文献一覧: 今井俊 (著者)

41 0 0 0 COVID-19ワクチン接種後に帯状疱疹を発症した8例

著者: 今井俊輔志水陽介吉田憲司石河晃
出版者: 公益社団法人日本皮膚科学会
雑誌: 日本皮膚科学会雑誌 (ISSN:0021499X)
巻号頁・発行日: vol.132, no.3, pp.487-490, 2022-03-20 (Released:2022-03-22)
参考文献数: 17

Pfizer/Modernaコロナワクチン接種後に帯状疱疹を発症した症例の論文報告は海外で散見されるが本邦では未だない.今回我々は症例を8例経験した.平均年齢66.5歳,男女比1:3と女性に多く,37.5%が初回投与から2回目接種までの間に発症.接種後発症までの日数は8.75日だった.また,帯状疱疹患者数も昨年と比し増加傾向であることが判明した.コロナ禍において帯状疱疹の診断にあたり,コロナワクチン接種日を記録し,症状を記載しておくことが今回の後向き調査を可能にすると考え,皮膚科医に向けて速報的な報告を行った.

2023-04-09 07:18:07
41 + 108 Twitter

34 0 0 0 OA 薬局薬剤師を対象としたメディアによる「くすりの危険性」に関する報道に起因する患者からの相談応需の実態調査

著者: 今井俊吾阿部真也松井洸柏木仁佐藤夕紀武隈洋吉町昌子菅原満
出版者: 一般社団法人日本医薬品情報学会
雑誌: 医薬品情報学 (ISSN:13451464)
巻号頁・発行日: vol.24, no.2, pp.75-87, 2022-08-31 (Released:2022-10-11)
参考文献数: 17

Objective: In our previous study, we revealed that articles on "dangerous drugs" in weekly magazines are inadequate and incomplete with respect to scientific validity, and that there may be many aspects that need to be improved. Next, the extent to which medical professionals, including doctors, pharmacists, and nurses, received consultations by patients owing to such media reports and what countermeasures are implemented requires clarification. In the present study, as a first step, we performed a questionnaire survey of community pharmacists to clarify the occurrence of such consultations.Methods: A questionnaire survey was conducted among 698 community pharmacists. The survey was conducted over 10 days from December 8 to 17, 2021.Results: Out of the 698 community pharmacists, 545 responded (response rate: 78.1%). Of these, 323 (59.3%) had experienced consultations from patients owing to media reports on the dangers of drugs. Of the 323 respondents, 215 (66.6%) had experienced these consultations less than five times. In contrast, 83 respondents (25.7%) reported more than 10 such consultations. Of the 545 respondents, 190 (34.9%) responded that they routinely perform measures to deal with media reports on the dangers of drugs. The most common routine measure was the "regular checking of various media sources (including preparation of responses when receiving consultation requests)."Conclusion: Our results indicated that more than half of the community pharmacists had experienced receiving consultations from patients, although only approximately 30% were adopting routine measures. This suggests that community pharmacists have been affected to some extent by these media reports, and that further countermeasures need to be implemented.

2023-09-11 18:21:41
34 + 80 Twitter

17 0 0 0 OA 豊胸術後に発生した乳癌の3例

著者: 塩見尚礼近藤雄二小道広隆片野智子宮沢一博原田佐智夫稲葉征四郎上田泰章今井俊介
出版者: Japan Surgical Association
雑誌: 日本臨床外科医学会雑誌 (ISSN:03869776)
巻号頁・発行日: vol.57, no.7, pp.1592-1596, 1996-07-25 (Released:2009-02-10)
参考文献数: 6

豊胸術後に発生した稀な乳癌の3例を経験した.症例1は43歳の女性.豊胸術後11年目に外傷にてシリコンバッグ破裂.以来乳腺腫瘤の生検を繰り返され, 3年後に乳癌と診断され,左Brp+Ax,広背筋皮弁移植を行った.症例2は56歳の女性,豊胸術後24年目に右腋窩リンパ節腫脹を認め,自潰してきたため当院受診.多発性骨転移を認める進行例であった.術前化学療法を行った後両側Brt-Axを施行した.症例3は66歳の女性.豊胸術後28年目に左乳房緊張感を主訴に受診.腫瘍摘出術にて乳癌と診断されBrt+Axを施行した.豊胸術後の乳癌は本邦では1970年以来37例の論文報告をみるに過ぎず.稀な疾患である.自験例3例を含め,文献的考察を加えて報告した.

2019-07-14 22:58:35
17 + 13 Twitter

16 0 0 0 OA 週刊誌に掲載された「危ないクスリ」に関する情報の整理とその適切性評価

著者: 今井俊吾柏木仁佐藤夕紀武隈洋菅原満
出版者: 一般社団法人日本医薬品情報学会
雑誌: 医薬品情報学 (ISSN:13451464)
巻号頁・発行日: vol.24, no.1, pp.1-10, 2022-05-31 (Released:2022-06-11)
参考文献数: 11
被引用文献数: 1

Objective: Recently, special features on “dangerous” prescription drugs have been frequently published in few mass media platforms, such as weekly magazines. However, to our knowledge, there have been no prior studies, systematically organizing and evaluating the contents of these articles (e.g., drugs and their side effects that are reported). In this study, we aimed to evaluate the relevance of the information on “dangerous drugs” that was published in weekly magazines using the modified “Media Doctor” instrument.Methods: We extracted articles on “dangerous” prescription drugs from 10 weekly magazines for which the table of contents of previous issues are available on their official websites. Information regarding the target drugs and their classifications was compiled and organized. The relevance of the extracted news articles was assessed by two independent evaluators. The evaluation index was based on the modified “Media Doctor” instrument, and 9 evaluation criteria were used to assign the following categories: satisfactory, unsatisfactory, or not applicable.Results: A total of 1,064 articles were screened, and 19 articles were selected for further evaluation. A total of 179 drugs (belonging to 34 drug classes) were listed. The most frequently mentioned class of drugs included hypnotics and sedatives, and the most frequently listed was triazolam. Of the 19 articles, 11 had zero items that were judged satisfactory by both the evaluators. The number of unsatisfactory items was widely distributed, but in 11 of the 19 articles, five and more items were judged unsatisfactory by both the evaluators.Conclusion: We revealed that a wide variety of drugs have been termed as “dangerous” by weekly magazines. Additionally, we found that these articles were inadequate and incomplete with respect to scientific validity, and that there are many aspects that require further improvement.

2023-11-03 11:41:31
16 + 36 Twitter

5 0 0 0 OA 血液培養陽性例への抗菌薬使用に関する積極的介入は患者アウトカムの改善に貢献する ~Antimicrobial stewardshipの実践とその効果~

著者: 山田武宏鏡圭介今井俊吾秋沢宏次岩崎澄央福元達也石黒信久井関健
出版者: 公益社団法人日本薬学会
雑誌: YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日: vol.137, no.7, pp.917-925, 2017 (Released:2017-07-01)
参考文献数: 16
被引用文献数: 3

Bacteremia is one of the most serious infectious illness resulting from nosocomial infection. Therefore, appropriate antimicrobial chemotherapy should be provided as soon as possible to patients exhibiting symptoms of infectious disease and having positive blood culture results. Antimicrobial stewardship (AS) guidelines were recently released by the Infectious Diseases Society of America. The guidelines recommend “proactive intervention and feedback” as one of the core strategies for implementing optimal antimicrobial drug use to improve patient outcomes in clinical settings. We began using the AS program for optimizing antimicrobial chemotherapy in patients with positive blood culture results. The results of blood cultures and antimicrobial prescriptions for the corresponding patients were daily reviewed by a pharmacist and a physician, members of the infection control team (ICT). If the antimicrobial agents selected were inappropriate, ICT made a recommendation to the attending physicians who prescribed the antibiotics. To evaluate the outcomes of this program, we conducted a single-center, retrospective investigation for near a hundred of patients who underwent intervention by infection-control physician and pharmacist. Resolution of bacteremia (determined by blood culture results) was 96.3% in the group that accepted intervention, whereas only 16.7% of the cases resolved in the group that did not accept intervention. These results strongly suggest the importance of the infection disease-specialist team intervention. This program could become an important method for improving clinical outcomes in patients with bacteremia.

2017-07-05 23:04:06
5 + 17 Twitter

4 0 0 0 薬局薬剤師による「患者への聞き取り」に基づいて実施された疑義照会の実態解明と医療安全への貢献度評価

著者: 今井俊吾難波正志柏木仁佐藤夕紀武隈洋菅原満
出版者: 一般社団法人日本薬局学会
雑誌: 薬局薬学 (ISSN:18843077)
巻号頁・発行日: pp.nt.2020-0025, (Released:2021-03-10)
参考文献数: 10

薬剤師は安全な薬物療法の提供のために,患者から必要な情報を「聞き取る」ことが重要である.しかし,薬局薬剤師の「聞き取り」に対し,一部の一般市民は厳しい視線を投げかけており,患者の理解を促すためのエビデンス構築が急務である.本研究は「患者への聞き取り」に基づき実施された疑義照会に着目し,その実態解明と医療安全への貢献度評価を試みた.解析には北海道大学病院の近隣薬局の疑義照会データを用いた.その結果,聞き取りに基づく疑義照会は「薬学的疑義照会の 33.3%を占め,高い許諾割合(98.5%)を有し,用法や用量などの疑義照会分類において,医療安全への貢献度が高い」ことが見いだされた.また,このうち「医師からの説明と処方内容が食い違う」ことが発端となった事例が,特に医療安全へ貢献していることが示された.「患者への聞き取り」に基づく疑義照会の有用性を広く調査するための基礎となる知見が創出された.

2023-09-27 13:16:40
4 + 23 Twitter

3 0 0 0 OA 2種のバンコマイシンTDM解析ソフトの予測性に関する比較検討

著者: 今井俊吾山田武宏西村あや子沖洋充熊井正貴宮本剛典笠師久美子井関健
出版者: Japanese Society of Drug Informatics
雑誌: 医薬品情報学 (ISSN:13451464)
巻号頁・発行日: vol.16, no.4, pp.169-178, 2015 (Released:2015-03-10)
参考文献数: 13

Objective: To attain optimal blood concentration rapidly, it is needed to perform initial dose setting appropriately when vancomycin (VCM) used. In order to design initial dose settings of VCM more currently, we compared the predictive performance of two types of VCM therapeutic drug monitoring (TDM) analysis software retrospectively.Method: We utilized two TDM analysis software, SHIONOGI-VCM-TDM ver.2009 (VCM-TDM) and “Vancomycin MEEK TDM analysis software Ver. 2.0” (MEEK), based on patient’s background. 112 patients who received VCM and performed TDM were analyzed during the period from October 2011 through September 2012 and compared the actual trough level with the predictive trough level. The predictive performance was evaluated by calculating ME (mean prediction error), MAE (mean absolute prediction error), and RMSE (root mean squared error). Age, gender, and a renal function were evaluated as patient’s background.Results: VCM-TDM gave good predictive performance for patients overall. When classified patient’s background complexly (sex, age, and renal function), as for male patients, VCM-TDM showed good predictive performance except for the group over 65 years old and CCr over 85 mL/min. For female patients, the difference of predictive performance was not accepted by all groups.Conclusion: These results suggest, for male patients, we should use VCM-TDM for initial dose settings except for the group over 65 years old and over CCr 85 mL/min. For the other patients, we consider that both of software can be used. These new findings seem to contribute to proper dosage settings of VCM.

2022-05-26 23:07:47
3 + 6 Twitter

2 0 0 0 OA 下顎埋伏智歯抜歯術におけるセフカペンピボキシルとアモキシシリンの手術部位感染予防効果の比較

著者: 山神彰山田武宏北川善政大廣洋一佐藤淳石黒信久今井俊吾小林正紀井関健
出版者: 一般社団法人日本医療薬学会
雑誌: 医療薬学 (ISSN:1346342X)
巻号頁・発行日: vol.45, no.5, pp.254-261, 2019-05-10 (Released:2020-05-10)
参考文献数: 20
被引用文献数: 2 4

Third-generation oral cephalosporins are broad-spectrum antimicrobial agents and constitute one of the most used antibiotic classes in Japan. In the “National Action Plan on Antimicrobial Resistance (AMR),” the Japanese government declared implementation of efforts to reduce the use of oral cephalosporins by 50% by 2020, compared to 2013. Antimicrobial resistance generally occurs due to inappropriate use or low-dosage exposure to antibiotic agents. Therefore, the choice of appropriate antibiotics is essential for implementing antimicrobial stewardship. To evaluate the prophylactic effects of antibiotics in impacted mandibular third molar surgery, we compared the rate of surgical site infection (SSI) in patients who were administered cefcapene-pivoxil (CFPN-PI) orally with that in patients who received amoxicillin (AMPC) orally. We conducted a retrospective study by reviewing the medical charts of patients from Hokkaido University Hospital from April 2016 to March 2017. The patients evaluated were classified into two groups: the AMPC group (n = 164) and the CFPN-PI group (n = 129). The SSI ratio of the CFPN-PI group was significantly higher than that of the AMPC group (CFPN-PI group, 11.6% (15/129); AMPC group, 2.4% (4/164); P = 0.002). Multivariate logistic regression analysis demonstrated that “use of CFPN-PI for prophylactic treatment” and “hospitalization after surgery” were independent factors related to the onset of SSI following impacted mandibular third molar surgery. These results demonstrated that AMPC was more effective than CFPN-PI in the prevention of SSI after impacted mandibular third molar surgery, and its regulated dosage can effectively contribute to the optimal use of antimicrobial prophylactic treatment.

2022-12-23 14:42:09
2 + 34 Twitter

2 0 0 0 OA フラクタルカインと炎症性疾患

著者: 今井俊夫西村美由希南木敏宏梅原久範
出版者: 日本臨床免疫学会
雑誌: 日本臨床免疫学会会誌 (ISSN:09114300)
巻号頁・発行日: vol.28, no.3, pp.131-139, 2005 (Released:2005-06-30)
参考文献数: 54
被引用文献数: 9 12

炎症や免疫反応は生体局所で生じることから明らかなように,免疫細胞の時空間的局在は緻密に制御されている.免疫細胞は細胞接着分子と細胞遊走因子を巧みに利用して,炎症部位やリンパ組織に到達する.フラクタルカイン/CX3CL1は,ケモカインと細胞接着分子の2つの活性を併せ持ち,活性化血管内皮細胞上に発現する細胞膜結合型ケモカインである.その受容体CX3CR1は,NK細胞やcytotoxic effector T細胞(TCE)などの細胞傷害性リンパ球と成熟マクロファージや粘膜樹状細胞などの病原体や異常な細胞の排除に深く関わる免疫細胞に発現している.最近の臨床病態やマウス疾患モデルでの研究から,フラクタルカインは,関節リウマチや粥状動脈硬化症などの慢性炎症疾患にも深く関与していることが示唆されている.本稿では,フラクタルカインの特徴的な機能と炎症疾患における役割について概説する.

2021-06-28 20:57:03
2 + 5 Twitter

2 0 0 0 OA CA125およびTPA産生性卵巣漿液性嚢胞腺癌培養株の樹立とその性状

著者: 清塚康彦今井俊介野田恒夫森本純司森山郁子一條元彦螺良義彦
出版者: 特定非営利活動法人日本臨床細胞学会
雑誌: 日本臨床細胞学会雑誌 (ISSN:03871193)
巻号頁・発行日: vol.27, no.6, pp.926-935, 1988-11-22
被引用文献数: 1

2014-03-16 04:00:10
2 + 0 Twitter

https://ci.nii.ac.jp/naid/110001282975

1 0 0 0 OA レンバチニブ及び放射線治療後の再肝切除による集学的治療が奏功した門脈腫瘍栓を伴う早期再発肝細胞癌の1例

著者: 神雄太西山亮小金井雄太木村大輝青山純也中野容今井俊一下河原達也山田暢江川智久
出版者: 一般社団法人日本肝臓学会
雑誌: 肝臓 (ISSN:04514203)
巻号頁・発行日: vol.64, no.12, pp.641-648, 2023-12-01 (Released:2023-12-11)
参考文献数: 25

50代男性.未治療B型慢性肝炎の既往があり,人間ドックで肝腫瘤を指摘され,精査の結果肝細胞癌(Hepatocellular carcinoma:HCC)の診断に至った.病変はS8に2カ所あり,開腹肝前区域切除を行い,病理組織診断でvp2を認めた.術後2カ月で施行した造影CT検査で門脈左枝に門脈腫瘍栓(Portal vein tumor thrombosis:PVTT)を認めた.術後早期再発したPVTTであり再肝切除後の再発のリスクが高いと考え,観察期間を設けるためLenvatinib(LEN)投与を開始した.PVTTは放射線定位照射したが,術後9カ月に肝右葉微小転移が指摘された.LEN投与下にPVTTと微小転移は増悪を認めず,AFP値が正常化したため,再発後11カ月で再肝切除を行った.その後,微小転移に対してサイバーナイフを施行し完全寛解した.現在,初回術後43カ月無再発生存中である.

2023-12-11 08:08:27
1 + 0 Twitter

1 0 0 0 OA 薬局薬剤師による「患者への聞き取り」に基づいて実施された疑義照会の実態解明と医療安全への貢献度評価

著者: 今井俊吾難波正志柏木仁佐藤夕紀武隈洋菅原満
出版者: 一般社団法人日本薬局学会
雑誌: 薬局薬学 (ISSN:18843077)
巻号頁・発行日: vol.13, no.1, pp.68-78, 2021 (Released:2021-04-27)
参考文献数: 10

2022-10-23 18:04:35
1 + 2 Twitter

1 0 0 0 OA Performance Status不良群におけるナルデメジンの有効性の検証

著者: 加藤信太郎齋藤佳敬小野田紘子熊井正貴今井俊吾敦賀健吉武隈洋菅原満
出版者: 公益社団法人日本薬学会
雑誌: YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日: vol.142, no.7, pp.755-760, 2022-07-01 (Released:2022-07-01)
参考文献数: 19
被引用文献数: 1

Naldemedine (Nal) is widely used as a therapeutic drug against opioid-induced constipation. However, patients in phase III trials are limited to those with good performance status (PS). Cancer patients may have inferior PS owing to progression of symptoms and adverse events from chemotherapy. Therefore, it is important to survey the efficacy of Nal in patients with poor PS. This study aimed to evaluate Nal efficacy in patients with poor PS. We retrospectively investigated patients from July 2017 to June 2019 and compared Nal efficacy between patients with good and poor PS. The efficacy of Nal was evaluated using changes in the number of spontaneous bowel movements 7 days before and after the introduction of Nal with reference to previous reports. Multivariate analysis was performed to reveal whether poor PS affects Nal efficacy. In total, 141 patients at the Hokkaido University Hospital were analyzed. The effective rate of Nal from day 1 to day 7 of administration was 71.7% and 71.4% in the patients with good and poor PS, respectively, that from day 1 to day 2 of administration was 61.1% and 57.1%, respectively, and that from day 3 to day 7 of administration was 60.2% and 71.4%, respectively, suggesting an absence of significant differences. Furthermore, results of multivariate analysis showed that “best supportive care” and “body weight (55 kg and above)” reduced Nal efficacy. In conclusion, Nal showed similar effectiveness in patients with poor PS as that in those with good PS.

2022-07-02 09:40:49
1 + 4 Twitter

1 0 0 0 OA リネゾリド投与患者における嘔吐発現の因果関係の検証

著者: 堤竹蔵今井俊吾山田勝久山田武宏笠師久美子小林正紀井関健
出版者: 公益社団法人日本薬学会
雑誌: YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日: vol.139, no.7, pp.1055-1061, 2019-07-01 (Released:2019-07-01)
参考文献数: 20
被引用文献数: 2

Linezolid (LZD), an antimicrobial agent against methicillin-resistant Staphylococcus aureus, demonstrates good bone and joint penetration, and is used for prosthetic bone and joint infections. Recently, we observed vomiting in several patients administered LZD. However, there are few reports on the incidence rate of, and risk factors for, LZD-induced nausea and vomiting. In this study, we aimed to verify the relationship between LZD administration and vomiting. Patients administered LZD at the Department of Orthopedic Surgery of Hokkaido University Hospital between November 2008 and December 2017 were enrolled in the study. The primary endpoint was the comparison of the vomiting rate between patients administered LZD (LZD group) and those administered other antibiotics (non-LZD group). For the secondary endpoint, to verify the risk factors of vomiting, a univariate logistic regression analysis was performed. In total, 130 patients were included in this study; 77 patients in the LZD group, and 53 in the non-LZD group. Vomiting occurred in 18 patients in the LZD group and 4 patients in the non-LZD group (23.4% and 7.5%, respectively); this was significantly higher in the LZD group. In the univariate logistic regression analysis, LZD administration, gender (female), age ≥65 years, renal impairment (creatinine clearance <60 mL/min) and concomitant use of rifampicin were extracted as potential risk factors of vomiting. The results of this study reveal a possible relationship between LZD administration and vomiting.

2019-07-01 23:11:25
1 + 1 Twitter

1 0 0 0 Zuckerラットの遺伝子型による血清生化学的/組織学的特性

著者: チョウヨンマン今井俊夫高見成昭西川秋佳
出版者: 日本毒性学会
雑誌: 日本トキシコロジー学会学術年会
巻号頁・発行日: vol.35, pp.178, 2008

【目的】Zucker fattyラットは突然変異レプチン受容体遺伝子faのホモ接合体(fa/fa)で、若齢期から著しい肥満を呈し、単純性肥満/糖尿病モデルとして用いられている。一方、ヘテロ接合体(Fa/fa)及び野生型(Fa/Fa)のZucker leanラットは肥満にならないことから、ホモ接合体の対照として用いられているが、その生理学的/解剖学的な違いについての詳細は明らかではない。今回、Zuckerラットが乳腺発がんモデルとして応用可能か否かを検討する目的で、各遺伝子型動物の血清生化学的検査及び肝臓/乳腺/脂肪組織の組織学的検査を実施した。【材料と方法】6-7週齢の各遺伝子型の雌ラットあるいは10%コーン油添加飼料で5週間飼育したFa/fa及びFa/Fa雌ラットを対象とした。【結果】血清総コレステロール、インスリン及びレプチン濃度は、Fa/fa及びFa/Faに比しfa/faでは有意に(p<0.05)高値を示した。中性脂肪及び血糖値には遺伝子型間の明らかな差はみられなかった。組織学的には、Fa/fa及びFa/Faに比しfa/faでは乳腺組織の発達が著しく乏しく、脂肪組織においては細胞肥大が認められた。Fa/faとFa/Faの比較において、基礎飼料飼育下では主な血清生化学値に明らかな差はみられなかったが、10%コーン油飼料を与えることにより、Fa/faではHDL-コレステロール値は僅かながら有意に(p<0.05)低下したのに対し、Fa/Faでは変化を示さなかった。Fa/fa及びFa/Faのいずれにおいても、コーン油を与えることによる肝臓/乳腺/脂肪組織の組織学的変化はみられなかった。【結論】fa/faは乳腺発がんモデルへの応用には適さないが、Fa/fa及びFa/Faは脂肪負荷により脂質代謝と乳腺発がんとの関連性を解析するモデルとしての応用が可能であることが示唆された。