著者

西田 修 小倉 裕司 井上 茂亮 射場 敏明 今泉 均 江木 盛時 垣花 泰之 久志本 成樹 小谷 穣治 貞広 智仁 志馬 伸朗 中川 聡 中田 孝明 布宮 伸 林 淑朗 藤島 清太郎 升田 好樹 松嶋 麻子 松田 直之 織田 成人 田中 裕 日本版敗血症診療ガイドライン2016作成特別委員会

出版者

一般社団法人 日本集中治療医学会

雑誌

日本集中治療医学会雑誌 (ISSN:13407988)

巻号頁・発行日

pp.24S0009, (Released:2016-12-26)

著者

岡本 幸太 神元 有紀 北村 亜紗 森下 みどり 阪本 美登 高倉 翔 二井 理文 渡邉 純子 高山 恵理奈 村林 奈緒 大里 和広 池田 智明

出版者

日本産科婦人科学会

雑誌

日本産科婦人科學會雜誌

巻号頁・発行日

vol.68, no.2, 2016

著者

清水 健太郎 小倉 裕司 中川 雄公 松本 直也 鍬方 安行 霜田 求 田中 裕 杉本 壽

出版者

一般社団法人 日本救急医学会

雑誌

日本救急医学会雑誌 (ISSN:0915924X)

巻号頁・発行日

vol.21, no.4, pp.185-190, 2010

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生体肝移植のドナーとしての意思決定に対して家族間で軋轢が生じ,臨床倫理問題について検討が必要であった症例を経験したので報告する。症例は40代,女性。薬剤性肝障害で意識障害が進行するため当院へ転院となった。来院時,肝性脳症III度,PT 19%,総ビリルビン濃度26.6mg/dlであった。集中治療を行ったが患者の意識状態が悪化したため,家族に最後の治療手段として生体肝移植の選択肢を提示した。ドナー候補は離婚した父親だけであった。父親は移植ドナーを希望したが,内縁の妻は手術に反対であった。手術までの過程で家族関係は急激に悪化したが,最終的には医学倫理委員会でドナーの同意権の妥当性を確認した上で,父親の意思を尊重して手術が行われた。患者は,肝不全,敗血症を合併して数カ月後に死亡した。意識障害を伴う難治性の急性肝不全症例では,最後の治療手段として生体肝移植を患者家族に提示した時点で,ドナー候補は,「自由な意思決定」が望まれるが,「時間的制約」の中で心理的圧力を受ける。ドナー候補の意思決定のいかんに関わらず,ドナー候補・家族に対する心理的な支援体制が必要である。

著者

佐藤 樹典 小倉 暢之 入江 徹

出版者

日本建築学会

雑誌

日本建築学会計画系論文集 (ISSN:13404210)

巻号頁・発行日

vol.84, no.755, pp.269-275, 2019

被引用文献数

1

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&nbsp;This study aims to consider the value and possibility of a design method that integrates regional design and environmental design, through the five proposals in the competition for the new House of Parliament.<br>&nbsp;The major argument was how to integrate the modernism style and Thai regional design and, at the same time, the architectural ideology for responding to environmental and economic issues pervaded in Thailand.<br>&nbsp;The 5 proposals that made the final judgment stage of the design competition for the new House of Parliament suggest an aspect of a Thai architectural image that responds to demands from a society and an age. All 5 of the final proposals decide their form originating from regional design, but the judgment uses a system that also evaluates their environmental efficiencies. Thus, ways of suggesting national identity as well as improving environmental performance were expected, namely the way of integrating regional design and environmental design.<br>&nbsp;The environmental designs affecting the forms of the 5 proposals respond to the rating credits of LEED2009, which are related to heat island effects and energy efficiency. Especially, reducing heat load is an essential factor among the 5 proposals, not only to be recognized by LEED but also to clear the OTTV&middot;RTTV rating system that has operated in Thailand for many years.<br>&nbsp;And it is clarified that integrating methods are classified into two types according with types of environmental design, the &ldquo;Supplemental environmental design: incorporate supplementary environmental design into form based on regional design,&rdquo; and the &ldquo;Interactive environmental design: both regional design and environmental design affect deeply for the process of deciding the form.&rdquo; Furthermore, these integrating methods are classified into two types of expression, the &ldquo;Similized regional design&rdquo; and the &ldquo;Metaphorical regional design&rdquo;.<br>&nbsp;Through this design competition, it is suggested that architectural compositions that integrate regional design and environmental design are formulated in this age, in which both factors are demanded. These methods are also adaptable for other building types as possibilities for contemporary architecture observing through the tendency of architects in the age placing a high priority on environmental performance considering the effects of the environmental rating system on architectural compositions.

著者

鈴木 宏哉 田中 茂穂 城所 哲宏 高倉 実 喜屋武 享 安部 孝文 田中 真紀 田中 千晶

出版者

一般社団法人日本体力医学会

雑誌

体力科学 (ISSN:0039906X)

巻号頁・発行日

vol.68, no.1, pp.59, 2019

著者

竹内 竜也 幾留 沙智 森 司朗 石倉 忠夫 中本 浩揮

出版者

日本スポーツ心理学会

雑誌

スポーツ心理学研究 (ISSN:03887014)

巻号頁・発行日

2019

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The purpose of the present study was to clarify the influence of individual differences in the automatic imitation tendency on efficiency in observational motor learning. First, twenty participants each having higher or lower automatic imitation tendency were chosen from 210 according to their reaction times in the imitation-inhibition task indicating automatic imitation tendency. Each group performed the observational motor learning that alternately repeated action observation and execution. The participants in each group were further divided into two groups: appropriate model group that observed a model performing the task correctly and inappropriate model group that observed a model performing the task incorrectly. Results revealed that when participants observed the appropriate model, people with higher imitation tendency demonstrated better task performance in the acquisition phase and retention test than did those with a lower imitation tendency. On the other hand, when the participants observed the inappropriate model, the higher imitation tendency group exhibited lower performance in the acquisition phase and the retention test than did the lower imitation tendency group. Additionally, the higher tendency group was more influenced by difference between the appropriate and inappropriate model than was the lower tendency group in learning efficiency. These findings indicate that individual differences in the automatic imitation tendency affect the learning efficiency and retention in observational motor learning. Further, automatic imitation is likely to have a strong influence on observational motor learning regardless of the learnersʼ intention.

著者

佐藤 朝美 椿本 弥生 朝倉 民枝

出版者

日本教育工学会

雑誌

日本教育工学会論文誌 (ISSN:13498290)

巻号頁・発行日

vol.37, no.3, pp.229-239, 2013

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子どものNarrative Skillの発達には,家族としてのNarrative(Family Narrative:FN)が重要な役割を果たすという.親自身が家族としての経験の意味づけを家族内コミュニケーションにおいて行っていくことが,子どものNarrative Skillにおけるストーリーの意味づけの行為に影響する.本研究では,Family Narrative Consortiumが作成した指標を手がかりに,Digital Storytellingを活用した家族内コミュニケーションの活動をデザインし,FN向上の支援を行った.実証実験の結果,活動により,FNの向上が観察された.一貫性とインタラクションが特に向上した家族には,相手の発言を受け止め,意見を出し合いながらテーマに対する家族の意味を構築している様子がみられた.また,この活動自体の家族にとっての意味を考え,ワークシートの記述を詳細に行っていた.

著者

高倉 新喜

出版者

山形大学

雑誌

山形大学法政論叢

巻号頁・発行日

vol.54, pp.59-72, 2012-09-30

著者

浅野 豊美 土屋 礼子 青山 瑠妙 米倉 律 小菅 信子 武井 彩佳 成田 龍一 平川 幸子 丁 智恵 李 海燕 中山 大将 木村 幹 加藤 恵美 金 泰植 小林 聡明

出版者

早稲田大学

雑誌

新学術領域研究(研究領域提案型)

巻号頁・発行日

2017-06-30

著者

田畑 肇 坂本 和仁 門倉 豪臣 蓑毛 博文 瀬戸山 孔三郎 谷口 康徳 福岡 香織 北村 知宏 所 和美 洲加本 孝幸 宮前 陽一

出版者

日本毒性学会

雑誌

日本トキシコロジー学会学術年会 第38回日本トキシコロジー学会学術年会

巻号頁・発行日

pp.20139, 2011 (Released:2011-08-11)

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Fluoride is a natural component of the biosphere, the 13th most abundant element in the earth’s crust. Fluoride has been known to play an important role in mineralization of bone and teeth, and can be therapeutically used at low doses for dental care and prevention or at high doses for the treatment of osteoporosis. Particularly in cases of the development of a fluoride compound as a proprietary drug, liberated fluoride ions may bring the risk of causing dental or skeletal fluorosis in animals treated with high doses of fluoride drugs in toxicity studies. However, there are limited data on changes in fluoride levels in hard tissues of the body over animal life spans. In the present work, we obtained plasma, teeth (incisors and molars), bones (alveolar, femur and tibia) and nails from SD rats at 8, 11, 20, 33, 46, 59 and 72 weeks of age and determined fluoride levels individually. Fluoride accumulated time-dependently in bones, nails and molars in a similar manner, with fluoride levels increasing 2-3 folds from 8 to 72 weeks of age. In contrast, fluoride levels in plasma and incisors, which grow continuously in living rats, showed almost constant values. These data can be used not only as a historical database for the effective evaluation of data from toxicology studies, but also as a contribution to biological characterization of SD rats.

著者

相山 律男 永井 久子 沢田 誠吾 横倉 輝男 糸川 秀治 中西 守

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.10, pp.2810-2813, 1992-10-25 (Released:2008-03-31)

参考文献数

16

被引用文献数

12 16

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Self-association of irinotecan hydrochloride (CTP-11) in an aqueous solution was studied using UV, circular dichroism (CD), 1H-NMR and the quasi-elastic light scattering (QLS) method. The UV spectra showed a hypochromic effect in the aqueous solution. In the CD spectra, typically positive Davydov splitting was observed and the Δε value was reduced sigmoidally when the concentraion of CTP-11 was decreased. In the 1H-NMR, the aromatic signals of higher concentration shifted to a diamagnetic direction compared with those of lower concentration. These observations suggested that CPT-11 molecules are present as monomer in the lower concentration, and the self-association with positive helicity occurs by vertical stacking more than 10 μM of concentration. Its molecules form complete aggregates at more than 2 mM of the concentration. Results of QLS which coincided in the prediction of partition coefficient experiments suggested that CPT-11 molecules formed dimer under the condition. By the regression analysis of CD spectral data, the equilibrium constant for the self-association was calculated to be 2.41×10-4 M-1.

著者

沢田 誠吾 八重樫 隆 古田 富雄 横倉 輝男 宮坂 貞

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.41, no.2, pp.310-313, 1993-02-15 (Released:2008-03-31)

参考文献数

22

被引用文献数

13 20

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7-Ethylcamptothecin (1d), a model which does not have any site on the A-ring for further modification was converted into water-soluble derivatives by opening the E-ring lactone. 1d was heated in N, N-dimethylenediamine to yield amide 2a, and this was then acylated to furnish 3a-q, which were soluble in water as their HCl salts. The propionyl (3b), butyryl (3c) and methylthiopropionyl (3h) derivatives showed higher activity than the sodium salt of 1d. The acyl group makes the derivatives more lipophilic, and ease of hydrolysis of amide 2a to 1d is thought to be necessary for significant activity.

著者

八重樫 隆 沢田 誠吾 古田 富雄 横倉 輝男 山口 健太郎 宮坂 貞

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.41, no.5, pp.971-974, 1993-05-15 (Released:2008-03-31)

参考文献数

10

被引用文献数

6 10

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The structure of the N-amino pyridone (4a) obtained by the reaction of camptothecin (1a) with hydrazine was determined by X-ray crystallography. A mixture of 7-etylcamptothecin (1b) and hydrazine hydrate was stirred at room temperature, and the hydrazide (2b) was isolated as its diacetate 2c. Treatment of the 17-O-acetyl amide (5a) with hydrazine gave 1b (74% yield) and the N-amino lactam 6 (11% yield). Compounds with bulky acyl groups, 5c-e, gave 6 in modest yields. The N-amino lactam 6 was smoothly dehydrated into the pyridone 4d by refluxing in hydrazine hydrate.

著者

八重樫 隆 野方 健一郎 沢田 誠吾 古田 富雄 横倉 輝男 宮坂 貞

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.1, pp.131-135, 1992-01-25 (Released:2008-03-31)

参考文献数

19

被引用文献数

9 10

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Water-soluble derivatives having the lactone ring intact were synthesized starting from 7-ethyl-10-hydroxycamptothecin (1). Glycosides (2) of the phenolic hydroxyl group of 1 were obtained by reaction with acetylated α-bromosugars in acetone or aqueous acetone in the presence of potassium carbonate, followed by deprotection.Phosphates (3) were prepared by reaction of 1 with phosphoryl chloride in pyridine or with dibenzylchlorophosphoridate.Sulfates (4) were obtained by reaction of 1 with sulfur trioxide-pyridine complex in the presence of a tertiary amine.The organic ammonium salts of monophosphate (3p) and sulfates (4a and 4b) showed significant activity against L1210 in vivo.

著者

沢田 誠吾 松岡 俊一 野方 健一郎 永田 洋 古田 富雄 横倉 輝男 宮坂 貞

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.39, no.12, pp.3183-3188, 1991-12-25 (Released:2008-03-31)

参考文献数

28

被引用文献数

39 57

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20(S)-Camptothecin derivatives having nitro, amino, chloro, bromo, hydroxyl and methoxyl groups in the A-ring were synthesized. B-Ring hydrogenated camptothecin (2a) was converted into 10-hydroxycamptothecin (6e) by treatment with lead tetraacetate in trifluoroacetic acid. 10-Substituted derivatives (6) were obtained by a photoreaction of N-oxides (9). The cytotoxicity o the A-ring modified camptothecins was evaluated against KB cells in vitro and leukemia L1210 in mice. 7-Ethyl-10-hydroxycamptothecin (6i) was identified as a potential derivative for further modification.

著者

沢田 誠吾 岡島 悟 相山 律男 野方 健一郎 古田 富雄 横倉 輝雄 杉野 栄一 山口 健太郎 宮坂 貞

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.39, no.6, pp.1446-1454, 1991-06-25 (Released:2008-03-31)

参考文献数

18

被引用文献数

144 197

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Nevel 36 derivatives (6), bonding the phenolic hydroxyl group of 7-ethyl-10-hydroxycamptothecin (4) with diamines through a monocarbamate linkage, were synthesized and their antitumor activity was evaluated in vivo. The derivatives were soluble in water as their HC1 salts wiht the E lactone ring intact and exhibited significant antitumor activity. One of the derivatives, 6-27 showed excellent activity against L1210 leukemia and other murine tumors.The structure of its hydrochloride trihydrate (CPT-11) was determined by spectroscopic and crystallographic methods.

著者

鈴木 真之 浜本 真規子 久利 恭士 上杉 春香 小倉 正義 能勢 有希

出版者

名古屋大学

雑誌

名古屋大学大学院教育発達科学研究科紀要. 心理発達科学 (ISSN:13461729)

巻号頁・発行日

vol.52, pp.183-197, 2005

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It has been ten years since school counseling was installed into Japanese public schools. Their activities were, however, being restricted because of the several limitations. On this condition, primary protection should be focused on for school counselors to be more effective. For the first, in this article, we reviewed conventional activities that had already been conducted in school setting and that could be seen to have the characteristics of primary protection, respectively each for students, families and teachers. Secondary, we pointed out that these programs were not against the conventional Japanese education system, rather the ones that would help it. Thereafter, some of the primary protection programs that had not been prevailed yet, were introduced. Finally, in discussion, we indicated it important for school counselors to give teachers an idea of primary protection and suggested the way to install those programs into current Japanese educational setting.国立情報学研究所で電子化したコンテンツを使用している。

著者

沢田 誠吾 野方 健一郎 古田 富雄 横倉 輝男 宮坂 貞

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.39, no.10, pp.2574-2580, 1991-10-25 (Released:2008-03-31)

参考文献数

14

被引用文献数

44 56

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A radical substitution reaction of 20(S)-camptothecin (1) with methanol furnished 7-hydroxymethylcamptothecin (2). Reaction of 1 with primary alcohols higher than methanol gave 7-alkylcamptothecins (4), of which alkyl groups were one carbon less than the alcohols used and also 7-hydroxyalkylcamptothecins (5). For the preparation of 7-alkylcamptothecin (4), aldehydes were used as a radical source and several alkylated derivatives were synthesized. 7-Acyloxymethyl derivatives (6), 7-carbaldehyde (7), iminomethyl derivatives (10), acid (11), esters (12) and amides (13) were synthesized starting from 2. 7-Ethyl-(4b) and 7-propylcamptothecin (4c), acyloxymethyl compounds 6a, 6c and ethyl ester (12b) exhibited higher antitumor activity than 1 against L1210 in mice.

著者

倉林 秀男

出版者

獨協大学外国語学部交流文化学科

雑誌

Encounters : 獨協大学外国語学部交流文化学科紀要 = Encounters (ISSN:1884801X)

巻号頁・発行日

no.4, pp.83-98, 2016-03

著者

奥田 稔 高坂 知節 三宅 浩郷 原田 康夫 石川 哮 犬山 征夫 間口 四郎 新川 秀一 池野 敬一 松原 篤 稲村 直樹 中林 成一郎 後藤 了 小野寺 亮 遠藤 里見 亀井 民雄 室井 昌彦 馬場 廣太郎 島田 均 舩坂 宗太郎 大橋 伸也 鄭 正舟 小澤 実佳 八木 聰明 大久保 公裕 後藤 穣 服部 康夫 上野 則之 柏戸 泉 大塚 博邦 山口 潤 佃 守 池間 陽子 坂井 真 新川 敦 小林 良弘 佐藤 むつみ 山崎 充代 藤井 一省 福里 博 寺田 多恵 小川 裕 加賀 達美 渡辺 行雄 中川 肇 島 岳彦 齋藤 等 森 繁人 村上 嘉彦 久松 建一 岩田 重信 井畑 克朗 坂倉 康夫 鵜飼 幸太郎 竹内 万彦 増田 佐和子 村上 泰 竹中 洋 松永 喬 上田 隆志 天津 睦郎 石田 春彦 生駒 尚秋 鈴木 健男 涌谷 忠雄 宮國 泰明 夜陣 紘治 森 直樹 田頭 宣治 宮脇 浩紀 青木 正則 小林 優子 高橋 正紘 沖中 芳彦 遠藤 史郎 池田 卓生 関谷 透 奥園 達也 進 武幹 前山 忠嗣 恒冨 今日子 増山 敬祐 浅井 栄敏 土生 健二郎 中崎 孝志 吹上 忠祐 角田 憲昭 渡辺 隆 野口 聡 隈上 秀伯 吉見 龍一郎 茂木 五郎 鈴木 正志 大橋 和史

出版者

耳鼻と臨床会

雑誌

耳鼻と臨床 (ISSN:04477227)

巻号頁・発行日

vol.42, no.5, pp.633-658, 1996-09-20 (Released:2013-05-10)

参考文献数

21

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通年性アレルギー性鼻炎患者211例を対象に, KW-467910mg/日 (KW群) の有効性, 安全性および有用性をoxatomide 60mg/日 (OX群) を対照薬として多施設二重盲検群間比較試験により検討した.最終全般改善度の「改善」以上は, KW群61-6%, OX群57.6%で, 両群間に有意差は認められなかつたが, 同等性の検証を行った結果, KW群はOX群と比較して同等ないしそれ以上と考えられた. 概括安全度の「安全性に問題なし」と評価された症例は, KW群68.0%, OX群61.4%で, 両群間に有意差は認められなかった. 主な副作用症状は両群とも眠気であった. 有用度の「有用」以上は, KW群54.9%, OX群50.5%であり両群間に有意差はなかったが, KW群の方がやや有用率が高かった.以上の成績より, KW-4679は通年性アレルギー性鼻炎に対して, 臨床的に有用性の高い薬剤であると考えられた.