著者
Yohei MOCHIZUKI Ryohei SUZUKI Yuyo YASUMURA Takahiro SAITO Takahiro TESHIMA Hirotaka MATSUMOTO Hidekazu KOYAMA
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.18-0718, (Released:2019-04-02)
被引用文献数
3

Beta-blockers are used to treat cats with hypertrophic obstructive cardiomyopathy (HOCM). However, there are various hemodynamic responses to beta-blockers. This retrospective study aimed to explore the relationship between the response to carvedilol and the presence of geometric abnormalities. Medical records were reviewed for 16 cats diagnosed with HOCM. Cats were divided into two groups based on the velocity of the left-ventricular outflow-tract after carvedilol treatment (responder: eight cats, non-responder: eight cats). Baseline intergroup comparison revealed that anterior mitral valve leaflet length and diastolic left-ventricular posterior-wall thickness were significantly greater in the non-responder group. Longer anterior mitral valve leaflet and thicker left-ventricular posterior-wall may cause poor response to carvedilol. Thus, these properties may predict a lack of response to carvedilol therapy.
著者
深海 菊絵
出版者
日本文化人類学会
雑誌
日本文化人類学会研究大会発表要旨集 日本文化人類学会第44回研究大会 (ISSN:21897964)
巻号頁・発行日
pp.134, 2010 (Released:2010-12-20)

「ポリアモリー(polyamory)」とは、複数の者を同時に「誠実」に愛する恋愛実践、とその実践者たちを指す。本発表の目的は、ポリアモリー実践者たちの葛藤の語りに注目し、偶発的で予測不可能な日常の中で、彼/彼女たちがいかに他者との関係を築いているのか、という問いを探究することである。具体的には、(1)ポリアモリー理念を共有する仲間たちの関係性、(2)ポリアモリー関係にある者同士の関係性、の二方向から検討を試みる。
著者
藤本 修平 小向 佳奈子 光武 誠吾 杉田 翔 小林 資英
出版者
日本理学療法士学会
雑誌
理学療法学 (ISSN:02893770)
巻号頁・発行日
vol.44, no.6, pp.456-462, 2017 (Released:2017-12-20)
参考文献数
37

【目的】リハビリテーション(以下,リハビリ)分野の自費診療を行っている病院・施設において,Web サイト上の質の評価を行うこととした。【方法】リハビリ分野において自費診療を行っている病院,施設を抽出するために,自費診療とリハビリに関する検索語を選定し,Web サイトの検索を行った(Database:Google)。対象のWeb サイトに対し,e ヘルス倫理コード2.0,医療広告ガイドライン,医療機関ホームページガイドラインを参考にWeb サイトの質の評価を行った。【結果】Web サイト内の治療の効果やリスクに関する情報について,引用を示して記載したものは45 件中1 件(2.2%)であり,その他の医療広告ガイドラインの項目についても遵守割合が低いものが認められた。【結論】リハビリ分野において自費診療を行っている病院・施設のWeb サイトは誇大に広告されている可能性があり,情報提供者は治療の利害情報の正確な提供が必要である。
著者
杉浦 嘉泰 宇川 義一
出版者
日本神経学会
雑誌
臨床神経学 (ISSN:0009918X)
巻号頁・発行日
vol.57, no.1, pp.1-8, 2017 (Released:2017-01-31)
参考文献数
54
被引用文献数
1 3

てんかんは大脳神経細胞の過剰な電気的興奮によって起こり,近年神経細胞の電気的活動に深く関わるイオンチャネルの遺伝子変異が,てんかんの原因として報告されてきた.またこの変異イオンチャネルの電気生理学的機能解析により,てんかんを発症する病態が明らかとなってきた.本稿ではイオンチャネルの機能異常から見たてんかんの病態と,抗てんかん薬の作用機序について概説する.
著者
田中 明美 津田 喬子 竹内 昭憲 笹野 寛 前田 光信
出版者
Japan Society of Pain Clinicians
雑誌
日本ペインクリニック学会誌 (ISSN:13404903)
巻号頁・発行日
vol.10, no.1, pp.26-32, 2003-01-25 (Released:2009-12-21)
参考文献数
23

慢性難治性疼痛に, 他の要因による疼痛や心的外傷が加わったことを契機にして薬物依存に陥った2症例の治療を経験した. 症例1は38歳男性, 指の再接着術後の断端痛による慢性疼痛を抱えていたが, 転院を契機に右上肢の痙攣を伴う疼痛性障害が増悪して薬物依存になった. 症例2は56歳男性, 椎間板ヘルニアの手術後の failed back syndrome として慢性疼痛を治療していたところ, 交通事故による頸椎挫傷後に上下肢の痙攣を伴う疼痛性障害を発症して薬物依存になった. 両症例とも過去の他院麻酔科治療歴から, 神経ブロック治療による除痛が困難であると判断して薬物依存を絶つことに治療目標をすえ, 交感神経ブロック療法に加えて心理療法により病状の理解と疼痛の認知を行い, 定期的に通院治療を続ける適正な痛み行動へと導いた. その結果, 両症例は慢性疼痛を受容して, 薬物に依存する行動がみられなくなった. 慢性疼痛患者の疼痛制御には, 心理テストの結果を踏まえた心理療法が適切に行われるべきである.
著者
堀川 佑惟 岡 隆
出版者
日本社会心理学会
雑誌
社会心理学研究 (ISSN:09161503)
巻号頁・発行日
vol.34, no.2, pp.85-93, 2018-11-30 (Released:2018-12-15)
参考文献数
36

We attempted to develop and validate the Japanese 20-item version of the Attitudes Toward Lesbians and Gay Men Scale (ATLG-J20) based on the original scale developed by Herek (1988). The ATLG-J20 consisted of 20 statements, 10 about lesbians (ATL-J Subscale) and 10 about gay men (ATG-J Subscale), and respondents indicated their levels of agreement or disagreement with those statements. The results showed that ATL-J and ATG-J have factorial validity, reliability, and convergent validity. Moreover, the correlations between those subscales and social desirability responses were not significant. Although there was no significant correlation between those subscales and implicit attitudes, it was suggested that ATLG-J20 is a valid scale as an explicit measure.
著者
Kei Segawa Miki Watanabe-Matsui Toshitaka Matsui Kazuhiko Igarashi Kazutaka Murayama
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.247, no.3, pp.153-159, 2019 (Released:2019-03-09)
参考文献数
30
被引用文献数
8

Heme is one of the key factors involved in the oxidative stress response of cells. The transcriptional repressor Bach1 plays an important role in this response through its heme-binding activity. Heme inhibits the transcriptional-repressor activity of Bach1, and can occur in two binding modes: 5- and 6-coordinated binding. The Cys-Pro (CP) motif has been determined to be the heme-binding motif of Bach family proteins. The sequence of Bach1 includes six CP motifs, and four CP motifs are functional. With the aim of elucidating the molecular mechanism of heme-Bach1 regulation, we conducted biophysical analyses focusing on the C-terminal region of mouse Bach1 (residues 631-739) which is located after the bZip domain and includes one functional CP motif. UV-Vis spectroscopy indicated that the CP motif binds heme via 5-coordinated bond. A mutant, which included a cysteine to alanine substitution at the CP motif, did not show 5-coordination, suggesting that this binding mode is specific to the CP motif. Surface plasmon resonance revealed that the binding affinity and stoichiometry of heme with the Bach1 C-terminal region were KD = 1.37 × 10–5 M and 2.3, respectively. The circular dichroism spectrum in the near-UV region exhibited peaks for heme binding to the CP motif. No significant spectral shifts were observed in the far-UV region when samples with and without heme were compared. Therefore, disordered-ordered transition such as “coupled folding and binding” is not involved in the Bach1-heme system. Consequently, the heme response of this C-terminal region is accomplished by disorder-disorder conformational alteration.
著者
奥田 紫乃 荒金 美幸 竹村 明久 岡嶋 克典
出版者
日本官能評価学会
雑誌
日本官能評価学会誌 (ISSN:1342906X)
巻号頁・発行日
vol.19, no.2, pp.99-105, 2015-10-15 (Released:2016-10-15)
参考文献数
13
被引用文献数
1

To understand the multimodal effects of soft drink color and flavor on the predicted palatability and taste, we prepared six differently colored water in individual plastic bottles: yellow, orange, red, purple, blue, and green, by dissolving artificial colorants with mineral water. We also used four types of essence: lemon, apple, strawberry, and mint. Each essence was placed on a smelling-strip on the underside of the bottle cap. In the visual experiment, subjects observed one of the colored waters without any olfactory cues. In the olfactory experiment, they observed non-colored water and smelled the underside of the cap. In the visual-olfactory experiment, they observed one of the colored waters while smelling an essence. Subjects evaluated the predicted palatability, sweetness, sourness, and bitterness in each experiment. As a result, palatability was higher for the yellow color with lemon flavor, and red color with strawberry flavor. In addition, the contribution ratios of flavor to color were 1.24 for palatability, 4.61 for sweetness, 1.91 for sourness, and 1.98 for bitterness.
著者
小西 純一 西野 保行 淵上 龍雄
出版者
Japan Society of Civil Engineers
雑誌
日本土木史研究発表会論文集 (ISSN:09134107)
巻号頁・発行日
vol.9, pp.227-238, 1989-06-20 (Released:2010-06-15)
参考文献数
9

官設鉄道が標準桁として採用したクーパー型トラス桁は10種類で、そのうち100ft上路を除く9種類263連が1899年から1915年にかけて架設された。耐用年数は線区によりかなり異なるが、東海道本線で47年程度、中央本線で66年程度であり、経年88年で今なお使用中のものもある。現在使用中の桁は、転用桁を含めて合計72連となっている。クーパー型の採用はそれまでの英国系からの全くの方向転換であり、連続性はない。クーパー型を少し設計変更した100fしと300ftの国産桁が存在した、輸入ピン結合トラスの最後を飾るのは、阿賀野川釜ノ脇橋梁ほかのカンチレバー式架設工法によるトラスである。わが国の橋梁技術者たちは、米国流の進んだプラクティスを体得すると同時に、アイパーを主体のピン結合トラスの欠点を見抜き、リベット結合に改め、輸入から国産へと転換し・技術的な自立を一段と進めることになる。【明治期、鉄道橋、トラス桁】
著者
李 活雄 村島 健一郎
出版者
日本音声学会
雑誌
音声研究 (ISSN:13428675)
巻号頁・発行日
vol.6, no.2, pp.98-104, 2002-08-30 (Released:2017-08-31)

This paper is concerned with how n-/l- (or r-) variation in loanwords among Cantonese speakers in Hong Kong takes place in different phonetic environments. Previous researches point out that the ongoing merger of n- into l- in a syllable initial position in Cantonese often has influences on the borrowing of words from other languages and the learning of foreign languages. For example, when they introduce English words into Cantonese, Cantonese speakers are likely to realise n- as l- like "notes" /nouts/ as [lok. si]. Our survey with 204 non-sense words written in Japanese hiragana, however, shows that there is no statistical significance between the percentage of errors of n- and l- (or r-) in any phonetic environment except when a nasal precedes r-. In that case, it is realised as n- significantly. The result may suggest that n-/l- (or r-) variation in loanwords among the Cantonese speakers occurs in a two-way manner, namely n- → l- and l- → n-, which is a new finding when compared with the previous researches.
著者
小川 剛生
出版者
中世文学会
雑誌
中世文学 (ISSN:05782376)
巻号頁・発行日
vol.54, pp.25-34, 2009 (Released:2018-02-09)
著者
林 佳世子
出版者
日本中東学会
雑誌
日本中東学会年報 (ISSN:09137858)
巻号頁・発行日
vol.3, no.2, pp.74-109, 1988-03-31 (Released:2018-03-30)

Immediately after the conquest of Byzantine Constantinople by the Ottomans in 1453, the city began to be developed as the Ottoman capital, Istanbul. In order to discover the remaking process of Istanbul as an Islamic city, the documents concerning vakif (pious endowment) by Sultan Mehmed the Conqueror have great importance, because his construction of some pious or charitable institutions (e.g. mosques, medreses and hospitals) and a number of markets were undertaken within the framework of the vakif system, which contributed remarkably to the reorganization of Istanbul. Therefore the study of vakfives (endowment deeds) and other account registers concerning his vakif should provide valuable information on the details of this process. It should be also noted that these documents contain valuable information about the topography of the city of that period, since vakif of Sultan Mehmed covered almost all the districts of walled Istanbul and Galata. In spite of their obvious significance, usage of these documents as historical sources has been quite limited up till now. One of the reasons for this condition must be the insufficiency of the textual critique of the documents, which appear in several manuscripts some of which show great differences. Since none of the vakfiye manuscripts has ever been investigated in detail, much less compared with each other, the relationship between these manuscripts has not been exactly explained, even though they have been used by many scholars without comprehending their real character. In this paper, I will attempt to compare these documents in detail and show how and when each vakfiye was compiled. This fundamental work should better enable them to be utilized as historical source materials. At present nine original or copied vakfiyes of Sultan Mehmed concerning with walled Istanbul and Galata are known in the archives in Turkey. These are; 1: Topukapi Sarayi Muzesi Kutuphanesi Hazine No.1808 (published by T. Oz in 1935) 2: Turk ve Islam Eserleri Muzesi No.2202-666 (published by O. Ergin in 1945) 3: Basbakanlik Osmanli Arsivi Ali Emiri Tasnifi Fatih No.63 4: Basbakanlik Osmanli Arsivi Ali Emiri Tasnifi Fatih No.71 5: Tapu ve Kadastro Genel Mudurlugu Yeni No.2199 6: Topukapi Sarayi Muzesi Arsivi E.7744-4 (published by T. Oz in 1935) 7: Turk ve Islam Eserleri Muzesi No.2182-646 8: Tapu ve Kadastro Genel Mudurlugu Yeni No.2166 9: Vakiflar Genel Mudurlugu Anadolu Defteri, Fatih Vakfiyesi (published by Vakiflar Umum Mudurlugu in 1938) As a result of the analysis of these vakfiyes and other registers of the vakif. the following points become clear. (1) The first assignment of Sultan Mehmed's vakif to the Ayasofya Mosque was made around 1456. It can be known that there were two groups of property assigned to that vakif. One group includes shops and kerbansarays, the construction of which began in 1456 according to Kritoboulos' chronicle. The other includes mukata'a (rent) of the houses which remained from the Byzantine period and were inhabited by immigrants into Istanbul. Examination of the vakif documents of Sultan Mehmed makes it clear that the assignment of the mukata'a of those houses to vakif is closely related to the survey of the city buildings carried out by Cubbe Ali in 1455 or 56. Although Dursun Bey and Asikpasazade wrote that the levy of mukata'a was given up immediately after the survey, vakfive No.2 and the register of 1489/90 show that a part of mukata'a remained in the vakif property. It should be noted, however, that the vakfiye made at the time of this assignment has not yet been found. (2) In 1463, construction of a new institutional complex called Fatih Imareti was begun. The complex contained a mosque, eight medreses, eight small medreses, a hospital and a traveler's hostel. Up to 1472-3, during the service of Grand Vezir Mahmud Pasa, only the great mosque (Fatih Cami'i) and the eight(View PDF for the rest of the abstract.)
著者
Eiji Kawasaki
出版者
The Japanese Society for Pediatric Endocrinology
雑誌
Clinical Pediatric Endocrinology (ISSN:09185739)
巻号頁・発行日
vol.23, no.4, pp.99-105, 2014 (Released:2014-11-06)
参考文献数
19
被引用文献数
26 95

Type 1 diabetes (T1D) is an organ-specific autoimmune disease caused by the autoimmune response against pancreatic β cells. T1D is often complicated with other autoimmune diseases, and anti-islet autoantibodies precede the clinical onset of disease. The most common coexisting organ-specific autoimmune disease in patients with T1D is autoimmune thyroid disease, and its frequency is estimated at > 90% among patients with T1D and autoimmune diseases. The prevalence of anti-thyroid antibodies in children with T1D at disease onset is about 20% and is particularly common in girls. Furthermore, patients with anti-thyroid antibodies are 18 times more likely to develop thyroid disease than patients without anti-thyroid antibodies. Therefore, for early detection of autoimmune thyroid disease in children with T1D, measurement of anti-thyroid antibodies and TSH at T1D onset and in yearly intervals after the age of 12 yr is recommended. Anti-islet autoantibodies are predictive and diagnostic markers for T1D. The most frequently detected autoantibodies in Japanese patients are GAD autoantibodies (~80%) followed by IA-2 autoantibodies (~60%), insulin autoantibodies (~55%) and ZnT8 autoantibodies (~50%). In a combined analysis, 94% of Japanese patients with T1D can be defined as having type 1A diabetes. Furthermore, autoantibodies to ZnT8 and IA-2 are associated with childhood-onset and acute-onset patients. Thus, it is important to develop a diagnostic strategy for patients with type 1A diabetes in consideration of the age or mode of disease onset.
著者
田中 昌一郎 粟田 卓也 島田 朗 村尾 敏 丸山 太郎 鴨井 久司 川崎 英二 中西 幸二 永田 正男 藤井 寿美枝 池上 博司 今川 彰久 内潟 安子 大久保 実 大澤 春彦 梶尾 裕 川口 章夫 川畑 由美子 佐藤 譲 清水 一紀 高橋 和眞 牧野 英一 三浦 順之助 花房 俊昭 小林 哲郎 日本糖尿病学会1型糖尿病調査研究委員会
出版者
一般社団法人 日本糖尿病学会
雑誌
糖尿病 (ISSN:0021437X)
巻号頁・発行日
vol.54, no.1, pp.65-75, 2011 (Released:2011-03-29)
参考文献数
19
被引用文献数
8

日本糖尿病学会1型糖尿病調査研究委員会の緩徐進行1型糖尿病分科会(旧日本糖尿病学会緩徐進行1型糖尿病調査委員会)では委員会委員の所属する施設において発症から5年以内の新規受診糖尿病687例を前向き(2004年4月~2009年12月)に登録し膵島関連自己抗体(glutamic acid decarboxylase[GAD]抗体,insulinoma-associated protein 2[IA-2]抗体およびinsulin autoantibodies[IAA])の測定を行った.2型糖尿病と思われる症例で膵島関連自己抗体が一種でも陽性の場合には緩徐進行1型糖尿病:slowly progressive IDDM(以下SPIDDM)と病型区分した.その結果,1)2型糖尿病と思われる症例の10%(49/474, 95%信頼区間:8-13%)にSPIDDMが認められた.2)膵島関連自己抗体陰性の2型糖尿病に比しSPIDDM例の自己免疫性甲状腺疾患の合併頻度,HbA1c値,初診時のインスリン治療の頻度は有意に高く,BMIは有意に低かった.3)SPIDDMではGAD抗体の頻度(69%,34/49)はIA-2抗体の頻度(39%,19/49)やIAA(29%,14/44)の頻度に比し有意に高かった.4)SPIDDMでは急性発症1型糖尿病に比し膵島関連自己抗体の単独陽性例が高頻度だった.以上の結果から2型糖尿病と思われる症例に高頻度にSPIDDM症例が含まれる可能性があること,SPIDDMは2型糖尿病や急性発症1型糖尿病と異なる臨床的特徴を呈することが全国規模調査で明らかとなった.
著者
月本 昭男
出版者
一般社団法人 日本オリエント学会
雑誌
オリエント (ISSN:00305219)
巻号頁・発行日
vol.24, no.1, pp.34-48, 1981-09-30 (Released:2010-03-12)
被引用文献数
1

There are two types of divination by means of birds in Ancient Mesopotamia. The first one is auspicium, namely the practise of divining the future by the observation of the flight and behaviour of birds. We have more than 350 kinds of such omina in texts of relatively good condition.As to the relation between protases and apodoses in these omina, we can find out at least three principles which explain the reason why a positive apodosis results from a certain protasis, and a negative from another:1. principle of metaphor; an example: “if a falcon puts a raven to death the king will win over his enemy” because the falcon is compared to the king, and his enemy to the raven.2. principle of association; an example: the appearance of a black (gi6) bird wakes an association of an eclipse (an. gi6) in the future.3. principle of the dichotomy of space; an example: the existence of a falcon at the right side of a man divines a favourable future for him, while the same falcon at the left side means a malicious one.Several protases which seem extremely unlikely to happen in reality must be interpreted as the products of the imagination.The second type is concerned with the physical peculialities of sacrificial birds. There has been a discussion among scholars about “a bird” (mušen=issuru) in certain types of ominous texts. Owing to the courtesy of Mrs. G. A. Matheson, the Keeper of Manuscripts of the John Rylands Library (Manchester), we published here one more late OB text of such a type which reports the observation of “a bird”.
著者
岸本 麻子 金 義慶 南 豊彦 中川 のぶ子 多田 直樹 井野 千代徳
出版者
耳鼻と臨床会
雑誌
耳鼻と臨床 (ISSN:04477227)
巻号頁・発行日
vol.52, no.2, pp.97-103, 2006-03-20 (Released:2013-05-10)
参考文献数
10

真性唾液過多症の1例を報告した。患者は24歳の女性で15歳頃より唾液過多を自覚していた。今日まで心因性のものとして加療されてきたが効果なく当科を紹介受診した。安静時唾液量は5分間で9-10mlと非常に多く、RI検査では両側の顎下腺で集積が低下していた。これは分泌に集積が追い付かない現象と理解した。唾液腺造影ではワルトン氏管の拡張が認められた。これは恒常的に多量な唾液が分泌されての現象ととらえた。顎下神経節をブロックして唾液量が著しく低下したことより顎下腺が責任腺と考えた。治療として抗ヒスタミン剤、マイナートランキライザー、H1受容体ブロッカー、カルバマゼピンを選択し投与した。結果、カルバマゼピンにてやや有効と判定された。最終的に左顎下腺摘出術を行ったが、結果は予想以上に良好で手術後49日目の安静時唾液量は1.5mlで、自覚的にも有効と判定された。
著者
小西 純一 西野 保行 渕上 龍雄
出版者
Japan Society of Civil Engineers
雑誌
日本土木史研究発表会論文集 (ISSN:09134107)
巻号頁・発行日
vol.5, pp.207-214, 1985-06-25 (Released:2010-06-15)
参考文献数
15
被引用文献数
1

A historical sketch of railway truss girders constructed in Meiji era (1858-1912) is described. This is the first part dealing with the 200ft double Warren truss girders which is believed to be a representative of the British school of design. A total of 112 girders were imported from England and erected in 1886-1898, 22 of which were made of wrought iron and remainings were wrought iron and steel combined girders. In April 1985, 18 girders are still stand, most of them are in use, though 9 of them are shortened.
著者
内藤 結花 石井 正和 川名 慶治 坂入 由貴 清水 俊一 木内 祐二
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.129, no.6, pp.735-740, 2009-06-01 (Released:2009-06-01)
参考文献数
9
被引用文献数
5 8

Pharmacists in a community pharmacy may recommend an over-the-counter (OTC) drug to patients with headache. However, it is not clear how pharmacists should distinguish the symptoms of patients and facilitate appropriate self-medication. Here, we investigated the role of pharmacists in a community pharmacy in recommending OTC drugs for self-medication by patients with headache and elucidated their future needs using a questionnaire intended for doctors and pharmacists. More than half of the pharmacists surveyed did not have any experience with recommending OTC drugs for patients with headache. To distinguish between patients for whom pharmacists should “recommend OTC drugs” and patients who should be encouraged “to consult a hospital or clinic,” doctors thought that pharmacists should use an “assistance tool to diagnosis headache, such as a screener for migraine” and “guidelines for chronic headache.” However, few pharmacists used these tools. About 68% of doctors indicated that it would be “meaningful” for pharmacists to distinguish patients with headache. Moreover, both doctors and pharmacists thought that pharmacists should provide patients not only with “instruction on the use of drugs” but also suggest “when to consult a hospital or clinic.” However, 32% of doctors indicated that it is “meaningless” for pharmacists to attempt to distinguish patients with headache and expressed concern about the increase of patients who overuse headache medication. These findings provide useful information to guide pharmacists in community pharmacy when recommending OTC drugs for self-medication by patients with headache.