著者

星屋 博子 山本 泰之 藤井 政志

出版者

The Society of Cosmetic Chemists of Japan

雑誌

日本化粧品技術者会誌 (ISSN:03875253)

巻号頁・発行日

vol.24, no.3, pp.193-201, 1991-03-30 (Released:2010-08-06)

被引用文献数

1 1

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The structure of eye and lashes is individual variations. Our evaluation and taste for mascara are greatly affected by that structure. It's necessary to make the system of conformity with individual eye and lashes, for the good choice of mascara.First of all, we checked up the structure of eye and lashes, such as the number, length and direction of eyelashes, the width of eye and so on. Next, we investigated the influence in sensory evaluation and taste for mascara caused by difference of structure. Lastly, we tried to correspond to different types of mascara.The result was that there are individual variations in the length and number of eyelashes rather than eye, no difference between men and women.Three major items as follows were important factors of the finishing and taste of mascara. They were “the length of eyelashes”, “the amount of eyelashes” and “the width of eye”, We could classify persons into seven groups according to these three items, who evaluated four types of mascara.In the usage test, we could select the best of four types of mascara for seven groups with different style in their eye and lashes.

著者

広常 正人

出版者

公益財団法人 日本醸造協会

雑誌

日本醸造協会誌 (ISSN:09147314)

巻号頁・発行日

vol.99, no.12, pp.836-841, 2004-12-15 (Released:2011-09-20)

参考文献数

15

被引用文献数

2 3

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清酒の美肌効果は日本酒をよく飲む相撲取の肌の張りや艶に現れていると言われている。 実際, 手の甲に垂れた清酒のひとしずくを摺り込むことによりなんとなくしっとりとした感じを受けるものである。 今回, これらの効果をもたらす物質が清酒中に特異的に存在し, この物質を酵素化学的に増強させる方法について解説していただいた。 今後, この物質についての機能性への注目度が高まり, 清酒の食品機能性の-つとしてクローズアップされるテーマと思われる。

著者

吉田 周 平井 規央 上田 昇平 石井 実

出版者

THE LEPIDOPTEROLOGICAL SOCIETY OF JAPAN

雑誌

蝶と蛾 (ISSN:00240974)

巻号頁・発行日

vol.70, no.3-4, pp.109-136, 2019-11-30 (Released:2019-12-20)

参考文献数

26

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Based on the label information of butterfly specimens collected in Kyoto Prefecture, Japan by Dr. Tadachika Minoura, the distribution of butterfly species in and around Kyoto City in the early Showa period (1930’s to 1950’s) was inferred and compared with the Red Lists of Kyoto Prefecture and the Ministry of the Environment. The specimens contained 63 species and 961 individuals collected at 50 sites in Kyoto Prefecture from 1904 to 1969, including 7 species listed in the Red List of Kyoto Prefecture 2015 or Ministry of the Environment 2018. In particular, it became clear that several species listed on the Red Lists such as Fabriciana nerippe and Eurema laeta were distributed in the Saga or Kinugasa areas, which are now an urban area. Thus Minoura’s collection was proved to an important means for inferring the butterfly fauna in and around Kyoto City in the early Showa period.

著者

林 慶一

出版者

公益社団法人 東京地学協会

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.105, no.6, pp.723-727, 1996-12-25 (Released:2009-11-12)

被引用文献数

1 2

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.41, no.10, pp.657-659, 2003-10-25 (Released:2009-05-25)

著者

Shungo Imai Yoh Takekuma Takayuki Miyai Mitsuru Sugawara

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.43, no.1, pp.188-193, 2020-01-01 (Released:2020-01-01)

参考文献数

18

被引用文献数

22

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This study aimed to construct an optimal algorithm for initial dose settings of vancomycin (VCM) using machine learning (ML) with decision tree (DT) analysis. Patients who were administered intravenous VCM and underwent therapeutic drug monitoring (TDM) at the Hokkaido University Hospital were enrolled. The study period was November 2011 to March 2019. In total, 654 patients were included in the study. Patients were divided into two groups, training (patients who received VCM from November 2011 to December 2017; n = 496) and testing (patients who received VCM from January 2018 to March 2019; n = 158) groups. For the training group, DT analysis of the classification and regression tree algorithm was performed to construct an algorithm (called DT algorithm) for the initial dose settings of VCM. For the testing group, the rates of attaining the VCM therapeutic range (trough value = 10–15 and 10–20 mg/L) with the DT algorithm and three conventional dose-setting methods were compared for model evaluation. The DT algorithm was constructed to be used for patients with estimated glomerular filtration rate ≥50 mL/min and body weight ≥40 kg. As a result, the recommended daily doses ranged from 20.0 to 58.1 mg/kg. In model evaluation, the DT algorithm obtained the highest rates of attaining the VCM therapeutic range compared to conventional dose-setting methods. Therefore, our DT algorithm can be applied to clinical practice. In addition, ML is useful for setting drug doses.

著者

Tokutaro Sato Masao Oouchi Hiroari Nagakubo Tooru Chiba Susumu Ogawa Chiharu Sato Kazuhiko Sugimura Motosi Fukuda

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.185, no.1, pp.25-29, 1998 (Released:2005-12-16)

参考文献数

17

被引用文献数

4 4

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Hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) is a common intermediate metabolite of cholesterol synthesis and ketone formation in the liver. In order to study the effect of HMG-CoA reductase inhibitor (pravastatin) on ketone formation, changes in the plasma levels of ketone bodies by treatment with pravastatin were studied in 18 non-insulin dependent diabetics with hypercholesterolemia. Body mass index, diabetic control, and plasma free fatty acid levels were not changed during the study, and the plasma levels of cholesterol decreased significantly from 250±25 to 211±34 mg/100 ml after 6 months of pravastatin treatment. The plasma levels of acetoacetic acid also significantly decreased from 37.7±22.6 to 28.4±13.4 μmol/l, and those of 3-hydroxybutyric acid and total ketone bodies also tended to decrease after pravastatin treatment. These results suggest that pravastatin decreases ketone formation in hepatic mitochondria besides cholesterol synthesis in hepatic microsome.

著者

Gwyneth MILBRATH Audrey SNYDER Marcus MARTIN

出版者

Disaster Nursing Global Leader Degree Program

雑誌

Health Emergency and Disaster Nursing (ISSN:21882053)

巻号頁・発行日

pp.2018-0008, (Released:2019-10-31)

参考文献数

12

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Aim: Disaster preparedness education is one approach to improving the preparedness of the health and public sector work force. The purpose of this report is to describe one approach to improving disaster preparedness for nurses and other health professionals through the unique opportunities available through academic study abroad. This report will describe the process of developing, approving, and implementing a disaster preparedness course in Saint Kitts and Nevis as a model for other programs.Methods: This case report was written based on the experiences of the authors who have together developed and implemented an interdisciplinary study abroad program in disaster preparedness and global health at three different institutions. Common strategies and barriers are described to model and encourage others to produce similar programs in other locations.Results: The major steps involved in creating a disaster preparedness study abroad program are selecting an international partner, developing course curriculum, writing a course program proposal, recruiting students, and maintaining international partnerships. As an example, the program in Saint Kitts and Nevis is described and incorporates learning strategies, including guest lectures, applied activities, service learning, cultural experiences, and simulation activities.Conclusion: This case report provides an example of how to propose, develop, and implement a study abroad course in disaster preparedness. As disaster preparedness, response, and management is a multidisciplinary field, early exposure to diverse training and knowledge in a new environment can prepare nurses and professionals from other disciplines to contribute to a culture of disaster preparedness both in their chosen communities and across the globe.

著者

森本 康彦

出版者

一般社団法人 CIEC

雑誌

コンピュータ&エデュケーション (ISSN:21862168)

巻号頁・発行日

vol.38, pp.18-27, 2015-06-01 (Released:2015-12-01)

被引用文献数

1

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高等教育機関を中心に,教育の質保証・質向上の実現のためにeポートフォリオが急速に導入され,初等中等教育においても,学びの過程で生成される児童生徒の学習記録をICT機器を用いて蓄積し,いわゆるeポートフォリオとして学習指導や学習評価に活かそうとする取り組みが始まっている。一方,学習行動ログやICTの操作ログなどの学習履歴データを分析・可視化するラーニングアナリティクスが注目を集めている。しかし,ラーニングアナリティクスにおいて,どんな意味のある有用なデータをeポートフォリオとして蓄積・分析し,学習者にどのように提示すべきかなどの教育的観点からの議論は十分にされていない。そこで,本論文では,eポートフォリオを活用した学習におけるラーニングアナリティクスについて明らかにする。さらに,教育ビッグデータのあり方について言及するとともに,教育ビッグデータに対応した新時代のeポートフォリオシステムのコンセプトである「eポートフォリオ2.0」について説明する。

著者

西 和夫

出版者

一般社団法人 日本建築学会

雑誌

日本建築学会論文報告集 (ISSN:03871185)

巻号頁・発行日

vol.260, pp.137-144, 1977-10-30 (Released:2017-08-22)

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Early in Edo period in Hamamatsu, there were some carpenters named Hamamatsu-toryo. Some of them worked in Edo and emploied later by the Tokugawa Shogunate. The main contents of this paper is as follows. 1. Hamamatsu-toryo, early in Edo period.-Sato, Sugiura, Kuwabara, Tsuzuki, Watanabe and Asahara. 2. Daikugashira, the master carpenter in Hamamatsu, Den-e-mon Sugiura. 3. Asahara family.-family history, family tree. 4. Hamamatsu-toryo and Sakujikata-Daikutoryo, carpenters in the organization of the Tokugawa Shogunate.

著者

天野 尹

出版者

一般社団法人 日本輸血・細胞治療学会

雑誌

日本輸血学会雑誌 (ISSN:05461448)

巻号頁・発行日

vol.29, no.6, pp.597-606, 1984 (Released:2010-03-12)

参考文献数

8

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The term of 37 years, from 1925 to 1961, could be divided into five periods. The first corresponds to one with a stable and high birth rate, the second to that of Japan-China War, the third to that of World War II, the fourth to that of postwar with its rapid drop in birth rate and the fifth to that with a low birth rate since then. This classification of period shows the change of historical conditions of Japan.The materials for the test of homogeneity were prepared from random sample from the cards of the registered donors in Shimane, Yamaguchi, Akita and Iwate Prefectures and Bernstein's method was applied to estimate the gene frequencies (p: gene of A, q: gene of B, r: gene of O).The results of the test of homogeneity between each period could be expressed as follows: in Shimane Prefecture; q in the third period decreased, in Akita Prefecture; q in the third peroid decreased, in Yamaguchi Prefecture; p in the fourth period increased and in Iwate Prefecture, q in the latter half of the fifth period decreased.The effect of hybridisation, areal biased donation, immigration and inbreeding must be considered as possible factors in the change of gene frequency.There is very little hybridisation in Japan and is not relevant here.Areal biased donation which means an increase or a decrease of coming donors from particular districts was demonstrated in the survey of Shimane blood center, and in the population size of the blood center level this biased donation shows no significant change of gene frequency.An assumption of 4% immigration, from Akita to Shimane Prefecture, revealed no change of gene frequency, but when immigration amounted to 10% in two or more years the test verified that there is a significant change in the distribution of gene frequency. But such an excessive immigration is not the real condition in prefectures of country-side.If there is an effect of inbreeding, there must be a significant difference of p2, q2 and r2 between the first period and the fifth period, since the fifth period corresponds to the second generation of the first period. But the results of these computations were not significant in any of the four prefectures. The change of previously mentioned social and historical conditions have led to decrease of the number of birth, the fractionising of population, the temporary isolation of inhabitans and then subsequent relaease of fractionising and isolation. The consequence of these changes is the so called “bottle-neck effect”.In countries of the world where a high frequency of hybridisation takes place the results such as mentioned here would be difficult to obtain.

著者

小坂 信生

出版者

社団法人 日本泌尿器科学会

雑誌

日本泌尿器科學會雑誌 (ISSN:00215287)

巻号頁・発行日

vol.50, no.12, pp.1227-1253, 1959-12-20 (Released:2010-07-23)

参考文献数

98

著者

赤司 和昭 中村 泰治 伊從 慶太 大隅 尊史

出版者

日本獣医皮膚科学会

雑誌

獣医臨床皮膚科 (ISSN:13476416)

巻号頁・発行日

vol.25, no.4, pp.217-220, 2019 (Released:2019-12-27)

参考文献数

16

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ベンガル,1歳1ヶ月齢,未去勢雄が,8ヶ月前から継続する両耳の耳垢蓄積および瘙痒を主訴に来院した。耳垢の直接鏡検でDemodex catiに形態学的に合致するニキビダニの生存虫体が多数検出された。その他の皮膚に症状は認めなかった。10%イミダクロプリド/1%モキシデクチン製剤0.8 mlを2週間毎,計4回背部に塗布したが,ニキビダニは消失しなかった。その後,フルララネル製剤(約41 mg/kg)を単回経口投与したところ,投与39日目後に症状の改善およびニキビダニの陰転を認めた。

著者

吹田 浩

出版者

一般社団法人 日本オリエント学会

雑誌

オリエント (ISSN:00305219)

巻号頁・発行日

vol.41, no.2, pp.166-180, 1998 (Released:2010-03-12)

著者

井手口 彰典

出版者

The Japanese Association for the Study of Popular Music

雑誌

ポピュラー音楽研究 (ISSN:13439251)

巻号頁・発行日

vol.8, pp.3-16, 2004-12-28 (Released:2009-10-29)

参考文献数

22

被引用文献数

1

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筆者の考えによれば、いわゆる「ストリートミュージシャン」という言葉によって示される対象は、特に90年代後半からの日本において大きく変質してきている。旧来的には当然であった「芸を演じる」という感覚を持ち合わせない者たちが出現しているのだ。しかしそのような変質に着目する研究的視点は未だ少なく、旧来的なストリートミュージシャン像との間に混乱をきたしている。本論文は、近年現れた「非-芸人」とでも呼びうる新たなストリートミュージシャンを、特に他者との関係性から分析し、旧来的なものとは区分して捉える重要性を提言する。またそのような異質なストリートミュージシャンたちが現れてきた背景を明らかにし、その活動が生み出される機制を考察する。

著者

野田 幸裕名 鍋島 俊隆 毛利 彰宏

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.130, no.2, pp.117-123, 2007 (Released:2007-08-10)

参考文献数

48

被引用文献数

1 1

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非競合的N-methyl-D-aspartate(NMDA)受容体拮抗薬であるフェンシクリジン(PCP)の乱用者は,統合失調症と類似した精神症状(PCP精神病)を惹起することから,統合失調症にはグルタミン酸作動性神経の機能低下が関係しているという「グルタミン酸作動性神経系機能低下仮説」が提唱された.PCPは単回で投与した場合には一過性の多様な薬理効果を示すが,連続投与した場合は,依存患者が摂取を中止した後も,その精神症状が数週間持続する様に,動物モデルでも行動変化が持続する.例えばPCPをマウスに連続投与すると休薬後において運動過多が増強(自発性障害:陽性症状様作用)され,強制水泳ストレスによる無動状態が増強(意欲低下の増強:陰性症状様作用)され,水探索試験における潜在学習や恐怖条件づけ試験における連合学習が障害(認知機能障害)される.このモデル動物を用いた研究により,統合失調症の病態解明,新規治療薬の開発につながることが期待されている.

著者

五賀 友継 松尾 牧則

出版者

日本武道学会

雑誌

武道学研究 (ISSN:02879700)

巻号頁・発行日

vol.51, no.2, pp.89-99, 2018-12-28 (Released:2019-12-28)

参考文献数

54

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The aim of this study was to consider the influence of “Medical Research on Kyudo”, which was conducted by surgeons in Tokyo Provisional First Army Hospital from 1939 to 1941, and which subsequently lead to the dissolution of Kyudoyosoku. This research also looks to clarify the sequence of events during that period from historical records, research contents, and the reaction of archers after the publication of “Medical Research on Kyudo”. The results can be summarized as follows:1) Kyudo was adopted at the Tokyo Provisional First Army Hospital in 1939 as part of a rehabilitation program for disabled veterans with the aim of not only restoring military spirit, but also improving body posture.2) Following the adoption of kyudo, Tokyo Provisional First Army Hospital began the “Medical Research on Kyudo” project to select the most suitable kyudo forms to aid rehabilitation. Impact on the lungs and spinal cord were examined by radiographing the chest of the archers while performing the techniques of chukan-uchiokoshi and shomen-uchiokoshi. The research concluded that skeletal deformity and chest muscle distortion could occur with the chukan-uchiokoshi style. Moreover, the research assumed that incorrect lung position could trigger the risk of pleural inflammation and several diseases with chukan-uchiokoshi, but not with shomen-uchiokoshi.3) The results of the research study were widely publicized in kyudo and budo magazines, medical academic papers, newspapers and presentations not only for the kyudo archers, but also for the general public. This widespread dissemination of information also lead to the criticism of Kyudoyosoku from outside the kyudo field. This intensified pressure on the Greater Japan Martial Virtues Association, which had adopted chukan-uchiokoshi in Kyudoyosoku, to announce a strong statement denying the research on August 22, 1941.4) In our research, we could not confirm any other cases where the Greater Japan Martial Virtues Association got into such a situation as this to give a statement against criticism of kyudo’s essential rule. Therefore, it is conceivable that “Medical Research on Kyudo” gave validity or medical justification to criticize Kyudoyosoku. Taken together, the overall criticism from kyudo archers, budo martial artists, doctors, and society in general, and specifically the results from the “Medical Research on Kyudo” that indicated harm to the human body, was one of the main factors that lead to the elimination of the kyudo rationale, or the dissolution of Kyudoyosoku.

著者

神永 正史

出版者

日本語学会

雑誌

日本語の研究 (ISSN:13495119)

巻号頁・発行日

vol.12, no.4, pp.52-68, 2016-10-01 (Released:2017-04-03)

参考文献数

21

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中古中期の仮名散文における「~てあり」の例文には,変化の結果状態を表すものとして,「(変化)主体+自動詞+てあり」と,「(動作)対象+他動詞+てあり」の形態を示す二つの構文がみられる。この「~てあり」の二つの構文と,「~たり」のもつ同じ二つの構文との比較を試みた。その結果,「~たり」には,主体の自発的変化,動作的変化,因果的変化の結果と,対象変化の結果を表す用法があるが,「~てあり」には,主体の因果的変化の結果を表す用法がないことを明らかにした。「~たり(たる)」は中世後期には衰退していき,その各用法は「~てある」や「~てゐる」に継承されていくが,その継承において,「~てある」や「~てゐる」構文の主語が,動詞「ある(在る)」「ゐる(居る)」の主語の性情による制限と関わるかどうかによって,京阪と東国では異なっていることも示した。この異なりの結果は,現代共通語のテアル,テイルの振る舞いの違いに結びつくのではないかと思われる。

著者

西川 美幸

出版者

一般社団法人 日本物理学会

雑誌

日本物理学会講演概要集 67.2.2 (ISSN:21890803)

巻号頁・発行日

pp.354, 2012-08-24 (Released:2018-02-15)

著者

渡邊 芳之 佐藤 達哉

出版者

日本パーソナリティ心理学会

雑誌

性格心理学研究 (ISSN:13453629)

巻号頁・発行日

vol.2, no.1, pp.68-81, 1994-03-31 (Released:2017-07-24)

被引用文献数

1

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Any behavioral regularity that constitutes a personality construct is the product of an interaction between person and situation. Consequently, one cannot empirically confirm the existence of cross-situational consistency in the behavior associated with such a construct, from observation of behavioral regularity alone, if any. Perceived cross-situational consistency in behavior appears to be mostly resulted from confusing temporal stability for such consistency, reflecting a failure to distinguish different observational viewpoints. Therefore, any causal account of behavior by means of observation-derived personality constructs has no logical basis. Although behavior could still be predicted from personality constructs on the basis of its temporal stability alone, the logic of such prediction is totally different from that of traditional theories of personality. These arguments should clearly show that at least part of the so-called "person-situation debate" is a pseudo-question.