著者
小森 日菜子 小林 さやか 川田 伸一郎
出版者
独立行政法人 国立科学博物館
雑誌
国立科学博物館研究報告A類(動物学) (ISSN:18819052)
巻号頁・発行日
vol.50, no.1, pp.33-48, 2024-02-22 (Released:2024-02-22)
参考文献数
65

A mounted skin of unknown species belonging to genus Canis deposited in the National Museum of Nature and Science, Tokyo (NSMT) is certificated morphologically and bibliographically. The specimen label is described as ‘a kind of Yamainu’ and M831 of the Tokyo Imperial Household Museum collection, while the specimen catalog says that M831 was derived from an individual kept at Ueno Zoo and that it was disposed of after. This specimen seemed to be confused with another one. So, we examined the morphological characteristics of this specimen and traced the history of Canis sp. specimens of the Tokyo Imperial Household Museum collection and Canis sp. kept at Ueno Zoo. As a result, measurements of this mounted skin were reasonable to be within the range of specimens previously identified as Japanese wolves. We confirmed that this specimen is correctly labeled as M831. This specimen M831 was considered to be one of two wolves that arrived at Ueno Zoo from Iwate Prefecture, Japan, in 1888. Therefore, it is thought that this specimen is a Japanese wolf. This study may have revealed a new Japanese wolf skin specimen that had previously been overlooked.
著者
江口 英利 三森 功士
出版者
九州大学
雑誌
基盤研究(C)
巻号頁・発行日
2016-04-01

本研究はイベルメクチンがYAP1の阻害により胃癌に対して抗腫瘍効果を有すかを明らかにする。イベルメクチンを胃癌細胞および胃癌マウスモデルに投与すると腫瘍増殖抑制効果を認めた。またその機序として、Hippo経路の転写因子であるYAP1は細胞増殖関連遺伝子であるCTGFを誘導するが、イベルメクチン感受性胃癌細胞においてイベルメクチンの投与によりYAP1 mRNA、核内YAP1蛋白が減少し、CTGFの発現が減弱した。つまり、イベルメクチンはHippo経路のYAP1発現を抑制することにより細胞増殖を抑制しうる。また胃癌症例において、YAP1高発現群は予後不良であった。
著者
髙岡 良成 森本 直樹 三浦 光一 野本 弘章 渡邊 俊司 津久井 舞未子 前田 浩史 五家 里栄 礒田 憲夫 室井 一男 山本 博徳
出版者
一般社団法人 日本肝臓学会
雑誌
肝臓 (ISSN:04514203)
巻号頁・発行日
vol.61, no.1, pp.11-17, 2020-01-01 (Released:2019-12-27)
参考文献数
28
被引用文献数
1 2

症例は74歳男性.2018年X月に大動脈弁置換術の際に輸血を施行した.術後2カ月頃から肝機能障害を認め,HEV-IgA抗体およびHEV-RNA陽性(genotype 3b)でE型肝炎と診断した.その後の解析で輸血前のHEV-IgG抗体陽性,HEV-RNA陰性であったことからE型肝炎既感染例と考えられた.また輸血に使用した凍結新鮮血漿からHEV-RNAが検出され,解析できた遺伝子配列が患者由来HEVとほぼ一致したため,輸血によるE型肝炎と判断した.本邦では2017年までに本例を含めると,少なくとも26例の輸血後E型肝炎が発症し,その報告数は増加しつつある.北海道地区では輸血製剤において核酸増幅検査によるHEVスクリーニング検査が行われているが,それ以外の地区では施行されていない.よって全国での核酸増幅検査によるHEVスクリーニングの早期導入が望まれる.
著者
森 義則 水谷 修太郎 園田 孝夫 古山 順一
出版者
社団法人 日本泌尿器科学会
雑誌
日本泌尿器科學會雑誌 (ISSN:00215287)
巻号頁・発行日
vol.60, no.4, pp.279-285, 1969 (Released:2010-07-23)
参考文献数
17
被引用文献数
2 3

Recently we encountered a male bearing a XX sex chromosome constitution. The patient is a 25-year-old unmarried male. He complained of loss of sexual potency. He is 154cm in height and 50Kg in weight. No gynecomastia was noted. There were no webbed neck and no cubitus valgus. The external genitalia appeared normal in size. A small testis measuring 2×1.5×1.5cm was felt in both scrotal sacs. An exploratory laparotomy failed to reveal any female internal sexual organs. No urogenital sinus was detected. Histology of both testes showed no spermatogenesis. The basement membrane of seminiferous tubules showed hyalinization. In interstitial tissue, clusters of Leydig cells were observed.Sex chromatin was positive in cells of buccal mucosa smears. Chromosomal analysis was performed in peripheral blood, skin and testis. The majority of cells are found to contain 46 chromosomes including a pair of apparently normal XX sex chromosomes in these three tissues. It was concluded that, this patient, although phenotype is a male, has normal female karyotype.
著者
前田 雅子 前田 稔彦 松元 加奈 森田 邦彦
出版者
一般社団法人 日本プライマリ・ケア連合学会
雑誌
日本プライマリ・ケア連合学会誌 (ISSN:21852928)
巻号頁・発行日
vol.38, no.4, pp.335-339, 2015 (Released:2015-12-25)
参考文献数
11
被引用文献数
3

目的 : 診療時グラム染色検査の導入が抗菌薬の使用動向に影響を及ぼすかを検討することを目的とした.方法 : グラム染色導入前後での抗菌薬の種類・使用量の動向, 診療経過の動向を後方視的に調査した.結果 : 抗菌薬処方頻度 (100 人当たり) は, マクロライド系は20.9件 (2006年) から3.6件 (2012年) , 第三世代セフェム系は7.9件 (2005年) から2.4件 (2012年) に減少の一方, ペニシリン系は1.6件から3.9件に増加した. それにともなって1人当たりの抗菌薬消費額が約1/5に低下した. 小児急性副鼻腔炎患者50人当たりの抗菌薬不使用患者数は9倍に増加した一方, 治療期間中に抗菌薬2種類以上を処方された患者数は26名から9名に減少し, 治癒に要した日数は約6日間短縮された.結論 : グラム染色導入がよりよい抗菌薬使用につながる取り組みとなる可能性が示唆された. 多施設での研究的取り組みによる評価の必要性が考慮される.
著者
森川 洋
出版者
The Human Geographical Society of Japan
雑誌
人文地理 (ISSN:00187216)
巻号頁・発行日
vol.14, no.5, pp.377-395, 1962-10-28 (Released:2009-04-28)
参考文献数
31
被引用文献数
2 2

The purpose of this article is to classify the characteristics of the distribution of Japanese towns before the industrial revolution. To qualify such towns, the author uses “Kyomhseihyo” (1880), the national statistics on population and products, and limits as town the settlements with over 2, 000 persons, but some fishing villages may be exceptionally contained among them.The author thinks that the distribution of those towns is analogous to that “alten Kulturländer” called by G. Schwarz, which roughly speaking is related to the density of rural population (Fig. 1.) There was a dense net of towns with much urban populatin in coastal and basin regions (densely populated), where there were also large towns like Tokyo (725, 000), Osaka (363, 000), Kyoto (136, 000), Nagoya (117, 000), Kanazawa (108, 000) etc. (Fig. 2 and 3). Of course, the agglomeration of towns and urban population in those days were not in so large scale as in the present day.But the distribution of towns in those days can not be explained by population density only. The ratio of urban population per Kuni, regional division in those days (Fig. 4) and the hierarchical structure of towns were related more closely to scale of regional centres than to economic richness of the areas. For example, the large regional centre Toitori (36, 000) and some small towns (2-3, 000) lay in Inaba-Kuni, so that the ratio of urban population per Kuni was raised (exclusively) by the urban population of Tottori.Most of such regional contres were castle towns in feudal age, and their scale was in proportion to that of territories of “Daimyoes”, feudal lords. The origin of small towns was mosily market towns, coaching towns, and port-towns, which had grown in proportion to regional economic development.Therefore, the distribution of towns in early Meiji-era was related to hitstorical conditions in feudal age everywhere.
著者
小森 めぐみ
出版者
日本社会心理学会
雑誌
社会心理学研究 (ISSN:09161503)
巻号頁・発行日
vol.33, no.3, pp.149-155, 2018-03-25 (Released:2018-03-25)
参考文献数
18

This study attempted to replicate Kamise, Hori, and Okamoto’s (2010) survey on perceived occupational stigma among Japanese workers by conducting a survey with employees in a host club—a male cabaret club—in the Kansai region, Japan, to investigate their perceived occupational stigma, coping strategies, occupational self-esteem, and egalitarian sex-role attitudes. The results showed that host-club employees perceived extreme occupational stigma, where novices, part-time workers, and those with fewer work assignments showed higher levels of perceived stigma. Regarding coping strategies, attribution of discrimination and disengagement were used frequently, while valuing and group identification were used only rarely. Structural equation modeling showed that group identification positively enhanced occupational self-esteem. However, contrary to previous research, individuals who perceived more stereotyping rarely used group identification. Stigma awareness facilitated attribution of discrimination, resulting in lowered occupational self-esteem, and egalitarian sex-role attitude significantly influenced valuing and attribution of discrimination.

37 0 0 0 OA うた日記

著者
森鴎外 著
出版者
春陽堂
巻号頁・発行日
1907
著者
三浦 麻子 小森 政嗣 松村 真宏 前田 和甫
出版者
公益社団法人 日本心理学会
雑誌
心理学研究 (ISSN:00215236)
巻号頁・発行日
vol.86, no.2, pp.102-111, 2015 (Released:2015-06-25)
参考文献数
32
被引用文献数
4 17

In this article, we investigated the expression of emotional responses to the 2011 Great East Japan Earthquake by analyzing the frequency of negative emotional terms in tweets posted on Twitter, one of the most popular social media platforms. We focused on differences in time-series variations and diurnal changes between two kinds of disasters: natural disasters (earthquakes and tsunamis) and nuclear accidents. The number of tweets containing negative emotional responses increased sharply shortly after the first huge earthquake and decreased over time, whereas tweets about nuclear accidents showed no correlation with elapsed time. Expressions of anxiety about natural disasters had a circadian rhythm, with a peak at midnight, whereas expressions of anger about the nuclear accident were highly sensitive to critical events related to the accident. These findings were discussed in terms of similarities and differences compared to earlier studies on emotional responses in social media.
著者
鈴木 恵輔 加藤 晶人 光本 (貝崎) 明日香 沼澤 聡 杉田 栄樹 中村 元保 香月 姿乃 井上 元 柿 佑樹 中島 靖浩 前田 敦雄 森川 健太郎 土肥 謙二
出版者
日本救急医学会関東地方会
雑誌
日本救急医学会関東地方会雑誌 (ISSN:0287301X)
巻号頁・発行日
vol.42, no.2, pp.35-38, 2021-03-31 (Released:2021-03-31)
参考文献数
10

ジフェンヒドラミンは抗ヒスタミン薬であり過量内服により多彩な中毒症状を呈するが, 重症例では最悪死に至ることがある。近年インターネットなどで取り上げられ, 自殺目的での中毒症例の増加が懸念されている。今回, 市販の抗ヒスタミン薬の大量服薬により心肺停止に至った症例を経験したので報告する。17歳女性。公園内で倒れているところを通行人が発見し救急要請。ジフェンヒドラミン12,000mg内服したと推定され, 救急隊現着時には心肺停止状態であった。当院救命救急センター来院時も心肺停止状態であり蘇生することはできず永眠となった。後日ジフェンヒドラミンの血中濃度を測定したところ, 来院時の血中濃度は26.73µg/mLと過去に報告されている心肺停止症例と比較しても高値であった。OTC医薬品として簡単に手に入る薬剤での死亡症例のため治療側も販売側も十分に注意していく必要があると考えられる。
著者
森重 敏子
出版者
The Japanese Society for Hygiene
雑誌
日本衛生学雑誌 (ISSN:00215082)
巻号頁・発行日
vol.23, no.2, pp.219-224, 1968-06-30 (Released:2009-09-30)
参考文献数
9

Since 1961, the area of Fukuoka City as well as other areas of Japan has been polluted by radioactive fallout brought about mainly by the fission and fusion bomb test in Red China. In this area periodic measurements of radioactive fallout deposits were measured on the Standard Diet proposed by the Department of Welfare in Japan. In addition measurements were taken on several kind of vegetables (well washed), dairies, row milk, short necked clam and the Tapes Philippiarium. Results obtained from these surveys are as follows:1) The level of radioactivity of the fallout deposited on the vegetables resulting from the 1st, 2nd and 5th tests of the atmic bomb in Red China increased remarkably from 10 times to 200. This is much higher than that of the usual amount of fallout on vegetables. Especially noted was that a somewhat higher level of radioactivity than normal level was maintained for several months during the time of the 5th test.2) Increase and decrease of radioactivity on seasonal vegetables fluctuated approximately with those of the radioactive fallout deposited on the vegetables. The level of radioactivity on the vegetables increased sharply from normal level measured on them after the test.3) Although radioactivity level on the vegetables had increased from the usual level, the level measured on dairy and row milk did not fluctuate remarkably during the test.4) The degree of radioactivity in the short necked clam with shell removed fluctuated considerably more than the usual level, eg. 0.5 to 38.9. However there was no evidence of increase of radioactivity in the clam after the test.5) The degree of radioactivity in the Standard Diet in Japan increased slightly in 1967 compared to that of former years.6) Giant particles of radioactive fallout precipitated on spinach just after the fifth test of the Atomic Bomb in Red China were discovered by means of autoradiography. Removal of these particles could not be completely successfully accomplished with a soapless soap.
著者
田浦 太志 正山 祥生 森元 聡
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.45, no.4, pp.178-184, 2005 (Released:2005-07-25)
参考文献数
10
被引用文献数
2 2

Cannabis sativa produces novel secondary metabolites called cannabinoids. Among them, Δ1-tetrahydrocannabinol (THC), the psychoactive component of this plant, has attracted a great deal of attention, because this cannabinoid is shown to exert a variety of therapeutic activities such as the relief of nausea caused by cancer chemotherapy. To reveal the mechanism of THC formation in Cannabis sativa, we attempted biosynthetic studies. Consequently, we established that Δ1-tetrahydrocannabinolic acid (THCA), the precursor of THC, is derived from cannabigerolic acid and that this reaction is catalyzed by the novel oxidocyclase, THCA synthase. Here, we show the biochemical and structural properties of THCA synthase.
著者
小森 哲志 鍵村 達夫
出版者
一般社団法人 日本薬剤疫学会
雑誌
薬剤疫学 (ISSN:13420445)
巻号頁・発行日
vol.18, no.2, pp.95-111, 2014-03-25 (Released:2014-04-30)
参考文献数
11
被引用文献数
1

薬剤疫学研究において,薬剤への曝露と有害事象発生との因果関係を検討するための代表的な手法として,コホート研究とケース・コントロール研究という2つの研究手法がある.いずれの研究の背景にも,疾病が発生してくる元となるリスク集団の存在を想定することができる.コホート研究では,リスク集団のなかに研究コホートを設定し,それを直接調べようとする.一方,ケース・コントロール研究では,同じ研究コホートからコントロールをサンプリングすることにより,その一部を調べようとする.このように考えることで,コホート研究とケース・コントロール研究を統一的な視点から理解することができる.ここでは,コントロールをサンプリングする方法の例をいくつか示し,そのサンプリング方法によって得られる曝露効果の指標について概観した.(薬剤疫学 2013; 18(2): 95-111)