著者

Eunji KOH Yun Chan JUNG Heung-Myong WOO Byung-Jae KANG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0456, (Released:2017-01-06)

被引用文献数

14

---

The purpose of this study was to establish an optimized protocol for the production of alginate-encapsulated canine adipose-derived mesenchymal stem cells (cASCs) and evaluate their suitability for clinical use, including viability, proliferation and in vivo cell retention. Alginate microbeads were formed by vibrational technology and the production of injectable microbeads was performed using various parameters with standard methodology. Microbead toxicity was tested in an animal model. Encapsulated cASCs were evaluated for viability and proliferation in vitro. HEK-293 cells, with or without microencapsulation, were injected into the subcutaneous tissue of mice and were tracked using in vivo bioluminescent imaging to evaluate the retention of transplanted cells. The optimized injectable microbeads were of uniform size and approximately 250 μm in diameter. There was no strong evidence of in vivo toxicity for the alginate beads. The cells remained viable after encapsulation, and there was evidence of in vitro proliferation within the microcapsules. In vivo bioluminescent imaging showed that alginate encapsulation improved the retention of transplanted cells and the encapsulated cells remained viable in vivo for 7 days. Encapsulation enhances the retention of viable cells in vivo and might represent a potential strategy to increase the therapeutic potency and efficacy of stem cells.

著者

Hironari OSADA Misato OGAWA Ayana HASEGAWA Makoto NAGAI Junsuke SHIRAI Kazuaki SASAKI Minoru SHIMODA Hiroshi ITOH Hirotaka KONDO Keitaro OHMORI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0451, (Released:2016-12-29)

被引用文献数

11

---

It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25, il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs. The results suggest that epithelial cell-derived cytokines may not be an inducer of Th2-type immunity in the gut of dogs with CE, and decreased expression of IL-33 may be involved in induction of FRE. Further studies are required to clarify roles of epithelial cell-derived cytokines, especially IL-33, in the pathogenesis of canine CE.

著者

Danny W. Scott William H. Miller Jr.

出版者

日本獣医皮膚科学会

雑誌

獣医臨床皮膚科 (ISSN:13476416)

巻号頁・発行日

vol.22, no.4, pp.255-256, 2016 (Released:2016-12-28)

参考文献数

2

著者

関口 大陸 稲見 昌彦 川上 直樹 舘 すすむ

出版者

横断型基幹科学技術研究団体連合(横幹連合)

雑誌

横幹連合コンファレンス予稿集 第1回横幹連合コンファレンス

巻号頁・発行日

pp.50, 2005 (Released:2006-06-27)

---

従来ロボットは製造業等の現場において人の身代わりとして何らかの作業を行うという目的で研究が進められていた.これに対し我々はUIとしてのロボット-Robotic User Interfaceの研究の一環として,遠隔地に置かれたロボットの動きを同期させることによりコミュニケーションをとることを目指したRobotPHONEの研究を行ってきている.本発表では,RobotPHONEの研究を元に商品化された「IP ロボットフォン」の設計と開発について紹介する.

著者

Shinji Matsui Hiroshi Hiroshima Yoshihiko Hirai Masaru Nakagawa

出版者

The Society of Photopolymer Science and Technology (SPST)

雑誌

Journal of Photopolymer Science and Technology (ISSN:09149244)

巻号頁・発行日

vol.27, no.1, pp.61-72, 2014-07-08 (Released:2014-08-08)

参考文献数

60

被引用文献数

2 5

---

The effectiveness of condensable gas, used as ambience, in UV nanoimprint lithography has been demonstrated. Bubble defect problem, which is inherent in UV nanoimprint under non vacuum ambience, can be solved by PFP condensable gas. UV nanoimprint lithography using PFP was validated for 45 nm pattern fabrication under thin residual layer conditions, which are required for UV nanoimprint used as UV nanoimprint lithography. PFP reduces the viscosity and demolding force of UV curable resins. These properties are helpful in increasing the throughput and reliability of UV nanoimprint. PFP occasionally produces large shrinkages, and degrades pattern quality depending on UV curable resin. These drawbacks can be mitigated by selecting UV curable monomers with a low PFP absorption. In the end, we have demonstrated the satisfied LER and LWR values requested in 22 nm node NAND flash memories and 20,000 repeated imprints with a single mold by UV nanoimprint using PFP.

著者

伊藤 明

出版者

一般社団法人 日本体育学会

雑誌

体育学研究 (ISSN:04846710)

巻号頁・発行日

vol.3, no.1, pp.20, 1958 (Released:2016-12-31)

著者

山中 裕

出版者

日本学士院

雑誌

日本學士院紀要 (ISSN:03880036)

巻号頁・発行日

vol.34, no.3, pp.151-189, 1977 (Released:2007-05-30)

著者

梅谷 繁樹

出版者

JAPANESE ASSOCIATION OF INDIAN AND BUDDHIST STUDIES

雑誌

印度學佛教學研究 (ISSN:00194344)

巻号頁・発行日

vol.32, no.1, pp.317-320, 1983-12-25 (Released:2010-03-09)

著者

杉浦 直

出版者

The Human Geographical Society of Japan

雑誌

人文地理 (ISSN:00187216)

巻号頁・発行日

vol.43, no.5, pp.415-438, 1991-10-28 (Released:2009-04-28)

参考文献数

77

被引用文献数

1 3

---

One of the important problems in social geography is to examine the relationship between the spaces defined by institutional bases and real life spaces of people, in other words, between so-called formal regions and substantive regions. An institutional space, such as an administrative area, does not usually remain as a pure formal region, but grows to a territory with some actual involvement of people. If the institutional framework were abolished, for example, the substantive framework of regions would not likely disintegrate immediately, but would persist for a certain period of time. In Japan the division of feudal clan territories had long been fixed in the Edo Period, but it was almost entirely replaced by a new prefectural system after the Meiji Revolution. This paper attempts to examine to what degree a former clan boundary has influenced the affiliations and organizations of people and how the actual integration has proceeded since the institutional framework of feudal territory dissapeared, through a case study of a region comprised of the Oniyanagi and Aisari Districts, northeastern Japan, where a former clan boundary divided these two districts.The Oniyanagi and Aisari Districts now belong to the same incorporated municipal unit, Kitakami, Iwate Prefecture, but in the Edo Period the former belonged to the territory of the Morioka Clan (Nanbu Territory) and the latter was a part of the Sendai Clan (Date Territorry). In this study the four aspects of spatial organizations, i. e. 1) administrative areas, 2) social and cultural spaces, 3) economic spaces, and, 4) communal life spaces, and their changes from the beginning of the Meiji Period to the present are examined with special attention to the separation and integration of the above two districts, through an intensive field research. And we consider, through this research, the territoriality of a region where its institutional framework has been drastically changed.According to our research it is shown that each community of the two districts has had its own cohesiveness, to varying degrees, in each aspect of the spatial organizations through the history of the modern era (after the Meiji Revolution) of Japan. In other words the two districts discussed here have continued to show a strong feeling of territoriality even after the former feudal boundary was abolished. However, it is also true that integration of the two districts in administration as well as in educational activities were tried several times repeatedly, and cooperation and intercommunication in social and cultural lives were also often attempted, especially in recent times after Kitakami was established as a city in 1954. Namely, the opposing forces toward separation as well as integration have operated among these former border areas, and the relationship between these forces has created the essential character of the history in this region.Although it is not easy to indicate the exact factors which cause the above-mentioned phenomena, we can suggest some general notions. First, as for the conditions which have supported the separation and independence of each district, the following information can be summed up; 1) cultural differences and perception gap caused by a continuing barrier function of the former clan boundary, 2) differences in agricultural practices and irrigation systems which are closely related to the physical conditions of each district, and, 3) social secession which would be fed back to further separation in social organizations. Second, the backgrounds for the movements toward integration can be summarized by indicating following three factors; 1) geographical conditions, especially the lack of evident physical dividing lines at the border area, 2) enlargement of economic regions, especially the growing urbanization of Kitakami, and, 3) political situations, especially the formation of large administrative units such as Iwate Prefecture or the city of Kitakami.

著者

田中 博道 高橋 隆子 富樫 浩之 上田 亨

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.26, no.11, pp.3322-3329, 1978-11-25 (Released:2008-03-31)

被引用文献数

5 8

---

Starting from 1-β-D-ribofuranosyl-2-oxo-4-imidazoline-4-carboxylic acid (1), obtained from uridine, various 2, 5'-O-cycloimidazole nucleosides have been prepared. The 2-oxo function of 1 was also converted to the 2-chloro and 2-thione functions. Whereas the circular dichroism (CD) spectra of 1 and related 2-oxo derivatives exhibited negative bands, their 5-bromo derivatives showed positive bands. All 2, 5'-O-cycloimidazole nucleosides showed strong negative CD bands which were in contrast to the results in the 8, 5'-O-cyclopurine nucleosides. The relationship between the sign of the CD bands and the orientation of the base moieties in imidazole nucleosides was discussed.

著者

宮澤 修平 岡野 和夫 下村 直之 川原 哲也 浅野 修 吉村 寛幸 河合 隆利 左右田 茂 吉田 豊 里 忠 町田 善正 山津 功

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.2, pp.521-523, 1992-02-25 (Released:2008-03-31)

参考文献数

14

被引用文献数

2 4

---

Optically active platelet-activating factor (PAF) receptor antagonist, (+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8, 11-dimethyl-2, 3, 4, 5-tetrahydro-8H-pyrido[4', 3' : 4, 5]thieno[3, 2-f][1, 2, 4]triazolo[4, 5-a][1, 4]diazepine (E6123), was synthesized on large-scale by optical resolution using (+)-dibenzoyl-D-tartaric acid. An X-ray crystallographic analysis clearly indicated that the absolute configuration of the synthesized E6123 was S.

著者

宮澤 修平 岡野 和夫 下村 直之 / 川原 哲也 浅野 修 吉村 寛幸 宮本 光明 佐久間 義範 村本 賢三 尾葉石 浩 原田 耕吉 梶間 隆 山田 浩司 角田 創 片山 敏 阿部 信也 浅川 直樹 左右田 茂 堀江 透 里 忠 町田 善正 片山 幸一 山津 功 Isao YAMATSU

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.39, no.12, pp.3215-3220, 1991-12-25 (Released:2008-03-31)

参考文献数

27

被引用文献数

6 9

---

A series of triazolodiazepines was synthesized and evaluated for anti-platelet activating factor (PAF) activities. Structure-activity relationship (SAR) studies on this series revealed that the introduction of a methyl group into the 8-position of the thienodiazepine nucleus can lead to a lengthening of the duration of action. Introduction of a methyl group produced an asymmetric center and the enantiomers so formed were separated with an optical resolving column. In the in vitro assay system, the (+)-isomers displayed 50-200 times more potent anti-PAF activity than the (-)-isomers. After comparison of toxicology and pharmacokinetics, (+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8, 11-dimethyl-2, 3, 4, 5-tetrahydro-8H-pyrido[4', 3' : 4, 5]thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepine (35(+)-isomer, E6123) was selected from among the compounds synthesized as a candidate for clinical study.

著者

白楽 ロックビル

出版者

公益社団法人 日本工学教育協会

雑誌

工学教育 (ISSN:13412167)

巻号頁・発行日

vol.54, no.1, pp.1_61-1_69, 2006 (Released:2006-06-16)

参考文献数

7

被引用文献数

1 2

---

We are discussing about many aspects of research integrity of individual scientist, who faces the globalization of research ethics in the traditional culture and custom of Japan. Topics are scientific misconduct (fabrication, falsification, and plagiarism) in writing paper and presenting research results. Managements of research material, research record, grant money, authorship, and conflict of interest are also analyzed and discussed. Finally, we make 5 recommendations to improve research integrity in Japan.

著者

清水 勤二

出版者

公益社団法人 日本工学教育協会

雑誌

工業教育 (ISSN:18839002)

巻号頁・発行日

vol.1, no.2, pp.34-45, 1953-12-25 (Released:2009-04-10)

著者

千葉 剛 佐藤 陽子 鈴木 祥菜 梅垣 敬三

出版者

公益社団法人 日本栄養・食糧学会

雑誌

日本栄養・食糧学会誌 (ISSN:02873516)

巻号頁・発行日

vol.68, no.4, pp.147-155, 2015 (Released:2015-08-24)

参考文献数

12

被引用文献数

1 5

---

以前に実施した調査において, 特定保健用食品 (特保) を治療目的で用い, 服用している医薬品と同様の保健機能を謳った特保の利用者がいることが示された。本調査では特保と医薬品との併用の実態を明らかとするためアンケート調査を行った。特保を疾病治療目的に利用している人の割合は利用者の年代が上がるにつれて増え, また, 受診なしに比較し受診あり (通院中・入院中) で有意に高かった。また, 医薬品を併用し, 中には服用医薬品と同じ用途で特保を利用しているにもかかわらず, 医師・薬剤師に相談している利用者は, 14.6%と低かった。この時, 特保と医薬品の併用者において体調不良 (下痢・便秘等) を感じている人は10.3%であった。多くの特保製品は通常の食品形態をしていることから, 適切に使用していれば医薬品と相互作用を起こす可能性は低いと思われるが, 医薬品を服用している際には, 医師・薬剤師に相談することが好ましいと考えられる。

著者

山下 雄也 郭 伸

出版者

日本神経学会

雑誌

臨床神経学 (ISSN:0009918X)

巻号頁・発行日

vol.54, no.12, pp.1151-1154, 2014 (Released:2014-12-18)

参考文献数

10

---

ALSの病理学的指標であるTDP-43病理の形成メカニズムは未解明であり,引き金になるTDP-43の易凝集性断片形成に関与するプロテアーゼやその活性化メカニズムに関する合理的な説明はなかった.われわれは,孤発性ALSのもう一つの疾患特異的分子変化である,RNA編集酵素ADAR2の発現低下を再現するALSの分子病態モデルマウスの解析から,異常なCa2+透過性AMPA受容体発現を介したカルパインの活性化が,凝集性の高いTDP-43断片を形成することを明らかにした.この分子カスケードに通じるメカニズムは,孤発性ALSのみならず他の神経疾患に観察されるTDP-43病理形成にも当て嵌まることが強く示唆されたので概説する.

著者

徳岡 敬子 森 理三郎 一色 賢司

出版者

Japanese Society for Food Science and Technology

雑誌

日本食品工業学会誌 (ISSN:00290394)

巻号頁・発行日

vol.39, no.1, pp.68-71, 1992-01-15 (Released:2009-04-21)

参考文献数

11

被引用文献数

3 4

---

AITを主成分とするカラシ抽出物製剤が,糖濃度の高い食品から分離された5菌株の酵母の生育に対してどのような影響を及ぼすかをAw 0.97~0.86で検討し,次の結果を得た.いずれの菌株も,含気包装ではAw0.86あるいは0.89まで生育したのに対し,カラシ抽出物製剤封入包装では全てのAwにおいて生育が完全に阻止された.ヘッドスペース中のAIT濃度は封入後24~48時間で平衡に達し,そのときの濃度は2μg/mlであった.これらの酵母に対するAITの最小生育阻止濃度は3~15ng/mlで,かなり低い濃度で酵母の生育が抑えられることが明らかになった.

著者

林 哲也 戸邉 亨

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.42, no.11, pp.758-764, 2004-11-25 (Released:2009-05-25)

参考文献数

15

著者

井出野 尚 大久保 重孝 玉利 祐樹 伊豫部 紀子 村上 始 竹村 和久

出版者

日本感性工学会

雑誌

日本感性工学会論文誌 (ISSN:18840833)

巻号頁・発行日

vol.13, no.4, pp.535-541, 2014 (Released:2014-11-28)

参考文献数

12

被引用文献数

2

---

We examined the effect of discount rate presentation (e.g. 40% off) on the consumers' decision making process using eye movement equipment. Ten female participants (average age: 48.4 years old) were asked to choose between two options. The discount rate of option one was higher than that of option two, although total price of option one was higher than that of option two. All eye movements were recorded during experiment in order to examine participants' decision making process. To recheck this finding, we conducted a control experiment without discount rates. The result of the control experiment suggested that the presentation of discount rate influenced the participants' decision strategy.

著者

小見山 章 中川 雅人 加藤 正吾

出版者

日本森林学会

雑誌

日本森林学会誌 (ISSN:13498509)

巻号頁・発行日

vol.93, no.5, pp.220-225, 2011 (Released:2011-12-29)

参考文献数

25

被引用文献数

3 18

---

樹形法則を構造的・力学的に解析した既往のパイプモデルと静力学モデルに基づいて, 日本の冷温帯林を構成する樹木について, 様々な場所や樹種に共通して適用できる相対成長関係が存在するかどうかを検討した。岐阜県の冷温帯林2カ所で, 20種81本の樹木 (最大DBH: 61.9 cm) を伐倒して地上部重と, それらを含む12種19本について根系 (最大DBH: 72.3 cm) を掘りあげて根重を調べた。他の研究者が公表した冷温帯樹種における地上部重と根重のデータと比較対照した上で, 地上部重 (22種157本) と根重 (13種33本) を用いて, 2種類の相対成長式を誘導した。幹比重を使用したモデル誘導型の共通式は, その推定値に地上部重で12.59%, 根重で17.67%の相対誤差があった。これら共通式の相対誤差は, 以前から使用されてきた従来型の通常式の相対誤差 (それぞれ18.62%, 22.25%) より小さかった。提案する共通式は, 冷温帯林で現存量や成長量を非破壊的に求める際に, 場所や樹種に対する汎用性, および推定値の再現性を相対的に高める手段になる。