著者

今釜 崇 田中 浩 徳重 厚典 伊達 亮 田口 敏彦

出版者

西日本整形・災害外科学会

雑誌

整形外科と災害外科 (ISSN:00371033)

巻号頁・発行日

vol.61, no.2, pp.204-207, 2012-03-25 (Released:2012-06-26)

参考文献数

11

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関節リウマチに対しインフリキシマブ(IFX)投与により臨床的寛解が得られ,投与を中止した症例の経過,特徴を検討した.IFX投与を行った93例中,DAS28の基準で寛解が6カ月以上維持され,患者の同意を得てIFX投与を中止し,1年以上経過観察を行った6例を対象とした.Bio free remissionを1年以上維持できた症例は3例で,3年以上の長期寛解例2例はいずれもSteinbrocker stage II,罹病期間も比較的短い症例で,IFX投与1回目から寛解を獲得していた.またIFX中止前に,Booleanの寛解基準を6カ月以上満たしていたものもこの2例のみであった.長期にBio free remisionを継続する要因として,発症早期で,骨破壊の進行がなく,DASよりも厳格なBooleanの寛解基準を満たすIFXの著効例であることが示唆された.

著者

山口 智之 片岡 直己 冨田 雅史 坂本 一喜 新保 雅也 牧本 伸一郎

出版者

日本臨床外科学会

雑誌

日本臨床外科学会雑誌 (ISSN:13452843)

巻号頁・発行日

vol.73, no.7, pp.1722-1726, 2012 (Released:2013-01-25)

参考文献数

11

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症例は55歳,女性.慢性関節リウマチに対しインフリキシマブの投与を受けていた.全身倦怠感と採血上の貧血の進行を認め,下部消化管内視鏡検査を受けたところ,回腸末端の潰瘍性病変を認め,生検の結果腸結核の診断となった.胸部CT検査では全肺野に小粒状陰影を認め粟粒結核と診断され,喀痰TB-PCR陽性,塗末で抗酸菌陽性であり,腸結核,粟粒結核の診断となり結核専門病院へ紹介入院となった.このころから腹痛と頻回の下痢を認めていた.結核専門病院を退院後,腹痛が増強したため受診し,CT検査上回盲部の狭窄像と回腸直腸瘻を認めたため外科紹介となった.回盲部切除術と直腸瘻孔部の縫合閉鎖を行った.術後は正常便となり特に合併症なく17日目に退院となった.インフリキシマブが結核発症の危険因子であるのは周知の事実であるが,腸瘻を形成する症例は極めて稀であるので文献的考察を加え報告する.

著者

唐帆 健浩

出版者

一般社団法人 日本耳鼻咽喉科学会

雑誌

日本耳鼻咽喉科学会会報 (ISSN:00306622)

巻号頁・発行日

vol.117, no.6, pp.782-787, 2014-06-20 (Released:2014-07-12)

参考文献数

18

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「飲み込む際にむせる」 「飲み込みにくい」 という嚥下障害を疑うような症状の患者は, 耳鼻咽喉科を受診することが多い. 日本耳鼻咽喉科学会が編集した 「嚥下障害診療ガイドライン」 には, 耳鼻咽喉科一般外来で行う嚥下障害の診療指針が示されており, 診療所などの耳鼻咽喉科一般外来を担当する医師が自ら, 基本的な診察と嚥下内視鏡検査を経て, 嚥下障害患者への対応を決めることを推奨している. すなわち, 自身で嚥下指導・訓練を行うか, より専門的な医療機関へ紹介するかを判断することになる. 一般外来で施行が可能な嚥下指導や嚥下訓練にはかなりの制限があるが, 対象を絞ることで対応は可能となる. 一連の診察および検査を行った結果, 嚥下内視鏡検査で何らかの異常を認めるが明らかな誤嚥がなく, 精神・身体機能は嚥下指導を行う上で十分に維持されている患者, 例えば, 液体嚥下の際に, 軽度の喉頭流入を認めるだけの, 認知症のない高齢者などが対象となる. 加齢により, 嚥下動態にはさまざまな変化がみられ, これらが相互に作用して, 代償ができなくなる高齢者は少なくない. 嚥下指導とは, 食事に適した食事環境, 姿勢・頭位や食形態の工夫など一般的な誤嚥予防や対応策を説明することである. 嚥下訓練とは, 嚥下動態を考慮して機能の改善を図り, 安全な経口摂取を目指す訓練である. 嚥下指導や訓練は, 条件を満たせば診療報酬を算定することが可能である. 医師の指導のもとに看護師や准看護師が, 口腔ケアや嚥下指導を行う場合にも摂食機能療法として算定できる. 一般外来で嚥下障害のトリアージを行い, 自身で嚥下指導と訓練を行うには, 知識と技量がある程度必要である. 経験が不十分であれば, 日耳鼻嚥下障害講習会等にて, 嚥下機能評価や嚥下訓練の手技を学ぶことが望ましい. 耳鼻咽喉科一般外来で, 嚥下障害診療が広く行われるようになることを期待したい.

著者

Yukio Ozaki Yoko Takeuchi Miyuki Iwato Satomi Sakazono Hiroshi Okubo

出版者

園芸学会

雑誌

Journal of the Japanese Society for Horticultural Science (ISSN:18823351)

巻号頁・発行日

pp.CH-073, (Released:2014-07-18)

被引用文献数

1 4

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The origin of a spontaneous triploid asparagus plant from crosses of 2x × 2x was investigated by SSR and flow cytometric analyses. One hundred and twenty-four progeny were obtained from crosses between a diploid female ‘Gold Schatz’ and a diploid male ‘Hokkai 100’. SSR analysis proved that two and one genes were transmitted from the maternal and paternal parents, respectively, at each SSR locus of one progeny, 07M-61, whereas one gene each was from the female and male parents in the other diploid progeny. Triploidy of 07M-61 was confirmed by flow cytometric analysis. It was suggested that the triploid plant was derived from fertilization between an unreduced egg and reduced sperm nuclei, given its SSR genotypes. It was also suggested that the unreduced maternal gamete was derived from first division restitution (FDR) or second division restitution (SDR) with chiasma occurrence during meiosis. There were no noticeable morphological differences between the triploid and diploid progeny.

著者

八木澤 猛

出版者

一般社団法人 日本鉄鋼協会

雑誌

鉄と鋼 (ISSN:00211575)

巻号頁・発行日

vol.74, no.9, pp.1721-1726, 1988-09-01 (Released:2009-05-29)

参考文献数

20

著者

小笠原 徳子 高野 賢一 阿部 亜由美 才川 悦子 海崎 文 関 伸彦 吉野 真代 今野 綾美 山内 誠 新谷 朋子 四ツ柳 高敏 氷見 徹夫

出版者

日本小児耳鼻咽喉科学会

雑誌

小児耳鼻咽喉科 (ISSN:09195858)

巻号頁・発行日

vol.34, no.3, pp.360-365, 2013 (Released:2014-03-20)

参考文献数

17

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先天性小耳症は発生頻度の低い稀な先天奇形であるが,外表奇形として出生直後より認識され,聴力評価などで耳鼻咽喉科を初診することが多い。外表奇形に対する手術は本邦では形成外科で施行される。今回我々は当院形成外科にて耳介形成術を施行した患児73例に対して,外表奇形の分類,聴力評価,味覚障害の有無,顔面神経麻痺の評価,中耳・内耳奇形の有無について解析を行い,外表奇形とそれぞれの項目に関して比較検討をおこなった。さらに国内外における従来の報告と本解析に相違があるかを検討した。  小耳症は,片側小耳症が90%をしめ,多くは外表奇形に対する治療が中心となる。しかしながら,聴力の継続的評価や真珠腫性中耳炎の早期発見,外耳道形成術,伝音再建の適応など耳鼻咽喉科医が把握,対応する事項の重要性が再認識された。

著者

Hirokazu Ohminami Kikuko Amo Yutaka Taketani Kazusa Sato Makiko Fukaya Takashi Uebanso Hidekazu Arai Megumi Koganei Hajime Sasaki Hisami Yamanaka-Okumura Hironori Yamamoto Eiji Takeda

出版者

日本酸化ストレス学会

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.55, no.1, pp.15-25, 2014 (Released:2014-07-01)

参考文献数

41

被引用文献数

1 5

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A dietary combination of sucrose and linoleic acid strongly contributes to the development of metabolic disorders in Zucker fatty rats. However, the underlying mechanisms of the metabolic disorders are poorly understood. We hypothesized that the metabolic disorders were triggered at a stage earlier than the 8 weeks we had previously reported. In this study, we investigated early molecular events induced by the sucrose and linoleic acid diet in Zucker fatty rats by comparison with other combinations of carbohydrate (sucrose or palatinose) and fat (linoleic acid or oleic acid). Skeletal muscle arachidonic acid levels were significantly increased in the sucrose and linoleic acid group compared to the other dietary groups at 4 weeks, while there were no obvious differences in the metabolic phenotype between the groups. Expression of genes related to arachidonic acid synthesis was induced in skeletal muscle but not in liver and adipose tissue in sucrose and linoleic acid group rats. In addition, the sucrose and linoleic acid group exhibited a rapid induction in endoplasmic reticulum stress and abnormal lipid metabolism in skeletal muscle. We concluded that the dietary combination of sucrose and linoleic acid primarily induces metabolic disorders in skeletal muscle through increases in arachidonic acid and endoplasmic reticulum stress, in advance of systemic metabolic disorders.

著者

勝又 俊雄

出版者

一般社団法人 日本オリエント学会

雑誌

オリエント (ISSN:00305219)

巻号頁・発行日

vol.31, no.2, pp.34-54, 1988 (Released:2010-03-12)

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In 1979 at Anemospilia in Archanes, north of Knossos, Y. Sakellarakis unearthed ruins of a rectangular temple which had been destroyed by earthquake in the Middle Minoan IIIA period (c. 1700 B. C.). The temple consists of three rooms and a corridor, where a pair of clay foot models in life size was found. The excavator indicated that the clay feet could have belonged to an anthropomorphic wooden cult image, xoanon. The hypothesis has supported strongly those views which insist on its existence in the period. The aim of this article is to proceed with a negative argument to the views, and to clarify the meaning of the clay foot models in the find-contexts.To begin with, attentions should be paid to the following four facts. 1) Fourteen models so far discovered from seven sites in Crete and one in Kea are rarely found in pairs. 2) Usually they are found in non-shrine contexts and not in shrines of a palace or a country house. 3) They do not represent bare feet, but most likely some sort of footgears are painted on them. 4) Statues and figures in large scale existed certainly in the palatial periods in Minoan Crete. However, they should not be interpreted automatically as a xoanon. In fact, the fragments are always found in the context as a votive.The above analysis leads to a conclusion that no archaeological evidence supports the view which maintains the existence of xoanon in the palatial periods. If it were so, what is the role of the fourteen clay foot models in the find-contexts?It is evident that our models are not votives, since feet models dedicated to deities should be barefooted as we see in numerous examples from the Asklepieion in the classical Corinth. It is also agreed that ‘epiphany’ of deity was a central element in Minoan rituals in the palatial periods, since there existed no cult images. Pictorial representations of epiphanies include scenes where a small deity hovers in the air or descends before the worshippers. Such representations as these could imply a deity perceived by the worshippers, but invisible. Therefore, the clay foot models must symbolize the presence of such invisible deity in ritual, which could have taken place outdoors as shown on a gold ring from Isopata. Consequently The clay feet should not necessarily be found in shrines.

著者

積山 薫

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

vol.57, no.6, pp.342-349, 1987-02-27 (Released:2010-07-16)

参考文献数

16

被引用文献数

8 9 6

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Three experiments on mental rotation were carried out to investigate conditions under which hand images are operated kinesthetically. In Experiment 1a, either a left or right hand was presented in a photographic slide, and subjects' task was left-right identification. In Exp. 2, each slide consisted of two hands, identical hands or mirror-imaged hands, and same-different judgment was required. In Exp. 3, two hands were presented successively, requiring same-different (mirror-reversed) judgment. On the other hand, subjects in Exp. 1b were asked to rate physical difficulty of actual hand movements to imitate stimuli. Six to 12 undergraduate students served as subjects in each experiment. The results suggested that subjects' mental operations of hand images were kinesthetic in Exp. 1a but visual in Exp. 2 and 3, on the basis of comparison between reaction times in the three experiments and the ratings in Exp. 1b. Conditions which give rise to kinesthetic image processes were argued in relation with task structures.

著者

藤井 健生 山口 静馬 佐伯 徹郎

出版者

一般社団法人 日本人間工学会

雑誌

人間工学 (ISSN:05494974)

巻号頁・発行日

vol.38, no.1, pp.63-68, 2002-02-15 (Released:2010-03-12)

参考文献数

12

被引用文献数

2 2 3

著者

奥村 彰久 早川 文雄 久野 邦義 夏目 淳 渡辺 一功

出版者

一般社団法人 日本小児神経学会

雑誌

脳と発達 (ISSN:00290831)

巻号頁・発行日

vol.26, no.6, pp.475-479, 1994-11-01 (Released:2011-08-10)

参考文献数

8

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脳室周囲白質軟化症 (PVL) 17例の出生予定日の頭部CT所見を, 正常発達を確認した児50例と比較した.脳室周囲白質の域性低吸収域は正常発達児の40%に認められ, 必ずしも病的な所見とはいえなかった.それに対し, 脳室周囲白質の孤立性低吸収域・脳室壁の不整・半卵円中心の著明な低吸収域はPVLに特徴的であった.新生児期CT所見が軽度・中等度異常の例では, 年長に達した時点のMRI所見とは55%で, 運動発達予後とは50%で, 異常の程度が一致した.CT所見が重度異常の児はMRI所見・予後とも重篤であった.重症のPVLでは半卵円中心の著明な低吸収域が特徴的で, その範囲はMRI所見・予後と関連が認められた.

著者

原田 武

出版者

日本海水学会

雑誌

日本海水学会誌 (ISSN:03694550)

巻号頁・発行日

vol.38, no.5, pp.291-299, 1985 (Released:2013-02-19)

参考文献数

34

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The elemental constitution of organisms, rocks and metals was found to have linear relations to that of the earth crust.Logarithms of the ratios of sample concentration to those of seawater were used as ordinate, Y=log (CSA/CWA), and those of the earth crust as abscissa, X=log (CEC/CSW).Regression lines, Y=A+BX, describe “omnipresence of elements” semiquantitatively.These samples were classined into 3 groups according to the inclination of the regression lines, B: i) B=1 (0.8 to 1.02);rocks, oxides, carbonate, phosphate, coal, ii) B=0.5 (0.4 to 0.7);organisms, metals, river water, petroleum, iii) B=0;seawater.The author used two parallel lines to the regression line instead of curves which were used usually, to express the 90% confidence interval. The elemental constitution of the samples composed of cells: microorganisms, plants, animals, muscle, bone, liver, was described by only one regression line.The inclination of regression lines changed in line with chemical reactions;e.g.values of B were decreased as much as 1 or 0.5 by dissolution, where seawater or river water formed from rocks, decreased ca by 0.5 by metal formation from oxide, and they were incresed by 1 or 0.5 by precipitation, where sediments or organisms formed from seawater.

著者

Yoshihisa Tomoda Kenji Umemura Takashi Adachi

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.58, no.1, pp.202-203, 1994-01-23 (Released:2008-02-08)

参考文献数

16

被引用文献数

37 88 80

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Alginate lyase-lysate (A.L.L., Algin-Oligo(R)), which had been prepared by degrading sodium alginate by alginate lyase, was found to have a growth-promoting effect on the elongation of barley roots, and especially that of the radicle, the effective concentration of A.L.L. for elongation of the roots being 100-3000μg/ml, with no inhibition at the highest concentration. When a radicle was brought into contact with A.L.L., it responded by initiating elongation within 2 to 4h. The elongation rate increased from 2.9mm/h to 5.3mm/h. Treatment with A.L.L. resulted in about a 2-fold increase in the alcohol dehydrogenase activity of the control under hypoxic conditions.

著者

松葉 一孝 牛田 俊 奥 宏史

出版者

一般社団法人 日本機械学会

雑誌

日本機械学会論文集C編 (ISSN:18848354)

巻号頁・発行日

vol.78, no.792, pp.2797-2807, 2012 (Released:2012-08-25)

参考文献数

26

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This paper reports the experimental results of the dynamic modelling using MIMO closed-loop system identification, controller design and implementation for hovering flight of a radiocontrolled helicopter. The helicopter is set on our handcrafted supporting device, and it has the roll, side-to-side and up-and-down motions that controlled by the aileron and the throttle. Several dynamic models with defferent orders are derived from closed-loop system identification experiments with the MOESP-type closed-loop subspace model identification method (CL-MOESP). Then, we compared their model with the real system, and LQR with a full state observer is designed and implemented.

著者

小原 章裕 平松 直子

出版者

一般社団法人 日本家政学会

雑誌

日本家政学会誌 (ISSN:09135227)

巻号頁・発行日

vol.48, no.7, pp.637-642, 1997-07-15 (Released:2010-03-09)

参考文献数

10

被引用文献数

4

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Most plant foods such as vegetables, fruit, seaweed and mushrooms contain antimutagenic or anticarcinogenic compounds. These compounds may be altered or lost during processing and cooking. Therefore, it is very important to investigate the change in antimutagenicity of a food due to processing and cooking. The objective of the first stage of this study was to examine the antimutagenicity of water-soluble and fat-soluble substances in plant foods. Food samples were selected from popular seasonal vegetables that are commonly available. The water-soluble fraction and fat-soluble fraction were extracted from each freeze-dried plant food with a 0.1 M phosphate buffer and methyl alcohol, respectively. The antimutagenic activity was evaluated by the Ames method to examine the mutagenicity of Trp-P-1, Trp-P-2 and 2-hydroxy- (1-N-nitrosoindolyl) propionic acid (NIHP) toward Salmonella typhimurium TA 98.Twenty percent of the forty plant juices tested reduced the mutagenicity of Trp-P-1 by more than 50 %, and 35% of the extracts from the other 29 vegetables reduced mutagenicity of NIHP by more than 50 %. Eighty three percent of the water-soluble fractions extracted from 24 freeze-dried plant foods showed antimutagenic activity toward Trp-P-2. On the other hand, only 25% of the fat-soluble fractions from the freeze-dried plant foods showed antimutagenicity, although a few of them demonstrated very strong activity. Seventeen percent of the tested plant foods had antimutagenicity in both the water-soluble and fat-soluble fractions. Most of the plant foods tested contained antimutagens in their water-soluble fractions.

著者

藤井 秀二 村上 善紀 原田 寧

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.141, no.5, pp.275-285, 2013 (Released:2013-05-10)

参考文献数

35

被引用文献数

1 2

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抗TNF製剤は,リウマチ(RA)などの自己免疫疾患の治療に欠かせない薬剤となっている.ゴリムマブは,これまでの抗TNF製剤の優れた有効性を保持したまま,従来の抗TNF製剤において長期治療の障害になってきた抗薬物抗体の出現,投与部位反応,適切な投与間隔および複数の投与経路を有することなどの点を改善することを目標として開発されたヒト型抗ヒトTNFα抗体である.ゴリムマブは,抗体製剤としては,物理化学的な安定性に優れ,TNFαに対する強い親和性および中和活性を示した.また,ゴリムマブは IgG1のFc領域を有し,FcRnに結合するため体内での半減期が長く,また,Fcγ受容体に結合することから,インフリキシマブおよびアダリムマブと同様な生物活性を示すことが予想された.ゴリムマブのRAに対する海外臨床試験は,2001年から開始され,米国では2009年4月,欧州では2009年10月に承認された.日本での臨床開発は,2006年から第I相単回投与試験を開始し,第II/III相試験を経て2011年7月に承認された.これらの臨床試験において,ゴリムマブを4週間隔で皮下投与したときRAに対する症状および徴候の軽減,身体機能改善および関節破壊進展抑制効果が認められ,安全性も確認された.また,これらの臨床試験から,ゴリムマブはRAの疾患活動性に応じた投与量の選択が可能なこと,単剤でも使用できること,抗ゴリムマブ抗体の陽性率が低いこと,注射部位反応の発現率が低いこと,既存の抗TNFα製剤を使用していた患者にも有効性を示すことなどの特徴が明らかとなった.本稿ではゴリムマブのこのような特徴を紹介する.

著者

西 泰行 稲垣 照美 近江谷 亮太 立川 力 小寺 正雄 福富 純一郎

出版者

一般社団法人 ターボ機械協会

雑誌

ターボ機械 (ISSN:03858839)

巻号頁・発行日

vol.39, no.8, pp.467-474, 2011 (Released:2014-03-13)

参考文献数

6

被引用文献数

5

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This study is aimed at development of the extra-low head water turbine for an open channel from a viewpoint of using effectively unused hydropower energies, such as an irrigation channel. Then, paying attention to the cross-flow runner, authors eliminated the casing and tried the application as a water turbine for an open channel. In this paper, water turbine performance, the flow situation characteristics, and the flow in the runner were experimentally investigated about the water turbine. As a result, the following facts became clear. When initial depth of water is shallow, turbine efficiency is high in a low rotation region, and when initial depth of water is deep, turbine efficiency is high in a high rotation region. Unlike the runner in which the cross-flow runner which does not have a bottom plate has a bottom plate, air bubbles do not stagnate between blades to blade. Moreover, winding up of the water by a blade does not arise. Therefore, in a wide range rotation region, an output and turbine efficiency improves substantially.

著者

野口 正見

出版者

日本フードシステム学会

雑誌

フードシステム研究 (ISSN:13410296)

巻号頁・発行日

vol.4, no.2, pp.11-20, 1997-12-27 (Released:2010-12-16)

参考文献数

1

著者

泉谷 希光

出版者

一般社団法人 日本人間工学会

雑誌

人間工学 (ISSN:05494974)

巻号頁・発行日

vol.20, no.2, pp.69-71, 1984-04-15 (Released:2010-03-11)

著者

Po-Yu Tseng Der-Cherng Tarng Wu-Chang Yang Chih-Yu Yang

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.53, no.14, pp.1589-1590, 2014 (Released:2014-07-15)

参考文献数

2

被引用文献数

4