著者

遠藤 みなみ 佐藤 和紀 堀田 龍也

出版者

一般社団法人 日本教育工学会

雑誌

日本教育工学会研究報告集 (ISSN:24363286)

巻号頁・発行日

vol.2022, no.2, pp.27-31, 2022-06-27 (Released:2022-06-27)

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本研究では,クラウド上のスプレッドシートを利用して振り返りを入力する実践の初期段階における児童の意識調査を行った.その結果,児童は,スプレッドシートでの振り返りの効果については【今後の学習に役立つ】,【タイピングが速くなる】と回答した.効率については【修正がしやすい】,【速く書くことができる】と回答した.一方で,負担については【ファイルを開く手間】,【タイピングが大変】と回答した.不満については,【ネットの接続に時間がかかる】と回答した.

著者

武藤 憲哉 菅谷 一樹 全田 吏栄 三澤 友誉 矢野 徹宏 鈴木 剛 小野寺 誠 伊関 憲

出版者

一般社団法人 日本臨床救急医学会

雑誌

日本臨床救急医学会雑誌 (ISSN:13450581)

巻号頁・発行日

vol.25, no.3, pp.607-610, 2022-06-30 (Released:2022-06-30)

参考文献数

10

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心室細動の原因が薬剤性の低カリウム血症と考えられた症例を経験した。症例は70歳,女性。就寝中に唸り声を上げていたところを娘に発見され,胸骨圧迫された。救急隊が心室細動に対して3回の電気ショックを施行し,自己心拍再開した。検査所見からは虚血を示唆する所見は乏しく,血清カリウム2.7mEq/L と低値を認めていた。芍薬甘草湯およびイトラコナゾールが処方されていたことから,薬剤性低カリウム血症により心室細動をきたしたと判断した。緊急カテーテル検査は施行せず,電解質補正,目標体温管理療法を行った。不整脈の出現はなく経過し,神経学的予後も良好で第28病日に近医へ転院した。芍薬甘草湯は甘草を含有しており,低カリウム血症となる。イトラコナゾールにも低カリウム血症の副作用があり,今回どちらが被疑薬かは不明であるが,薬剤性の低カリウム血症が原因で心室細動をきたしたと考えられた。高齢者では処方理由が不明であっても,副作用に電解質異常がある薬物を内服している可能性があり,低カリウム血症を認めた場合には,薬剤性の可能性についても注意を払う必要がある。

著者

橋元 良明

出版者

社会言語科学会

雑誌

社会言語科学 (ISSN:13443909)

巻号頁・発行日

vol.20, no.1, pp.5-15, 2017-09-30 (Released:2018-02-07)

参考文献数

8

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本稿では,筆者が中心となって5年ごとに実施してきた「日本人の情報行動調査」のデータから,文字消費量の推移をたどり,文字消費に関わるタイプ分けを行ってそれぞれの特徴を分析する.1995年以降,新聞,雑誌,書籍の活字の閲読時間は全年齢層で減少し続けている.一方,ネット上でのメールやソーシャルメディアの利用時間は増加を続けており,前者と後者の時間量は10代20代においては2005年で逆転した.2015年調査のデータでは,活字と電子文字を合わせた文字の消費時間の総計は20代が年齢層別にみて最も多く,現代の若者の文字の消費量は,有史以来,最高のレベルにあると言っても過言ではない.活字の閲読時間と電子文字の消費時間からクラスター分析を行い,活字タイプと電子文字タイプ,中庸(平均)タイプの3タイプを析出した.活字タイプ,電子文字タイプは男性比率が高く,未婚率が高い傾向が見られ,活字タイプは社会的階層が高いという自己認識をもっていた.また,活字タイプは政治関心が高く,政治的有効性感覚も高かった.中庸タイプはメール,ソーシャルメディア,新聞閲読において平均的であり,社会階層の自己認識も「中の中」が多かった.「いつもやらなければならないことに追われているように感じる」という感覚をたずねた「タスク・オブセッション」については,活字タイプで低く,電子文字タイプ,中庸タイプにおいてともに高かった.

著者

加藤 明彦

出版者

一般社団法人 日本透析医学会

雑誌

日本透析医学会雑誌 (ISSN:13403451)

巻号頁・発行日

vol.55, no.6, pp.349-355, 2022 (Released:2022-06-28)

参考文献数

26

被引用文献数

1

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透析患者の栄養評価法に関する最近の話題は,Nutritional Risk Index for Japanese Hemodialysis patients(NRI–JH)とGLIM(the Global Leadership Initiative on Malnutrition)基準である.NRI–JH は日本人血液透析患者向けの新たな栄養指標であり,短期的な生命予後の予測に優れる.一方,GLIM 基準の予後予測能は,透析患者では感度,特異度とも低いため,従来の栄養評価法が優先される.Asian Working Group for Sarcopenia(AWGS)2019 によると,透析患者の27~68%にサルコペニアを合併している.診断項目にある握力および5 回椅子立ち上がりテストのカットオフ値は,予後予測に有用である.透析患者の栄養障害には,経腸栄養剤(oral nutritional supplements:ONS)による経腸栄養が第一選択であり,3 か月以上の継続が勧められる.透析時静脈栄養(intradialytic parenteral nutrition:IDPN)は,少なくともエネルギー≥20 kcal/kg/日,たんぱく質≥0.8 g/kg/日を摂取している透析患者が対象となる.現在,透析患者でも一般用のアミノ酸製剤やキット輸液製剤が使えるため,ONS とIDPN で必要量を確保できない場合には中心静脈栄養を検討する.

著者

村田 修 家戸 敬太郎 那須 敏朗 宮下 盛 和泉 健一 熊井 英水

出版者

Japanese Society for Aquaculture Science

雑誌

水産増殖 (ISSN:03714217)

巻号頁・発行日

vol.48, no.4, pp.677-678, 2000-12-20 (Released:2010-10-28)

参考文献数

6

被引用文献数

1

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Chemical compositions of the dorsal muscle of hybrids, yellowtail, Seriola quinqueradiata _??_ × goldstriped amberjack S. aureovittata _??_ (termed as YG) and purplish amberjack S.dumerili_??_ × goldstriped amberjack _??_(termed as PG) were compared with each parents fish species. The lipid content of YG was remarkably higher than that of goldstriped amberjack. In collagen content concerning texture, though YG was lower than goldstriped amberjack, it was significantly higher than yellowtail. Crude protein, total extractive nitrogen and collagen content of PG showed the intermediate value of the parents fish species.

著者

〓橋 英恵

出版者

一般社団法人 日本体育・スポーツ・健康学会

雑誌

体育学研究 (ISSN:04846710)

巻号頁・発行日

vol.51, no.3, pp.315-324, 2006 (Released:2008-01-25)

参考文献数

27

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This paper examines (1) the profile of Dr. Kenzo Futaki, (2) why he advocated the abdominal breathing method, and the purpose and effects of the method, (3) how the Futaki breathing method is performed, and (4) how it compares with the Okada method. The Futaki breathing method involves abdominal breathing, and was originally advocated because anyone could use it. Futaki clearly indicated that his method was not original, but was inspired by, and borrowed from, Atsutane Hirata's method. Hirata's method is a return to an Eastern style of breathing technique, as compared to the practices of the time, which were largely Western-inspired training methods, i.e. with little emphasis on breathing at all. Futaki was a boy of frail constitution until he tried Hirata's method when he was 16-17 years old. He attributed his newfound health to this method. Later he became a doctor, and researched the method further. He found medical/scientific support for the Hirata method. The Futaki method, abdominal breathing, differs significantly from the Okada method, known as reverse breathing or chest-type breathing.

著者

Hiroyuki Tsugita Maho Aoyama Noriaki Satake Makoto Saito Yusuke Hiratsuka Akira Inoue Shin Takayama Mitsunori Miyashita

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.254, no.3, pp.155-161, 2021 (Released:2021-07-03)

参考文献数

20

被引用文献数

2

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Management of nausea is an important dimension of palliative care. The first choice for treating nausea is antiemetics, but their efficacy is inadequate. Acupressure intervention for nausea in cancer patients has been studied as a non-pharmacological therapy, and appears to have had some effect. However, such a therapy has not been well reviewed in patients with terminal cancer. The purpose of this study was to clarify the feasibility of acupressure intervention and examine its safety and preliminary efficacy. We recruited cancer patients that fulfilled the eligibility criteria and were admitted to the palliative care unit, from August 2018 to February 2019, in Tohoku University Hospital, Japan. We conducted a longitudinal assessment of acupressure intervention in a single arm. We identified the patient’s research accomplishments and evaluated possible fainting due to the vagal reflex and symptom severity. Descriptive statistics were used to calculate the completion rate for the feasibility and Wilcoxon signed-rank tests to compare the average of continuous variables for the safety and efficacy. Twelve patients participated in this study and completed the procedure. Their average age was 70 years (SD = 9.3), and the most common primary cancer sites were the rectum and pancreas. The blood pressure and pulse rate did not drop sharply. Four patients exhibited decreased nausea but there was no statistically significant difference (P = 0.5). We suggested that acupressure has high feasibility and safety, as an intervention for patients with terminal cancer. However, no significant differences were observed regarding its effect on nausea.

著者

Masaya Iwamuro Takehiro Tanaka Sakiko Kuraoka Kenta Hamada Makoto Abe Yoshiyasu Kono Hiromitsu Kanzaki Seiji Kawano Yoshiro Kawahara Hiroyuki Okada

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.13, pp.1931-1938, 2022-07-01 (Released:2022-07-01)

参考文献数

16

被引用文献数

4

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Objective This study aimed to determine the prevalence and endoscopic features of zinc acetate dihydrate tablet-associated gastric lesions. Methods We retrospectively examined the endoscopic features of 47 patients taking zinc acetate dihydrate tablets who underwent esophagogastroduodenoscopy. Results Gastric mucosal alterations, including redness, erosions, ulcers, and adhesion of the white coat, were observed in 29 of 47 patients (61.7%). Among patients with gastric lesions (group A), there was a significantly higher percentage of symptomatic patients in comparison to patients without lesions (group B) (65.5% vs. 22.2%; p<0.01). The background characteristics of the two groups did not differ to a statistically significant extent. On esophagogastroduodenoscopy, mucosal redness (n=27, 93.1%), erosions (n=26, 90.0%), adhesion of the white coat (n=25, 86.2%), and ulcers (n=9, 31.0%) were observed. None of the 19 patients who previously underwent esophagogastroduodenoscopy had gastric lesions before starting zinc acetate dihydrate. Esophagogastroduodenoscopy was performed after the cessation of zinc acetate dihydrate intake in six patients, and revealed the resolution of gastric lesions. Conclusion Gastric lesions were observed in 29 of 47 patients who were taking zinc acetate dihydrate tablets. The most common endoscopic findings were mucosal redness (93.1%), erosions (90.0%), adhesion of the white coat (86.2%), and ulcers (31.0%). Although the exact pathogenesis is uncertain, we believe that understanding the unique manifestations of this gastric lesion will help physicians manage adverse events in patients taking zinc acetate dihydrate tablets.

著者

齊藤 陽花 金松 萌々花 南條 優 下﨑 高 小泉 遥香 佐藤 和紀 森下 孟

出版者

一般社団法人 日本教育工学会

雑誌

日本教育工学会研究報告集 (ISSN:24363286)

巻号頁・発行日

vol.2022, no.2, pp.96-101, 2022-06-27 (Released:2022-06-27)

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本研究では,X大学の教員養成学部1年生を対象に,高校時のオンライン授業の経験の有無が,ICT活用指導力にどのような影響を及ぼすのか検討することを目的として,それらに関するアンケートを実施した.その結果,①オンライン授業の経験をしていた学生の割合は,高校2年次が最も高く,次いで高校3年次,また,高校1年次はオンライン授業の経験はほとんどなく,②オンライン授業の経験により,オンライン授業に対する肯定的な意見や情報モラル指導に関する意識を持つことができると示唆された.

著者

安部 主晃 川人 潤子 大塚 泰正

出版者

日本パーソナリティ心理学会

雑誌

パーソナリティ研究 (ISSN:13488406)

巻号頁・発行日

vol.23, no.1, pp.29-37, 2014-07-30 (Released:2014-08-26)

参考文献数

30

被引用文献数

2

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従来の研究では,再確認傾向の高い者が対人ストレスイベントを経験しやすく,さらに抑うつを悪化させやすいことが報告されている。しかし,再確認傾向と対人ストレスイベントとの関連を詳細に検討した研究はほとんど認められない。本研究では,対人葛藤,対人劣等,対人摩耗という対人ストレスイベントの三つの側面に対する再確認傾向の影響を検討した。そして,対人ストレスイベントが,再確認傾向から抑うつに対する影響を媒介するかについても検討した。102名の大学生が第1回調査(Time 1)と3週間後の第2回調査(Time 2)において質問紙に回答した。その結果,対人劣等が,再確認行動から抑うつに対する影響を媒介した。大学生の抑うつを予防するために,再確認傾向やそれに伴い発生する対人劣等を改善することが重要である可能性がある。

著者

荻野 智之 玉木 彰 解良 武士 金子 教宏 和田 智弘 内山 侑紀 山本 憲康 福田 能啓 道免 和久

出版者

一般社団法人 日本呼吸ケア・リハビリテーション学会

雑誌

日本呼吸ケア・リハビリテーション学会誌 (ISSN:18817319)

巻号頁・発行日

vol.24, no.1, pp.124-130, 2014-04-30 (Released:2015-11-13)

参考文献数

29

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【目的】健常成人を対象に,体幹前傾角度や上肢支持姿勢の違いが肺気量位,胸腹部呼吸運動,呼吸運動出力に及ぼす影響を調査した.【方法】測定肢位は,安静立位,体幹前傾30°位,60°位,各体幹前傾姿勢での上肢支持(on handとon elbow)の7姿勢とした.肺気量位の測定は呼気ガス分析器を用い,胸腹部呼吸運動はRespiratory Inductive Plethysmograph(RIP)を用いて測定した.さらに呼吸運動出力として各姿勢時のairway occlusion pressure 0.1 s after the start of inspiratory flow(P0.1)を測定した.【結果】上肢支持位で肺気量位は有意に増加し,胸郭も拡張位となった.しかし,同じ体幹前傾角度での上肢支持による有意な変化や上肢支持姿勢の違いによる有意な変化はみられなかった.P0.1も姿勢による有意な変化はみられなかった.【結語】健常成人男性においては,上肢支持位で肺気量位は増加し,胸郭も拡張位となるが,上肢支持と体幹前傾姿勢による加算的効果や交互作用は認められないものと考えられた.

著者

Cyrus Ghaznavi Daisuke Yoneoka Yuta Tanoue Stuart Gilmour Takayuki Kawashima Akifumi Eguchi Yumi Kawamura Hiroaki Miyata Shuhei Nomura

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20220064, (Released:2022-07-02)

参考文献数

32

被引用文献数

10

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BackgroundIncreases in human mobility have been linked to rises in COVID-19 transmission. The pandemic era in Japan has been characterized by changes in inter-prefectural mobility across state of emergency declarations (SOE) and travel campaigns, but they have yet to be characterized.MethodsUsing Yahoo Japan mobility data extracted from the smartphones of more than 10 million Japanese residents, we calculated the monthly number of inter-prefectural travel instances, stratified by residential prefecture and destination prefecture. We then used this adjacency matrix to calculate two network connectedness metrics, closeness centrality and effective distance, that reliably predict disease transmission.ResultsInter-prefectural mobility and network connectedness decreased most considerably during the first SOE, but this decrease dampened with each successive SOE. Mobility and network connectedness increased during the Go To Travel campaign. Travel volume between distant prefectures decreased more than travel between prefectures with geographic proximity. Closeness centrality was found to be negatively correlated with the rate of COVID-19 infection across prefectures, with the strength of this association increasing in tandem with the infection rate. Changes in effective distance were more visible among geographically isolated prefectures (Hokkaido and Okinawa) than among metropolitan, central prefectures (Tokyo, Aichi, Osaka, and Fukuoka).ConclusionsThe magnitude of reductions in human mobility decreased with each subsequent state of emergency, consistent with pandemic fatigue. The association between network connectedness and rates of COVID-19 infection remained visible throughout the entirety of the pandemic period, suggesting that inter-prefectural mobility may have contributed to disease spread.

著者

Toshinori Hirai Hidefumi Kasai Masahiro Takahashi Satomi Uchida Naoko Akai Kazuhiko Hanada Toshimasa Itoh Takuya Iwamoto

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.45, no.7, pp.948-954, 2022-07-01 (Released:2022-07-01)

参考文献数

35

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Some population pharmacokinetic models for amiodarone (AMD) did not incorporate N-desethylamiodarone (DEA) concentration. Glucocorticoids activate CYP3A4 activity, metabolizing AMD. In contrast, CYP3A4 activity may decrease under inflammation conditions. However, direct evidence for the role of glucocorticoid or inflammation on the pharmacokinetics of AMD and DEA is lacking. The pilot study aimed to address this gap using a population pharmacokinetic analysis of AMD and DEA. A retrospective cohort observational study in adult patients who underwent AMD treatment with trough concentration measurement was conducted at Tokyo Women’s Medical University, Medical Center East from June 2015 to March 2019. Both structural models of AMD and DEA applied 1-compartment models, which included significant covariates using a stepwise forward selection and backward elimination method. The eligible 81 patients (C-reactive protein level: 0.26 [interquartile range; 0.09–1.92] mg/dL) had a total of 408 trough concentrations for both AMD and DEA. The median trough concentrations were 0.49 [0.31–0.81] µg/mL for AMD and 0.43 [0.28–0.71] µg/mL for DEA during a median follow-up period of 446 [147–1059] d. Three patients received low-dose oral glucocorticoid. The final model identified that AMD clearance was 7.9 L/h, and the apparent DEA clearance was 10.3 L/h. Co-administered glucocorticoids lowered apparent DEA clearance by 35%. These results indicate that co-administered glucocorticoids may increase DEA concentrations in patients without severe inflammation.

著者

Hideyuki Terazono Masami Tsuchiya Yosuke Maki Naoki Yoshikawa Yosuke Kawahara Keiko Nishimura Keisuke Shinohara Daisuke Ogawa Riho Mori Yoshihiro Iwamoto Fumio Itagaki Hiroyuki Masuko Masahito Yonemura Mayako Uchida

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.45, no.7, pp.856-862, 2022-07-01 (Released:2022-07-01)

参考文献数

19

被引用文献数

1

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It is essential for oncology pharmacists to update their knowledge, skills, and ethical attitudes. The Japanese Society of Pharmaceutical Oncology is an academic society for healthcare professionals involved in cancer treatment. It has conducted in-person seminars every year to cultivate the knowledge necessary for practicing advanced cancer medicine. Owing to the coronavirus disease (COVID-19) pandemic, the society was obligated to conduct a web-based seminar this year. A questionnaire survey was conducted before and after the webinar to explain how it works and to assess the learning attitudes of beginner and moderately skilled pharmacists in the field of oncology. Questionnaire surveys were conducted with the participants before and after watching the webinar. The questionnaires sought to determine participants’ perspectives on the webinar and their knowledge of the seven modules. Of the 1756 webinar attendees, 1661 (94.6%) answered the pre-webinar survey and 1586 (90.3%) answered the post-webinar survey. Results indicate that the median post-webinar knowledge score was significantly higher than the median pre-webinar score (p < 0.001) in all modules. Principal component analysis of the degree of knowledge of seven modules revealed that the improved score group consisted of those from younger age groups, with less experience as pharmacists, non-society members, and those with less experience in past society seminars. Moreover, the web-based seminar provided a uniform learning effect throughout the country without distinguishing between urban and rural learners. The web-based educational program was an acceptable educational tool for Japanese oncology pharmacists.

著者

佐藤 多佳子 松本 修

出版者

全国大学国語教育学会

雑誌

全国大学国語教育学会国語科教育研究:大会研究発表要旨集 130 (ISSN:24321753)

巻号頁・発行日

pp.51-54, 2016-05-28 (Released:2022-03-15)

著者

田井 達也 山口 佳津騎 黒川 直弘 新村 航 松原 亜紀 渡邊 政博 元木 貴大 田中 裕章 芳地 一 小坂 信二

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.7, pp.771-774, 2022-07-01 (Released:2022-07-01)

参考文献数

17

被引用文献数

1

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We report a haemodialysis patient with end-stage renal failure whom a pharmacist aided in the management of acyclovir (ACV) encephalopathy, which may have been related to valacyclovir hydrochloride (VACV) administered without sufficient dose reduction. The patient 78 years was admitted with a tentative diagnosis of varicella zoster viral meningitis. A pharmacist suspected ACV encephalopathy related to excessive VACV administration and raised a query with the attending physician. According to the pharmacist's proposal, ACV administration was discontinued and continuous hemodiafiltration (CHDF) was performed. On day 5 of hospitalisation, the consciousness disorder was improved. In this report, we showed the detailed CHDF conditions of the present case, and the contribution of a pharmacist to treating and avoiding ACV encephalopathy was discussed.

著者

加藤 信太郎 齋藤 佳敬 小野田 紘子 熊井 正貴 今井 俊吾 敦賀 健吉 武隈 洋 菅原 満

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.7, pp.755-760, 2022-07-01 (Released:2022-07-01)

参考文献数

19

被引用文献数

1

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Naldemedine (Nal) is widely used as a therapeutic drug against opioid-induced constipation. However, patients in phase III trials are limited to those with good performance status (PS). Cancer patients may have inferior PS owing to progression of symptoms and adverse events from chemotherapy. Therefore, it is important to survey the efficacy of Nal in patients with poor PS. This study aimed to evaluate Nal efficacy in patients with poor PS. We retrospectively investigated patients from July 2017 to June 2019 and compared Nal efficacy between patients with good and poor PS. The efficacy of Nal was evaluated using changes in the number of spontaneous bowel movements 7 days before and after the introduction of Nal with reference to previous reports. Multivariate analysis was performed to reveal whether poor PS affects Nal efficacy. In total, 141 patients at the Hokkaido University Hospital were analyzed. The effective rate of Nal from day 1 to day 7 of administration was 71.7% and 71.4% in the patients with good and poor PS, respectively, that from day 1 to day 2 of administration was 61.1% and 57.1%, respectively, and that from day 3 to day 7 of administration was 60.2% and 71.4%, respectively, suggesting an absence of significant differences. Furthermore, results of multivariate analysis showed that “best supportive care” and “body weight (55 kg and above)” reduced Nal efficacy. In conclusion, Nal showed similar effectiveness in patients with poor PS as that in those with good PS.

著者

飯島 清美子 山口 忍 渡辺 尚子 綾部 明江

出版者

一般社団法人 日本公衆衛生看護学会

雑誌

日本公衆衛生看護学会誌 (ISSN:21877122)

巻号頁・発行日

vol.5, no.2, pp.144-153, 2016 (Released:2016-09-02)

参考文献数

27

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目的:本研究は,市町村保健師が精神保健分野の個別対応で抱える困難を表す内容を明らかにし,実践への示唆を得る事を目的とする.方法:市町村に勤務する保健師を対象に,半構造化面接法を用いてデータ収集を行い,質的記述的に分析した.結果:8名の市町村保健師の協力が得られ,市町村保健師が精神保健分野の個別対応で抱える困難は,476のコード,45の小カテゴリー,11の中カテゴリー,4つの大カテゴリーが抽出された.市町村保健師は【当事者・家族への対応の難しさ】を感じ,社会資源の少なさや支援拒否,支援効果のわかりづらさから【当事者がもつ生活しづらさの改善の難しさ】があり,【市町村という立場での連携・組織体制構築の不足】や【支援の際に起こる保健師の感情コントロールの難しさ】でも困難を感じていた.考察:市町村保健師自身は,精神保健分野の対応技術の獲得,否定的感情のコントロール,当事者理解を進めていく必要がある.

著者

大和 武彦

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.53, no.6, pp.487-499, 1995-06-01 (Released:2009-11-16)

参考文献数

67

被引用文献数

15 17

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The catalytic applications of Nafion-H, a superacidic perfluororesinsulfonic acid in organic synthesis are reviewed. Nafion-H, the acid form of a commercial Nafion-K ionomer, is a highly acidic (H0≥-12) solid catalyst superior to conventional resinsulfonic acids such as sulfonated polystyrenes in its catalytic activity, thermal stability and chemical resistance.Nafion-H catalyst is effective in a wide range of liquid and gas phase reactions, including electrophilic substitutions on aromatic nuclei, dehydration of alcohols, rearrangements, polymerizations and so on. Nafion-H and related perfluoroalkanesulfonic acids are not only much stronger acids but are also stable in corrosive environments and at temperature up to 210°C. Furthermore, specific advantages of using insoluble resins as catalysts include i) ease of by-product separation from the main reaction product usually by simple filtration; ii) prevention of intermolecular reaction of reactive species or functional groups by simulating high dilution conditions; iii) the possibility of reusing recovered reagents as well as eliminating the use of volatile or noxious substances.

著者

Komei Mizokami Shoji Kawakami Shujiro Inoue

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-22-0021, (Released:2022-05-21)

参考文献数

2

被引用文献数

1