著者

Mitsuru Matsukura Junji Mochizuki Shinya Misawa Yoshiki Hata

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.1, no.12, pp.630-631, 2019-12-10 (Released:2019-12-10)

参考文献数

1

著者

GAO Meiling CHEN Fei SHEN Huanfeng BARLAGE Michael LI Huifang TAN Zhenyu ZHANG Liangpei

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2019-060, (Released:2019-08-18)

被引用文献数

10

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Summer heat waves pose a great threat to public health in China. This paper took Wuhan (one of the four hottest furnaces cities in China) as an example to explore several strategies for mitigating the surface urban heat island (UHI) measured by the land surface temperature, including the use of green roofs, cool roofs, bright pavements, and alternations in urban building patterns. The offline urbanized High-Resolution Land Data Assimilation System (u-HRLDAS) was employed to conduct 1-km resolution numerical simulations, which also accounts for the effects of abundant lakes in Wuhan on UHI evolution with a dynamic lake model. The diurnal cycle and spatial distribution of simulated UHI were analyzed under different mitigation strategies. Results show that considering lake effects reduces the daytime (nighttime) UHI intensity by about 1.0 K (0.5 K). Employing green roofs and cool roofs are more effective in mitigating daytime UHI than the use of bright pavements. The maximum UHI reduction is about 2.1 K at 13:00 local time by replacing 80% of conventional roofs with green roofs. The UHI mitigation efficiency increases with larger fractions of green roofs, and increased albedo of roofs and roads. In contrast to the green roofs, cool roofs and bright pavements which are ineffective in nighttime, changing urban building pattern to mitigate the UHI is effective throughout the day. “Height-driven building structure changing” (raising the building height, and meanwhile changing the fraction of impervious surface in each grid to keep the total building volume intact) can reduce the surface UHI intensity by 0.4-0.9 K, and “density-driven building structure changing” (distributing building density uniformly and the building height are modified to make the total building volume unchanged) reduces UHI by 1.2-2.6 K. These results showed new insights in mitigating the urban heat islands for a mega city like Wuhan and provides a practical guideline for policymakers to offer a more habitable city.

著者

江藤 名保子

出版者

一般財団法人 アジア政経学会

雑誌

アジア研究 (ISSN:00449237)

巻号頁・発行日

vol.61, no.4, pp.61-80, 2015-10-31 (Released:2015-11-10)

参考文献数

52

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Chinese nationalism tends to excessively react to some specific problems which oppose to Japan, USA or West European countries in particular. This “anti-West” sentiment of the Chinese society has been regarded as the “trauma” of invasion by the Great Powers. Yet when reviewing Chinese cognition after the national foundation in 1949, there were the times when Chinese nationalism expanded without connecting to the “anti-West” assessment. For example, despite the rise of “patriotism” in the 1980s, Chinese public opinion took a conciliatory attitude to the Western countries, especially to Japan. Similarly, it was observed that while the nationalism kept on surging, Chinese public sentiments towards Japan continuously improved from 2006 to 2010. These phenomena can’t be explained by a simple logic that “the surge of nationalism promotes anti-foreignism.” This paper hypothesizes the contemporary Chinese nationalism as multiple political thought in order to examine the dynamism of its “anti-West” logics. Here, the centripetal force of Chinese official nationalism is extracted as the four elements; national identity, socialism, economic development and notion of great power. Using these factors, this paper discusses the mechanism how Chinese nationalism links to the “anti-West” sentiments. In conclusion, this paper argues that the “anti-West” sentiments is not only an extension of the historical trauma, but it is also promoted by official nationalism. At the same time, however, it is also pointed out two elements of the official nationalism—economic development and notion of great power—functioned to offset the public “anti-West” feelings.

著者

佐野 享子

出版者

日本教育制度学会

雑誌

教育制度学研究 (ISSN:2189759X)

巻号頁・発行日

vol.1998, no.5, pp.115-119, 1998 (Released:2019-12-07)

著者

山本 由似 塩田 倫史 大和田 祐二 福永 浩司

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.131, no.4, pp.497-501, 2011-04-01 (Released:2011-04-01)

参考文献数

23

被引用文献数

1 2

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Haloperidol as a potent dopamine D2 receptor (D2R) antagonist was a major tranquilizer to treat schizophrenia patients. However, the D2R blocking action in dorsal striatum is thought to cause extrapyramidal symptoms as adverse effects. However, the pathophysiological mechanism underlying extrapramidal symptoms induced by chronic treatment of haloperidol remains unclear. We recently found that lacking of heart-type fatty acid binding protein (H-FABP) in the brain aggravate catalepsy behavior induced by haloperidol. Here, we examined neuronal mechanism of augmentation of haloperidol-induced catalepsy in H-FABP null mice. Notably, catalepsy induced by haloperidol, a D2 antagonist, is augmented, whereas catalepsy induced by SCH23390, a D1 antagonist, was not affected in H-FABP null mice. Interestingly, haloperidol-induced acetylcholine (ACh) release in the dorsal striatum was markedly enhanced in H-FABP null mice compared to wild mice. We also defined the co-localization of D2R with H-FABP in the ACh interneurons in the striatum. Taken together, H-FABP regulates dopaminergic neuronal activity through interaction with D2R in rodent brain. The increased ACh release in the striatum accounts for haloperidol-induced catalepsy.

著者

Daisuke NISHIO–HAMANE Takahiro TANAKA Tadashi SHINMACHI

出版者

Japan Association of Mineralogical Sciences

雑誌

Journal of Mineralogical and Petrological Sciences (ISSN:13456296)

巻号頁・発行日

vol.114, no.5, pp.252-262, 2019 (Released:2019-12-05)

参考文献数

30

被引用文献数

8

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Minakawaite, a new mineral with a RhSb composition, in association with a platinum–group mineral (PGM) placer is found from a small stream crossing the clinopyroxenite mass in serpentinite mélange of the Kurosegawa belt on the northeast side of Hikawa Dam, Haraigawa, Misato machi, Kumamoto Prefecture, Japan. Almost all PGM placer grains are based on isoferroplatinum, of which the rims are often covered by tulameenite and tetraferroplatinum. This isoferroplatinum–based grain contains small inclusions and accessories consisting mainly of osmium, erlichmanite, laurite, bowieite, cuprorhodsite, and ferhodsite–like mineral. Minakawaite occurs as the outmost surface layer with a rose gray metallic luster on the nub consisting of cuprorhodsite, ferhodsite–like mineral and/or Rh(Ge,Cu,Fe) mineral in association with an isoferroplatinum–based grain. The density of minakawaite is 10.04 g/cm3, calculated using the empirical formula and powder X–ray diffraction (XRD) data. Minakawaite has a pale gray color under the microscope in reflected light, and pleochroism is weak as a variation from pinkish pale gray to bluish pale gray. Anisotropy is moderate as reddish gray to bluish gray. Average results of ten energy dispersive X–ray spectroscopy (EDS) analyses give Rh 46.83, Sb 48.97, As 4.08 and total 99.88 wt%. The empirical formula is Rh0.998(Sb0.882As0.120)Σ1.002, based on 2 atoms per formula unit. Minakawaite is orthorhombic (Pnma) with a = 5.934(7) Å, b = 3.848(3) Å, c = 6.305(4) Å, and V = 144.0(2) Å3 (Z = 4). The seven strongest lines of minakawaite in the powder XRD pattern [d in Å(I /I0) (hkl )] are 2.860(63) (111), 2.774(35) (102), 2.250(47) (112), 2.199(100) (211), 2.162(38) (202), 1.923(49) (020), and 1.843(51) (013). Minakawaite is identical to the synthetic RhSb phase with MnP–type structure. PGM including minakawaite may occur with chromite in the magma chamber of the clinopyroxenite. Minakawaite was named in honor of Japanese mineralogist, Prof. Tetsuo Minakawa (b. 1950) of Ehime University for his outstanding contribution to descriptive mineralogy from Kyushu and Shikoku, Japan.

著者

篠原 厚子 千葉 百子 武内 裕之 木下 勝之 稲葉 裕

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.60, no.4, pp.418-425, 2005-11-15 (Released:2009-02-17)

参考文献数

29

被引用文献数

1 3

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Objective: The relationships between element concentrations and sperm parameters in semen samples were investigated.Methods: Semen samples (n=113) were donated voluntarily by male partners of infertile couples. The concentrations of fourteen elements (Na, K, P, Ca, Zn, Mg, Fe, Cu, Se, Mn, Sn, Co, Ni, and Cd) in semen were determined by atomic absorption spectrometry, fluorometry, or colorimetry. Element concentrations in seminal plasma and in sperm were also measured.Results: Element concentrations in semen were in the order Na>P, K>Ca>Zn>Mg>>Fe>Cu, Se>Mn>Sn, Ni, Co, Cd. When the samples were divided into two groups in terms of sperm concentration and number, the Se concentration in semen with normal parameter values (sperm concentration≥20×106 and sperm number≥40×106), 99.4±37.4ng/ml, was higher than that in semen with abnormal parameter values (sperm concentration≤20×106 and/or sperm number≤40×106), 72.1±33.9ng/ml (p<0.001). A clearer positive correlation between the Se concentration and the sperm concentration was observed in the sperm portion (r=0.853, p<0.001) than in semen (r=0.512, p<0.001) and seminal plasma (r=0.292, p=0.003). Statistically significant correlations were also observed between the concentration of Se, P, Zn, Cu, Fe, or Mn in semen, the sperm portion or seminal plasma and the sperm concentration, semen volume or abnormal morphology, although correlation coefficients were small.Conclusion: Among biologically essential elements in semen of infertile males, Se was a good indicator of sperm concentration; however, other trace elements did not indicate clear relationships between their concentrations and sperm parameters.

著者

茂木 啓司 野澤 知世 鈴木 巧 中村 年希

出版者

行動経済学会

雑誌

行動経済学 (ISSN:21853568)

巻号頁・発行日

vol.13, pp.1-15, 2020 (Released:2019-12-02)

参考文献数

17

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本論の目的は,奨学金が過剰に受給される原因を明らかにするとともに,それを解消するための施策について検討することである.高校生と大学生を対象に,奨学金の借入が必要な状況を想定した仮想的質問を含む質問紙調査を行ったところ,奨学金を借りる選択をした被験者のうち約42%は将来の破産リスクを過小に評価していた.さらに,奨学金申請フォーマットについて,毎年の借入金額を選択するもの,および選択肢を部分的に記入式にしたものの方が,実際の申請フォーマットよりも被験者の借入金額が有意に小さくなった.以上より,奨学金の過剰受給を解消するため,利用者に対して「延滞のリスクを強調すること」および「申請書類のフォーマットを変更すること」が有効であるといえる.

著者

Jeongok Yang Joongsook Lee Bomjin Lee Sora Jeon Bobae Han Dongwook Han

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.4, pp.599-603, 2014 (Released:2014-04-23)

参考文献数

26

被引用文献数

6 9

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[Purpose] The purpose of this study was to determine the effects of adjusting the scapula into its ideal position through active scapular protraction on the muscle activation and function of the upper extremity. [Subjects] Twenty female college students aged 19–21 without any physical or functional disability were the subjects of this study. They had no history of injury to their upper extremities or hands. [Methods] After the initial measurements the experimental group was asked to perform active scapular protraction; then, their grip strength and muscle activation were measured again. Every action was maintained for 5 seconds and repeated 3 times. The mean values of the measurements were analyzed. A resting of 1 minute was given between each action. [Results] The results revealed a significant change in the experimental group’s grip strength after active scapular protraction had been performed. The surrounding muscles of the scapula, such as the serratus anterior, upper trapezius, flexor carpi ulnaris, flexor carpi radialis and palmaris longus, showed significant changes in muscle activation after active scapular protraction. The muscles of the upper extremity also showed significant changes after active scapular protraction. [Conclusion] The adjustment of scapula into its ideal position through active scapular protraction increased the activations of the muscles surrounding the shoulder joint and improved the function of the upper extremity.

著者

三宅 茜巳 井上 透 松家 鮎美

出版者

デジタルアーカイブ学会

雑誌

デジタルアーカイブ学会誌 (ISSN:24329762)

巻号頁・発行日

vol.2, no.4, pp.376-384, 2018-10-01 (Released:2018-11-20)

参考文献数

60

被引用文献数

1

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デジタルアーカイブは知識基盤社会を支える重要な役割を果たすものと期待されているが、課題も多く存在する。そうした課題の中で、本論では、デジタルアーカイブの開発・管理・活用を担う人材育成にテーマを絞り考察した。大学やNPO法人日本デジタル・アーキビスト資格認定機構が進めてきたデジタル・アーキビスト育成教育の事例と英語圏(米・加・英・豪)における教育の事例を概観する中で、大学や協会による専門職としての質保証を伴う教育や再教育が必要であることが明らかになった。また、デジタルアーカイブを運用する現場での情報を教育にフィードバックすることにより、採用や待遇改善等キャリアパスの形成につなげていくことが重要であると結論付けた。

著者

斎藤 嘉朗 中村 亮介

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.139, no.12, pp.1557-1562, 2019-12-01 (Released:2019-12-01)

参考文献数

15

被引用文献数

2

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Severe cutaneous adverse reactions (SCARs) are important in postmarketing drug safety because SCAR patients were highest in the adverse drug reaction relief system of Japan. The SCAR symptoms of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) include high fever, severe mucosal impairment, and epidermal necrosis-induced erosions and blisters. Approximately 600 cases of SJS and 300 cases of TEN are reported annually in Japan. Many suspected drugs such as acetaminophen, lamotrigine, allopurinol, and carbamazepine have been reported. Over the last 15 years, an association between human leukocyte antigen and SJS/TEN onset has been reported with several drugs. Pathophysiological examinations in those reports revealed marked CD8-positive T cell infiltration into epidermal lesions, and the presence of cytotoxic granulysin, soluble Fas ligand, and tumor necrosis factor (TNF)-α in blister fluid. Therefore, SJS and TEN are immunological disorders that lead to epidermal necrosis and are consequently treated with the systemic administration of corticosteroids and with high-dose intravenous immunoglobulin therapy and plasma exchange in severe cases. Additionally, because the epidermal necrosis has characteristics similar to those of organ rejection after transplantation, the administration of cyclosporine, an immunosuppressant that inhibits helper T cell activation, has been attempted. Further, the administration of the TNF-α inhibitor etanercept has also been reported. This review summarizes current knowledge on the mechanisms of onset of SJS/TEN and their treatments.

著者

Liangtao XU Yijun ZHANG Fei WANG Xi CAO

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.97, no.6, pp.1119-1135, 2019 (Released:2019-12-05)

参考文献数

56

被引用文献数

3

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The charge structure evolution of a mesoscale convective system with an anomalous or inverted charge structure, observed in the Severe Thunderstorm Electrification and Precipitation Study, a field project on the Colorado–Kansas border in summer 2000, is simulated using the Weather Research and Forecasting (WRF) model coupled with electrification and discharge processes. Two noninductive electrification schemes are used, based on the liquid water content (LWC) and the graupel rime accretion rate (RAR). The simulation with the LWC-based electrification scheme cannot reproduce the inverted charge structure with a positive charge region sandwiched by two negative charge layers, while the RAR-based electrification scheme produces the evolution process of a normal–inverted–normal charge structure in the convective region, which is consistent with the observations. In the low RAR (< 2 g m−2 s−1) region, graupel is mainly negatively charged when it bounces off ice crystals, while the ice crystals take up positive charge. However, in the zone where the inverted charge structure forms, a strong updraft (> 16 m s−1), high LWC (> 2 g m−3), and high RAR (> 4.5 g m−2 s−1) region appears above the height of the −20°C layer, so that a positive graupel charging region is generated above the −20°C layer of the convective region, resulting in a negative dipole charge structure with negatively charged ice crystals above the positively charged graupel. The negative dipole is superposed on the positive dipole (positive above negative) charge structure at the lower position to form an inverted tripole charge structure.

著者

柴田 克成 後藤 祐樹

出版者

日本認知科学会

雑誌

認知科学 (ISSN:13417924)

巻号頁・発行日

vol.24, no.1, pp.96-117, 2017-03-01 (Released:2017-09-01)

参考文献数

111

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It is propounded that in order to avoid the “frame problem” or “symbol grounding problem” and to create a way to analyze and realize human-like intelligence with higher functions, it is not enough just to introduce deep learning, but it is significant to get out of deeply penetrated “division into functional modules” and to take the approach of “function emergence through end-to-end reinforcement learning.” The functions that have been shown to emerge according to this approach in past works are summarized,and the reason for the difficulty in the emergence of thinking that is a typical higher function is made clear.  It is claimed that the proposed hypothesis that exploration grows towards think-ing through learning, becomes a key to break through the difficulty. To realize that,“reinforcement learning using a chaotic neural network” in which adding external ex-ploration noises is not necessary is introduced. It is shown that a robot with two wheels and a simple visual sensor can learn an obstacle avoidance task by using this new reinforcement learning method.

著者

菊池 友和 山口 智 五十嵐 久佳 小俣 浩 鈴木 真理 田中 晃一 磯部 秀之 三村 俊英

出版者

社団法人 全日本鍼灸学会

雑誌

全日本鍼灸学会雑誌 (ISSN:02859955)

巻号頁・発行日

vol.61, no.1, pp.51-58, 2011 (Released:2011-06-27)

参考文献数

19

被引用文献数

3

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【はじめに】本邦でVDT作業者のQOLや作業能力を指標とした鍼治療に関する報告は極めて少ない。 そこで、 この前向き研究では鍼治療がVDT作業者のQOLと作業能力に及ぼす影響について検討した。 【方法】VDT作業者61例、 男性41例、 女性20例である。 鍼治療は1回/週、 個々の頸や肩の症状に応じて行った。 評価はSF-36とWAIを、 初診時と1ヵ月後の値を統計学的に検討した。 【結果】VDT作業者のSF-36は、 身体的健康度、 精神的健康度、 体の痛み、 日常役割機能 (身体) が上昇し、 活力も上昇する傾向が認められWAIも上昇した。 治療前のSF-36の各項目とWAI値、 さらに鍼治療後における体の痛みとWAI値の改善率に正の相関関係が認められた。 【結論】鍼治療によりVDT作業者の有する頸肩こりの症状が改善するとともに、 QOLと作業能力が向上した。 今後増加が予想されるVDT作業者のQOLや作業能力の向上に対し、 鍼治療の有用性が高いことが示唆された。

著者

鈴木 真理 山口 智 五十嵐 久佳 小俣 浩 菊池 友和 田中 晃一 磯部 秀之 大野 修嗣 三村 俊英 君嶋 眞理子

出版者

社団法人 全日本鍼灸学会

雑誌

全日本鍼灸学会雑誌 (ISSN:02859955)

巻号頁・発行日

vol.60, no.5, pp.829-836, 2010 (Released:2011-05-25)

参考文献数

19

被引用文献数

1 1

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【はじめに】近年、 情報化の発達により、 VDT作業者は急増している。 VDT作業者における心身の疲労は以前から問題視されているが、 多くのVDT作業者が有する頸肩こりや眼疲労に対する鍼治療効果についての報告は数少ない。 そこでこの前向き研究では、 VDT作業者の愁訴に対する鍼治療効果について検討した。 【方法】対象はVDT作業者61例 (男性41例、 女性20例) である。 鍼治療は、 週1回、 計4回、 個々の頸や肩の症状に応じて、 円皮鍼を用いて行った。 評価は、 頸こり・肩こりと眼疲労を自己記入式で行った。 VAS値の経時的変化、 また鍼治療前と4週後のVAS値より改善率を算出し、 眼疲労と頸こり・肩こりの関連について検討した。 【結果】鍼治療により頸こり、 肩こり、 眼疲労のVASの値はともに、 初診時より徐々に減少を示した。 また、 眼疲労と頸こり・肩こりの改善率には正の相関が認められた。 【結論】VDT作業者の頸や肩のこりに対し鍼治療を行い、 頸肩こりが軽減するとともに、 眼疲労も改善することが示された。 鍼治療は産業医学の分野で有用性の高いことが示唆された。

著者

金 銀珠

出版者

日本語学会

雑誌

日本語の研究 (ISSN:13495119)

巻号頁・発行日

vol.12, no.4, pp.118-134, 2016-10-01 (Released:2017-04-03)

参考文献数

15

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本稿は中古語の名詞節において主語を表示する「の」と「が」および無助詞の機能の違いを節内の主語,述語,被修飾語の総合的特徴と構造体系の相互関係に注目して明らかにした。中古語の名詞節における主語の表示は「構造の大きさ」と「指示」という二つの指標で条件づけられ,無助詞は節の内部の小さい構造の主語を表示する形態で,「の」は節の構造が拡張されている時の主語を表示する形態として機能している。「が」は「の」と無助詞の中間に位置する。各形態には特異な使用分布が観察されるが,これは本質的には構造の大きさに依拠して現れる相互補い合いの現象である。「が」は前接語を強く「指示」する機能を持ち,これにより主語の表示には「構造の大きさ」とは別の新たな指標が加わる。「が」は前接語に人を指す語を取ることが多かったことが機縁で節内述語が活動述語に偏るようになったと考えられる。

著者

川畑 篤史 坪田 真帆 関口 富美子 辻田 隆一

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.154, no.5, pp.236-240, 2019 (Released:2019-11-15)

参考文献数

31

被引用文献数

1

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化学療法誘発性末梢神経障害(CIPN)はがん患者のQOLを著しく損ない,治療の継続を困難にする可能性のある有害事象であるが,現在,CIPNを回避する有効な対策はほとんどない.そのためCIPNの発症メカニズムを解明し,臨床応用可能なCIPN発症抑制薬・治療薬を開発することは喫緊の課題である.我々は,CIPNの発症にdamage-associated molecular pattern(DAMP)タンパク質の1つであるhigh mobility group box 1(HMGB1)が関与することを明らかにしている.また,日本において播種性血管内凝固症候群(DIC)治療薬として承認されているthrombomodulin αが,抗がん薬投与に伴って細胞外に放出されるHMGB1をトロンビン依存的に分解することでCIPNの発症を阻止できることを報告している.このように,HMGB1あるいはその受容体を標的とする薬物を用いることで近い将来CIPNの発症を抑制できるようになることを期待したい.

著者

菅原 大地 武藤 世良 杉江 征

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

pp.89.17049, (Released:2018-09-20)

参考文献数

38

被引用文献数

4

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This study examined the semantic organization of positive emotions among university and graduate students in Japan. A total of 100 participants individually sorted 132 positive-emotion words into categories using flash cards. Hierarchical cluster analysis of the sorted terms yielded a comprehensive map of the concept. We found, at the highest level of abstraction, two large distinctions: “other-oriented positive emotions” and “self-oriented positive emotions.” The former included (a) aijo (love), (b) kantan (wonder), and (c) ikei/sonkei (awe/respect), while the latter included (d) nagomi/yorokobi (peacefulness/joy), (e) ikigomi (enthusiasm), and (f) hokori (pride) at the basic level. Further, these basic categories contained 11 subordinate categories. These findings suggest that in semantic organization, positive emotions are generally classified according to the self–other dimension and that 11 subordinate categories have different features.

著者

Takuya E. KISHIMOTO Kazuyuki UCHIDA James K. CHAMBERS Mun Keong KOK Nguyen V. SON Takanori SHIGA Miyuki HIRABAYASHI Nanako USHIO Hiroyuki NAKAYAMA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0486, (Released:2019-12-04)

被引用文献数

16

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To clarify the prevalence of canine intracranial tumors in Japan, a retrospective study was performed using data on 186 canine intracranial tumors. Of 186 cases, 159 cases (85.5%) were primary and 27 cases (14.5%) were secondary intracranial tumors. Among primary intracranial tumors, meningioma (50.9%) was the most common, followed by glial tumors (21.4%) and primary intracranial histiocytic sarcoma (12.6%). These 3 tumors were most frequently found in middle-aged to elderly dogs without any sex predilection. Regarding glial tumors, the incidence of oligodendroglial tumors (79.4%) was higher than that of astrocytic tumors (17.6%). A significant breed predisposition (P<0.05) was observed for meningioma in Rough Collie, Golden Retriever, Miniature Schnauzer, and Scottish Terrier; for glial tumors in Bouvier de Flandres, French Bulldog, Newfoundland, Bulldog, and Boxer; for primary intracranial histiocytic sarcoma in Pembroke Welsh Corgi, Siberian Husky, and Miniature Schnauzer. The high incidence of oligodendroglial tumors in dogs and the breed predisposition for primary intracranial histiocytic sarcoma in Pembroke Welsh Corgi have not been reported in previous epidemiological studies on canine tumors. Since the incidence of intracranial tumors was vary among dog breeds, the present results demonstrate the uniqueness of the canine breed population in Japan.

著者

Jean-François Gibrat

出版者

The Biophysical Society of Japan

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.16, pp.444-451, 2019 (Released:2019-11-29)

参考文献数

13

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This paper presents a preliminary work consisting of two contributions. The first one is the design of a very efficient algorithm based on an “Overlap-Layout-Consensus” (OLC) graph to assemble the long reads provided by 3rd generation technologies. The second concerns the analysis of this graph using algebraic topology concepts to determine, in advance, whether the assembly of the genome will be straightforward, i.e., whether it will lead to a pseudo-Hamiltonian path or cycle, or whether the results will need to be scrutinized. In the latter case, it will be necessary to look for “loops” in the OLC assembly graph caused by unresolved repeated genomic regions, and then try to untie the “knots” created by these regions.