著者
石岡 学 藤村 達也 佐川 宏迪 日高 利泰
出版者
京都大学
雑誌
基盤研究(C)
巻号頁・発行日
2023-04-01

青春が大衆化しそのあり方が変容していった高度経済成長期において、青春はどのように表象されたのか。そしてそのイメージは、現実にその時期に青年期を送った者たちの青春のありようにどのような影響を与えたのか。本研究では、この問題を総合的に明らかにすることを目的とする。イメージ構築については、ポピュラーカルチャー(映画・TVドラマ・流行歌・マンガなど)において青春がどのように描かれたのかを分析する。実態的側面については、受験雑誌・人生雑誌・学校文集・手記などの分析を通して、多様な立場に身を置く若者たちの残した語りから、彼ら・彼女らが自身の青春をどう認識し意味づけたのかを明らかにする。
著者
Naoyuki NISHIO Shin-Ichiro NISHIDA Shintaro NAKATANI
出版者
THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES
雑誌
TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, AEROSPACE TECHNOLOGY JAPAN (ISSN:18840485)
巻号頁・発行日
vol.19, no.4, pp.469-476, 2021 (Released:2021-07-04)
参考文献数
16
被引用文献数
1

The rover for future Mars exploration will be expected to have higher rough terrain traveling performance compared with conventional rovers. In this paper, we propose a rover with a weight of about 30 kg that can be transported to Mars by a Japanese rocket. The purpose of this study is to propose and develop a hinge-type movable center-of-gravity mechanism wherein the bending of the rover's body with a motor shows high rough terrain-driving performance with minimum degrees of freedom. The proposed mechanism's performance is evaluated by conducting travel experiments on a assumed terrain, that is, a hard rock with a grade inclination of 45 deg and a height of 0.15 m above the sand. The effectiveness of the proposed mechanism in getting over a step was confirmed by conducting experiments using a prototype model.
著者
加藤 利次 井上 馨 秋山 佑介 大橋 功基
出版者
一般社団法人 電気学会
雑誌
電気学会論文誌D(産業応用部門誌) (ISSN:09136339)
巻号頁・発行日
vol.136, no.9, pp.615-621, 2016-09-01 (Released:2016-09-01)
参考文献数
11
被引用文献数
4 2

A grid-connected inverter is indispensable for photovoltaic power generation and smart grid systems, and it must be designed for stable operation. The impedance method based on the Nyquist criterion is often utilized to analyze the stability of grid-connected inverter systems. The impedance method is based on the eigen values of the product of the inverter output admittance and the line impedance matrices in the frequency domain. However, the frequency characteristics have so far been derived only for inverters with analog control systems. A new frequency analysis method for inverters with digital control systems is proposed in this paper. First, a stability analysis example for a three-phase LCL-type inverter controlled digitally is shown and the results are compared and validated with those by simulation using a Saber simulator. Finally, they are also compared and validated with experimental results digitally controlled by a DSP-based system.
著者
Keita Aida Kentaro Kamiya Nobuaki Hamazaki Ryota Matsuzawa Kohei Nozaki Takafumi Ichikawa Takeshi Nakamura Masashi Yamashita Emi Maekawa Minako Yamaoka-Tojo Atsuhiko Matsunaga Junya Ako
出版者
International Heart Journal Association
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
vol.61, no.3, pp.571-578, 2020-05-30 (Released:2020-05-30)
参考文献数
40
被引用文献数
7 10

The simplified frailty scale is a simple frailty assessment tool modified from Fried's phenotypic frailty criteria, which is easy to administer in hospitalized patients. The applicability of the simplified frailty scale to indicate prognosis in elderly hospitalized patients with cardiovascular disease (CVD) was examined.This cohort study was performed in 895 admitted patients ≥ 65 years (interquartile range, 71.0-81.0, 541 men) with CVD. Patients were classified as robust, prefrail, or frail based on the five components of the simplified frailty scale: weakness, slowness, exhaustion, low activity, and weight loss. The primary endpoint was the composite outcome of all-cause mortality and unplanned readmission for CVD.Patients positive for greater numbers of frailty components showed higher risk of all-cause mortality or unplanned CVD-related readmission (P for trend < 0.001). Classification as both frail (adjusted HR: 3.27, 95% confidence interval [CI]: 1.49-7.21, P = 0.003) and prefrail (adjusted HR: 2.19, 95% CI: 1.00-4.79, P = 0.049) independently predicted the composite endpoint compared with robust after adjusting for potential confounding factors. The inclusion of prefrail, frail, and number of components of frailty increased both continuous net reclassification improvement (0.113, P = 0.049; 0.426, P < 0.001; and 0.321, P < 0.001) and integrated discrimination improvement (0.007, P = 0.037; 0.009, P = 0.038; and 0.018, P = 0.002) for the composite endpoint.Higher scores on the simplified frailty scale were associated with increased risk of mortality or readmission in elderly patients hospitalized for CVD.
著者
Zhuo Zhao Jing Bai Chang Liu Yansong Wang Shuang Wang Furong Zhao Qiufang Gu
出版者
SOCIETY FOR FREE RADICAL RESEARCH JAPAN
雑誌
Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)
巻号頁・発行日
vol.73, no.2, pp.161-171, 2023 (Released:2023-09-01)
参考文献数
51

Metabolic differences between colorectal cancer (CRC) and NI (NI) play an important role in early diagnoses and in-time treatments. We investigated the metabolic alterations between CRC patients and NI, and identified some potential biomarkers, and these biomarkers might be used as indicators for diagnosis of CRC. In this study, there were 79 NI, 50 CRC I patients, 52 CRC II patients, 56 CRC III patients, and 52 CRC IV patients. MS-MS was used to measure the metabolic alterations. Univariate and multivariate data analysis and metabolic pathway analysis were applied to analyze metabolic data and determine differential metabolites. These indicators revealed that amino acid and fatty acids could separate these groups. Several metabolites indicated an excellent variables capability in the separation of CRC patients and NI. Ornithine, arginine, octadecanoyl carnitine, palmitoyl carnitine, adipoyl carnitine, and butyryl carnitine/propanoyl carnitine were selected to distinguish the CRC patients and NI. And methionine and propanoyl carnitine, were directly linked to different stages of CRC. Receiver operating characteristics curves and variables importance in projection both represented an excellent performance of these metabolites. In conclusion, we assessed the difference between CRC patients and NI, which supports guidelines for an early diagnosis and effective treatment.
著者
瀬川 修一 高瀬 貴仁 高澄 耕次 小杉 隆之 中村 剛
出版者
Brewing Society of Japan
雑誌
日本醸造協会誌 (ISSN:09147314)
巻号頁・発行日
vol.111, no.2, pp.107-116, 2016 (Released:2018-05-28)
参考文献数
15

1)マウスの肝臓を用いたALDH酵素活性評価において,清酒由来の成分に阻害活性が認められた。2)清酒からALDH阻害活性を有する物質を疎水性吸着樹脂,陽イオン交換樹脂,ODSカラム,NH2カラムにより分離・精製後,LC/TOF-MSによる精密分子量測定を行った結果,α-GGが同定された。3)マルトースとグリセロールからα-グルコシダーゼを用いて合成したα-GGはALDH阻害活性を示した。4)市販の清酒に含まれるα-GGを測定した結果,約4~19 mg/mlの濃度であり,醸造アルコールを添加した清酒では低値の傾向が認められた。
著者
磯川 修太郎 志波 大輝 赤穂 良晃 白崎 加純 岩崎 任 一二三 亨 大谷 典生
出版者
日本救急医学会関東地方会
雑誌
日本救急医学会関東地方会雑誌 (ISSN:0287301X)
巻号頁・発行日
vol.43, no.4, pp.132-136, 2022-12-28 (Released:2022-12-28)
参考文献数
9

築地市場の魚屋に勤務する70歳代, 男性。来院4日前から悪寒と来院前日からの呼吸困難を主訴に聖路加国際病院救急外来を受診した。結膜充血や関節痛, 肝腎機能障害, 炎症反応やCK上昇, 血小板減少に加え, 築地市場内でネズミとの曝露歴があったことからレプトスピラ症が疑われ入院した。入院時に採取した血清および尿検体を使用したPCR検査でレプトスピラ鞭毛遺伝子flaBが検出され, レプトスピラ症と診断した。入院後は呼吸循環障害のため集中治療室に入室したが, 人工呼吸器や腎代替療法は要さず, 入院第14病日に自宅退院とした。来院当日と2週間後, 1カ月後, 3カ月後に実施した顕微鏡下凝集試験では, L. interrogans serovar Canicolaなどの複数の血清型で抗体価は陽転化していた。東京都内でのレプトスピラ症では, ネズミとの職業曝露歴を聴取することが, 診断やその後の管理に有用であった。
著者
花岡 輝彦 樋口 宗隆 梶本 貴紀 池田 卓 藤田 弘輝
出版者
マツダ株式会社
雑誌
マツダ技報 (ISSN:02880601)
巻号頁・発行日
vol.39, pp.235-240, 2022 (Released:2022-12-26)
参考文献数
3

近年,電気自動車に搭載されるリチウムイオン電池は高エネルギー密度化,高出力密度化が進んでおり,それに伴い異常時の電池の発火リスクが高まるなどの安全性低下が懸念されている。特にLiNi0.8Mn0.1Co0.1O2等のニッケル比率の高い層状岩塩型の活物質を正極に用いた電池セルは,エネルギー密度が高い一方で,内部短絡などの異常発生時において発熱量が大きいため安全性が低下することが報告されており,これら材料を含む車載用電池パックの安全性の確保が課題となっている。この課題に対して,電池の安全性をシミュレーションモデルで検証することで開発の手戻り削減などの効率化が期待できる。そこで本研究では活物質の組成の違いがセル異常時の発熱量に及ぼす影響を明らかにし,異常時の電池セル及びモジュールの温度挙動を素早く計算できる1次元シミュレーション技術を確立した。また,モジュールの安全性の向上を目的に,構築したモデルを用いてモジュール部材の材質変更による温度上昇抑制の効果検証を実施した。本稿ではその取り組みについて報告する。
著者
才田 祐人 髙島 一昭 山根 剛 山根 義久
出版者
日本獣医循環器学会
雑誌
動物の循環器 (ISSN:09106537)
巻号頁・発行日
vol.46, no.2, pp.29-35, 2013 (Released:2014-09-12)
参考文献数
21

Cats diagnosed as aortic thromboembolism were performed with monotherapy using anticoagulant agent or combined therapy using thrombolytic agent, the efficacy of those therapies were discussed. Survival time, hours of forelimb or hind limb paralysis onset, palpable or not of pressure of femoral artery (unilateral or bilateral) on the first day, the days for palpable pressure of femoral artery, and pulmonary edema or not on the first day, were discussed between each therapy group. Fifteen cats were identified as having had a prescription filled for anticoagulant therapy using low molecular weight heparins (low molecular weight heparins group: n=8) or thrombolytic therapy using tissue plasminogen activator (low molecular weight heparins group+tPA group: n=7) between 2002 and 2011. The half survival time of low molecular weight heparins group and low molecular weight heparins group+tPA group were 742 and 5 days, respectively, in low molecular weight heparins group, survival time was longer significantly than that of low molecular weight heparins group+tPA group (p<0.05).
著者
山口 剛司 大工谷 新一 渡邊 裕文 大沼 俊博
出版者
関西理学療法学会
雑誌
関西理学療法 (ISSN:13469606)
巻号頁・発行日
vol.7, pp.75-80, 2007 (Released:2008-01-18)
参考文献数
7

Foot function deteriorates after varus sprain of the ankle joint, and impairs smooth body movement in some cases. Dysfunction of the peroneal muscles, such as muscle weakness and delayed reaction time, occurs after varus sprain, and great importance has been attached to strengthening of the peroneal muscles in exercise therapy. Our exercise therapy targets stable posture control in weight-bearing on the little toe side, and we consider that not only the peroneal muscles but also varus muscles of the foot are important with regard to muscle activity in this position. In this study, we investigated muscle activity of the varus muscles of the foot and plantar pressure distribution on the supporting side in inward step positions as an exercise menu. Compared to the baseline position regarded as 0 cm, muscle activity increased at an inward step distance of 10 and 20 cm, and significantly increased at 30 and 40 cm (p<0.01). It is suggested that the inward steps induced weight-bearing on the little toe side, and forced tilting of the lower leg outward, during which the varus muscles may have acted to brake the outward tilting of the lower leg. This suggests that the varus muscles of the foot are important for posture control in weight-bearing on the little toe side.
著者
Mika Sakamoto Hirofumi Suzuki Kei Yura
出版者
The Biophysical Society of Japan
雑誌
Biophysics and Physicobiology (ISSN:21894779)
巻号頁・発行日
vol.16, pp.68-79, 2019 (Released:2019-02-15)
参考文献数
41
被引用文献数
3 4

Transport of small molecules across the cell membrane is a crucial biological mechanism for the maintenance of the cell activity. ABC transporter family is a huge group in the transporter membrane proteins and actively transports the substrates using the energy derived from ATP hydrolysis. In humans, there are 48 distinct genes for ABC transporters. A variation of a single amino acid in the amino acid sequence of ABC transporter has been known to be linked with certain disease. The mechanism of the onset of the disease by the variation is, however, still unclear. Recent progress in the method to measure the structures of huge membrane proteins has enabled determination of the 3D structures of ABC transporters and the accumulation of coordinate data of ABC transporter has enabled us to obtain clues for the onset of the disease caused by a single variation of amino acid residue. We compared the structures of ABC transporter in apo and ATP-binding forms and found a possible conformation shift around pivot-like residues in the transmembrane domains. When this conformation change in ABC transporter and the location of pathogenic variation were compared, we found a reasonable match between the two, explaining the onset of the disease by the variation. They likely cause impairment of the pivot-like movement, weakening of ATP binding and weakening of membrane surface interactions. These findings will give a new interpretation of the variations on ABC transporter genes and pave a way to analyse the effect of variation on protein structure and function.