著者
于 亜 高橋 正明
出版者
大手前女子大学
雑誌
大手前女子大学論集 (ISSN:02859785)
巻号頁・発行日
no.30, pp.105-128, 1997
著者
高橋 昌也 新井 克明 本間 真人 鈴木 勝 佐藤 信一 幸田 幸直
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.28, no.2, pp.172-175, 2002-04-10 (Released:2011-03-04)
参考文献数
9
被引用文献数
2 1

To investigate the description of the expiration date and manufacturing number on the drug packages, “pillow” packages and “heat-seal” packages, the questionnairing was carried out to pharmaceutical companies. Fifty-six drugs consisting of three hundred thirty-seven items, with sales of over 10 billion yen in 1998, were investigated at the corresponding 26 companies. The recovery rate of the questionnaire from the company was 100%, and the answer for all questions was also perfect. Three hundred fourteen items (93%) have had description regarding the manufacturing number and/or the expiration date on the heat-sealed packages. The manufacturing number took precedence over the expiration date. Of 269 pillow packages, 69 items (26%) have had description of manufacturing number and/or expiration date on the pillow package. There were 41 products (12%) that the company did not guarantee an expiration date being described on the box container when the packages were taken out from the box container.As a result, the description of the manufacturing number and expiration date on the packages, “pillow” and “heat-seal”, is still not complete even though the companies guarantee the expiration date when the drugs were stored with these packages. Since the information of the expiration date is necessary for the appropriate management of tablet and capsule products, it is required to describe manufacturing number and expiration date on every drug package including “pillow” and “heat-seal” packages.
著者
高橋 直
出版者
日本社会心理学会
雑誌
社会心理学研究 (ISSN:09161503)
巻号頁・発行日
vol.7, no.3, pp.200-209, 1992
被引用文献数
3

It is generally known that littering can not be controlled by merely physical technology but by controlling the littering behavior of individuals. This would seem to be the most important factor of control. As one effective technique for controlling littering behavior, a behavior modification technique has recently been discovered. This study evaluates the effectiveness of such a behavior modification technique to induce littering behavior in a naturalistic settings: the baseball stadium. The procedures used were as follows; (1) an operant contingency in the form of positive reinforcement procedures, (2) a positive prompting strategy, (3) a negative prompting strategy, (4) a litter bag only condition. The findings revealed a highly significant effect of treatment. There were significant differential effects between the different treatment strategies.
著者
田崎 耕市 高橋 治郎 板谷 徹丸 グレープス R.H. 鹿島 愛彦
出版者
日本鉱物科学会
雑誌
岩鉱 (ISSN:09149783)
巻号頁・発行日
vol.85, no.4, pp.155-160, 1990
被引用文献数
10

Many andesitic intrusions are exposed along the Median Tectonic Line (MTL) in northwestern Shikoku, Japan. Three dikes along the MTL and one intrusion occurring close to it were dated by the K-Ar method to estimate when the fault movement ceased. The dikes and intrusion are not deformed by the movement. The results give 15.1 to 15.4 Ma excluding severely altered one. The MTL in northwestern Shikoku region has not been active since about 15 Ma. Although a similar attenuation of active movement of the MTL during middle Miocene has been reported, the fault movement has continued in the other areas of southwestern Japan as demonstrated by Active Fault Research Group (1980). This may suggest that block displacement has been dominant since middle Miocene in the studied area. The age of the samples also indicates that the volcanic activity of Seto-uchi region started 15 Ma in northwestern Shikoku.
著者
千葉 薫 宮崎 勝巳 板谷 幸一 佐藤 誠二 高橋 保志 松原 和夫
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.28, no.1, pp.41-46, 2002-02-10 (Released:2011-03-04)
参考文献数
6

Hospital pharmaceutical preparations (HPP) are used in patients whose complications are not well controlled by the commercially available drugs or injections. The use of HPP is effective when HPP are proposed through clinical pharmacy services. A questionnaire was developed to evaluate the use of HPP and then was sent to 49 hospital pharmacies who belong to the Hokkaido Association for Hospital Pharmaceuticals.As a result, 32 institutions replied to questionnaire, thus indicating a recovery rate of 65%. HPP, including mixtures of injectable drugs, were used at 30 out of 32 institutions. According to the questionnaires, 11 hospitals manufactured 24 HPP which were used during clinical pharmacy services. Half of these preparations were used to care for adverse symptoms, such as stomatitis, induced by the cancer chemotherapy.The use of HPP prepared by clinical pharmacy services is closely related to patient's symptoms. The practical use of HPP is not only considered to improve drug compliance and the QOL of patients, but are also thought to enhance the general capabilities of pharmacists in clinical pharmaceutical practice.
著者
高橋 信明 丹羽 倫平 中野 了輔 冨塚 一磨
出版者
公益社団法人 日本薬理学会
雑誌
日本薬理学雑誌 (ISSN:00155691)
巻号頁・発行日
vol.147, no.4, pp.235-240, 2016 (Released:2016-04-09)
参考文献数
33
被引用文献数
1

抗体は,現在では医薬品創出に欠かせないフォーマットとして確立し,幅広く認知されている.だが,一口に抗体医薬といっても,複数の要素技術が採用されており,複合的な技術の蓄積が今日の繁栄を支えている.開発初期には,マウスで取得した抗体の抗原性が問題となっていた.この課題を,マウスなどの異種の動物由来の抗体を部分的にヒト抗体配列に置き換える,キメラ抗体技術や,ヒト化抗体技術,さらには,ファージディスプレイ法やヒト抗体産生遺伝子改変マウスなどによりヒト抗体を取得する方法を開発することにより克服してきた.一方,ADCC活性などの抗体本来の機能をさらに高めるポテリジェント(Potelligent®)技術や,新規機能を付加したバイスペシフィック抗体技術などを搭載した抗体薬品の臨床試験が進んでおり,徐々に上市され始めている.本レビューでは,現在までの抗体技術開発の経緯と将来の技術開発の展望を解説する.
著者
呉 景龍 古谷 慎平 楊 家家 高橋 智
出版者
一般社団法人 日本機械学会
雑誌
日本機械学会論文集C編 (ISSN:18848354)
巻号頁・発行日
vol.77, no.777, pp.2062-2070, 2011 (Released:2011-05-25)
参考文献数
10
被引用文献数
2 3

Driver safety is an important and often sensitive issue for seniors. Statistics show that the elderly are more likely than other drivers to receive traffic citations for failing to yield, turning improperly, and running red lights and stop signs all indications of decreased driving ability. Currently in Japan, half of the deceased in traffic accidents are elderly people. In present study, we focused on how the pedal placement affect on braking action in emergency. First, ten healthy young and ten elderly individuals were asked to perform a simple reaction experiment by foot. Then, the same subjects were instructed to complete a braking action experiment with different pedal placement condition. The results suggested that both simple reaction time and foot movement time of elderly subjects were significantly longer than that of young subjects. Moreover, the brake pedal force of elderly subjects was lower than that of young subjects. Thus, aging influenced both of simple reaction time and braking action in emergency. In addition, even the pedal placement changed characteristics of braking action of both young and elderly subjects, the most comfortable pedal placement of elderly subjects differed from young subjects.
著者
松元 亮治 高橋 博之
出版者
プラズマ・核融合学会
雑誌
プラズマ・核融合学会誌 (ISSN:09187928)
巻号頁・発行日
vol.89, no.12, pp.864-867, 2013-12

X線天文衛星やガンマ線望遠鏡等による観測を通して,突発的なX線・ガンマ線増光を示す天体が多数発見されてきた.これらのフレア現象では,太陽フレアに類似した天体表面で発生する磁気エネルギー解放に加えて,中心天体の周りに形成される降着円盤および降着円盤コロナ,中心天体近傍から噴出するジェット・アウトフロー中での磁気エネルギー解放と粒子加速が寄与していると考えられている.ブラックホール近傍から噴出するジェットやパルサー風では電磁エネルギーをいかにして熱エネルギーや運動エネルギーに変換するかが問題となっており,その機構として磁気リコネクションによる磁気エネルギー散逸が候補になっている.高エネルギー宇宙物理学分野は相対論的な磁気リコネクションおよび粒子加速の理論・シミュレーション研究と観測・実験の連携を通して急進展が期待される分野であり,100年来の課題である宇宙線加速機構の研究も新たな段階に入りつつある.
著者
中江 裕里 高橋 俊彦 宮部 雅幸 並木 昭義
出版者
THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA
雑誌
日本臨床麻酔学会誌 (ISSN:02854945)
巻号頁・発行日
vol.13, no.2, pp.189-192, 1993-03-15 (Released:2008-12-11)
参考文献数
15

軽度の耳下腺腫脹と著明な血清アミラーゼ値の上昇により術後耳下腺炎と診断された症例を経験した.耳下腺の腫脹は手術後1日目から6日間持続したが,炎症症状を欠き,局部の冷却湿布と通常の上腹部手術術後管理に準じた抗生剤および輸液管理により軽快した.耳下腺腫脹の原因としては手術中のバツキングによる腹圧上昇,気管内チューブによる咽頭反射の亢進による唾液腺の静脈うっ血に起因する耳下腺管の閉塞が考えられた.術後耳下腺炎はまれな合併症であるが,日常の麻酔管理における操作が原因となりうることを常に銘記すべきと思われた.
著者
今木 雅英 三好 保 藤井 正信 小島 俊男 多田 敏子 勢井 雅子 高橋 仁 山崎 亮治 藤田 久雄 大木元 繁 石本 寛子 伊藤 里美
出版者
The Japanese Society for Hygiene
雑誌
日本衛生学雑誌 (ISSN:00215082)
巻号頁・発行日
vol.46, no.4, pp.905-912, 1991-10-15 (Released:2009-02-17)
参考文献数
13
被引用文献数
2 2

The digestibilities of nutrients and energy in Shiitke mushrooms (Lentinus edodes) was measured in healthy adult males. A test diet was given for 5 days after 5 days on a basal diet which supplied 40g/day of protein and 45kcal/kg/day of energy. The test diet was identical with the basal diet except that shiitake was incorporated. Digestibility was calculated by the difference of fecal output between the test period and the basal period. The results obtained were follows:1. Shiitake 60g/day intake levelDigestibility of protein was 69.3±11.2%.Digestibility of fat was 66.6±24.9%.Digestibility of carbohydrate was 55.7±10.5%.The ratio of the total available energy to intake energy (Net Energy Availability) was 55.4±15.4%.2. Shiitake 40g/day intake levelDigestibility of protein was 85.5±23.8%.Digestibility of fat was 70.0±90.1%.Digestibility of carbohydrate was 65.8±13.1%.The ratio of the total available energy to intake energy (Net Energy Availability) was 67.4±25.9%.
著者
高橋 春成
出版者
The Association of Japanese Geographers
雑誌
地理学評論 (ISSN:00167444)
巻号頁・発行日
vol.52, no.11, pp.635-642, 1979-11-01 (Released:2008-12-24)
参考文献数
15
被引用文献数
3 1

The Japanese black bear (Selenarctos thibetanus japonicus) is a representative large wild mammal which has had close relations with the life of the Japanese. The animal has been an object of hunting from ancient times, because it is believed to have certain medicinal value. However, few studies have been done on the ecology of the Japanese black bear, or on its habitat distribution, both of which may be much affected by changes in man's life style. The purpose of this study is to ascertain primarily changes in the distribution of the Japanese black bear in the West Chugoku Mountains since the Taisho era (1912_??_1926). The location, which remained uninvestigated until this study, marks the western fringe of the animal's habitat in Japan. The findings are as follows: 1) From the Taisho era to early Showa (1926_??_1944), the Japanese black bear maintained its habitat in virgin broadleaf deciduous forests containing beeches (Fagus crenata Blume), horse chestnuts (Aesculus turbinata Blume), varieties of Japanese oaks (Quercus mongolica Fischer var. grosseserrata Rehd, et Wils; Quercus serrata Thunb), etc. Such forests supplied Japanese black bear's food (nuts, berries, buds, leaves, stalks, etc.) as well as provided tree hollows for hibernation. Thus, the bears seldom appeared in villages. At that time, the Japanese black bear commanded good prices mainly as material for medicine, and its hunting constituted one of the important side jobs in the winter season. 2) From around 1960, the virgin broadleaf deciduous trees have been replaced by Japanese cedar trees (Cryptomeria japonica D. Don) through afforestation. As a result, Japanese black bears, losing source of food and places for hibernation, have been driven out of their former habitat. They have thus started to hibernate in the vicinity of villages, or damaging crops and becoming a nuisance to the villagers. After World War II, hunting for Japanese black bears has declined due to the increased availability of synthetic medicine, but in contrast hunting for ellmination has increased.
著者
高原 健 難波 倫子 高橋 篤史 畑中 雅喜 山本 毅士 竹治 正展 山内 淳
出版者
一般社団法人 日本透析医学会
雑誌
日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy (ISSN:13403451)
巻号頁・発行日
vol.41, no.6, pp.371-376, 2008-06-28
参考文献数
16
被引用文献数
1

【目的】抗好中球細胞質抗体(ANCA)関連血管炎におけるびまん性肺出血合併例の予後は一般的に不良である.強力な免疫抑制療法が推奨されているが,感染症による死亡が多くみられることから,免疫抑制の程度についてはなお明確な基準はない.肺出血合併ANCA関連血管炎に対し,免疫抑制薬を使用することなく,ステロイド治療に血漿交換(PE)を併用し,その有用性について検討した.【方法】過去10年間に当院で経験したMPO-ANCA型急速進行性腎炎22例中,肺出血を合併した7例(男性2例)を対象とした.全例にPEを施行し,肺出血が改善するまで継続した.全例にステロイドパルスおよび後療法としてステロイド内服治療を行った.【結果】平均年齢は72±9歳,入院時MPO-ANCA titer 569±581EU,血清Cr 5.7±3.3mg/dL,観察期間は34±22か月であった.肺出血の初期症状として全例に血痰があり,低酸素血症を伴う強い呼吸困難,急激な貧血の進行,胸部CTにてびまん性間質影を認めた.3例に人工呼吸管理を要した.血痰出現から血漿交換開始までの期間は2.9±2.0日,平均3.5±1.3回のPEを行った.肺出血は全例治癒し,退院時に人工呼吸や酸素吸入を要する例はなかった.入院時全例に腎機能障害を認め,腎生検を施行した2例はpauci-immune半月体形成性腎炎で,5例が透析を必要とした.そのうち3例は維持透析に移行したが,ほかの例では腎機能の改善を認めた.重篤な感染症は認めず,16か月後に誤嚥性肺炎で失った1例を除き全例生存中である.【まとめ】肺出血合併ANCA関連血管炎は予後不良とされているが,早期診断の上,PEとステロイドの併用療法により予後を改善させ得ると考えられる.
著者
西田 睦 昆 健志 高橋 そよ 羽賀 史浩 殿岡 裕樹
出版者
特定非営利活動法人 産学連携学会
雑誌
産学連携学 (ISSN:13496913)
巻号頁・発行日
vol.15, no.1, pp.1_30-1_40, 2019

<p>昨今, 世界と日本社会は大きくかつ急速に変化しつつあり,大学が社会で大きな役割を果たすことへの期待がますます大きくなっている.琉球大学は創立時から「地域の発展に貢献する」ことをミッションとしてきたが,期待に応えるためにさらに様々な取組を強化する必要がある.そのための一環として,本学にリサーチアドミニストレーター(URA)が導入された.このURAが所属する研究企画室は,案件によって様々な部署と柔軟に連携を取ることによって,少人数でも効果的な活動を実現してきた.本稿では,4年近くにわたって進めてきた研究企画室の活動を,学内外セクターとの連携強化の試みに焦点を当てて紹介する.</p>