著者
Christin Rakers Daniel Reker J.B. Brown
出版者
日本化学会 情報化学部会
雑誌
Journal of Computer Aided Chemistry (ISSN:13458647)
巻号頁・発行日
vol.18, pp.124-142, 2017 (Released:2017-08-01)
参考文献数
72
被引用文献数
14

The identification of new compound-protein interactions has long been the fundamental quest in the field of medicinal chemistry. With increasing amounts of biochemical data, advanced machine learning techniques such as active learning have been proven to be beneficial for building high-performance prediction models upon subsets of such complex data. In a recently published paper, chemogenomic active learning had been applied to the interaction spaces of kinases and G protein-coupled receptors featuring over 150,000 compound-protein interactions. Prediction models were actively trained based on random forest classification using 500 decision trees per experiment. In a new direction for chemogenomic active learning, we address the question of how forest size influences model evolution and performance. In addition to the original chemogenomic active learning findings that highly predictive models could be constructed from a small fraction of the available data, we find here that that model complexity as viewed by forest size can be reduced to one-fourth or one-fifth of the previously investigated forest size while still maintaining reliable prediction performance. Thus, chemogenomic active learning can yield predictive models with reduced complexity based on only a fraction of the data available for model construction.
著者
Khaled ABOUELNASR Mohamed HAMED Samah LASHEN Mohamed EL-ADL Rasha ELTAYSH Michihito TAGAWA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.79, no.7, pp.1301-1309, 2017 (Released:2017-07-28)
参考文献数
41
被引用文献数
11

Platelet-rich plasma (PRP) has an important role in musculoskeletal surgery; however, it has been underutilized for accelerating the healing of abdominal wall defects in veterinary practice. Therefore, the aim of this study was to evaluate the use of commercial polyester/cotton fabric (Damour) as a new composite mesh for the repair of experimentally induced abdominal wall defects in canine models, and to investigate the possible role of PRP for improving such repair and reducing allied complications. For this purpose, abdominal wall defects were created in 24 healthy mongrel dogs and then repaired with mesh alone (control group) or mesh and allogenic PRP (PRP group). Dogs were euthanized after 2 or 4 months for gross examination of implantation site, detection of adhesion score and hernia recurrence. Moreover, tissue samples were collected for histological and gene expression analyses for neovascularization, collagen formation and tissue incorporation. Hernia recurrence was not recorded in PRP-treated dogs that also displayed significantly more neovascularization and less severe adhesion to the underlings (1.08 ± 0.51) in comparison to control group (2.08 ± 0.99). Histological and molecular evaluation confirmed the gross findings that collagen deposition, new vessel formation, and overexpression of angiogenic and myofibroplastic genes (COL1α1, COL3α1, VEGF and TGFβ1) were observed more frequently in the PRP group, at both time points. In conclusion, we found that addition of allogenic PRP to Damour mesh enhanced neovessel formation, and increased tissue deposition and incorporation, with subsequent reduction of peritoneal adhesion and recurrence rate.
著者
近藤 清兄
出版者
聖霊女子短期大学
雑誌
聖霊女子短期大学紀要 (ISSN:0286844X)
巻号頁・発行日
vol.34, pp.18-40, 2006-03-31

In this article the author describes the Exceptional Prosody in the Verbs of the Oga Subdialect of Akita, northeastern Japan. The prototypical complex verb with -Q/N- has the -Q/N ○'-(': nucleus) structure (B), while the normal verb with a nucleus has the ○...○'Cu prosodeme(A). (A) tao'su 'to take down' naxgu'ru 'to strike (with a fist)' (B) but-ta'osu 'to knock out'; but-<√bud- 'to beat' bun-na'xguru 'to punch out'; bun-<√bud- Every -Q/N ○'- complex verb has a nucleus, even if its latter element is originally nuke-free (C). (C) toxbasu 'to fly (something)' -but-to'xbasu 'to blow (someone) into outer space' korosu 'to kill' -buk-ko'rosu 'to kill (brutally)' The author also tries here to present a comparative complex verb list of the Oga dialect and the Kesen dialect (Iwate), quoting Dr. YAMAURA Harutsugu's introspective/descriptive data.
著者
望月 典樹 中村 壮亮 橋本 秀紀
出版者
一般社団法人 日本機械学会
雑誌
日本機械学会論文集 (ISSN:21879761)
巻号頁・発行日
vol.83, no.851, pp.17-00022-17-00022, 2017 (Released:2017-07-25)
参考文献数
32
被引用文献数
1

Immersive virtual reality system has a problem that the operability deteriorates if the shape of the virtual body is parted from the real body. The authors are assuming that this is caused by misfit of the body scheme, an internal model in the brain used to recall the body position, because it is initially tuned up to the real body instead of virtual body. Thus, the authors have proposed a method using VR technology called“ Body Scheme Calibration ”to change the body scheme adapting to the real body so as to fit the virtual body. However, in the previous approach, presented VR information was limited to visual information, and haptic information normally occurring from interaction with surrounding object was neglected. Therefore, this paper investigated the effect of haptic information on Body Scheme Calibration. As an experimental result, it was verified that the effect of additional haptic information is trivial, and the complex haptic interface for this calibration might be omissible.
著者
小栗 徳丸
出版者
北海道大学観光学高等研究センター = Center for Advanced Tourism Studies, Hokkaido University
雑誌
CATS 叢書 (ISSN:21853150)
巻号頁・発行日
vol.8, pp.17-64, 2016-03-31

コンテンツ・ツーリズム研究の射程 : 国際研究の可能性と課題 = The Scope of Contents Tourism Studies : Proceedings of the Symposium: "International Comparative Research on the Spreading and Reception of Culture through Contents Tourism", held at Hokkaido University(15-16 March 2015).
著者
稲葉 佳之 厳 網林
出版者
公益社団法人 日本都市計画学会
雑誌
都市計画論文集 (ISSN:09160647)
巻号頁・発行日
vol.44.3, pp.55-60, 2009-10-25 (Released:2017-01-01)
参考文献数
10

本研究は、都市近郊地域における農地利用の粗放化、つまり耕作放棄や駐車場・置場等への転用の発生について、20年間・5時期の時系列的変遷とそこから生じる空間パターンを解明することを目的とする。対象地域は神奈川県藤沢市西北部の市街化調整区域およそ737haとし、1/2500スケールで粗放地6種類、農地2種類、都市的土地利用2種類の土地利用図をGISで作成し、土地利用政策、農業政策、空間条件指標との関連を考察した。結果、20年間で全転換面積中の粗放地のシェアが拡大していること、粗放地を経由した都市的土地利用への転換が大きく減少し、粗放地が土地利用転換過程の一時的な利用形態ではなくなっている可能性があること、また、農用地区域、圃場整備などの農業政策は一部を除いて粗放地の発生を十分に抑制しない可能性があることが明らかとなった。
著者
堀 麻佑子 沼田 恵太郎 中島 定彦 嶋﨑 恒雄
出版者
日本基礎心理学会
雑誌
基礎心理学研究 (ISSN:02877651)
巻号頁・発行日
vol.34, no.2, pp.246-252, 2016-03-31 (Released:2016-05-13)
参考文献数
16

People prefer unambiguity to ambiguity in decision making under ambiguity. This phenomenon, known as “ambiguity aversion,” is thought to be influenced by environmental and psychological factors. The present research demonstrated the effects of choice opportunity (the availability of choice of cards), competition (the presence vs. absence of a competitor), and stimulus familiarity (familiar playing cards vs. unfamiliar tarot cards) on choice of ambiguity. Participants preferred the ambiguous deck of cards when they were allowed to choose playing cards. In the tarot-card task, however, they did not show a preference for the ambiguous deck even if they could choose the cards by themselves. The competition factor had no effect on the participants' choice. These findings indicate that choice opportunity and stimulus familiarity affect decision making under ambiguity.
著者
廣森 友人
出版者
全国英語教育学会
雑誌
全国英語教育学会紀要 (ISSN:13448560)
巻号頁・発行日
vol.23, pp.361-372, 2012 (Released:2017-04-24)

Recent research investigating how the motivation to learn English can be enhanced has included several studies that discussed numerous motivational strategies (i.e., methods and techniques to generate and maintain the learners' motivation). However, in order for the outcomes of these studies to be fully utilized in actual classroom settings, they need to be used diagnostically and applied directly to the subsequent educational improvement. This study examined how English learners perceive motivational strategies, and whether instructional practice in keeping with the appraisal of these perceptions influences their motivation toward English learning. The results showed that (1) learners with different motivations appraised the effectiveness of motivational strategies in different ways, and (2) less motivated learners seemed to benefit the most from the instructional practice using motivation diagnosis as references. Based on the results, some educational implications and directions for future research are provided.
出版者
日経BP社 ; 1985-
雑誌
日経マネー (ISSN:09119361)
巻号頁・発行日
no.386, pp.68-70, 2014-09

消費増税で株は下がるの?経済講義3 キーワード国内景気生活が楽になった気はしないけど… 消費増税で景気はどこまで悪くなるのか——。この4〜6月、投資家は戦々恐々と成り行きを見守っていた。3月に大きな駆け込み需要が発生したことで、4月以降の反動は…
著者
安藤 英由樹
出版者
日本基礎心理学会
雑誌
基礎心理学研究 (ISSN:02877651)
巻号頁・発行日
vol.35, no.2, pp.136-141, 2017-03-31 (Released:2017-06-07)
参考文献数
8

We propose a method to solve problems that are difficult to solve only from engineering knowledge by using phenomena modeled in psychology fields such as “sensory-motor loop” and “sensory-perception mechanism.” We will be explained, a method to induce behavior without paying attention by the vestibular electric stimulation method that causes a physical response despite unconscious stimulation. And, a method of communicating/learning nonverbal skills by causing the body response under consciousness by synthesizing and switching first-person visual stimuli. The last, A highly realistic stereoscopic display method that makes it possible to significantly lower the cost of the apparatus than conventional methods by adding parallax to multi slit view.
著者
小泉 武栄 青柳 章一
出版者
学術雑誌目次速報データベース由来
雑誌
地理学評論. Ser. A (ISSN:00167444)
巻号頁・発行日
vol.66, no.5, pp.269-286, 1993
被引用文献数
8

わが国の高山地域には,化石周氷河斜面と呼ばれる岩塊斜面や礫斜面が広く分布する.化石周氷河斜面における岩屑の供給期を明らかにするために,北アルプス薬師岳西面の石英斑岩地域の岩屑斜面を調査地に選び,岩屑表面に生じた風化皮膜の厚さを測定した.その結果,主稜線から斜面の下方に向かって,風化皮膜の厚さを異にする,次の4種類の斜面堆積物と1つの氷河性堆積物を確認することができた.A:風化皮膜をもたない岩屑.分布は狭く,稜線沿いの一部に限られる.B:平均0.8mmの厚さの風化皮膜をもつローブ構成礫.これは東南尾根の一部にのみ分布する.C:西側斜面を広く覆う,平均2.4mmの厚さの風化皮膜をもつ粗大な岩塊群.稜線から海抜2,750m付近までは斜面の大半を覆う. D:平均4.0-44mmの厚さの風化皮膜をもつ人頭大の亜円礫.これはCの岩塊群に覆われなかった斜面上の窪みと斜面の下方にのみ分布する. E:平均7.8mmの厚さの風化皮膜をもつ,モレーンの丘の構成礫.平滑斜面末端の海抜2,600m付近に分布する.<br> 次に風化皮膜の厚さから岩屑の供給された年代を推定するための基準値の設定を目的として,稜線の東側にある金作谷カール内の氷河堆積物の風化皮膜を調べた.ここにはおよそ2万年前の最終氷期最盛期頃に形成されたと考えられるM字形モレーンと,4-5万年前の最終氷期前半の亜氷期に堆積したと考えられる古期モレーンとがあり,風化皮膜の厚さはそれぞれ4.6mmと8.0mmであった.またこれらとは別にプロテーラスランパートも認められ,その構成礫の風化皮膜の厚さは2.6mmであった.このうちモレーンから得られた2つの値を基準にして風化皮膜の成長曲線を描き,それをもとに西側斜面の堆積物の供給された年代を推定すると,古い順に,Eは4-5万年前,Dは1.8万-1.9万年前,Cはおよそ1万年前,そしてBはおよそ3,000年前となった.またAは現在ないし現在にごく近い時期と考えられる.この年代と堆積物の性質から考えると,Eは最終氷期前半の氷河堆積物,Dは最終氷期最盛期頃の周氷河性の斜面堆積物かアブレージョンティル,Cは晩氷期(おそらく新ドリアス期頃)の周氷河性の凍結破砕礫,Bはネオグラシエーション期の凍結破砕礫とみることができる.またAは現在またはごく近い過去の凍結破砕礫であろう.<br> このように化石周氷河斜面における岩屑の供給期は一回だけでなく,最終氷期以降少なくとも3回はあり,主要な岩屑供給期は寒冷な時期に一致していることが明らかになった.またカール内のプロテーラスランパートも晩氷期に形成された可能性が大きい.
著者
島村 真介 須賀 一博 江澤 良孝 青木 繁
出版者
公益社団法人 日本材料学会
雑誌
材料 (ISSN:05145163)
巻号頁・発行日
vol.57, no.10, pp.1043-1048, 2008-10-15 (Released:2008-10-18)
参考文献数
6
被引用文献数
1 1

The impact characteristics of a cue in billiards are investigated for the case where a ball is hit on the right or the left part to give a spin. The efficient computational method developed in the previous paper is extended for this investigation. The extended method is verified with an experiment using a high speed camera, i,e., the ball trajectory calculated with the extended method is shown to agree well with that measured using a high speed camera. It is shown from a numerical simulation that the impact force, the ball velocity, the spinning velocity and the deviation of the ball trajectory from the hitting direction increase with increase in the Young's modulus and density of a shaft. Because the proposed analytical method can predict quantitatively these impact characteristics of a cue, it is useful for designing an easy-to-use cue.