著者
白井 詩沙香 上田 真由美 小野 淳 兼宗 進 竹村 治雄 長瀧 寛之 西田 知博 村上 正行
出版者
大阪大学
雑誌
基盤研究(B)
巻号頁・発行日
2023-04-01

本研究では,高等学校の共通教科「情報」および大学の一般情報教育において,主体的・対話的で深い学びを実現するために,体験的な学びを通して情報の科学的な理解を促進する教材と授業内外の学習活動を効果的に活用した授業モデル,ならびに多様な学びを対象とした自己調整学習支援環境を設計・開発し,その効果を検証することを目的とする。この目的を達成するために,(1)共通必履修科目「情報I」を対象に,体験的な実習教材および反転授業を取り入れた授業モデルの開発と評価,(2)新学習指導要領を踏まえた大学の一般情報教育の授業設計,(3) 多様な学習活動データに基づく自己調整学習支援環境の開発と評価に取り組む。
著者
江 文 菁 岡本 和彦 西出 和彦
出版者
日本建築学会
雑誌
日本建築学会計画系論文集 (ISSN:13404210)
巻号頁・発行日
vol.81, no.727, pp.1887-1894, 2016 (Released:2016-09-30)
参考文献数
10

1. Introduction Harmonious care home, which is often called “Toyama-style day care service, ” is a developing welfare system started in Toyama Prefecture in 2003, which offers appropriate services for everyone in a home-like atmosphere, regardless of their age or disabilities. This study aims to compare the interannual changes of users' activities and postures in two Toyama-style day care service centers which had been researched 3 years ago in order to find out what kind of space is important and needed in harmonious care home to accommodate diverse and aging users. 2. Methods In our last research, 4 centers (NI, FU, SI and OR) were selected through questionnaires and interview and our survey found that elderly is the main user in SI and OR. In this research therefore, NI and FU were selected to be compared with the old data. We observed, using the same method to the old research, the activity place and posture of users during day- care time by plotting users' and staff's locations, postures and behaviors on floor plan. 3. Results and Discussions Because there are more chairs and sofas in common space than in room space, users stay longer in common space. Users have lunch and tea in common space. While they play music, use computer and take a nap in room space. As there were more activities needing to sit on chairs, tables and beds in room space, so that fewer users stay by sitting on the flooring/carpet. Since there were beds in room space in 2010, users stay longer than lying in the common space. But in 2013, users stay lying in the common space become longer. One supposed reason is a new user who couldn't keep her posture was playing with towel lying on the carpet all day. Many of elderly used to sit on the floor before, however in 2013 they sit on the chair/wheelchair or lie down on the bed/carpet more. Because of accommodating not only new elderly with less healthy condition, but also existing users getting weaker every year, sitting on the floor is getting harder to be observed. The combination of chair, sitting floor and lying floor is good for diverse users, however the main furniture for these combinations is tend to be sofas/chairs or carpets/rugs. This combination should be easily changed in accordance with users' conditions. 4. Conclusions Findings are as follows: 1) Not only new users like severely handicapped, babies or small kids, but also existing users getting weaker should be considered. 2) Common space is most important because furniture layout is easily customized for accepting each posture according to users' conditions. Room space layout belongs to the characteristics of rooms. 3) It is needed to layout furniture like bed, tatami mat or carpet for severely handicapped who would like to share the common space with other users. As Toyama-style is supposed to accept divers users while most of them are elderly now, this flexibility found in this study should be shared among all Toyama-style centers.
著者
二本松 明
出版者
日本自律神経学会
雑誌
自律神経 (ISSN:02889250)
巻号頁・発行日
vol.59, no.1, pp.96-100, 2022 (Released:2022-04-23)
参考文献数
30

合谷穴への鍼刺激による第一背側骨間筋の誘発筋電図F波(振幅F/M比)と,第一背側骨間筋部の局所酸素飽和度(regional oxygen saturation:rSO2)の変化との関連について述べた.鍼刺激は,合谷穴(第2中手骨の中点にある経穴)へ太さ0.18 mmの鍼を深さ10 mm刺入した.合谷穴に鍼刺激を行うと第一背側骨間筋の振幅F/M比が増加し,同部位のrSO2は増加した.また鍼刺激開始30秒後について振幅F/M比とrSO2の間に関連を認めたが,150秒後,300秒後の関連については有意なものではなかった.鍼刺激開始30秒後の運動神経の興奮と筋血流量の増加は,鍼刺激の感覚情報が高次中枢を介して同期して惹起された現象が主に関与するものと考えられ,鍼刺激150秒後,300秒後の変化については,運動神経の興奮と,筋血流量の増加がそれぞれ別個に惹起された現象が主に関与するものと考えられた.
著者
Yasushi Ohmachi Tomomi Imamura Mizuyo Ikeda Eriko Shishikura Eunjoo Kim Osamu Kurihara Kazuo Sakai
出版者
JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
雑誌
Journal of Toxicologic Pathology (ISSN:09149198)
巻号頁・発行日
vol.28, no.2, pp.65-71, 2015 (Released:2015-05-28)
参考文献数
15
被引用文献数
15 21

To evaluate the effectiveness of sodium bicarbonate (SB) in removing uranium and protecting animals from uranium toxicity, we intramuscularly administered 1 mg/kg of uranyl nitrate to 8-wk-old male SD rats, and 20 min after administration of uranyl nitrate, the animals were given a single oral administration of SB at 0.1, 0.3 or 1 g/kg. The SB treatment at a dose of 0.3 g/kg or more raised the pH of the rats’ urine until 4 h after treatment, and it significantly reduced the uranium amounts in the kidneys at 1 day after treatment. In another experiment, rats were intramuscularly administered 1 mg/kg of uranyl nitrate, and 20 min later, the animals were treated with sodium bicarbonate (0.1 or 1 g/kg). The rats were autopsied at 1, 3 and 7 days after uranium treatment. High-dose SB resulted in a significant increase in urinary uranium excretion in the first 24 h and a reduction of uranium deposition in the kidneys and femurs, and it also significantly suppressed uranium-induced renal toxicity, as shown by both histopathology and clinical chemistry at 3 days after uranium treatment. Low-dose SB did not show such marked effects. Our findings demonstrated that the uranium decorporation effect of sodium bicarbonate was observed at the dosage showing urine alkalinization in rats and that decorporation effect of sodium bicarbonate might be beneficial if it is administered immediately after incorporation of soluble uranium.
著者
田原 加奈子 Tabaru Kanako
出版者
早稲田大学
巻号頁・発行日
2023

早大学位記番号:新9324
著者
甲斐 温子 Kai Atsuko
出版者
早稲田大学
巻号頁・発行日
2023

早大学位記番号:新9230
著者
片桐 準二 ドルゴル スレン オユンゲレル ダワー 中西 令子 浮田 久美子 牧 久美子 Junji KATAGIRI DOLGOR Suren OYUNGEREL Davaa Reiko NAKANISHI Kumiko UKITA Kumiko MAKI
出版者
国際交流基金
雑誌
国際交流基金日本語教育紀要 (ISSN:13495658)
巻号頁・発行日
no.12, pp.57-72, 2016

モンゴルでは初中等段階の日本語学習者が全体の約7割を占めるに至っているが、初中等教育全体で統一したシラバスや教材がない。そこでモンゴル日本語教師会は「初中等教育機関向け日本語教科書作成プロジェクト」を実施し、モンゴル日本語教育スタンダードと共に教科書シリーズ『にほんご できるモン』を開発することとした。同スタンダードの理念は(1)社会の中で自分の考えを自由に表現し、相互理解するのに必要な外国語能力の育成、(2)子供たちが自分自身の力で学習を進めていく能力の育成であり、教科書にはプロフィシェンシー重視と自律学習支援の2つの特徴がある。新教科書を使用する教師とのやり取りから教科書が改善でき、学習者自身も話す能力の向上を感じているという報告を聞くが、一方で、教師には「書くことが学習である」という従来からのビリーフがあり、教科書が変わっても新しい教え方にならない等の課題が残っている。
著者
加藤 伸江
出版者
日本建築学会
雑誌
日本建築学会計画系論文集 (ISSN:13404210)
巻号頁・発行日
vol.85, no.776, pp.2227-2232, 2020 (Released:2020-10-30)

In this study, I clarify meaning and how to read ‘Block’. ‘Block’ is described in ‘The Tale of Genji’ of the Heian era. ‘Block’ is included in the words indicating the model of Shindenzukuri. It is generally a Chinese‐style reading now. The diary which a noble of the Heian era left is written in a kanji mainly. Therefore, It is not revealed how this kanji was read. The literary work of the Heian era is a hiragana letter. ’Block’ is written by a hiragana letter in ‘The Tale of Genji’. ‘Block’ has two meanings. It is ‘Block’ and ‘Distance’. Ancient ‘Block’ is a block based on ‘Jobo’ City System. The biography book of ‘The Tale of Genji’ says ‘Yomachi’ by a hiragana letter. As for how to read ‘Block’, biography book notation of ‘The Tale of Genji’ becomes the evidence. It applies to the diary which a noble wrote. Both were written in the Heian era. The interpretation about ‘Yomachi’ comes to be referred to a supplementary explanation book of ‘The Tale of Genji’ afterwards. The confusion of the meaning of the word ‘Machi’ occurs. The biography book of ‘The Tale of Genji’ writes ‘Yomachi’ by a hiragana letter. This study clarified how to read ‘Block’ indicating the division of ‘Jobo’ City System.
著者
野村 恭也 原田 勇彦 林田 哲郎
出版者
日本耳科学会
雑誌
臨床耳科 (ISSN:18845800)
巻号頁・発行日
vol.10, no.1, pp.228-229, 1983 (Released:2011-08-10)
参考文献数
6
著者
Kumiko Hamano Hiroshi Nishiyama Akiko Matsui Manaka Sato Masakazu Takeuchi
出版者
The Japan Endocrine Society
雑誌
Endocrine Journal (ISSN:09188959)
巻号頁・発行日
vol.64, no.4, pp.449-456, 2017 (Released:2017-04-29)
参考文献数
24
被引用文献数
7 7

In 855 Japanese patients with type 2 diabetes receiving once weekly dulaglutide 0.75 mg in 3 phase 3 studies, the effects on efficacy and safety at week 26 (last observation carried forward) were investigated in a post hoc descriptive analysis of subgroups of age (<65 years [young], ≥65 years [elderly]) and body mass index (BMI [<25 kg/m2, ≥25 kg/m2]). The 4 subgroups were as follows: 1) the young/low-BMI subgroup (Y/L) (n = 255); 2) the young/high-BMI subgroup (Y/H) (n = 386), 3) the elderly/low-BMI subgroup (E/L) (n = 137), and 4) the elderly/high-BMI subgroup (E/H) (n = 77). The mean changes from baseline in glycated hemoglobin (HbA1c) and body weight, respectively, were -1.69% and -0.29 kg in the Y/L subgroup; -1.48% and -0.09 kg in the Y/H subgroup; -1.68% and -0.20 kg in the E/L subgroup; and -1.72% and -0.26 kg in the E/H subgroup. The incidences of nausea and hypoglycemia, respectively, were 6.7% and 11.0% in the Y/L subgroup; 7.0% and 8.0% in the Y/H subgroup; 10.2% and 18.2% in the E/L subgroup; and 3.9% and 22.1% in the E/H subgroup. Dulaglutide improved HbA1c regardless of age or BMI; a higher incidence of hypoglycemia was observed in elderly patients compared to younger patients.
著者
Hiroyuki Matsuura Fukiko Ichida Tsutomu Saji Shunichi Ogawa Kenji Waki Masahide Kaneko Masahiro Tahara Takashi Soga Yasuo Ono Satoshi Yasukochi
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.80, no.11, pp.2362-2368, 2016-10-25 (Released:2016-10-25)
参考文献数
24
被引用文献数
52 55

Background:The 1st nationwide survey by the Japanese Society of Pediatric Cardiology and Cardiac Surgery of acute or fulminant myocarditis (AMC/FMC) in children revealed that the survival rate of FMC was only 51.6%. The 2nd nationwide survey was performed to evaluate the recent outcomes of pediatric myocarditis.Methods and Results:Questionnaires regarding patients aged ≤18 years with AMC/FMC during the period from January 2006 to December 2011 were mailed. A total of 221 cases (age 6.5±5.3 years, 116 boys and 105 girls) were reported. There were 145 (65.6%) and 74 cases (33.5%) of AMC/FMC, respectively; the type of myocarditis was not reported in the remaining 2 cases (0.9%). Viruses were identified in 56 cases (25.3%), including coxsackie B in 9 and influenza A in 8. Histopathology by either endomyocardial biopsy or autopsy was obtained in 38 cases (19.2%). Intravenous immunoglobulin was effective in 49 (34.3%) of 143 cases. Steroid therapy was effective in 20 (32.8%) of 61 cases. Mechanical circulatory support was given in 54 cases (24.4%) and 94.2% of them were patients with FMC. The survival rates for the whole study population, acute myocarditis, and FMC were 75.6%, 91.0%, and 48.6%, respectively.Conclusions:The survival rate of children with myocarditis was almost identical to that of 10 years ago. (Circ J 2016; 80: 2362–2368)
著者
種村 健太郎 古川 佑介 大塚 まき 五十嵐 勝秀 相崎 健一 北嶋 聡 佐藤 英明 菅野 純
出版者
日本毒性学会
雑誌
日本毒性学会学術年会 第39回日本毒性学会学術年会
巻号頁・発行日
pp.S5-5, 2012 (Released:2012-11-24)

個体の胎生期-幼若期の脳は、その発生-発達段階にある。その期間に、遺伝子という設計図を元にして、脳の基本構造が出来ると共に、神経活動(主に神経伝達物質とその受容体を介した神経シグナル)による微調整がなされ、脳が完成に向かう。すなわち、脳は「活動」しつつ、その「形態・機能」を完成させていく。従って、この時期の神経作動性化学物質の暴露による神経シグナルのかく乱は、一時的な神経症状を呈するだけに留まらず、脳構造や神経回路の形成過程に影響を及ぼす危険を高める。そして、こうした影響が不可逆的に固定されたまま成長した結果、成熟後に遅発性行動異常等の脳高次機能障害として顕在化することが危惧される。しかしながら、従来の神経毒性評価手法は成熟動物への化学物質投与による急性~亜急性の、痙攣、麻痺といった末梢神経毒性を主対象としており、遅発性の中枢神経機能に対する影響評価への対応は、比較的に立ち遅れてきた。こうした問題に対して、我々は、マウスを用いて、①神経作動性化学物質の胎生期~幼若期暴露、②複数の行動解析試験を組み合わせたバッテリー式の情動-認知行動解析による行動異常の検出、及び③行動異常に対応する神経科学的物証の収集、により遅発性の中枢神経毒性検出系の構築を進めてきた。 本シンポジウムでは、モデル化学物質として、イボテン酸(イボテングダケ等の毒キノコとされる一部のテングタケ属に含まれる)を用いた解析として、幼若期(生後2週齢)における単回強制経口投与による、成熟期(生後12~13週齢時)の不安関連行動の逸脱、学習記憶異常、情報処理不全といった異常行動と、それと対応する海馬の形態所見、及び遺伝子発現プロファイルについて紹介する。さらに、遅発中枢影響としての異常発現のメカニズム解明を目的とした、イボテン酸投与後の遺伝子発現変動解析結果についても議論したい。
著者
橘 省吾
出版者
公益社団法人 日本表面真空学会
雑誌
表面と真空 (ISSN:24335835)
巻号頁・発行日
vol.63, no.4, pp.189-194, 2020-04-10 (Released:2020-04-10)
参考文献数
16

Hayabusa2 explored a near-Earth C-type asteroid (162173) Ryugu for 17 months (June 2018–November 2019) including two landing operations for sample collection. Ryugu has a top shape with an equatorial ridge, and its bulk density of 1.19±0.03 g cm-3 suggests that Ryugu is a rubble-pile body with a large macro-porosity of ∼50–60%. The surface has a very low geometric albedo (∼0.02), darker than most of meteorite samples, and shows a weak but ubiquitous 2.72-µm absorption feature of hydrous minerals. The surface samples will be delivered to the Earth at the end of 2020. Detailed analysis of Ryugu samples will reveal the history of Ryugu and the Solar System from the beginning to the present.