著者

倉橋惣三 著

出版者

東洋図書

巻号頁・発行日

1934

著者

倉橋惣三 著

出版者

乾元社

巻号頁・発行日

1948

著者

倉橋惣三 著

出版者

清水書房

巻号頁・発行日

1946

著者

坂倉 又吉

出版者

公益財団法人 日本醸造協会

雑誌

日本釀造協會雜誌 (ISSN:0369416X)

巻号頁・発行日

vol.75, no.12, pp.976-976, 1980-12-15 (Released:2011-11-04)

著者

高倉 喜信

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.116, no.7, pp.519-532, 1996-07-25 (Released:2008-05-30)

参考文献数

59

被引用文献数

5 7

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With a rapid progress in biotechnology, a variety of endogenous macromolecular substances have become a novel class of therapeutic agents. This review will focus on the development of delivery systems for macromolecular drugs. Current status and future perspectives in this research field are reviewed mainly based on the results obtained in our laboratory. First of all, we studied pharmacokinetic characteristics of macromolecules in relation to their physicochemical properties such as molecular weight and electric charge. Based on this information, we first developed macromolecular prodrugs as a delivery system for low molecular weight drugs. An antitumor antibiotic, mitomycin C (MMC) were covalently conjugated with dextran and various types of macromolecular prodrug of MMC were developed for tumor targeting. Secondly, delivery systems for protein drugs such as soybean trypsin inhibitor, uricase, and recombinant superoxide dismutase (SOD) were developed. In particular, successful targeting of SOD to the liver, kidney and blood circulation was achieved by chemical modification of the protein drug. Finally, we have been trying to develop delivery systems for nucleic acid drugs involving antisense oligonucleotides and plasmid DNA. Prior to the development of delivery systems, we found that the pharmacokinetics of the nucleic acid drugs are decided by their physicochemical properties as polyanions even if these materials contain genetic information. Several approaches were tested to control the in vivo behavior of the oligonucleotides and plasmid DNA based on the finding. Thus, we have established the strategy for rational design of delivery systems for various types of macromolecular drugs based on the pharmacokinetic considerations. This methodology can be a formidable tool for the development of clinically applicable macromolecular drugs.

著者

福島 啓吾 梶原 真二 石倉 聡 勝谷 範敏 後藤 丹十郎

出版者

一般社団法人 園芸学会

雑誌

園芸学研究 (ISSN:13472658)

巻号頁・発行日

vol.16, no.2, pp.177-184, 2017 (Released:2017-06-30)

参考文献数

33

被引用文献数

2

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本実験は,吸水種子湿潤低温処理方法がトルコギキョウの生育および切り花形質に及ぼす影響を明らかにしようとした.無処理を対照とし,10°Cの暗黒条件下で5週間の低温処理を播種前または播種後に行う6処理区についてロゼット性の異なる‘キングオブスノー’と‘ロココマリン’を用いて比較検討した.低温処理終了から定植までの育苗は,日最低気温が21.0~25.5°Cの範囲で推移し平均23.0°C,日最高気温が26.0~43.5°Cの範囲で推移し平均37.2°Cの条件の下で実施した.抽苔,発蕾および開花率は,ロゼット性にかかわらず種子低温処理により無処理と比較して有意に高まったが,低温処理方法による差はなかった.ロゼット性の強い‘ロココマリン’において定植から抽苔,発蕾および開花までの日数は,無処理と比較して種子低温処理により有意に減少した.切り花形質は,両品種ともに種子低温処理各区に大きな差はなかった.以上から,高温期に育苗する作型では,種子低温処理を行うことが重要であり,処理方法は低温による生育促進効果に影響を及ぼさないことが明らかになった.

著者

金城 春野 小倉 暢之

出版者

日本建築学会

雑誌

日本建築学会計画系論文集 (ISSN:13404210)

巻号頁・発行日

vol.83, no.744, pp.307-314, 2018

被引用文献数

2

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&nbsp;More than 75,000 emergency houses, called the standard prefabricated house, were built in Okinawa after the war in approximately four years, beginning in 1946, which made a great contribution to reconstruction. The standard prefabricated house was designed by a local architect named Hisao Nakaza (1904-1962) at the U.S. naval military government Okinawa public works department on Nov. 30, 1945.<br>&nbsp;The purpose of this study is to clarify the details of the situation about the process, the design and the supply system of the standard prefabricated house, and to also clarify the actual factor of the massive and quick supply. This paper consists of five chapters.<br>&nbsp;Chapter 1 describes the background based on the career and articles of Nakaza and why he began to design the standard house. According to his career, he had experience with evacuation house construction in wartime. After the experience was evaluated, Nakaza designed the standard house at the U. S. naval military government Okinawa public works department.<br>&nbsp;Chapter 2 considers the standard house plan situation of the U.S. naval government from directions. The naval government gave orders that let local people resettle from camps to their original places of residence on October 23, 1945. Therefore, the government had to supply houses. The direction of October 31, 1945 shows the design guide of the houses. It is thought that the scale and materials of the standard prefabricated house were decided based on this.<br>&nbsp;Chapter 3 analyzes the design drawing. The standard prefabricated house responded to the situation of a lack of engineers in that the frames of the walls and roof trusses were designed as prefabs which were produced at a factory. Furthermore, the design can respond to the lack of material flexibly, and the choice of finishing materials depending on the local situation is possible.<br>&nbsp;Chapter 4 investigates Nakaza's article and the Okinawa public works department relations documents, and understands the supply system. For approximately four months, from January to May in 1946, the constructions were instructed by three people, including Nakaza. From the period of May, 1946 to the end of 1949, constructions were carried out by an organized system by the public works department of Okinawa civil administration. The department was able to settle the U.S. government budget directly. Architectural division managed the material yards and carried out construction by construction units. In addition, motor pools of the land transport division took transports.<br>&nbsp;Chapter 5 analyzes the monthly construction number on the activity reports of the U.S. military government and assumes the construction end time. Construction was carried out most actively during the periods from the beginning of 1946 to mid 1947. The first action system was good; more than 4,000 houses a month in December, 1946 and January, 1947 were built. There are construction reports until October, 1949, which show that the houses were built until about the end of 1949. A total of about 76,815 houses were supplied within four years, from January, 1946 to October, 1949.<br>&nbsp;As above, the standard prefabricated house was designed by architect Hisao Nakaza, and supervised by the U.S. military government, and managed by local government, and constructed by mutual support among residents.<br>&nbsp;The main reasons to be able to serve a large quantity and quick supply are as follows. (1) The houses were a prefabricated type which the residents could easily build. (2) The design could respond to the lack of material flexibly, and the choice of finishing materials depending on the local situation was possible. (3) The compact organization system could perform the stocking, manufacturing, sending, and budgeting execution of the construction.

著者

長倉 保

出版者

公益財団法人 日本醸造協会

雑誌

日本釀造協會雜誌 (ISSN:0369416X)

巻号頁・発行日

vol.68, no.10, pp.723-725, 1973-10-15 (Released:2011-11-04)

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70万都市の江戸, この巨大消費市場にたいして展開される近畿, 東海の1200有余の醸酒家の競争0酒造業を体制維持のために掌握しようとする幕府。僧坊の酒から商品である都市の酒へ発展した近世の酒造業の姿である。

著者

飯倉 義之

出版者

比較日本文化研究会 ; [1994]-

雑誌

比較日本文化研究

巻号頁・発行日

no.15, pp.53-63, 2012-09

著者

奥倉辰行

出版者

写

著者

板倉 修司 奥田 純子 宇田川 加苗 田中 裕美 榎 章郎

出版者

日本環境動物昆虫学会

雑誌

環動昆 (ISSN:09154698)

巻号頁・発行日

vol.17, no.3, pp.107-115, 2006-10-14

参考文献数

36

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イエシロアリとヤマトシロアリのニンフと職蟻に含まれる灰分,食物繊維,グリコーゲン,脂質,窒素,還元糖,トレハロースおよび水分を定量した.粗タンパク質抽出物のアミノ酸組成,エーテル抽出物に含まれる脂質の脂肪酸組成を分析した.シロアリ乾燥質量に対する総脂質含有率とタンパク質含有率(キチン由来の窒素を除いた推定値)は,イエシロアリのニンフで各々64.33%,15.50%,職蟻で46.46%,29.80%,ヤマトシロアリのニンフで69.08%,9.83%,職蟻で61.15%,20.98%であった.これら2種類のシロアリには,リノール酸(必須脂肪酸),オレイン酸,パルミチン酸およびステアリン酸,さらに必須アミノ酸(ヒスチジン,イソロイシン,ロイシン,メテオニン,フェニルアラニン,バリンなど)および非必須アミノ酸(アラニン,システイン,グルタミン酸,グリシン,プロリン,チロシンなど)が含有されていた.

著者

倉橋 弘 比嘉 由紀子 津田 良夫

出版者

日本衛生動物学会

雑誌

衛生動物

巻号頁・発行日

vol.56, 2005

著者

神経線維腫症1型診療ガイドライン改定委員会 吉田 雄一 倉持 朗 太田 有史 古村 南夫 今福 信一 松尾 宗明 筑田 博隆 舟崎 裕記 齋藤 清 佐谷 秀行 錦織 千佳子

出版者

公益社団法人 日本皮膚科学会

雑誌

日本皮膚科学会雑誌 (ISSN:0021499X)

巻号頁・発行日

vol.128, no.1, pp.17-34, 2018-01-20 (Released:2018-01-20)

参考文献数

152

著者

三分一 政男 中倉 英雄 大佐々 邦久

出版者

一般社団法人 資源・素材学会

雑誌

日本鉱業会誌 (ISSN:03694194)

巻号頁・発行日

vol.103, no.1188, pp.109-114, 1987-02-25 (Released:2011-07-13)

参考文献数

18

被引用文献数

2 1

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Zone settling rates of limestone, coal and kaolin-water slurrieswere investigated using vertical settling cylinders or a centrifuge. Zone settling was divided in dilute and intermediate modes depending on whether or not the aggregates were in contact and formed a network structure, and concentrate mode of intimate contact settling due to compression was followed. Although the higher initial height of slurry brought on the higher settling rate in the intermediate, it was found that in the region of rather lower initial height the settling rate became solely a function ofconcentration.Comparing experimental values with known analytical derivations, Richardson and Zaki's equation modified by Michaels and Roberts' equation were effective for the dilute and the concentrate, respectively. And also, Michaels method of capillary model was impressive for the intermediate in which the settling rate was depended on both of concentration and initial height. It was demonstrated that when the initial height was low enough to correlate the settling rate only with concentration, settling rate of the intermediate was well coincided with predicted rate appling Kynch's theory on the dilute. Zone settling rates of rather wide range of concentration and initial height were able to be summerized as expressed in a figure.If the initial composition is uniform the slurry concentration in centrifuge is independent of radius, but decreases everywhere within the suspension at the same rate with respect to time. Centrifugal settling rate was calculated on the basis of that it was able to be calculated from the settling rate in a gravitational field, field acceleration and slurry concentration accounting for the changingconcentration. Equilibrium thickness of centrifugal sediment waspredicted in the manner which took into account the relationshipbetween compressive pressure and porosity in the sediment. Usingthese values led to good correlation of experimental and calculated sedimentation process in centrifuge over the range of this investigation.

著者

宮崎 真理子 山本 多恵 渡邊 順子 藤倉 恵美 吉田 舞 秋保 真穂 良知 弘務 福士 太郎

出版者

一般社団法人 日本透析医学会

雑誌

日本透析医学会雑誌 (ISSN:13403451)

巻号頁・発行日

vol.51, no.1, pp.62-64, 2018

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<p>東北大学病院の血液浄化療法部は病院の中央特殊診療部門に属し, 腎臓学, 透析医学, 泌尿器科学をサブスペシャリティとする医師が, 全診療科の血液浄化療法に横断的に関わっている. 診療科の入院患者を対象に透析装置12台, 持続血液濾過透析10台の規模で, 直接の担当医ではないため, 緊急呼び出しは少ない. 結果的に女性医師が育児中も継続可能な環境を提供できる. しかし, 臓器別診療科が高度医療を実践する中で, 血液浄化療法のプロフェッショナルとして認知されるためには, 集中治療医学, 急性血液浄化, アフェレシスなどの領域の知識をもち, 各科の難治性疾患病態, 治療内容を理解し, 適切なタイミングで最適の血液浄化療法はいかなるものかを判断するなど, 常に研鑽が必要である. 「直面する現実の制約を理解する職場」 である必要はあるが, 「女性が働きやすい職場」 で満足することなく, ダイバーシティーを推進する先進的組織を目指す取り組みを考える.</p>

著者

小倉 孝誠

出版者

慶應義塾大学藝文学会

雑誌

芸文研究 (ISSN:04351630)

巻号頁・発行日

no.89, pp.1-17, 2005

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立仙順朗教授退任記念論文集現代の病いの風景エイズの意味づけドミニック・フェルナンデス『除け者の栄光』(一九八七)エルヴェ・ギベールとエイズの表象

著者

長岡 優 西田 究 青木 陽介 武尾 実 大倉 敬宏 吉川 慎

出版者

特定非営利活動法人 日本火山学会

雑誌

日本火山学会講演予稿集

巻号頁・発行日

vol.2017, pp.88-88, 2017

著者

倉田 賀世

出版者

日本評論社

雑誌

法律時報 (ISSN:03873420)

巻号頁・発行日

vol.89, no.9, pp.46-52, 2017-08

著者

山田 勉 末次 美知夫 有吉 元司 奥井 年 小柳 賢徳 朝倉 一 与那城 洋子 山田 芳郎 喜多 芳明 九州大学附属図書館医学分館

出版者

The Japan Medical Library Association

雑誌

医学図書館 (ISSN:04452429)

巻号頁・発行日

vol.38, no.3, pp.223-259, 1991

著者

鎌倉 芳信

出版者

日本文学協会

雑誌

日本文学 (ISSN:03869903)

巻号頁・発行日

vol.39, no.4, pp.12-21, 1990-04-10 (Released:2017-08-01)

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泡鳴が北海道放浪から帰って知り合い、同棲、結婚する遠藤清子は、同棲直後、青踏運動に参加する。泡鳴は清子の手前、彼女の行動を理解し、青踏運動も支援するが、実際には泡鳴は、「新しい女」達の考えにはほど遠い旧思想の持ち主であった。そのため、この時書かれた「毒薬を飲む女」は、表面を新しい思想で装った自己に遠慮して、本当の自分の姿を明らかにしない、いわゆる<追求不尽>の作品として終わっている。