiro James Kazama Akira Murasawa Hiroshi Otani Asami Abe Satoshi Ito Hajime Ishikawa Kiyoshi Nakazono Takeshi Kuroda Masaaki Nakano Ichiei Narita

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.2, pp.121-126, 2016 (Released:2016-01-15)

参考文献数

33

被引用文献数

3 34

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Objective Rheumatoid arthritis (RA) is a chronic inflammatory disease accompanied by periarticular and systemic osteoporosis. Fibroblast growth factor 23 (FGF23), which is mainly produced by osteocytes, circulates to the kidneys and regulates bone metabolism. We herein assessed serum FGF23 and its relationship to inflammation and osteoporosis in patients with RA. Methods Sixty-one patients with RA were included. Serum concentrations of FGF23 were determined using a sandwich enzyme-linked immunosorbent assay. Results The mean (± standard deviation) serum FGF23 concentration was 34.9±9.2 (range, 21.0-61.0) pg/mL. The serum FGF23 level was significantly and positively correlated with the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, disease activity score-28 based on the ESR (DAS-28 ESR) and DAS-28 CRP (r=0.261, p=0.044, r=0.280, p=0.029, r=0.409, p=0.001 and r=0.421, p=0.001, respectively). The serum matrix metalloproteinase-3 level was also significantly and positively correlated with the serum FGF23 level (r=0.331, p=0.015). Concentrations of type I collagen cross-linked N-telopeptide in the serum was significantly correlated with the serum FGF23 level (r=0.272, p=0.034). Neither the bone mineral density in the femoral neck nor lumbar was significantly correlated with the serum FGF23 level. Serum phosphate, calcium, 25-hydroxy vitamin D, and intact parathyroid hormone were not related to the serum FGF23 level. Conclusion In patients with RA, serum FGF23 is correlated with inflammation, the disease activity of RA, and bone absorption markers. Serum FGF23 may be associated with abnormal bone absorption related to RA inflammation. Further studies are necessary to clarify the mechanism underlying this association.

著者

Kohta Suzuki Zentaro Yamagata Miyuki Kawado Shuji Hashimoto

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.26, no.2, pp.76-83, 2016-02-05 (Released:2016-02-05)

参考文献数

23

被引用文献数

2 28

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Background: The effect of natural disasters on secondary sex ratio (SSR) and perinatal outcomes has been suggested. This study aimed to examine effects of the Great East Japan Earthquake on perinatal outcomes using vital statistics of Japan.Methods: Birth registration data from vital statistics of Japan between March 2010 and March 2012 were used. Pregnant women who experienced the earthquake were categorized according to their gestational period as of March 11, 2011, as follows: gestational weeks 4–11, 12–19, 20–27, and 28–36 (2011 group). Similarly, pregnant women who did not experience the earthquake were categorized according to their gestational period as of March 11, 2010 and used as controls (2010 group). We also categorized prefectures as “extremely affected”, “moderately affected”, and “slightly or unaffected” regions. SSR, birth weight, and gestational period were compared between both groups.Results: The number of singleton births was 688 479 in the 2010 group and 679 131 in the 2011 group. In the extremely affected region, the SSR among women at 4–11 weeks of gestation was significantly lower in the 2011 group compared with the 2010 group (49.8% vs 52.1%, P = 0.009). In the extremely affected region, children born to women who experienced the earthquake at 28–36 weeks of gestation had significantly lower birth weights.Conclusions: The SSR declined among women who experienced the earthquake during early pregnancy, particularly in the extremely affected region. However, no apparent negative effect of the earthquake on perinatal outcomes was observed, although birth weight of infants who were born to women who experienced the earthquake at 28–36 weeks of gestation were lower.

著者

Chen Friedman Bryan W. Joel Allen R. Schult Megan C. Leftwich

出版者

エアロ・アクアバイオメカニズム学会

雑誌

Journal of Aero Aqua Bio-mechanisms (ISSN:21851522)

巻号頁・発行日

vol.4, no.1, pp.25-31, 2015 (Released:2015-07-08)

参考文献数

12

被引用文献数

1 5

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Underwater propulsion that leaves little traceable wake structure while producing high levels of thrust is a highly desired goal. A potential biological model is the California sea lion, a highly maneuverable aquatic mammal that produces thrust primarily with its foreflippers without a characteristic flapping frequency. In an effort to mimic the sea lion flipper, a flipper from a sea lion carcass has been scanned using several non invasive methods with the goal of manufacturing a robotic flipper with identical geometry. The scanning methods are hereby compared for overall quality, accuracy, and level of detail captured.

著者

牧 輝弥 小林 史尚 柿川 真紀子 鈴木 振二 當房 豊 山田 丸 松木 篤 洪 天祥 長谷川 浩 岩坂 泰信

出版者

日本エアロゾル学会

雑誌

エアロゾル研究 (ISSN:09122834)

巻号頁・発行日

vol.25, no.1, pp.35-42, 2010-03-20 (Released:2010-03-25)

参考文献数

23

被引用文献数

2

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The microbial communities transported by Asian desert dust (KOSA) events have attracted much attention as bioaerosols, because the transported microorganisms are thought to influence the downwind ecosystems in Japan. In particular, halotolerant bacteria which are known to be tolerant to atmospheric environmental stresses were investigated for clarifying the long-range transport of microorganisms by KOSA. Bioaerosol samples were collected at high altitudes within the KOSA source area (Dunhuang City, China) and the KOSA arrival area (Suzu City, Japan). The microorganisms in bioaerosol samples grew in media containing up to 15 % NaCl, suggesting that bacteria tolerant to high salinities would remain viable in the atmosphere. The PCR-DGGE (Denaturing gradient gel electrophoresis) analysis using 16S rRNA genes sequences revealed that the halobacterial communities in bioaerosol samples belonged to the members of the genera Bacillus and Staphylococcus and that some bacterial species belonging to Bacillus subtilis group were similar among the samples of both cities. Moreover, some sequences of B. subtilis group were found to be identical for the species collected at high altitudes and on the ground surfaces. This suggests that active mixing of the boundary layer transports viable halotolerant bacteria up to the free atmosphere at the KOSA source area, while down to the ground surface at the KOSA arrival areas.

著者

瀧本 昭 多田 幸生 大西 元 長浦 一義 小坂 暁夫

出版者

公益社団法人 日本冷凍空調学会

雑誌

日本冷凍空調学会論文集 (ISSN:13444905)

巻号頁・発行日

vol.29, no.1, pp.23-30, 2012-03-31 (Released:2013-03-31)

参考文献数

4

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The development of a gas clean technology may be one of the most expecting techniques in a wide field from global environment to living conditions. In this paper, the authors proposed the new concept of a gas clean technology by utilizing negative air ions and ozone gas with the formation of mist. A system is composed of the heat exchanger of staggered fins and a electrostatic precipitator. The negative air ions and ozone gas generated by corona discharge provide an electric charge and bactericidal effects. Formation of the mist in the field of super-saturation state by cooling of the system can make them high efficiency. Experimental data showed that the present system allowed air to be sanitized in high efficiency.

著者

一柳 俊夫

出版者

法制史学会

雑誌

法制史研究 (ISSN:04412508)

巻号頁・発行日

vol.1966, no.16, pp.215-217, 1967-03-30 (Released:2009-11-16)

著者

島田 正文 葉山 嘉一 大澤 啓志 間野 伸宏 岩野 秀俊

出版者

一般社団法人 環境情報科学センター

雑誌

環境情報科学論文集 Vol.29(第29回環境情報科学学術研究論文発表会)

巻号頁・発行日

pp.13-16, 2015-11-25 (Released:2015-11-25)

参考文献数

7

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本研究は,藤沢市で行われた「藤沢市自然環境実態調査」を事例に,地域の生物に関する専門知識を有する市民と研究機関,行政の協働による調査の有効性について実証的に追求したものである。その結果は以下のようにまとめられる。協働の各主体は,調査方法や調査結果の解析・評価に至る全般に渡って関わった。特に,日本大学などの研究機関は,生物の分類群ごとの意見調整から調査全体のとりまとめに至るまで,各主体間の合意形成への中心的役割を果たした。本研究では,組織された3 種類の会議体を通じて,調査方法や結果の活用方法等が主体間で共有化されるなど本調査方法の有効性,調査の持続性等に関わる今後の課題が把握された。

著者

岩田 修二

出版者

公益社団法人 日本地理学会

雑誌

E-journal GEO (ISSN:18808107)

巻号頁・発行日

vol.2, no.1, pp.1-24, 2007 (Released:2010-06-02)

参考文献数

33

被引用文献数

2

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氷河湖決壊洪水(GLOF)による災害はブータンでも発生している.1998年と2002年に筆者を含むグループが氷河湖危険度調査を北西―北部ブータンで行った.その結果や過去の衛星画像の解析によると,ブータンのGLOFに関して最も危険とされるのはモレーンダム湖である.さまざまな氷河湖は,散らばった小氷河表面湖群 → 合体して巨大化した氷河表面湖 → 前面に氷体をもつモレーンダム湖 → モレーンのみのダム湖という発達段階のいずれかに位置づけられる.決壊洪水危険度査定のためには,定量的査定が試みられなければならない.危険な氷河として,ルナナ東部のトルトミ氷河湖,モンデチュウ西支流源頭部氷河湖群,クリチュウ上流のチベット側氷河湖が挙げられる.モニタリングのための衛星情報の提供,現地調査の援助,クリチュウ上流チベット側での調査・研究を進めるための中国側との交流が,さしあたって,実施されるべき日本からの貢献になろう.

著者

大庭 真人 岡本 雅史 飯田 仁

出版者

日本認知心理学会

雑誌

日本認知心理学会発表論文集 日本認知心理学会第7回大会

巻号頁・発行日

pp.74, 2009 (Released:2009-12-18)

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会話において,話し手の発話の分節に合わせ聞き手が動作を行う結果として話し手と聞き手との動作の間に同調が観られる事例が報告されている(Kendon, 1990).本研究では,コンテンツユーザとしての観客が漫才においてどのように笑いを享受するのかを分析するため,漫才師による公演を漫才師・観客ともに撮影収録した.漫才師2組に2本ずつの漫才を行ってもらい,230秒と298秒,357秒と262秒の映像音声データを収録した.このデータから,観客の同調現象に着目し,分析した.観客の漫才師に対する反応は「笑う」「拍手」をするといった非常に制限されたチャネルを通じて行われているようだが,実際には笑うという観客が同時に起こす反応に加え,漫才師が笑わせる合間の姿勢を変える動作においても,複数の観客間に同調現象が観察された.これは会場の離れた位置の観客間でも観察されており,漫才師に起因して生じることが分かった.

著者

岸井 兼一

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.127, no.5, pp.408-414, 2006 (Released:2006-07-01)

参考文献数

21

被引用文献数

1 2

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ルリコナゾールはジチオラン骨格を有し,光学活性な新規イミダゾール系抗真菌薬である.糸状菌,カンジダ属菌,癜風菌等に広い抗菌スペクトルを有し,特に皮膚糸状菌に対して強力な抗真菌活性を示した.Trichophyton (T) rubrumおよびT. mentagrophytesに対するMIC90値は,0.001 μg/mLであった.1%ルリコナゾールクリームをモルモット足底部皮膚に単回または反復塗布したとき,皮膚角層中に高濃度の薬物の貯留が認められ,モルモット足白癬モデルにおいて,短期間塗布で対照薬(塩酸テルビナフィン,ビホナゾール)より優れた治療効果を示した.作用メカニズムは真菌細胞膜の構成成分であるエルゴステロール合成系のラノステロール-14α-デメチラーゼ活性の阻害作用である.これまで実施されてきた足白癬に対する臨床試験では,その殆どが4週間の塗布期間でおこなわれてきた.ルリコンの臨床試験では塗布期間を半分の2週間で行い,塗布開始後4週間目に有効性判定した.第III相試験では足白癬に対し,ルリコンクリーム1%は2週間塗布(その後2週間はプラセボ塗布),対照薬(1%ビホナゾールクリーム)は4週間塗布で比較試験を実施し,塗布開始後4週目の時点で判定した結果,皮膚症状改善度はそれぞれ91.5%,91.7%,真菌学的効果は76.1%,75.9%となり,ルリコンクリーム1%および対照薬の皮膚症状改善度ならびに真菌学的効果はいずれもほぼ同等であり非劣性が検証された.ルリコンクリーム1%は短期間塗布で優れた臨床効果を示した.足白癬以外にも生毛部白癬,皮膚カンジダ症,癜風に対する臨床効果においても,これまで実施されてきた半分の塗布期間である1週間塗布で行い,優れた有効性安全性を確認した.また,ルリコン液1%は,2週間の塗布でルリコンクリーム1%とほぼ同等の有効性,安全性結果が得られた.